peptide

New Assays to Detect Disseminated Fungal Infections

...e that cleaves p -nitroaniline from a chromogenic peptide substrate. This in turn allows photometric readout. The entire test can be carried out with standard laboratory equipment. A related assay, Glucatell, is available for non-diagnostic purposes, for example, to test for fungal contamination in build...

Pharmexa A/S (DK) - Pharmexa presents data from influenza program

...tis and malaria. Its leading programs areGV1001, a peptide vaccine that has entered phase III trials inpancreatic cancer and phase II trials in liver cancer, and HIV andhepatitis vaccines in phase I/II. Collaborative agreements includeH. Lundbeck, Innogenetics, ImmunoVaccine Technologies and BavarianNordic. ...

ConjuChem Biotechnologies Reports PC-DAC:Exendin-4 Albumin Conjugate Data Presented at American Diabetes Association Annual Meeting

...lucagon-like peptide-1 (GLP-1) is aninsulinotropic peptide and an agonist for the GLP-1 receptor.Exendin-4 de...tide conjugate has a much longer half-lifethan the peptide alone. The product is a highly soluble liquidformulation that is injectable in a small volume with a...

Modigene Announces Successful Completion of Pharmacokinetic & Pharmacodynamic Pre-Clinical Experiments for Proprietary Long-Acting Human Growth Hormone, Long-acting Interferon Beta and Long-acting Erythropoietin

...nt of a long-acting version of GLP-1,a therapeutic peptide that is prescribed for diabetes type IIpatients, and is currently injected twice daily, and will continueto apply the technology to several other key blockbustertherapeutic proteins." Modigene's technology was discovered by researchers atWashington ...

New Flu Vaccine from PepTcell Could Provide Immunity Against All Strains of Influenza Virus

... in vitro tests. Thisexperiment confirmed that the peptide sequences in Flu-V are highlyconserved across strains, and that these peptides are naturallypresented on the surface of flu-infected cells, and therefore canbe recognised by the immune system. When the immunised mice were subsequently challenged wit...

Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure Reduction During Important Early Morning Period When Most Adverse Cardiovascular Events Occur

...e against angiotensinII. Angiotensin II is a small peptide in the body and part of theso-called renin-angiotensin system (RAS), an important regulator ofblood pressure. Angiotensin II causes blood vessels tonarrow, resulting in increased blood pressure. In a phase IIa clinicaltrial, vaccination with CYT006-A...

New Flu Vaccine From PepTcell Could Provide Immunity Against All Strains of Influenza Virus

... in vitro tests. Thisexperiment confirmed that the peptide sequences in Flu-V are highlyconserved across strains, and that these peptides are naturallypresented on the surface of flu-infected cells, and therefore canbe recognised by the immune system. When the immunised mice were subsequently challenged wit...

Ambrilia Highlights Encouraging Data for its HIV Integrase Inhibitor Program and Recent Developments at Annual Meeting

...treotide and Goserelin), ananti-cancer therapeutic peptide (PCK3145), a tumor andtumor-vasculature targeting (TVT) technology platform, as well asother anti-virals and immunomodulators. Exclusive worldwide rightsto PPL-100 and its related compounds have been granted to Merck& Co., Inc. in return for a $U...

Orchestra Therapeutics Announces New Phase II Clinical Data on NeuroVax Demonstrating Marked Expansion of Regulatory T Cell Populations in Patients With Multiple Sclerosis

...rchestra Therapeutics is investigatinghow this TCR peptide vaccine technology, pioneered withNeuroVax(TM), could be leveraged to develop similar therapeuticvaccines for other autoimmune diseases such as rheumatoid arthritis(RA) and psoriasis." In MS, a specific subset of a patient's own white blood cells,pa...

Merck's Investigational Migraine Treatment MK-0974 Significantly Improved Migraine Pain on Several Efficacy Measures in a Phase II Study

...74, aninvestigational oral calcitonin gene-related peptide (CGRP)receptor antagonist, significantly improved migraine pain relieftwo hours after dosing compared to placebo, and the relief wassustained through 24 hours. MK-0974 was generally well tolerated inthe study. Responses specific to other measures, su...

Immunomedics Reports Initial Clinical Results With Hpam4 For Pancreatic Cancer Therapy

...ed that pretargeting with TF10and Y-90 labeled HSG peptide can effectively cause the completeregression of human pancreatic cancer in mice at doses well belowthe maximum tolerated level. The other poster was on TF4 for the pretargeting of B-celllymphoma. Constructed with two sites that target the CD20 antig...

Data Demonstrated Metastatic Melanoma Response to Investigational Immunotherapy Ipilimumab

...rapy (i.e.,dacarbazine), interleukin-2, or a gp100 peptide vaccine. Theresults of this analysis also indicate...mbination withdacarbazine, interleukin-2, or gp100 peptide vaccine. The primaryendpoint of this analysis was to examine the kinetics of responseto ipilimumab i...

Pharmexa A/S (DK) - Long lasting immune response and survival to RAS vaccine

... Trond Buanes today gavea presentation titled "RAS peptide vaccination in resectedpancreatic cancer patients ... responseis possible following immunization with a peptide vaccine. Fivepatients that showed an immune response to the vaccine were stillalive in 2006, i.e. up...

Diatos Announces Positive Clinical Results for its DTS-201 Doxorubicin Prodrug Program

...arly in the tumorthrough enzymatic cleavage of the peptide by at least two enzymes:CD10 (Neprilysin / CALLA) and Thimet Oligopeptidase (TOP). Theyproduce two intermediate metabolites Ala-Leu-Dox and Leu-Dox whichenter stromal and tumor cells and are converted into freedoxorubicin. About Diatos Diatos is a ...

Generex Biotechnology Vaccine Strategy Presented at International Conference in London

... presentation was the immunogenicity ofproprietary peptide vaccines being developed by Antigen Express,both when used alone and in combination with other types ofvaccines. The Company is currently conducting a Phase II clinicaltrial of one of its peptides in breast cancer patients and a PhaseI trial in volun...

Palatin Technologies and King Pharmaceuticals Report Data Showing Improvements in Sexual Relationship and Self-Esteem in Patients with Erectile Dysfunction Treated with Bremelanotide

...ping targeted, receptor-specificsmall molecule and peptide therapeutics. Palatin's lead productcandidate, bremelanotide, is currently in Phase 2 clinical trialsfor both male and female sexual dysfunction. Palatin's internalresearch and development capabilities, anchored by its proprietaryMIDAS(TM) technology...

Gilead Announces Presentation of Long-Term Data for Ambrisentan, a Potential Treatment for Patients With Pulmonary Arterial Hypertension

...tivation of the ETA receptor byendothelin, a small peptide hormone, leads to vasoconstriction(narrowing of blood vessels) and cell proliferation. PAH isassociated with elevated endothelin blood levels. Ambrisentan hasbeen granted orphan drug designation for the treatment of PAH inboth the United States and E...

Global Rabies Treatment May be Possible with NanoViricides Drugs

...um chemicals ligandclass, rabies-specific receptor peptide ligand class, as well asrabies-antibody-derived ligand class were tested in both directintracerebral treatment as well as intraperitoneal treatmentmodalities. Human anti-Rabies Immunoglobulin (RIG), a commercialstandard rabies treatment, was used as ...

Palatin Technologies and King Pharmaceuticals Announce Plan To Present Results of Bremelanotide Phase 2b Studies in Men With Erectile Dysfunction

...ping targeted, receptor-specificsmall molecule and peptide therapeutics. Palatin's lead productcandidate, bremelanotide, is currently in Phase 2 clinical trialsfor both male and female sexual dysfunction. Palatin's internalresearch and development capabilities, anchored by its proprietaryMIDAS(TM) technology...

Pacgen Announces Positive Results from Phase I/II Trial of Novel Antifungal Drug

... of Pacgen's Clinical Advisory Board PAC-113 is a peptide based anti-fungal drug candidate targetingoral Can... PAC-113 PAC-113 is a 12 amino-acid antimicrobial peptide derived from anaturally occurring histatin protein found in saliva. This peptidealters the permeabil...

IR BioSciences Announces Promising Data from Study of Its Compound Homspera

...ed frommodified Substance P, a naturally occurring peptide immunomodulatorand homeostatic compound with the dual effect of improvingpulmonary function and the stimulation of the human immune system.For more information, please visit the company's website at<a target="_blank" href="http://www.immuneregen....

Drug for Treatment of Heart Failure Does Not Improve Survival, Compared to More Widely-used Medication

...for an early reduction of plasma B-typenatriuretic peptide level [an amino acid level that correlates withboth the severity of symptoms and the prognosis in congestive heartfailure] for levosimendan. These findings may be related to theshort duration of treatment in the trial, a selective effect oflevosimend...

Affymax Announces Phase 2 Clinical Trial Results of Once-Per-Month Hematide for the Treatment of Anemia in Patients with Early- and End-Stage Chronic Kidney Disease

...Hematide Hematide is a novel synthetic, pegylated peptide that binds toand activates the erythropoietin receptor. The product is beingdeveloped for treatment of anemia in chronic kidney disease andcancer. About Affymax, Inc. Affymax, Inc. is a biopharmaceutical company developing novelpeptide-based drugs ...

Helix BioMedix to Discuss Potential of Its Proprietary Peptides at the BIO International Convention

...e on the company's newgeneration of small molecule peptide (lipohexapeptide) technologyat the BIO Internation...g sixdistinct classes and hundreds of thousands of peptide sequences.The company's mission is to enrich clinical practice and thepatient and consumer experienc...

Affymax Announces Results From Phase 2 Clinical Trial of Hematide for the Treatment of Anemia in Dialysis Patients

...Hematide Hematide is a novel synthetic, pegylated peptide that binds toand activates the erythropoietin receptor. The product is beingdeveloped for treatment of anemia in chronic kidney disease andcancer. About Affymax, Inc. Affymax, Inc. is a biopharmaceutical company developing novelpeptide-based drugs ...

M. D. Anderson Cancer Center Researchers to Present CTCE-9908 Data at the AACR Annual Meeting

...with the Company. About CTCE-9908 CTCE-9908 is a peptide analog of the Chemokine SDF-1, and anantagonist of its receptor, CXCR4. SDF-1 is the only knownnaturally occurring chemokine that binds to CXCR4, which is presenton cancer cells of over 30 different tumor types. Activation bySDF-1 is believed to be c...

Emisphere Technologies, Inc. Reports Clinical Data on Oral Delivery of GLP-1 and PYY

...ous administration. The objective of thestudy with peptide YY 3-36 (PYY) was to establish the PYY plasmaconce...ar forms, as GLP-1(7-36) amideand GLP-1(7-37). The peptide was first identified following thecloning of cDNAs and genes for proglucagon in the early 1980s. The...

Inimex Product Candidate is First Immune Defense Regulator to Cure Infections Without Causing Harmful Inflammation

...hed as Scott, M.G. et al. (2007) "Ananti-infective peptide that selectively modulates the innate immuneresponse" in Nature Biotechnology (April 2007, vol. 25 No. 4) andwill be accessible online on March 25. About Inimex Pharmaceuticals Inimex Pharmaceuticals Inc. is focused on the development andcommercial...

ImmuneRegen BioSciences Announces Promising Data on Homspera Suggesting Potential as a Co-Therapeutic Agent

...ed frommodified Substance P, a naturally occurring peptide immunomodulatorand homeostatic compound with the dual effect of improvingpulmonary function and the stimulation of the human immune system.For more information, please visit the company's website at<a target="_blank" href="http://www.immuneregen....

Chemokine Therapeutics Announces Preliminary Results of CTCE-9908 Phase Ib/II Clinical Trial in Late Stage Cancer Patients

...20 or more doses. About CTCE-9908 CTCE-9908 is a peptide analog of the Chemokine SDF-1, and anantagonist of its receptor, CXCR4. SDF-1 is the only knownnaturally occurring chemokine that binds to CXCR4, which is presenton many cancer cells. This binding process is believed to becritical in angiogenesis and...

Scottish Scientists Test ‘Secret Weapon’ Against Tumours

... Notes to Editors: *A novel p53-derived apoptotic peptide de-represses p73 to causetumor regression in vivo. Helen S. Bell et al, 2007. Journal ofClinical Investigation. This research was funded by Cancer Research UK with support fromthe Biotechnology and Biological Sciences Research Council (BBSRC)and the...

IR BioSciences Announces Data Demonstrating Radilex Stimulation of Stem Cells Results in Hematopoietic Recovery Following Lethal Irradiation

...name used by the Company to describe the synthetic peptide Sar9,Met (O2)11-Substance P, an analog of the natu... is derived fromSubstance P, a naturally occurring peptide immunomodulator andhomeostatic compound with the dual effect of improving pulmonaryfunction and the ...

AOP Orphan Pharmaceuticals and Lantibio Announce Positive Phase II Study with Novel Cystic Fibrosis Therapy

...CF lung. Moli1901 is a stable19-residue polycyclic peptide produced by fermentation ofStreptomyces cinnamoneum. In previous published studies, Moli1901has been shown to increase chloride transport and fluid secretionswhen applied to airway epithelium in-vitro, and increases chloridepermeability in nasal epit...