Nodes in Medical Technology

Northern California Cancer Center's First-of-Its-Kind Research Reveals Low Socioeconomic Status Often Equals Poor Chance of Lymphoma Survival

... equally. The cancer involves the body's lymph nodes which fight infection and disease. It begins with an enlargement of the lymph nodes and symptoms can include fever, weight loss, ... It is called "follicular" lymphoma because lymph nodes seen under microscopes display unusual rounded ...

Researchers Train the Immune System to Deliver Virus That Destroys Cancer in Lab Models

... found that once the T-cells returned to the lymph nodes and spleen, the virus detached itself from the ... the presence of melanoma tumor cells in lymph nodes was significantly less, but not completely gone. ... days after a T-cell transfer, both the lymph nodes and spleen were free of melanoma tumor cells. ...

BioVex to Report Phase I/II Clinical Trial Results for the Front Line Treatment of Head and Neck Cancer With OncoVEX GM-CSF at the 2009 American Society of Clinical Oncology Meeting

... prior to surgery. Patients who present with tumor containing lymph nodes are particularly difficult to treat and approximately half of these ... by direct injection, at three dose levels, into tumor containing lymph nodes in combination with standard first line chemo radiotherapy every three ...

Inclusion of Six-Year Overall Survival Data in the Eloxatin(R) (oxaliplatin injection) Prescribing Information Granted FDA Priority Review

... nodes. In Stage III, the cancer has invaded one or more of the local lymph nodes but has not spread to distant sites. Metastatic colorectal cancer means that the cancer has spread to other nodes and/or organs in the body. Colorectal cancer is a leading cause of ....

Melanoma and Pregnancy: What Every Woman Needs to Know About the Risks, Prognosis

... for melanoma is based on three variables -- tumor thickness, presence or absence of ulceration, and whether the melanoma has spread to the lymph nodes or other organs. For example, if a tumor is less than 1 mm in depth (which is considered a "thin" melanoma, or in an early stage of the disease), no ...

Video: Afinitor(R) Approved in US as First Treatment for Patients With Advanced Kidney Cancer After Failure of Either Sunitinib or Sorafenib

... RCC, cancer cells develop in the lining of the kidney's tubes and grow into a tumor(8). If left untreated, the tumor can spread to neighboring lymph nodes and eventually other organs(9). RECORD-1 trial The FDA regulatory filing for Afinitor was based on data from RECORD-1 ( RE nal C ell ...

Video: Zometa(R) Reduces Risk of Breast Cancer Recurrence in Premenopausal Women, Study in The New England Journal of Medicine Reports

... III study that enrolled 1,803 premenopausal women with estrogen receptor-positive Stage I or II breast cancer, with fewer than 10 axillary lymph nodes involved. Patients were recruited for the study after curative surgery and initiation of goserelin treatment for ovarian suppression, and randomly ...

Arzerra(TM) (ofatumumab) Demonstrates High Response Rates in Patients With Fludarabine Refractory Chronic Lymphocytic Leukemia (CLL)

... DR), and patients who were refractory to fludarabine and considered inappropriate candidates for alemtuzumab due to bulky tumor masses in their lymph nodes (bulky fludarabine refractory; BFR). The primary endpoint of the study was assessment of objective response.* The overall objective response ...

The Leukemia & Lymphoma Society and Memgen Announce New Chronic Lymphocytic Leukemia Clinical Trial

... with high risk and treatment-resistant CLL. Most importantly, ISF35 was well-tolerated with only minimal side effects, reduced CLL cells and lymph nodes in nearly every patient, and when combined with chemotherapy produced complete or partial remissions in patients with 17p deleted CLL." ...

Susan G. Komen for the Cure(R) Makes Unprecedented Research and Local Program Grants

... the treatment of patients with advanced breast cancer. The majority of breast cancer deaths arise from the cancer spreading from the breast to lymph nodes and distant sites such as the lung and bone. Once the cancer spreads beyond the breast, the relative five-year survival rate drops from 98 to 26 ...

Breast MRI Scan Could Determine Need for Radiation Therapy

... surgery to remove the cancer and sample the lymph nodes, you reduce your ability to know whether there was cancer in the axillary (underarm) lymph nodes before the patient was treated with chemotherapy," Loiselle said. "This raises the question: is there another way to stage those lymph nodes? Our ...

Genomic Health Announces Data Supporting Use of Oncotype DX(R) to Accurately Assess HER2 Gene Expression in Breast Cancer Patients

... between central IHC and quantitative RT-PCR using Oncotype DX for determining HER2 status. The study analyzed 755 patients with 0 to 3 positive lymph nodes who were enrolled in Intergroup study E2197, a large adjuvant breast cancer trial evaluating two different chemotherapy regimens. The second study ...

Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III Melanoma Demonstrated Significant and Sustained Impact on Relapse-Free Survival

... alfa-2b arms, respectively (difference of 9.2 months). The improvement in RFS was more pronounced in patients with a lower tumor burden in the lymph nodes based on predefined subgroups. For the subgroup of patients with clinically non-palpable (microscopic) lymph node disease, the HR for RFS was 0.73 ...

Research Explains How Advanced Prostate Cancer Becomes Resistant to Androgen-Deprivation Therapy

... of better drugs to treat metastatic disease -- cancer that has spread beyond the prostate to distant sites throughout the body, such as bone, lymph nodes and internal organs. "So far we've targeted systemic, or circulating, androgens in men with advanced prostate cancer," Mostaghel said. "What these ...

Exelixis Reports Encouraging Phase 1 Data for XL184 at ASCO

... appears at a younger age, while dietary iodine deficiency and radiation exposure are risk factors for the sporadic form. MTC may metastasize to lymph nodes or other organs before it is ever diagnosed. Additionally, MTC does not take up radioactive iodine, which is commonly used to treat other types of ...

Video: Major Independent Trial Demonstrates Significant Anticancer Benefit of Zometa(R) in Women With Early-Stage Breast Cancer

... III study that enrolled 1,803 premenopausal women with estrogen-receptor-positive Stage I or II breast cancer, with fewer than 10 axillary lymph nodes involved. Patients were recruited for the study after curative surgery and initiation of goserelin treatment for ovarian suppression, and randomly ...

New Eloxatin(R) (oxaliplatin injection) Prescribing Information in the U.S. Includes Six-Year Overall Survival Data

... one or more of the local lymph nodes but has not spread to distant sites. Metastatic colorectal cancer means that the cancer has spread to other nodes and/or organs in the body. About 150,000 new cases are detected each year in the United States. Over a lifetime, about 1 in 19 people develop ...

Pharmion and MethylGene Start Phase 2 Combination Clinical Trial With MGCD0103 and Vidaza(R) in Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma

... regimen in its own right. About Hodgkin Lymphoma Hodgkin lymphoma (HL) is a cancer of the lymphatic system that begins in the lymph nodes and progresses to other organs, including the lungs, liver, bone and bone marrow. It is characterized by the presence of Reed-Sternberg cells. ...

Genomic Health Announces Eight Oncotype DX(R) Studies to Be Presented at 30th Annual San Antonio Breast Cancer Symposium

... utility of the 21-gene assay compared with Adjuvant! in hormone receptor (HR) positive operable breast cancer with 0-3 positive axillary nodes treated with adjuvant chemohormonal therapy (CHT): an analysis of intergroup trial E2197. "Presenter: Lori J. Goldstein, M.D. Saturday, Dec. 15, ...

Studies Showing Significant Survival Improvement with Taxotere(R)-based Regimens in the Induction Treatment of Patients with Locally Advanced Head and Neck Cancer are Published in the Same Issue of the New England Journal of Medicine

... nose and throat. The term encompasses cancers of the oral cavity, paranasal sinuses and nasal cavity, tongue, tonsils, pharynx, larynx, and lymph nodes in the upper part of the neck. About Taxotere(R) Indications and Usage Breast Cancer Taxotere(R) is indicated for the treatment of patients with ...

Taxotere(R) (docetaxel) Granted FDA Approval to Treat Locally Advanced Head and Neck Cancer Prior to Chemoradiotherapy and Surgery

... throat and voicebox. The term encompasses cancers of the oral cavity, salivary glands, paranasal sinuses and nasal cavity, pharynx, larynx, and lymph nodes in the upper part of the neck. "Head and neck cancer is particularly hard to treat and if not detected early has low survival rates," commented ...

Pharmion and MethylGene Announce U.S. Orphan Drug Designation Granted for MGCD0103 for the Treatment of Hodgkin's Lymphoma

... trials in hematological malignancies. About Hodgkin's Lymphoma Hodgkin's lymphoma (HL) is a cancer of the lymphatic system that begins in the lymph nodes and progresses to other organs, including the lungs, liver, bone and bone marrow. It is characterized by the presence of Reed-Sternberg cells. ...

Survival Data Available from Erbitux Study in First-Line Treatment of Advanced Head and Neck Cancer

... cancers of the tongue, the rest of the mouth, the salivary glands and inside the throat, the voice box, eye and orbit, thyroid and the lymph nodes in the upper neck. In addition, it is estimated that more than 12,900 Americans will die from this disease this year. Head and neck cancer most often ...

Survival Data Available From Erbitux Study in First-Line Treatment of Advanced Head and Neck Cancer

... cancers of the tongue, the rest of the mouth, the salivary glands and inside the throat, the voice box, eye and orbit, thyroid and the lymph nodes in the upper neck. In addition, it is estimated that more than 12,900 Americans will die from this disease this year. Head and neck cancer most often ...

Vertex Pharmaceuticals Announces New Data for Investigational HCV Protease Inhibitor Telaprevir to be Presented at 42nd Annual Meeting of the European Association for the Study of the Liver (EASL)

... Capacity Compared to Wild-Type HCV in Vivo and In Vitro," will be presented by Chao Lin of Vertex. -- "Ultrasound Evaluation of Perihepatic Lymph nodes During Antiviral Therapy with the Protease Inhibitor Telaprevir (VX-950) in Patients with Chronic Hepatitis C Infection," will be presented by Mireen ...

Micromet and MedImmune Present Data From Preclinical Study of New BiTE Molecule Targeting CEA

... Hematology. In an ongoing phase 1 study, MT103/MEDI-538 has shown potent elimination of tumor target cells in peripheral blood, bone marrow, lymph nodes and spleen of therapy-refractory non-Hodgkins lymphoma patients. About MedImmune, Inc. MedImmune strives to provide better medicines to patients, ...

MedImmune and Micromet Publish Data on Novel Anti-Cancer BiTE Molecule

... Hematology. In an ongoing phase 1 study, MT103/MEDI-538 has shown potent elimination of tumor target cells in peripheral blood, bone marrow, lymph nodes and spleen of therapy-refractory non-Hodgkins lymphoma patients. About MedImmune, Inc. MedImmune strives to provide better medicines to patients, ...

VioQuest Pharmaceuticals Announces Data Presentation for Its Akt Inhibitor VQD-002, at American Association for Cancer Research Annual Meeting

... in humans and the second leading cause of male cancer death in America. Prostate cancer mortality results from metastases to bones and lymph nodes and progression from androgen-dependent to androgen-independent disease. Therapeutics for these aggressive forms of cancers are lacking. Previously, ...

Micromet Achieves Milestone in BiTE Research Collaboration with MedImmune

... Hematology. In an ongoing phase 1 study, MT103/MEDI-538 has shown potent elimination of tumor target cells in peripheral blood, bone marrow, lymph nodes and spleen of therapy- refractory non-Hodgkins lymphoma patients. About Micromet, Inc. (

Newly Published Study Reveals Femara Improves Chances for Harder to Treat Early Breast Cancer Relapse in Postmenopausal Women

... Femara also demonstrated a significant reduction in the risk of recurrence to the same breast (local recurrence), the other breast and to the lymph nodes (regional recurrence). "Femara is the only aromatase inhibitor shown to significantly reduce the risk of distant metastases versus tamoxifen as ...

Eloxatin (oxaliplatin injection)-Based Chemotherapy Sets New Treatment Benchmark in Patients With Metastatic Colorectal Cancer

... the wall of the colon or rectum but has not yet spread to nearby lymph nodes. In Stage III, the cancer has invaded one or more of the local lymph nodes but has not spread to distant sites. Metastatic colorectal cancer means that the cancer has spread to other nodes and/or organs in the body. The ...

Ontak (denileukin diftitox) Achieves 49.1% Overall Response Rate in Phase III Trial of Cutaneous T-Cell Lymphoma (CTCL)

... endpoint of this study was to measure the total percentage of documented responders based on improvement in tumor burden in skin, blood and lymph nodes in each treatment arm, confirmed over three consecutive cycles. Secondary endpoints included progression-free survival, which is defined as the ...

Updated Study Results Reinforce Survival Benefit of Taxotere (Docetaxel) for Men with Advanced, Hormone-Resistant Prostate Cancer

... to the prostate, such as the muscles that help control urination, the rectum or the wall of the pelvis. The cancer may have also spread to lymph nodes near the prostate or, if it has metastasized, to other more distant places in the body. With early detection, the five-year survival rate of prostate ...

Caelyx Delays Time to Disease Progression as Maintenance Therapy in Patients with Metastatic Breast Cancer

... cancer (MBC) is the most advanced stage of breast cancer (stage IV), in which cancer cells have spread past the breast and axillary (underarm) lymph nodes to other areas of the body where they continue to grow and multiply. Breast cancer has the potential to spread to almost any region of the body. ...

Clinical Data Reported on Vidaza in Hematologic Malignancies and Advanced Solid Tumors

... (MDS and AML). (Back to top) About Hodgkin's Lymphoma Hodgkin's lymphoma (HL) is a cancer of the lymphatic system that begins in the lymph nodes and progresses to other organs, including the lungs, liver, bone and bone marrow. It is characterized by the presence of Reed-Sternberg cells. ...

Santaris Pharma Presents Positive Clinical Data on SPC2996 in Chronic Lymphocytic Leukaemia

... from the study were as follows. *A reduction in the number of cancerous B-lymphocytes (white blood cells) and a beneficial effect on lymph nodes and overall tumour response was observed in patients given 6 repeated doses of drug at 4mg/kg/infusion over a two week period, with the effects ...