Neural in Medical Technology

Neuralstem's Human Stem Cells Integrate into Nervous System of Rats with Animal Model of ALS

... 9 /PRNewswire-FirstCall/ -- Transplanted human neural stem cells (hNSCs) developed by Neuralstem, Inc. ... the first human clinical trial to treat ALS with neural stem cells is currently under review by the FDA. ... Medical Institutions, laboratory-grown human neural stem cells (hNSCs) isolated from a fetal spinal ...

Groundbreaking Paper Publishes Long Term Results of a Successful Phase I Clinical Trial Using Autologous Neural Stem Cells to Treat Parkinson's Disease

... the world's first clinical trial using autologous neural stem cells for the treatment of Parkinson's ... of Autologous Adult Human neural Stem Cells and Differentiated Neurons for ... how we were able to isolate patient-derived neural stem cells, multiply them in vitro and ...

Brain Stem Cells Can Be Awakened, Say Schepens Scientists

... for the PNAS study findings by demonstrating that neural stem cells exist in every part of the brain, but ... that only two parts of the brain contained neural stem cells and could turn them on to regenerate ... in culture or injected into the brain, stimulates neural stem cells to divide and become new neurons. ...

Myelin Removal Beads: Premium Efficiency for Neural Cell Separations and Antibody Stainings

... fragments represent the major contaminant. "When dissociating adult neural tissue, usually less than 5 percent of the cell suspension consists of ... to cell debris", explains Dr. Rebecca Biloune, Product Manager for neural Research Products at Miltenyi Biotec. "Removal of myelin leads to higher ...

Autism Genes Discovered; Help Shape Connections Among Brain Cells

... -Findings Suggest Biological Reasons for Altered Early neural Development- PHILADELPHIA, April 28 /PRNewswire-USNewswire/ -- A ... imaging that children with ASDs may have reduced connectivity among neural cells, and with anatomy studies that have found abnormal development of ...

Neuralstem Licenses Cleveland Clinic Spinal Cord Injection Technology

... much to do basic research and discovery, as to optimize our discovery of neural stem cells, and take them into the clinic and into patients. We believe ... patented technology enables, for the first time, the ability to produce neural stem cells of the human brain and spinal cord in commercial quantities, ...

Findings on Bladder-Brain Link May Point to Better Treatments for Problems in Sleep, Attention

... from rats' bladders. Building on their previous investigations of the neural circuits between the bladder and the brain, the researchers found that two ... diseases, such as irritable bowel disorder, may also affect the same neural circuitry, with similar neurobehavioral consequences. The National ...

Neuralstem Announces Issuance of Core Technology Patent in Europe

... patented technology enables, for the first time, the ability to produce neural stem cells of the human brain and spinal cord in commercial quantities, ... California San Diego. The company has also developed immortalized human neural stem cells for in-vitro use in drug development for the academic and ...

NexGenix Pharmaceuticals Presents Data on a Novel Small Molecule Inhibitor of Heat Shock Protein 90 (Hsp90) at the GTCbio Cancer Drugs Research & Development Conference

... for breast cancer, and to develop an oral formulation from the series for neural tumors, such as those found in Neurofibromatosis Type 2, and for ... company developing a novel Hsp90 inhibitor series for cancer, neural tumors and neurodegenerative disorders. NexGenix has assembled a team of ...

Novel Mechanism for Long-Term Learning Identified by Carnegie Mellon Researchers

... a sensory imbalance leading to increased plasticity in the cortex. "The neural mechanisms of learning and memory have been poorly understood," said ... student in the Department of Biological Sciences and the Center for the neural Basis of Cognition at Carnegie Mellon, and Tansu Celikel of the Department ...

Lack of Food Variety Puts Kids With Autism at Risk for Poor Nutrition

... "The fatty acid docosahexanoic is linked to other mental health issues, and this raises questions about whether there are functional issues in neural cells involving a deficiency of essential fatty acids," said Dr. Zimmer. "The main point of the study is we cannot rule that fatty acids are part of ...

Scientists Discover Why Teeth Form in a Single Row

... cells to treat malformations and to develop prevention strategies for cleft palate (e.g. the inclusion of folic acid in prenatal vitamins prevents neural tube defects in some cases). Cleft lip/palate occurs one in 700 live births. Along with Jiang, the work was led by Zunyi Zhang and Yu Lan ...

Neuralstem's ALS Trial on Clinical Hold

... can be approved and move forward." About Neuralstem Neuralstem's patented technology enables, for the first time, the ability to produce neural stem cells of the human brain and spinal cord in commercial quantities, and the ability to control the differentiation of these cells into mature, ...

Heavy Marijuana Use May Damage Developing Brain in Teens, Young Adults

... our work reinforces the idea that the adolescent brain may be especially vulnerable to risky behaviors such as substance abuse, because of crucial neural development that occurs during those years." The National Institute of Mental Health provided grant support for this research. Ashtari's and ...

Protein Shown to Play a Key Role in Normal Development of Nervous System

... to helping patients recover motor function after they suffer an injury to the spinal cord or other parts of the nervous system," said Kalb. "Often neural circuits remain intact after an injury, and are capable of reorganizing themselves, given the proper stimulation. If we can eventually manipulate ...

deCODE Files IND for DG071, a Novel PDE4 Modulator Being Developed for Alzheimer's and Other Cognitive Disorders

... safer means of targeting PDE4 to combat memory loss and cognitive deficits associated with Alzheimer's disease and other disorders in which neural signaling is reduced or impaired. In animal models, DG071 has been shown to significantly improve learning and long- and short-term memory at ...

Fralex provides update on timing of interim analysis results

... today provided an update on receiving results of the interim analysis for the RELIEF pivotal study. The trial is investigating the use of Complex neural Pulse or CNP(TM) therapy for the relief of chronic pain associated with fibromyalgia. The Independent Data Monitoring Committee ("DMC") is ...

Genetic Engineering & Biotechnology News Reports on the Growing Role of Ion-Channel Studies in Global Biotech R&D

... Engineering and Biotechnology News (GEN). Such interest is not surprising as ion channels play key roles in numerous biological processes such as neural signal transduction, cardiac, skeletal, and smooth muscle contraction, and epithelial transport of nutrients and ions, among others, according to ...

NARSAD Researchers Identify Specific Genes and Family Traits Linked to Schizophrenia, Bipolar Disorder and Depression

... located all over the brain -- called NMDA ( N-methyl-D-aspartate) receptors -- that are critical to learning, memory, brain development, and general neural processing. However, what causes low folate in people with schizophrenia is still open to question. One reason, confirmed by epidemiological ...

Molecular Therapy Succeeds in Preventing Craniofacial Birth Defect in Mice

... in the TCOF1 gene on chromosome 5 causes a high degree of cell death in the embryo, resulting in a deficiency in a cell population called the neural crest that is essential for generating most of the bone and cartilage that make up the head and face. Dr. Trainor's team showed in 2006 that the loss ...

'Brain Signature' for Cigarette Cravings Identified

... respond to visual, smoking-related cues, such as a picture of a cigarette or of someone smoking," said Lerman. "However, less is known about the neural basis of urges that arise naturally as a result of nicotine deprivation. This study was designed help fill this research gap." This joint ...

Ceregene Presents Long-term Follow-up From Phase 1 Trial of CERE-120 in Parkinson's Disease

... follow-up data from a Phase 1 clinical trial of CERE-120 in 12 patients with advanced Parkinson's disease. CERE-120 uses gene therapy to deliver the neural growth factor neurturin to the major area of neurodegeneration that occurs in the brains of Parkinson's disease patients. Long-term follow up ...

One Shot of Gene Therapy Spreads Through Brain in Animal Study

... to produce the desired enzyme. "We found that one subtype of AAV was particularly effective for transporting the gene," said Wolfe. "The neural pathways carried the virus throughout the brain, where the gene produced the enzyme. The enzyme then cleaned up the storage lesions to the point that ...

Stanford Researchers Track Human Stem Cells Transplanted Into Rat Brain

... Medicine have illuminated the path taken by human neural stem cells that were transplanted into the brains ... track cells in living animals, including in rat neural stem cells. If the point is to use the technique ... when the group placed those iron-filled human neural stem cells into the brains of rats--either ...

Millipore Corporation Announces New ReNcell Data from Collaboration with ReNeuron

... the release of new data concerning its ReNcell neural stem cell lines. The research was conducted by ... 12pt; mso-layout-grid-align: none"> The ReNcell neural stem cell lines are immortalized human ... have the ability to readily differentiate into neural cell types and will replicate indefinitely. ...

Addex Reports Positive Results in Phase IIa Clinical Trial With ADX10059 in Migraine

... shown that glutamate is largely responsible for signal transmission in the neural circuit involved in migraine, and mGluR5 receptors are found at ... class of medicines that modulate the effects of glutamate and thus offer a neural - nerve-based - therapy for migraine sufferers," commented Professor Peter ...

Sangamo BioSciences Announces Presentation of ZFP Therapeutic Data From Nerve Regeneration Program at American Society for Neural Therapy and Repair Meeting

... in the laboratory of Dr. Michael Fehlings who holds the Krembil Chair in neural Repair and Regeneration at the Krembil Neuroscience Center, Toronto ... hold promise as a unique therapy for spinal cord injury and other forms of neural injury." "Dr. Fehling's studies, particularly the experiments ...

DOR BioPharma Announces Publication Describing Results of Its Multivalent Botulinum Toxin Vaccine BT-VACC

... the threat of purposeful food contamination a real possibility for use of the toxin as a biological weapon. Because the toxin rapidly enters target neural cells, exposure is difficult to treat with any available therapeutic regimen other than supportive care. In extremely minute quantities, botulinum ...

DOR BioPharma Announces Issuance of European Patent for Its Oral Multivalent Botulinum Toxin Vaccine BT-VACC

... threat of purposeful food contamination with botulinum toxin a real possibility as a biological weapon. Because the toxin rapidly enters target neural cells, exposure is difficult to treat with any available therapeutic regimen other than supportive care. In extremely minute quantities, botulinum ...