Negative in Medical Technology

University of Michigan Study Shows SEQUENOM's MassARRAY Technology Identifies HPV Infections Missed by Standard Hybridization Test

... 15% of women in the study group determined to be negative for the presence of human papillomavirus (HPV) in ... HPV in nearly half (46.7%) of women who tested negative by the Hybrid Capture 2 (HC2) test, which is ... of the 75 cervical scraping samples that were negative for high-risk HPV by the HC2 test were positive ...

Study Demonstrating Lurasidone Is Effective in Patients With Schizophrenia Published in The Journal of Clinical Psychiatry

... measures, including the PANSS (Positive and negative Syndrome Scale) total score (-14.1 vs. -5.5; ... positive subscale (-4.3 vs. -1.7; p=0.006), PANSS negative subscale (-2.9 vs. -1.3; p=0.025) and CGI-S ... The condition is characterized by positive and negative symptoms, such as hallucinations, delusions, ...

CuraGen Updates CR011-vcMMAE Data at ASCO

... for metastatic disease was 4 (range 2-11). Triple negative disease (ER/PR/Her-2 negative) was present in 44% ... (1 confirmed), including a patient with triple negative disease. Fifty percent (50%) of patients showed ... or similar terms, variations of such terms or the negative of those terms. Such forward-looking statements ...

Scientists at The Karmanos Cancer Institute in Detroit Identify Potential New Target for Breast Cancer Therapy

... target for aggressive hormone receptor negative breast cancer tumors. (Logo: ... scientists tested 84 cases of hormone receptor negative human breast carcinomas and discovered that the ... in 74 percent of those cases. Hormone receptor negative breast carcinoma is considered an aggressive ...

Video: Partnership Unites UCB with Consumer Product Innovator OXO(R)

... and antibody testing for histoplasmosis may be negative in some patients with active infection. Empiric ... of tuberculosis in patients who tested negative for latent tuberculosis infection prior to ... of tuberculosis in patients who tested negative for latent tuberculosis infection prior to ...

First Candidate from Esperance's Targeted Anti-cancer Platform, EP-100, Establishes Preclinical Proof of Concept

... resistant ovarian cancer cells (OVCAR-3). As a negative control, the study utilized LHRH receptor negative SKOV-3 ovarian cancer cells. In in vitro ... and was slow-acting (p<0.005). LHRH receptor negative SKOV-3 cells were significantly less sensitive to ...

FDA Approves an Expanded Indication for Peginterferon-Based Combination Therapy for Patients With Chronic Hepatitis C

... and prior relapsers (patients who were HCV-RNA negative at the end of treatment and subsequently relapsed ... In the study, patients who were HCV-RNA negative at week 12 were treated for a total of 48 weeks ... therapy should not be started until a report of a negative pregnancy test has been obtained immediately ...

Novexel's NXL104/ceftazidime Combination Commences Phase II Clinical Trial in Hospital Patients With Complicated Urinary Tract Infections

... treat hospital infections that are caused by Gram negative bacteria, including those resistant to ... of hospital infections caused by resistant Gram negative bacteria. The start of our first Phase II ... will be targeting infections caused by Gram negative bacteria, including Enterobacteriaceae and ...

Most Cancer Treatment Studies Aren't Published, Study Finds

... trials. The researchers suspect that the rate of negative results is much higher in the studies that have ... Sponsors may not encourage researchers to publish negative results. For their part, medical journal editors may be less enthusiastic about negative studies. However, publication ...

MacroChem Announces Phase 2 Data for EcoNail(R) in the Treatment of Onychomycosis

... as negative mycology (negative fungal culture and negative KOH) and clear nail (as determined by expert ... 100% of patients had cultures that were negative for dermatophyte growth. Eight of the 37 patients ... of negative mycology (negative fugal culture plus negative KOH evaluation) at 48 weeks. The panel observed ...

Data Presented at the American Psychiatric Association (APA) Annual Meeting Demonstrate Iloperidone's Efficacy and Safety, With Low Rates of Movement and Metabolic Adverse Events

... (p=0.000093) -- The highest sensitivity and negative predictive value were seen with rs9643483 ... 2005 Sep 22;353(12):1209-23. (1) Positive and negative Symptom Scale Total (PANSS-T) (2) PANSS negative (PANSS-N), PANSS Positive (PANSS-P) (3) Brief ...

SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia

... is measured on 30-item Positive and negative Syndrome Scale (PANSS) scale. Each symptom was ... scale from 1-7. PANSS positive (7 items), negative (7 items), and general psychopathology (16 ... Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. ...

BiPar Begins Phase 2 Study of Lead PARP Inhibitor in Triple-Negative Breast Cancer Based on Overexpression Biomarker Data

... that are estrogen-negative and progesterone- negative were more likely to overexpress PARP, as ... even more likely to be overexpressed in triple- negative tumors. That suggests that PARP inhibition may be ... and progesterone-negative and 90 percent of HER2- negative patients. PARP is a well-characterized and ...

INVEGA(TM) Significantly Reduced Symptoms of Schizophrenia Compared to SEROQUEL(R) in Acutely Ill, Hospitalized Patients

... the PANSS, which includes positive symptoms, negative symptoms, disorganized thoughts and uncontrolled ... (hallucinations and delusions) and negative symptoms (depression, blunted emotions, and ... National Prescription Audit). (b) Positive and negative Syndrome Scale for Schizophrenia (PANSS) is ...

AspenBio Pharma Reports Strong Results with Appendicitis Triage Blood Test from Large Multiple Hospital Study

... risk of sending patients home because of a false negative diagnosis. The bottom line is we believe we can ... 99.9). Practically, this means a patient with a negative AppyScore has an extremely low likelihood of ... for life threatening mis-diagnoses. The false negative diagnosis of appendicitis could become much less ...

Genetic Differences Predict Anti-Inflammatory Benefits From Nutritional Products

... after botanical treatment than those who tested negative for the IL-1 gene variations. The genetic test ... No CRP effect was observed in the IL-1 genotype negative subjects. "We have known for many years that ... genetic groups based on being either positive or negative for the IL-1 gene variations that are associated ...

Schering-Plough Announces U.S. Filing of Mometasone Furoate/Formoterol Fumarate Combination for the Maintenance Treatment of Asthma

... for ASMANEX TWISTHALER. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit ... FORADIL AEROLIZER is initiated. You are encouraged to report negative side effects of prescription drugs to the FDA. Visit ...

UPDATE: US Oncology Research Network Participates in Phase III Follow-up Study to BiPar's Investigational Cancer Drug BSI-201

... of BSI-201 which is a very promising new treatment for metastatic triple negative breast cancer," says Dr. O'Shaughnessy. "We expect that accrual will be ... with gemcitabine and carboplatin. Phase II of the study in triple negative breast cancer patients found that BSI-201 + G/C resulted in a ...

SIMPONI(TM) (golimumab) Receives Positive Opinion From CHMP for Once-Monthly Subcutaneous Treatment of Rheumatoid Arthritis, Psoriatic Arthritis and Ankylosing Spondylitis

... or highly significant risk factors for tuberculosis infection and have a negative test for latent tuberculosis. Patients receiving SIMPONI should be ... tuberculosis during and after treatment, including patients who tested negative for latent tuberculosis infections. The use of TNF blocking agents ...

Dainippon Sumitomo Pharma Announces Lurasidone Phase III Data in Patients With Schizophrenia

... was associated with greater improvement on both the Positive and negative Syndrome Scale (PANSS) total score (primary endpoint) and the Clinical ... and genetic factors. The condition is characterized by positive and negative symptoms, such as hallucinations, delusions, disorganized thinking, lack ...

Schering-Plough Highlights Hepatitis C Clinical Data Presentations at the European Association for the Study of the Liver (EASL) Annual Meeting

... high baseline viral load (greater than or equal to 600,000 IU/mL), both negative factors for achieving SVR. Eligible patients were randomized to one ... Pregnancy REBETOL therapy should not be started until a report of a negative pregnancy test has been obtained immediately prior to planned initiation ...

Ground-Breaking Combination of All-Oral Agents Demonstrates Potential as Hepatitis C Treatment Regimen

... of adult patients with chronic hepatitis B (HBeAg positive and HBeAg negative chronic hepatitis B who have compensated liver disease and evidence of ... anemia). COPEGUS THERAPY SHOULD NOT BE STARTED UNLESS A REPORT OF A negative PREGNANCY TEST HAS BEEN OBTAINED IMMEDIATELY PRIOR TO INITIATION OF ...

Roche and Pharmasset Initiate Phase IIb Clinical Trial of R7128, Most Advanced Nucleoside Polymerase Inhibitor in Development for Chronic Hepatitis C

... of adult patients with chronic hepatitis B (HBeAg positive and HBeAg negative chronic hepatitis B who have compensated liver disease and evidence of ... anemia). COPEGUS THERAPY SHOULD NOT BE STARTED UNLESS A REPORT OF A negative PREGNANCY TEST HAS BEEN OBTAINED IMMEDIATELY PRIOR TO INITIATION OF ...

Novexel's NXL104/ceftazidime Combination Commences Second Phase II Clinical Trial in Hospital Patients With Complicated Intra-Abdominal Infections (cIAIs)

... is being developed to treat hospital infections that are caused by Gram negative bacteria, including those resistant to many currently used antibiotics. ... combination with the cephalosporin antibiotic ceftazidime for serious Gram negative infections, and the oral streptogramin antibiotic, NXL103, for the ...

Medarex Announces Initiation of Phase 1b Clinical Development Program with MDX-1106 for the Treatment of Cancer

... binding of PD-1 with one of two ligands (PD-L1 or PD-L2) is an important negative regulation pathway that suppresses or inhibits activated lymphocytes. ... as a strong correlation between increased PD-L1 expression on tumors and a negative survival prognosis in cancer patients. Preclinical studies indicate that ...

Hologic Releases the Results of the Cervista(TM) HPV Clinical Trials

... of the study were as follows: -- 100% CIN3 detection and a corresponding negative predictive value of 100%. Patients with CIN3 are at the highest risk of ... -- The sensitivity of the test for CIN2+ was 92.8%, with a corresponding negative predictive value of 99.1%. Patients with CIN2 are at risk of developing ...

Study Suggests Treatment with Paliperidone ER Significantly Improves Symptoms of Schizoaffective Disorder

... Mean modal dose for the higher dose (12mg/day) group (b) Positive and negative Syndrome Scale for Schizophrenia (PANSS) is a standard rating scale used ... from absent to extreme, and these are divided into both positive and negative symptoms (c) Mean modal dose for the lower dose (6mg/day) group (d) ...

Deer Farm Industry in Michigan Issues Statement on the Negative CWD Test Results at Kent County Deer Farm

... for CWD. The deer farm industry is issuing the following statement on the negative CWD test results on the rest of the herd at the Kent County Farm. The ... received welcome news when the Department of Agriculture released the negative CWD test results from tested herd at the location of Michigan's first CWD ...

New Survey Explores the Impact of Insulin Injections and Communications Between Patients and Healthcare Providers

... 14 percent of individuals surveyed felt that the insulin injections had a negative impact on their life (three percent experience a major negative impact/11 percent experience a moderate negative impact) and more than 29 ...

Soyfoods Do Not Impact Sperm Count

... with a decrease in fertility. Obesity may be the explanation for the negative findings of this study. Dr. Chavarro found high soyfood intakes are ... first to find this correlation. The research on soy in men has not found a negative impact on male hormones but rather has suggested a preventive effect in ...

Pharmasset Announces Initiation of Combination Study of Clevudine and Viread(R) for HBV by French National Agency for Research on AIDS and Viral Hepatitis (ANRS)

... of both drugs administered to 150 treatment-naive hepatitis B e-antigen negative HBV-infected patients for 96 weeks. At that time, all therapy will be ... ability to provide a sustained virologic response in patients with eAg negative chronic HBV infection, as either monotherapy or in combination, offering ...

New Meta-Analysis Confirms Safety Profile for NeoRecormon in Treating Anaemia in Cancer Patients

... in the British Journal of Cancer Reports That NeoRecormon use has no negative Impact on Overall Survival or Tumour Progression A new meta-analysis of ... shows that treating anaemia with NeoRecormon(R) (epoetin beta) has no negative impact on survival, tumour progression or deaths caused by blood clots, ...

IDM Pharma Announces Phase 2 Follow-Up Data Showing IDM-2101 is Well Tolerated With Positive Survival Trend in Non-Small Cell Lung Cancer Patients

... with IDM-2101, compared to a parallel external control group of HLA-A2 negative non-treated patients. "We continue to be encouraged by the positive ... are as follows: -- One-year survival IDM-2101 patients versus HLA-A2 negative patients (n=72) but otherwise comparable group -- 60 percent versus ...

St. Jude Study Shows How T Cell's Machinery Dials Down Autoimmunity

... through the T cell receptor could give rise to a subtle failing in negative selection, which gives rise over a long period of time to a few overly ... very big reduction in T cell receptor signal strength to have a defect in negative selection." The study also showed that different T cell functions ...

Overview of Asenapine Data from Olympia Trial Program Presented at American Psychiatric Association Annual Meeting

... patients, asenapine produced 19- to 20-point reductions in Positive and negative Syndrome Scale (PANSS) total score and was significantly superior to ... of approximately 400 patients with acute schizophrenia was considered a negative trial, as the active-control (olanzapine) differentiated from placebo ...

BiPar Sciences Expands Phase 2 Clinical Trials of BSI-201, a Novel DNA Repair Inhibitor, in Ovarian Cancer

... 15,000 annually in the United States. Patients with the hereditable BRCA- negative form of the disease account for about 15 percent of the patient ... The company is currently conducting a Phase 2 trial of BSI-201 in triple- negative breast cancer and is collaborating with the New Approaches to Brain Tumor ...

Pew Commission Says Industrial Scale Farm Animal Production Poses 'Unacceptable' Risks to Public Health, Environment

... in a study released today. Commissioners have determined that the negative effects of the IFAP system are too great and the scientific evidence is ... first developed simply to help increase farmer productivity and that the negative effects were never intended. Regardless, the consequences are real and ...

Supportive Oncology Services Accrues One Million Cancer Patient Self-Reported Assessments

... of PROs in caring for the patient and potentially predicting and avoiding negative outcomes has been recognized by the Institute of Medicine (Cancer Care for ... and we expect they will be useful in predicting and avoiding untoward negative events, thereby improving the patients' ultimate health outcome." About ...

Early Research Suggests Umbilical Cord Blood Cell Therapy May Reduce Progression of Alzheimer's Disease

... result from such matters; decreases in asset valuations; any continued negative effect from adverse publicity in the past year regarding the Company's business operations; any negative consequences resulting from deriving, shipping and storing specimens at a ...

Increasing Dairy Milk Production with Electrolyzed Drinking Water

... over the course of the study showed the EAU treated water was consistently negative for coliform organisms such as E. coli and other bacteria. Blood chemistry ... "forecasts," "potential," or "continue," or similar terms or the negative of these terms. Although we believe that the expectations reflected in ...