Nuclear in Medical Technology

Screening for Ischemia in Asymptomatic Patients With Type 2 Diabetes: Five- Year Outcomes in the DIAD Study

... presented today at the American Society of nuclear Cardiology Annual Scientific Session, seeks to ... 11:40 a.m. in Room 306. The American Society of nuclear Cardiology (ASNC) is the leader in education, advocacy, and quality for the field of nuclear cardiology. Serving more than 5,000 individuals ...

Cardinal Health Expands PET Nuclear Pharmacy Services to Support Clinical Drug Trials

... trial market will be discussed at the Society of nuclear Medicine's (SNM) 55th Annual Meeting, taking ... said John Rademacher, general manager of nuclear pharmacy services for Cardinal Health. "By ... in the world. The combination of that nuclear pharmacy expertise and the size of its network ...

Kosan Presents Preclinical Data on Nuclear Export Inhibitors, Novel Anticancer Agents, at AACR

... Many cargo proteins that depend on CRM1 for nuclear export, such as p53, Bcr-Abl and ... CRM1 cargo proteins in the nucleus, by blocking nuclear export, leads to the inhibition of cell growth ... of CRM1 inhibition, including nuclear export inhibition and cytotoxicity. Exposure of ...

Medivation Announces Positive New Efficacy Data From Phase 1-2 Trial of MDV3100 in Advanced Prostate Cancer Patients

... receptor with greater binding affinity than bicalutamide; impairs nuclear translocation and blocks DNA binding of the androgen receptor, one of the ... receptor antagonist that inhibits androgen receptor function by blocking nuclear translocation of the androgen receptor and DNA binding. About ...

Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs

... Since the cloning of Dolly the Sheep over a decade ago, somatic cell nuclear transfer (SCNT) has been considered a promising way to generate ... eggs. This is consistent with studies that indicate that eggs support nuclear remodeling, but not reprogramming of discordant animal combinations. ...

What is the Optimal Method of Ischemia Evaluation in WomeN: Preliminary Data from the WOMEN Study

... September 13, 2008 at 10:50 a.m. in Room 306. The American Society of nuclear Cardiology (ASNC) is the leader in education, advocacy, and quality for the field of nuclear cardiology. Serving more than 5,000 individuals in over 50 countries, ASNC ...

Nature Publication Reports on Key Role of Bile Acids in Glucose Metabolism and Insulin Signaling

... as metabolic integrators, activating major signaling pathways regulated by nuclear hormone receptors including the farnesoid X receptor (FXR) and G ... have published extensively on the role of bile acid signaling via the nuclear hormone receptor FXR and the G protein-coupled receptor TGR5. These ...

FluoroPharma Announces Positive Phase I Safety Results for CardioPET(TM), Coronary Artery Disease (CAD) Imaging Tracer for Positron Emission Tomography (PET)

... of Radiology at Harvard Medical School and the former Director of nuclear Medicine at Massachusetts General Hospital. H. William Strauss, MD, the ... to better quality CAD diagnoses." Dr. Strauss is the Clinical Director of nuclear Medicine at Memorial Sloan Kettering Cancer Center and Professor of ...

Study Reports Successful Cloning of Human Embryo Using Adult DNA

... ) The experiments, using a technique called somatic cell nuclear transfer (SCNT), provide key steps toward the development of ... entitled "Development of Human Cloned Blastocysts Following Somatic Cell nuclear Transfer (SCNT) with Adult Fibroblasts," is available online at: ...

Interview of the Vice President

... was aimed at the weaponization of fissile material for the creation of a nuclear weapon. What the NIE shows is that in about 2003, they, in effect, halted ... not to enrich uranium. The long pole in the tent in terms of developing nuclear weapons, traditionally, historically, has been developing fissile ...

First Skin Cancer Patients Treated With Electronic Brachytherapy (eBx) At University of Wisconsin Riverview Cancer Center

... healthy tissue and without the complex handling, resource logistics and costs associated with using radioactive isotopes. Xoft aligns with the nuclear Regulatory Commission's (NRC) directive to seek alternatives for radioactive medical isotopes. Commercially available for treatment of early stage ...

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

... the Medical College of Wisconsin. "This study demonstrates that ZFN technology bypasses the current need to conduct cumbersome experiments involving nuclear transfer (cloning) or embryonic stem cells and allows rapid creation of new animal models." In the study published in Science titled ...

Covance Announces Integrated Radiolabeled Clinical Pharmacology Studies

... With more than 130 AME studies completed, Covance's team of experts deliver integrated AME study services, including on site Authorized nuclear Pharmacist-formulated doses; cGMP formulation testing; AME study conduct and analysis of parent compound; total radioactivity; pharmacokinetic ...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

... in Diabetic Rodents (Oral Presentation) Authors: S.F. Murray, S.L. Booten, L.M. Watts, B.P. Monia, S. Bhanot. A Newly Identified Role of nuclear Receptor Corepressor, SMRT (Silencing Mediator of Retinoid and Thyroid) in Improving Hyperglycemia and Insulin Sensitivity in Obese and ...

PharmAthene Submits Proposal to BARDA in Response to Broad Agency Announcement for Advanced Research and Development for Valortim(R)

... Agency Announcement (BAA-BARDA-09-34) for advanced research and development of medical countermeasures for chemical, biological, radiological and nuclear threats. PharmAthene has requested funding to further develop Valortim(R), a fully human monoclonal antibody, for the prevention and treatment of ...

InteKrin Therapeutics to Present at the 2009 American Diabetes Association Annual Meeting

... world-class scientific and medical experts includes veterans from several successful BioPharma organizations, internationally recognized experts in nuclear receptors and metabolism, top scientists formerly with the Food and Drug Administration and key clinical and commercialization leaders. ...

InteKrin Therapeutics Announces Enrollment Completion of 360 Patient, 24 week Phase 2b Study

... world-class scientific and medical experts includes veterans from several successful BioPharma organizations, internationally recognized experts in nuclear receptors and metabolism, top scientists formerly with the Food and Drug Administration and key clinical and commercialization leaders. To ...

Lexicon Presents Clinical Data on LX1032 for Carcinoid Syndrome at European Neuroendocrine Tumor Society Meeting

... carcinoid. The meeting brings together leading neuroendocrine tumor experts from around the world in such fields as oncology, pathology, radiology, nuclear medicine, endocrinology, surgery and gastroenterology. The 2009 ENETS conference runs from March 5-7 in Granada, Spain. About Carcinoid ...

Alseres Pharmaceuticals Completes Enrollment in First Stage of the Altropane(R) POET-2 Phase III Program

... for clinical trials of molecular imaging agents, the study was designed to acquire the set of ALTROPANE images which will be used to train the expert nuclear medicine readers. The second stage of the planned POET-2 program will involve two concurrent, replicate, multi-center Phase III registration trials ...

Pulmo BioTech Inc. Announces Dual Listing on Frankfurt Borse

... is driven by PulmoScience's expectations of the improved safety and efficacy that PulmoBind will offer when compared to the current incumbent nuclear medicine based technology for the diagnosis of Pulmonary Embolism. In addition, early indications are that PulmoBind could be highly effective in ...

Medivation Completes Enrollment of Phase 1-2 Trial of MDV3100 in Castration-Resistant Prostate Cancer Patients

... prostate cancer. MDV3100 is a novel small-molecule androgen receptor antagonist that inhibits androgen receptor function by blocking nuclear translocation of the androgen receptor and DNA binding. About Medivation Medivation, Inc. is a biopharmaceutical company focused on ...

New Breast Imaging Technology Targets Hard-to-Detect Cancers

... using a high-resolution gamma camera that allows for imaging with very mild compression of the breast along with an injection of a low-dose nuclear material called a radiotracer, which is absorbed by the cells. Because cancerous cells have a higher rate of metabolic activity, the tracer is taken ...

New Insight Into the Controls on a Go-To Enzyme

... its function." To obtain that overall picture, St. Jude researchers used the analytical technique of X-ray crystallography, with help from nuclear magnetic resonance (NMR) spectroscopy. In this widely used method of determining protein structure, researchers first crystallize a protein to be ...

Landmark Study Demonstrates Potential of Radioimmunotherapy for Treatment of Indolent B-Cell Non-Hodgkin's Lymphoma

... indication as consolidation therapy following first-line therapy in newly diagnosed patients as well as removing the need for the pre-treatment nuclear medicine scan on the basis of studies such as FIT and accumulated safety data. We believe these steps will allow office ...

Quark Pharmaceuticals Announces Publication of Study on Use of siRNA against Proprietary Target for Inhibiting Tumor Growth and Sensitization of Cancer Cells to Chemotherapy

... target gene against non-small cell lung cancer (NSCLC) in the edition dated October 1, 2008. The paper, entitled "RNAi-Mediated Silencing of nuclear Factor Erythroid-2-Related Factor 2 Gene Expression in Non-Small Cell Lung Cancer Inhibits Tumor Growth and Increases Efficacy of Chemotherapy," ...

Xoft Showcases Interim Clincal Results for Breast Cancer Product and New Indications for Electronic Brachytherapy(eBx) at Astro Meeting

... healthy tissue and without the complex handling, resource logistics and costs associated with using radioactive isotopes. Xoft aligns with the nuclear Regulatory Commission's (NRC) directive to seek alternatives for radioactive medical isotopes. Commercially available for treatment of early stage ...

Electronic Brachytherapy a Viable Option for Early Stage Breast Cancer, According to Study Presented at ASCO Breast Cancer Symposium

... healthy tissue and without the complex handling, resource logistics and costs associated with using radioactive isotopes. Xoft aligns with the nuclear Regulatory Commission's (NRC) directive to seek alternatives for radioactive medical isotopes. Commercially available for accelerated treatment of ...

CeNeRx BioPharma Finalizes Plans to Initiate Phase II Trials for Its Novel Antidepressant Agent Tyrima(TM) Using Innovative Brain Imaging Study

... with the positive results from the Phase I program, support progression of Tyrima into Phase II trials." PET, or positron emission tomography, is a nuclear imaging technology that produces three-dimensional depictions of metabolic states in the human body, allowing researchers to view the path and amount ...

Pulmo BioTech Inc. Completes Bio-Distribution Studies

... the integrity of the lung's vascular system can then be imaged using the Gamma Cameras which are typically available in all hospitals with a nuclear Medicine department. It is important for diagnostic image quality that the PulmoBind molecule is only retained in the lungs, and we are very ...

Welchol(TM) Lowered A1C by a Mean 1 Percent or Greater When Added to Metformin-, Insulin-, or Sulfonylurea-Based Therapy in 47 Percent of Patients Evaluated

... have been proposed for the glucose-lowering effect of Welchol, including reductions in glucose absorption and effects on glucose metabolism via nuclear receptors in the intestine and/or the liver. The exact mechanism(s) is under investigation. About the Analyses For both analyses, data was ...

BRAVE-3 Questions Value of Abciximab in PCI for Heart Attack

... to compare how the two treatment strategies affected the final amount of heart attack damage, as gauged by blood flow in the heart muscle on a nuclear scan five to 10 days later. The researchers found no difference between the two groups: The damage involved 10 percent of the left ventricle, on ...

Bertrand Study Finds Significant Value in Breast-Specific Gamma Imaging (BSGI) as an Adjunctive Procedure in Breast Diagnostics

... Imaging (BSGI), a molecular imaging technique that images the metabolic activity of breast lesions through radiotracer uptake, and other general nuclear medicine imaging. Several leading medial centers around the country are now offering BSGI to their patients, including: Beth Israel Medical Center, ...

ACR Supports American Cancer Society Inclusion of CT Colonography (Virtual Colonoscopy) as Recommended Screening Tool for Colorectal Cancer in New Screening Guidelines

... (ACR) is a national professional organization serving more than 32,000 diagnostic radiologists, radiation oncologists, interventional radiologists, nuclear medicine physicians, and medical physicists, with programs focusing on the practice of radiology and the delivery of comprehensive health care ...

DATATRAK and COResearch to Collaborate on Six Cardiac Safety Projects

... expertise will allow for COResearch's imaging services to include: echocardiography, atherosclerotic imaging-carotid intima-media thickness, cardiac nuclear imaging, cardiac magnetic resonance imaging, quantitative coronary angiography, and cardiac computed tomography. DATATRAK International, Inc. is a ...

InteKrin Therapeutics Announces Initiation of Phase 2b Study in Type 2 Diabetes with INT131

... world-class scientific and medical experts includes veterans from several successful BioPharma organizations, internationally recognized experts in nuclear receptors and metabolism, top scientists formerly with the Food and Drug Administration and key clinical and commercialization leaders. To learn ...

Pixantrone Versus Doxorubicin in CHOP-R Therapy for First-line Treatment of Aggressive Non-Hodgkin's Lymphoma Preliminary Results Presented at American Society of Hematology (ASH) Annual Meeting

... status is assessed every three months during first year and every six months thereafter. Cardiac function, as determined by serial multi-gated nuclear scans (MUGA), is evaluated prior to initiation of therapy and then at the completion of every two cycles of therapy. Thus far, routine ...

Two Major Studies Show: Human Pluripotent Stem Cells without Cloning or Destroying Embryo

... are the studies which prompted Ian Wilmut, creator of Dolly the sheep and one of the world's leading authorities on the cloning process Somatic Cell nuclear Transfer (SCNT), to announce that he was abandoning SCNT to focus on reprogramming instead. The following summary and analysis was produced by ...

Cellectar Expands Clinical Management Team

... Pharmaceuticals, Inc., a cancer treatment pharmaceutical company located in Boulder, CO. Ms. Trembath brings 21 years of experience as a nuclear medicine technologist specializing in medical imaging, including 10 years of clinical trials research experience and nine years in ...

EntreMed Presents Data for Phase 2 Study of MKC-1 in Metastatic Breast Cancer

... segregation in the M-phase of the cell cycle, and induce apoptosis in multiple cell lines, consistent with a mechanism in which MKC-1 blocks the nuclear uptake of proteins essential to cell replication. Carolyn F. Sidor, M.D., M.B.A., EntreMed's Vice President and Chief Medical Officer, commented on ...