mutation

Researchers Discover Gene For Rare Skin Disorder

...nt of Goltz syndrome cases. Identifying a genetic mutation for Goltz syndrome is a criticalfirst step in understanding and eventually treating the condition,said Duane Alexander, director of the National Institute of ChildHealth and Human Development, the NIH institute that providedfunding for the Mental Ret...

Pharmasset Presents Clevudine and Racivir Data at the International HIV Drug Resistance Workshop

...ty against wild type HIV-1virus and that the M184V mutation confers resistance to entecavir.In addition, we sh...sof virus from responders indicated that the M184V mutation wasfound on all clones in addition to multidrug resistance-associatedmutations observed with first l...

Pharmexa A/S (DK) - Long lasting immune response and survival to RAS vaccine

...th two differentpeptide vaccines targeting the RAS mutation found in most instancesof pancreatic cancer indicates that a long lasting immune responseis possible following immunization with a peptide vaccine. Fivepatients that showed an immune response to the vaccine were stillalive in 2006, i.e. up to 10 year...

Kosan Presents Preliminary Phase 2 Data Showing Antitumor Activity of Hsp90 Inhibitor Tanespimycin in Metastatic Melanoma at ASCO

...astatic melanoma,including one patient with a BRAF mutation (V600E) who had failedprior chemotherapy (within 6...tients. One of the 6evaluable patients with a BRAF mutation (V600E) showed evidence ofanti-melanoma activity. An additional patient with BRAF mutationcontinues ...

Preclinical Study Finds Protease Inhibitor-Resistant HIV May Have Reduced Potential to Develop Resistance to Panacos' Bevirimat

...inthe PI-resistant virus. The bevirimat resistance mutation thatappeared in PI-resistant virus was located at the CA-SP1 junctionand has been observed previously in bevirimat resistance generationstudies. The CSHL conference presentation concluded that bevirimatresistance may be less likely to arise in PI-res...

Independent Publication Confirms Growing Therapeutic Challenge of T315I Mutation in Patients with CML, Notes ChemGenex

...gtonine). The paper "Targetedtherapy and the T315I mutation in Philadelphia-positive leukemias"by researchers ...utic challenge presented by theT315I Bcr-Abl point mutation in patients with chronic myeloidleukemia (CML). The T315I Bcr-Abl mutation is associated with thedev...

Independent Publication Confirms Growing Therapeutic Challenge of T315I Mutation in Patients with CML, Notes ChemGenex

...gtonine). Thepaper "Targeted therapy and the T315I mutation inPhiladelphia-positive leukemias" by researchers ... were T315I positive. • In summary the T315I mutation wasassociated with resistance to dasatinib in 31% of patients, and thetotal number of patients who w...

PTC Therapeutics Announces Additional Positive Interim Phase 2 Results of PTC124 in Duchenne Muscular Dystrophy

...linical trialparticipants are boys with a nonsense mutation in the dystrophingene, substantially elevated seru...ange of other genetic disordersin which a nonsense mutation is the cause of the disease. The FDAhas granted PTC124 Fast-Track designations and Orphan Drugdesign...

Targeting Specific Mutations Reveals Promising New Approach to Treating Genetic Disorders; Preclinical Data Published in Nature

...'swork in a mouse model of DMD in which a nonsense mutation precludesthe production of dystrophin. Loss of functional dystrophin, animportant muscle protein involved in maintaining the strength ofmuscle fibers, results in DMD. The data demonstrate that PTC124allows dystrophin to be made in cells in which it w...

ImClone Systems Showcases Extensive Research and Development Program at the AACR Annual Meeting

...Expression of epiregulinand amphiregulin and K-RAS mutation status may predict diseasecontrol in metastatic co...hcetuximab (ERBITUX(R)); #5671 Lievre et al. K-RAS mutation incolorectal cancer is a predictive factor of response andprogression free survival in patients trea...

AVEO Presents Preclinical Efficacy Data on AV-412, a Novel Oral Tyrosine Kinase Inhibitor of EGFR/HER2 for EGFR Mutant and Drug-Resistant Lung Cancer

... against tumors carryingthe EGFR kinase-resistance mutation EGFR L858R/T790M. These datawere presented today i...ngadenocarcinomas carrying the erlotinib-resistant mutation EGFRL858R/T790M. These in vivo results suggest that AV-412 may exertpotent clinical activity against...

Achillion Presents Positive Data on Novel Mechanism for Treating HCV at EASL Annual Meeting

...nt ofprotease or polymerase inhibition. "The high mutation rate of HCV necessitates the combination useof drugs with complimentary mechanisms of action in order tosuppress viral resistance. Therefore, the possibility thatcandidates with the unique NS4A antagonism mechanism may becomplementary to protease and...

Amicus Therapeutics Presents Preclinical Data from Studies of Plicera for Gaucher Disease

...zyme in cells derived from apatient with the N370S mutation and in mice that express the L444Pmutation. The N3... Plicera was removed. The N370S is the most common mutation associated with Gaucher disease in the Western world. These studies were published in the...