pathology

Myriad Genetics Presents Mathematical Comparison of Disease Modification Trial Designs at Alzheimer's ConferenceCurrent Flurizan Phase 3 Study Design May Demonstrate Disease Modification

...se (AD) is onethat has an impact on the underlying pathology of the disease andthus slows the rate of a patient's decline over the course oflong-term treatment. In contrast, the currently available ADmedicines are believed to treat the symptoms of AD withoutimpacting the underlying disease process or providing...

Introgen Reports Updated Phase 2 Advexin Data Correlating Improved Survival, Tumor Responses and Predictive p53 Biomarker

...errant p53 function by aroutine assay performed by pathology laboratories worldwidedetecting abnormally elevated levels of p53 protein in tumortissues. Introgen believes that application of molecular andclinical biomarkers can predict the patients who are most likely torespond to ADVEXIN treatment. About ADVE...

EntreMed's Aurora Kinase Inhibitor Induces Tumor Regression in Preclinical Models

...ngFLT3, c-Kit and CSF1R, which are involved in the pathology ofhematological cancers. Additionally, ENMD-981693 demonstratedpotent inhibition of a spectrum of targets linked to angiogenesis,including KDR (VEGFR2) and FGFR1. The compound was also shown toinduce apoptosis and cell cycle arrest in a broad range o...

Hemispherx Presents Potential Avian Influenza Treatment Breakthrough at Paris Conference

...t against avian influenza,reducing the severity of pathology resulting from infection ofestablished animal model non-human primates (macaques) by a highlypathogenic strain of avian flu. As noted in a 2006 Oxford University Clinical Research Unitstudy titled "Fatal outcome of human influenza A (H5N1) isassocia...

MedImmune Highlights Advances in Inflammatory Disease Pipeline With Series of Data Presentations

...n the activation of B cells, may contribute to the pathology of arange of disorders such as joint inflammation and sepsis." Data presented at AAI include: -- "Regulation of TLR9 dependent DNA Immune complex mediated cell activation by High Mobility Group Box Protein 1 (HMGB1) and Receptor f...

AVI BioPharma Reports Positive Pre-Clinical Influenza Data

...n of the lungsshowed that treated mice had reduced pathology when examined forinfiltrating cells or alveolar damage. "These data, in combination with other pre-clinical research,reinforce our belief that NEUGENE antisense compounds arepotentially well-suited to treating seasonal influenza Ainfections," said...

MedImmune Publishes New Data in Nature Immunology Demonstrating The Role HMGB1 May Play in Systemic Autoimmune Diseases

...s, and among our key areas of focus are thedisease pathology of lupus and the role of B cells inautoimmunity," said Anthony J. Coyle, vice president, research anddevelopment, and head, inflammation and autoimmunity research."These data, applicable to several programs within our pipeline,demonstrate a novel mec...

Myriad Genetics Presents Tumor Origin Technology at AACR

...e primary tumors due to the uncertainnature of the pathology results. The copy number analysis eitherconfirmed conclusions from pathological examination, or providednew information that could be used to give a more positivedetermination of tumor source. Copy number analysis can show thatboth tumors share a cha...

Onconase has Potential as Chemopreventive Agent in Mesothelioma, Reports World-Renowned Mesothelioma Researcher at AACR Annual Meeting

...oncologyprogram as well as a clinical professor of pathology with theUniversity of Hawaii's Cancer Research Center of Hawaii, andchairman of the Alfacell Thoracic Advisory Board. Previously, Dr.Carbone was Director of the Thoracic Oncology Program at LoyolaUniversity in Chicago, where he is also a tenured Prof...

Introgen Presents ADVEXIN Biomarker Data at Major Cancer Conference

...errant p53 function by aroutine assay performed by pathology laboratories worldwidedetecting abnormally elevated levels of p53 protein in tumortissues. Introgen believes that application of molecular andclinical biomarkers can predict the patients who are most likely torespond to ADVEXIN treatment. About ADVE...

Cleveland BioLabs Protectan CBLB502 Demonstrates Strong Survival Benefits as Mitigator Against Radiation-Induced Damage in Study

...ich20% of the animals survived. In addition, gross pathology resultsshowed that the majority of control animals displayed severe damageto the GI tract, while the CBLB502 treated animals did not. Thisdata demonstrates CBLB502's capacity as a mitigator ofgastrointestinal radiation-induced injury. Dr. Gudkov c...

Alnylam and Stanford University Scientists Discover New Role for microRNAs (miRNAs) in T Cell Biology and Immunity

...ell activity toward"self" antigens underscores the pathology in many autoimmunedisorders, antagomirs selective for miR-181a could define a futuretherapeutic strategy for the treatment of these diseases. About RNA Interference (RNAi) RNA interference, or RNAi, is a naturally occurring mechanismwithin cells fo...

Nventa Announces Presentation of Positive HspE7 Data from NCI-Sponsored Clinical Trial in Cervical Dysplasia

...er HPV types.Responses to HspE7 were determined by pathology of post-vaccinationLoop Electrosurgical Excision Procedure (LEEP) specimens. (LEEP isa standard procedure for patients with high grade dysplasia toremove the affected areas.) A pathologic complete response (pCR)was defined as a specimen negative for ...