CeNeRx BioPharma Obtains Rights to Novel Drug Candidate for Prevention and Treatment of Neurodegeneration Disorders
... --Orally Active Enhancer of Human
nerve Growth Factor Has Demonstrated Promising Activity ... orally active agent that enhances the effects of
nerve growth factor (NGF). CeNeRx intends to initiate ... CXB909 is a downstream enhancer of the effects of
nerve growth factor, an endogenously produced ...
Video: UCB Launches Vimpat(R) in the U.S. for Add-On Treatment of Epilepsy in Adults
... the activity of the nervous system to help
nerve cells communicate. Sometimes sodium channels are abnormally overactive and
nerve cells become too excited, which may produce a ... then regulates the activity of over-excited
nerve cells, which may contribute to the control of ...
Metastatic Bone Disease Patients Can Walk in Lazarus' Footsteps
... and weak. As the bones are replaced with tumor,
nerve endings in and around the bone send pain signals ... or cold to desensitize the bone by killing the
nerve endings in the vicinity of the metastasis. Once the
nerve endings are dead, interventional radiologists can ...
Got Pain?
... causing the fingers to curl toward the palm) and
nerve pain, explains Dr. Osterman. But new treatments, like arthroscopy, collagenase injections,
nerve wraps, desensitization techniques, therapeutic ... for patients with Dupuytren's contracture."
nerve pain ( ...
Patient Enrollment in Urgent(R) PC SUmiT Clinical Trial Completed Ahead of Schedule
... compare the effectiveness of percutaneous tibial
nerve stimulation (PTNS) using Urgent PC to a ... system is a proprietary, minimally invasive
nerve stimulation device designed for office-based ... of neuromodulation therapy targets specific
nerve tissue and disrupts the signals that lead to ...
Wrist Access Safer, Easier for Many Patients Undergoing Minimally Invasive Treatment of Blocked Heart Arteries
... keep it open. But there is a risk of bleeding and
nerve damage at the femoral artery access site. To ... significantly reduces the risk of bleeding and
nerve damage, suggests data on more than 5,000 ... used, there is a 2.8 percent risk of bleeding or
nerve damage, according to studies. Most patients spend ...
MRI Emerges As Vital Resource in Treatment of Back Pain
... pathology including; diseases of the spinal cord,
nerve roots, vertebrae, disks and blood vessels. With ... method available for patients with pacemakers,
nerve stimulators, or those who suffer from ... to find out which disk is causing pain, which
nerve is firing, which metabolites are present in ...
Sangamo BioSciences Provides Update on Company's 2008 Progress and 2009 Objectives
... significant
improvements in measures of
nerve health at 180 days post treatment.
-- ... observed in improvement in measures of
nerve health between placebo and
treated subjects at ... with moderate to severe DN with a
blocked
nerve and SB-509-703 in stem cell mobilization.
...
PharmAthene Initiates Phase I Clinical Trial of Nerve Agent Bioscavenger Protexia(R)
... recombinant bioscavengers for prophylaxis
against
nerve agent poisoning," stated David P. Wright, ... that Protexia(R) used as a prophylactic
against
nerve agents might offer important benefits over medical
countermeasures for
nerve agent poisoning," continued Mr. Wright. ...
Protein Shown to Play a Key Role in Normal Development of Nervous System
... protein helps precise
connections to form among
nerve cells may provide a basis for eventual
treatments ... promotes the growth of
dendrites, both in
nerve cell cultures and in the nervous system of mice.
Dendrites are branching extensions of
nerve cells that carry signals into
the cell. The most ...
Quark Pharmaceuticals Announces First RNAi Drug Candidate Having a Novel, Proprietary Structure Covered by Quark Intellectual Property
... different animal models of
acute and severe optic
nerve injury. In collaboration with Prof. Ann Logan
of ... of
retinal ganglion cell (RGC) death by optic
nerve crush (ONC). In a second
study of QPI-1007 in ... and also in
slow-progressing chronic optic
nerve injuries such as glaucoma. QPI-1007
has the ...
PharmAthene Presents Data for Protexia(R) and Valortim(R) at 2008 BARDA Industry Conference / PHEMCE Stakeholders Workshop
... on the battlefield or civilian victims of
nerve agent attacks.
Valortim(R), in co-development ... may
have efficacy as a therapeutic against
nerve agent exposure.
-- A study of Valortim(R) in a ... and degrade organophosphate poisons (e.g.
nerve agents) before they
cause neurological damage. ...
AMT Obtains License to Amgen's GDNF Gene to Develop Treatment for Parkinson's Disease with AMT's Proprietary Gene Therapy Platform
... is
caused by degeneration and death of
nerve cells in a specific part of the
brain. These ... a substance necessary for
communication between
nerve cells involved in the coordination of ... by Parkinson's disease."
Protect and improve
nerve cells with GDNF
The GDNF gene contains the ...
Sangamo BioSciences Initiates Phase 2 Clinical Trial of Treatment for Amyotrophic Lateral Sclerosis (ALS)
... cell mobilization.
VEGF-A has been shown to have
nerve protection properties as well as
promoting nerve, ... growth.
In ALS, the motor nerves comprised of
nerve cells in the brain and
spinal cord that control ... voluntary muscles, gradually
degenerate. As the
nerve cells begin to die, the muscles weaken and ....
The University of Nottingham in the British Midlands Announces Breakthrough in Parkinson's Disease Research
... model
with the type of brain degeneration, or
nerve cell loss, seen in Lewy body
disease and ... Lewy bodies is a key
event in the development of
nerve cell death associated with Parkinson's
disease. ... will help us to figure out what
happens when
nerve cells die in Parkinson's and from this to ...
Device Blocking Stomach Nerve Signals Shows Promise in Obesity
... the 31 obese participants who received the
vagal
nerve blocking device, also called VBLOC(TM) vagal ... initial assessment of whether
blocking the vagus
nerve electrically could cause obese patients to ... it uses high-frequency
electricity to block the
nerve impulses between the brain and the stomach
and ...
Headache Specialists Convene in Boston For 50th Annual American Headache Society Meeting
... in a variety of ways, such as by a virus,
nerve damage or even medication. Morphine and ... Near-Daily Migraines Stimulating a
nerve might be just the ticket to help relieve the pain of chronic migraine sufferers. Occipital
nerve stimulation, in which an implanted ...
Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting
... were observed in measurements of
nerve health and function in subjects
with mild to ... SB-509
is designed to address the actual
nerve damage. These data demonstrate that
SB-509 may ... there was a trend towards improvement in
nerve conduction
velocity (NCV), a measure of the ...
Sangamo BioSciences Provides Update on Diabetic Neuropathy Clinical Programs
... of the endpoint in
this trial -- recovery of
nerve conduction velocity or NCV -- these
additional ... in diabetic subjects that have
unmeasurable
nerve conduction velocity (NCV) in at least one of the ... with so-called "blocked nerves" or unmeasurable
nerve conduction
velocity measurements in the leg ...
Uroplasty Highlights Clinical Results From a Study of the Urgent(R) PC Neuromodulation System
... Study Results Comparing Percutaneous
Tibial
nerve Stimulation with Pharmaceutical Therapy at the ... minimally invasive percutaneous
tibial
nerve stimulation (PTNS) device designed for ... Multi-center Study Comparing
Percutaneous Tibial
nerve Stimulation with Pharmaceutical Therapy for ...
PharmAthene's Recombinant Butyrylcholinesterase (rBChE) May Play A Neuroprotective Role in Alzheimer's Disease
... to
additional areas beyond organophosphorous
nerve agent toxicity with
potentially important ... against acute organophosphorous (OP)
nerve agent toxicity.
About Chemical Weapons
Organophosphorous
nerve agents, or anti-cholinesterase agents, ...
Study Finds Starion Instruments' Tissue Welding Technology Safe and Effective in Parotidectomy Procedures
... particular interest was the incidence
of facial
nerve palsy since this is one of the most severe ... postoperative complications of
bleeding, facial
nerve paresis, salivary fistula, and gustatory ... this instrument can be used close to
the facial
nerve and that no current passes through the patient, ...
Sangamo BioSciences Announces Completion of Enrollment of Phase 2 Clinical Trial of ZFP Therapeutic for Diabetic Neuropathy
... improvements in motor and sensory
nerve conduction velocities
(NCV) and a trend towards ... of vibration, electrophysiological
testing using
nerve conduction velocity (NCV) to assess the rate at ... the direct therapeutic
effect of SB-509 on
nerve regrowth. This test may provide an ...
Diamyd Updates Gene Therapy Program and Outlines Plans for Phase I Clinical Trial for Treatment of Cancer Pain
... NP2, the company's first drug
candidate in its
nerve targeting drug delivery system (NTDDS) gene ... license rights to a
portfolio of patents for the
nerve Targeting Drug Delivery System (NTDDS).
This ... genes. The NTDDS has a natural
affinity for
nerve cells. Diamyd's initial NTDDS projects are ...
Dirucotide Does Not Meet Primary Endpoint in Phase III MAESTRO-01 Trial in Secondary Progressive Multiple Sclerosis
... MS is caused by damage to myelin, the protective sheath surrounding
nerve fibers in the central nervous system, resulting in disrupted
nerve impulses traveling to and from the brain and spinal cord(iii). Symptoms ...
July 2009 Mayo Clinic Health Letter Highlights a Positive Outlook, Bell's Palsy and Heart Valve Repair
...
The disorder is often related to a viral infection. The
nerve that controls facial muscles passes through a narrow corridor of bone on its way to the face. If the
nerve becomes inflamed or swollen, typically due to a viral infection, it can ...
UNT Health Science Center's Groundbreaking Research Applied to Protecting Brain After Traumatic Injury
...
In 1994, Simpkins discovered that estrogens were protective to
nerve cells and subsequently has demonstrated that, if administered soon after brain injury in animals, estrogens can protect
nerve cells and reduce neurological deficits. Application of these discoveries ...
Data Demonstrates Long-Term Reduction In Seizure Frequency With Novel Once Daily Anti-Epileptic Zebinix(R)
...
Epilepsy is characterised by abnormal firing of impulses from
nerve cells
in the brain. In partial-onset seizures, these bursts of electrical ... Nerve
impulses are triggered via voltage-gated sodium channels in the
nerve cell
membrane.
Treatment of partial-onset seizures, the most common ...
Autism Genes Discovered; Help Shape Connections Among Brain Cells
...
Neuronal cell-adhesion molecules are important because they affect how
nerve cells communicate with each other, thought to be an underlying problem in ... Ubiquitins are a class of enzymes that eliminate connections among
nerve cells, and are involved with processing and degrading neuronal ...
Study Shows Leconotide, an Investigative Calcium Channel Blocker, Has Potential as a Selective, Efficacious, Non-Opioid Pain Treatment
... or rate of electrical firing or production
of chemical messengers in
nerve cells. Calcium antagonists block calcium
channels. There are many types ... heart and blood vessels to lower
blood pressure). Calcium channels in
nerve cells are involved with many
functions (e.g., pain, memory and control of ...
Roskamp Institute Identifies New Class of Drugs to Treat Alzheimer's Disease
... response. This inflammatory response is thought to be detrimental to
nerve cells, eventually causing their destruction.
Recent research at ... more amyloid, and researchers have found that a specific receptor on the
nerve cell surface, known as CXCR2, is an interface between inflammation and new ...
Aiming at Multiple Alzheimer's Proteins May be Key to Success
... an accumulation of beta amyloid protein
"plaques" around the brain's
nerve cells and tau protein "tangles" within
these cells is connected to a ... of both beta amyloid and tau, before they begin to affect the
brain's
nerve cells. "Alzheimer's disease is a complex ailment and may have
overlapping ...
Uroplasty Enrolls First Patients in Urgent(R) PC Clinical Trial
... is a minimally
invasive, office-based, nonsurgical, percutaneous tibial
nerve stimulation
(PTNS) device that treats these symptoms. The Company believes ... PC system, which we
believe is the only FDA-approved minimally invasive
nerve stimulation
device designed for office-based treatment of urinary urgency, ...
FDA Lifts Clinical Hold on Genta's Tesetaxel, a Leading Oral Taxane
... myelosuppression
(low blood counts) and peripheral neuropathy (disabling
nerve damage).
With administration as an oral capsule, tesetaxel was developed ... unlike other oral taxanes that are currently in
clinical development,
nerve damage has not been a prominent side effect of
tesetaxel. Thus, the drug ...
Alseres Pharmaceuticals, Inc. to Address a Congressional Briefing on Paralysis Research and the Spinal Cord Injury Community at 'Working 2 Walk' in Washington, DC, April 13-15, 2008
... CETHRIN with the aim of
providing a first-ever therapeutic option for
nerve repair to patients with
acute spinal cord injury, we are committed to the ... initiatives. CETHRIN, a
recombinant-protein-based drug designed to promote
nerve repair after acute
spinal cord injury, demonstrated positive interim ...
NeurogesX Announces Preliminary Results from Second Phase 3 Clinical Trial in HIV-DSP
... About PHN and HIV-DSP
PHN is a painful condition affecting sensory
nerve fibers. It is a
complication of shingles, a second outbreak of the ... Following an initial infection, some of
the virus can remain dormant in
nerve cells. Years later, age, illness,
stress, medications or other factors ...
Sangamo BioSciences Reports 2007 Fourth Quarter and Year-End Financial Results
... sensory testing and clinically relevant trends toward improvement in
nerve conduction velocity in subjects with mild to moderate diabetic ... on stem cell mobilization,
ALS, cancer, HIV/AIDS, neuropathic pain,
nerve regeneration, Parkinson's
disease and monogenic diseases. Sangamo's core ...
Ceregene Presents Long-term Follow-up From Phase 1 Trial of CERE-120 in Parkinson's Disease
... in the United States. It is caused by a reduction
in dopamine containing
nerve cells of the midbrain. Dopamine is a
neurotransmitter involved in ... clinical
programs include CERE-110, an AAV2 based vector expressing
nerve growth
factor that is currently in Phase 1/2 studies for the treatment ...
Anesiva Defines Regulatory Pathway for Adlea with FDA
... and end-stage
osteoarthritis. Because it selectively acts on pain-sensing
nerve endings,
Adlea does not affect other
nerve fibers necessary for sensory or motor
sensations and proprioception. ...
Anesiva Initiates Phase 2 Trial with Adlea(TM) for Pain Relief Following Total Hip Replacement Surgery
... and end-stage
osteoarthritis. Because it selectively acts on pain-sensing
nerve endings,
Adlea does not affect other
nerve fibers necessary for sensory or motor
sensations and proprioception. ...