phosphatase

Genaera to Present Preclinical Data on Trodusquemine for the Treatment of Obesity at the American Diabetes Association 67th Scientific Sessions

...irst highly selective inhibitor of proteintyrosine phosphatase 1B (PTP-1B). PTP-1B is central to controllingthe function of both the leptin and insulin pathways. By inhibitingPTP-1B, MSI-1436 is expected to decrease appetite and normalizeblood sugar. Trodusquemine has produced consistent, sustainableweight loss ...

Hana Biosciences Presents Data On Two Programs At the American Society of Clinical Oncology Annual Meeting

...tor Receptor (EGFR) signaling pathway byinhibiting phosphatase activity. EGFR inhibitors or EGFRIs arecurrently used to treat non-small cell lung cancer, pancreatic,colorectal, and head & neck cancer. Approximately seventy-fivepercent of patients taking EGFRIs develop an associated skin rash.Loss of EGFR sig...

The Eloxatin-Based Regimen (FOLFOX4) Significantly Improved Progression Free Survival When Given Before and After Surgery in Patients With Resectable Liver Metastases From Colorectal Cancer

...udy by increase in transaminases and alkaline phosphatase was observed more commonly in the Eloxatin(R) combination arm. The incidence of increased bilirubin was similar on both arms. Changes noted on liver biopsies include: peliosis, nodular regenerative hyperplasia or sinusoidal alterations...

Lilly Studies Try to Shed Light on Impact of Race on Lung Cancer Treatment

...creatic cancer were neutropenia(24%-26%); alkaline phosphatase elevation (16%-20%); AST elevation(12%-17%); nausea/vomiting (12%-13%); ALT elevation (10%-11%);anemia (10%); leukopenia (9%-10%); thrombocytopenia (8%-10%);bilirubin elevation (4%-8%); and pain (2%-7%). The most commonadverse events (all grades) wer...

Data to be Presented at ASCO 2007 Highlights sanofi-aventis Commitment to Cancer Care and Research

...dy by increase in transaminases and alkaline phosphatase was observed more commonly in the Eloxatin(R) combination arm. The incidence of increased bilirubin was similar on both arms. Changes noted on liver biopsies include: peliosis, nodular regenerative hyperplasia or sinusoidal alterati...