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When Volume Matters, Immunoassay Systems Deliver

... lab productivity and that have evolved to require minimal maintenance or technician interaction. Here is a brief overview of some of the leading products in this competitive category. Note that each of the companies mentioned manufactures a range of devices to accommodate the size and production levels of b...

Monitoring Options Expand for Therapeutic Agents and Drugs of Abuse

...tures QuickScreen multi-panel dip cards that offer minimal exposure to the urine sample and selectivity for any combination of nine different drugs. The test card is dipped into the urine specimen and a built-in timer indicates availability of results. The slit-lid cover and a hinged leak-proof lid snap into...

Appendicitis: Evolving Tools to Diagnose a Classic Disease

... abdominal pain, nausea, and loss of appetite have minimal if any predictive value for appendicitis versus other abdominal conditions. Clinicians fail to appreciate appendicitis on presentation in 25-30% of children. Uncertainty often remains even after physical exam. The classic finding of right lower qu...

Immunoassay Systems - Your Laboratory Workhorse

... lab productivity and that have evolved to require minimal maintenance or technician interaction. Here is a brief overview of two prominent products in this highly competitive category. Note that each of the companies mentioned manufactures a range of devices to accommodate the size and production levels of ...

BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine

...tudies, BioVant has been shown to besafe and cause minimal dose-dependent inflammation at the injectionsite, and has been shown to both prevent the manifestation ofallergic response, and, to effectively 'switch off' establishedTh2-T-cell-associated allergic disease. About BioSante Pharmaceuticals, Inc. Bio...

Molecular Target of Bradmer's Neuradiab Further Validated by Independent Findings

...y to residual brain tumor cellsafter surgery, with minimal impact on normal brain tissue. Duringthe course of development at Duke University, over US$60 million inresearch grants and related support has produced a series of PhaseI and Phase II clinical trials on Neuradiab and closely relatedtechnologies. App...

Gene Therapy Eradicates Pancreatic Cancer in Preclinical Trial Targeting System's Success in Mouse Model Reported in Cancer Cell

...vitywas limited to pancreatic cancer cells and was minimal or absentfrom other cancers and three lines of normal pancreatic, lung andbreast cells. The next step was to load the vector with a weapon. The teampackaged its mutant version of the Bik gene along with C-VISA in aliposome. For comparison, the lipos...

Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ESMO Conference

...well toleratedat doses as high as 2000 mg/day with minimal toxicity. Moreover, nodose limiting toxicity has b...e been treated, CB7630 was welltolerated with only minimal toxicity in this post-docetaxelpopulation. In the 21 patients who have been in the study for over3 m...

Keryx Biopharmaceuticals, Inc. Announces Positive Phase I and Phase II Data on KRX-0401 in Patients with Relapsed/Refractory Multiple Myeloma and Waldenstrom's Macroglobulinemia

...d an overall response rate (partialresponse (PR) + minimal response (MR)) of 31%. In 16 evaluablepatients treated with perifosine plus bortezomib, there were 2 PR'sand 1 MR. Two additional MR's were observed on this combinationafter dexamethasone was added; both of these patients werepreviously refractory to...

An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes

...c transporter (OCT). Digoxin: Sitagliptin had a minimal effect on the pharmacokineticsof digoxin. Following administration of 0.25 mg digoxin concomitantlywith 100 mg of JANUVIA daily for 10 days, the plasma AUC of digoxinwas increased by 11%, and the plasma Cmax by 18%. Metformin: Co-administration of...

Publication on Pixantrone Preclinical Studies Demonstrates Reduced Cardiotoxicity Compared to Equiactive Doses of Doxorubicin and Mitoxantrone

...at treatment with pixantrone (BBR2778) resulted in minimal or no significant cardiotoxicity, whiledoxorubicin...r models pixantrone showedhigher effectiveness and minimal or lack of cardiotoxicity ascompared to mitoxantrone or doxorubicin. The findings reported inthis ar...

New Study Shows A1c Reduced Safely By Patients With Type 2 Diabetes Using Self-Adjusted Dosing Starting With Once-Daily Insulin Treatment Levemir

..., and,as shown in this study, the added benefit of minimal weightchange.” The new data were obtained...s were .02event/patient/month for both groups) and minimal weight change (.2kg for 303 Algorithm group and -.3 kg for Standard-of-Caregroup). About Levemir&re...

Late Breaking Data Released at ADA Showed that the Investigational Use of Januvia and Metformin as Initial Combination Therapy Provided Significant Glucose Lowering Efficacy over 54 Weeks in Patients with Type 2 Diabetes

...c transporter (OCT). Digoxin: Sitagliptin had a minimal effect on the pharmacokineticsof digoxin. Following administration of 0.25 mg digoxin concomitantlywith 100 mg of JANUVIA daily for 10 days, the plasma AUC of digoxinwas increased by 11%, and the plasma Cmax by 18%. Metformin: Co-administration of...

Positive Clinical Results for DG041 Lead Product Development Highlights at deCODE R&D Event

...ets a pathway not addressed by existingdrugs, with minimal impact on normal platelet function. DG031 and DG051 - Heart attack In its drug development programs targeting the leukotrienepathway for the prevention of heart attack, deCODE is advancing thereformulation of its FLAP inhibitor DG031 for re-entry i...

New Study Shows A1c Reduced Safely By Patients With Type 2 Diabetes Using Self-Adjusted Dosing Starting With Once-Daily Insulin Treatment Levemir

..., and, as shown in this study, theadded benefit of minimal weight change." The new data were obtained from...s were .02 event/patient/month for bothgroups) and minimal weight change (.2 kg for 303 Algorithm groupand -.3 kg for Standard-of-Care group). About Levemir(R...

Eurand's Zentase Effective in Treating Exocrine Pancreatic Insufficiency, Studies Show

... Zentase. -- Well Tolerated. There were minimal AEs, none of which led to discontinuation or study drug interruption. One serious AE was considered unrelated to study drug and resolved without discontinuation. The most commonly reported AEs were abdominal pain, steatorrhe...

Studies Show Efficacy and Safety of Alexion's Soliris in Broad Population of PNH Patients

... clone sizes, low levels of hemolysis,less anemia, minimal pre-treatment transfusion requirements andthose receiving steroids or erythropoietin. Dr. Muus noted, "In published clinical trials, Solirissignificantly reduced hemolysis in all PNH patients, which led toan improvement in anemia, patient function...

Metabasis Therapeutics Presents Results of Preclinical Studies for MB07811, Its Novel Product Candidate for the Treatment of Hyperlipidemia, at the Endocrine Society's Annual Meeting

...ats led to liver-selective tissuedistribution with minimal effects on gene expression inextra-hepatic tissues. The studies in rats and mice showed animproved safety profile, including no cardiac effects and reducedeffects on the thyroid hormone axis compared to KB-141. The second poster provides data show...

Study Shows Advantages of Complete Phase Ib Trial Over Separate Phase I Trials

...ditive properties of combination drugs,rather than minimal threshold, were studied, indicating the use oftwo drugs given together with no detrimental effects. The research found that the Complete Phase Ib trial has severaladvantages over conducting separate phase I trials. The advantagesinclude: a very rapi...

Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at ASCO Annual Meeting

...well tolerated at doses as highas 2000 mg/day with minimal toxicity. Moreover, no dose limitingtoxicity has b...e been treated, CB7630 was well toleratedwith only minimal toxicity in this post-docetaxel population. Inthe 13 patients who have been in the study for over 3 ...

Waismann Method Survey Reveals Dependency Risk for People Using Suboxone

.... During the procedure,the patient will experience minimal conscious withdrawal, and willbe able to return home within days. Over 65 percent of the patientswho are treated with the Waismann Method remain drug free after oneyear. The Waismann Foundation, founded by Clare Waismann, isheadquartered in Beverly H...

Microbia Announces Positive Phase 2 Results for Its Investigational Compound Linaclotide

... designed to exert its effect on the intestinewith minimal systemic exposure. In Phase 1 testing linaclotide waswell tolerated and was not detected in the systemic circulation ofhealthy subjects. Linaclotide is currently being studied in a pairof Phase 2 dose- ranging trials for IBS-C and CC. About Irritabl...

Cougar Biotechnology Announces Presentation of Positive CB7630 Clinical Data at AUA Annual Meeting

...well tolerated atdoses as high as 2000 mg/day with minimal toxicity. Moreover, nodose limiting toxicity has been observed in the trial to date. In the 30 patients who were evaluable in the Phase I/II trial,18 patients (60%) experienced a confirmed decline in prostatespecific antigen (PSA) levels of greate...

Positive results from placebo-controlled phase IIa study in patients suffering from house dust mite allergy

... orreactivity only up to the level of a predefined minimal symptomscore. Allergic rhinitis: a condition due to allergy that mimics a cold.Rhinitis means "inflammation of the nasal mucous membranes". Atopic dermatitis: a chronic skin disease; a certain type ofeczema. Is accompanied by an inherited tendency to...

Waismann Method Survey Reveals 65 Percent of Women Seeking Opiate Dependency Treatment Are Mothers

.... During the procedure,the patient will experience minimal conscious withdrawal, and willbe able to return home within days. Over 65 percent of the patientswho are treated with the Waismann Method remain drug free after oneyear. The Waismann Foundation, founded by Clare Waismann, isheadquartered in Beverly H...

Isotechnika Announces Interim Three Month Data from Phase 2b Kidney Transplant Trial

...l result in efficacy (lackof acute rejection) with minimal side effects that are typicallyseen with other calcineurin inhibitors such as cyclosporine andtacrolimus. A total of 332 de novo (newly transplanted) kidney transplantpatients will be enrolled in this trial. Patients will be placedinto one of four s...

Quest PharmaTech's Prostate Cancer Program Update

...tion of normal and cancerous prostatetissues, with minimal side effects. The use of 18 F FDG (flurodeoxyglucose) PET imaging pre and post PDT treatment, highlighted thecomplete shut down of metabolic activity at the tumor site 24 hoursafter PDT treatment. The practical application of this new PDT treatmen...

Aeolus Pharmaceuticals' AEOL 10113 May Play an Important Role Regulating the Oxidative Damage Induced by Ionizing Radiation

...adiotherapy balances maximumtumor destruction with minimal toxicity and damage to normaltissue. The "ionizing radiation" used in cancer radiotherapygenerates reactive oxygen species (ROS) and other free radicals.These free radicals cause DNA damage and cell death. Catalyticantioxidants, such as Aeolus' AEOL ...

Gilead Announces Presentation of Positive Phase III Data on Aztreonam Lysine for Inhalation in Patients With Cystic Fibrosis

...ted patients experienced improvementsexceeding the minimal clinically important difference inrespiratory symptoms compared to 37 percent of placebo-treatedpatients (p=0.0196). AIR-CF2 is the first randomized, controlledstudy of an aerosolized antibiotic to include and show improvementsin respiratory symptoms...

Aeolus Pharmaceuticals' AEOL 10113 Demonstrates Potential as a Protector of Healthy Normal Cells from Cancer Radiation Therapy

...adiotherapy balances maximumtumor destruction with minimal toxicity and damage to normaltissue. The "ionizing radiation" used in cancer radiotherapygenerates reactive oxygen species (ROS) and other free radicals.These free radicals cause DNA damage and cell death. Catalyticantioxidants, such as Aeolus' AEOL ...

Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51

...ivedegradation of DNMT1 in human cancer cells with minimal or noeffects on DNMT3A and DNMT3B that have been discovered. Thisaddresses an issue with re-activation of silenced tumor suppressorgenes by 5-Azacytidine (5-AzaC or Vidaza) and its congener 5-aza-deoxycydinite (5-aza-CdR or Decitabine or Dacogen). Th...

Cougar Biotechnology Presents Positive CB7630 Clinical Data at AACR Annual Meeting Late-Breaking Clinical Trials Session

...well tolerated at dosesas high as 2000 mg/day with minimal toxicity. Moreover, no doselimiting toxicity has b...e been treated, CB7630 was well toleratedwith only minimal toxicity in this post-docetaxel population. Inthe 13 patients who have been on study for over 3 mont...

Callisto Intends to Move Guanilib into Clinical Trials in Ulcerative Colitis

...o treat gastrointestinal diseases,while exhibiting minimal side effects or toxicity. Treatment withGuanilib down-regulated production of IL-17 by 50%, IL-23 by 70%and TNF by 50% in addition to showing reduction of other cytokinesincluding IL-4 and IL-5. Recent data on IBD suggest thatproinflammatory IL-17 an...

Targanta Reports Improved Ability of Oritavancin to Stop Bacteria Growth In Vitro Compared With Other Glycopeptide Antibiotics

... percent of the agent for up to 24 hours. ORI minimal inhibitory concentrations (MICs) for S. aur...sults showed a 2- to 4-fold increase in ORI minimal inhibitory concentration (MIC), compared with a greater than or equal to 64-fold increase for...

New Data Show Early Non-Response to Antipsychotic Treatment May Be Strong Predictor of Subsequent Non-Response for People with Schizophrenia

...n-responders(patients that did not show at least a minimal level of earlyimprovement) on symptom remission, physical and mental healthfunctioning, perceptions of medication influence, and totalhealthcare costs at eight weeks. Statistically significant findingsincluded: - Early response or non-response ...

Baxter Announces Final Phase I/II Data and Initiation of Phase III Clinical Trial for Candidate Pandemic H5N1 Influenza Vaccine

...njection sitereactions, headaches and fatigue. The minimal occurrence and lowlevel of side effects are similar to those reported for licensedegg-based, seasonal influenza vaccines. These final data confirmthe preliminary results of this study previously announced.Comprehensive analyses of the results of the ...

Isotechnika's independent data monitoring committee conducts review of phase 2b kidney transplant trial

...l result in efficacy (lackof acute rejection) with minimal side effects that are typicallyseen with other calcineurin inhibitors such as cyclosporine andtacrolimus. A total of 332 de novo (newly transplanted) kidneytransplant patients will be enrolled in this trial. Patients willbe placed into one of four se...