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Pharmacyclics Announces Data and Publication Characterizing Highly-Selective HDAC Inhibitor

... play a role in T-cell lymphoma and other immune mediated diseases. "To our knowledge, this is the first ... developing may be useful in addressing diseases mediated by T-cells such as T-cell lymphomas or certain ... innovative products to treat cancer and immune mediated diseases. The company is leveraging its ...

Novavax Announces Top Line Results of Phase IIa Clinical Trial for Its Seasonal Influenza VLP (Trivalent) Vaccine Candidate

... inducing not only anti-HA responses but also anti-neuraminidase and cell mediated immune responses. We believe these attributes of the VLP vaccine may ... tract, potentially reducing the severity of influenza disease; and cell mediated immune responses to M1 may lead to destruction of cells already infected. ...

Alba Therapeutics Presents New Data for Larazotide Acetate at the 2008 American College of Gastroenterology Annual Scientific Meeting

... The study showed that larazotide acetate inhibited increased permeability mediated with TNF-alpha and IL-4, which suggests the potential of larazotide ... and commercialization of therapies to treat auto-immune, immune mediated and inflammatory diseases and is located in Baltimore, Maryland. ...

SARcode and Sunesis Announce Start of Phase 1 Clinical Trial in Ocular Inflammatory Diseases

... 1 clinical trial of a small molecule LFA-1 product candidate for T-cell mediated ophthalmic diseases. Sunesis and SARcode entered into a license agreement ... immunomodulators/ anti-inflammatory agents for the treatment of T-cell mediated inflammatory diseases. About Sunesis Pharmaceuticals Sunesis is a ...

DG041 Blocks Platelet Aggregation Through a Novel Mechanism and does not Increase Bleeding Time When Given Alone or with Plavix(TM) or Aspirin

... out of this study is that DG041 was shown to substantially inhibit EP3 mediated platelet activation that is not being addressed by current therapy. This ... dramatically inhibit platelet aggregation as well as platelet activation mediated specifically through vasodilator-stimulated phosphoprotein (VASP), a ...

Pharmacyclics Novel Btk Inhibitor Shows Efficacy in Preclinical Models of Rheumatoid Arthritis and Lymphoma

... promise for potential use in humans with advanced RA and other immune mediated diseases. The inhibition of B-cell function and proliferation in the ... and inhibition of its function may be useful in the treatment of immune mediated diseases. Mast cells play a key role in the inflammatory process and are ...

GlaxoSmithKline Announces New Drug Application and Phase III Results for Rezonic(TM)/Zunrisa(TM) (Casopitant)

... associated with CINV. The central pathway is activated by substance P and mediated by neurokinin (NK-1) receptors that are highly concentrated in the brain. The peripheral pathway is stimulated by serotonin and mediated by 5-HT3 receptors located primarily in the gut.(7) NK-1 receptor ...

Tapestry Pharmaceuticals Presents Data on TPI 287 at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

... TPI 287 is less sensitive in a variety of cancer cell lines to MDR1 mediated efflux than other approved taxanes. MDR1 mediated drug efflux may be a primary cause of resistance to chemotherapy with ...

Jazz Pharmaceuticals and UCB Announce Second Phase III Study of Sodium Oxybate in Patients With Fibromyalgia Meets Primary Endpoints

... of gamma-hydroxybutyrate, an endogenous neurotransmitter and metabolite of GABA. While the precise mechanism of action is unknown, the effects may be mediated in part through interaction with GABA(B) and GHB receptors. Sodium oxybate is the active ingredient in XYREM(R), approved by the FDA and marketed by ...

MacroGenics and Lilly Achieve Targeted Patient Enrollment in PROTEGE, a Global Phase 2/3 Clinical Trial of Teplizumab in Type 1 Diabetes

... in the area of type 1 diabetes. Beyond diabetes, we also look forward to investigating teplizumab with MacroGenics to potentially treat other T-cell mediated autoimmune diseases." About Teplizumab Teplizumab, an investigational compound under development for the treatment of individuals with ...

Data Suggest Sodium Oxybate Significantly Improves Pain and the Core Symptoms of Fibromyalgia

... of gamma-hydroxybutyrate, an endogenous neurotransmitter and metabolite of GABA. While the precise mechanism of action is unknown, the effects may be mediated in part through interaction with GABA(B) and GHB receptors. Sodium oxybate is the active ingredient in XYREM(R), approved by the FDA for the ...

Proteolix, Inc. Drug Candidate, PR-957, Prevents Disease Progression in Rheumatoid Arthritis Models by Selective Inhibition of the Immunoproteasome

... hours after dosing and a complete amelioration of disease was achieved with a single dose. When compared to anti-TNF-a therapy (etanercept), PR-957 mediated a more rapid resolution of clinical symptoms, including joint inflammation, and was more effective than etanercept in a model of aggressive ....

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

... Monia, G.W. Cline, V.T. Samuel, G.I. Shulman. Matrix Metalloproteinase-9: Association With Insulin Resistance and Obesity and PKC-alpha mediated Regulation by Pioglitazone Authors: R. Unal, A. Yao-Borengasser, V. Varma, N. Rasouli, B. Phanavanh, C. Labbate, B.P. Monia, P.A. Kern, G. ...

Pixantrone in Combination with Chemotherapy Regimens Produces Overall Response Rates of 58-74% with Complete Remission Rates of 37-57% in Relapsed/Refractory Aggressive or Indolent NHL

... to the chemical compound believed to be responsible for enhanced DNA damage and binding to topoisomerase II enzyme, a key target for anthracycline mediated tumor death. These modifications are also hypothesized by the authors to underlie the drugs' low cardiotoxicity profile in preclinical animal studies ...

CEL SCI Collaborators Demonstrate Novel L.E.A.P.S. Vaccines Immunize Mice Against Tuberculosis Antigens and Suggest Potential to Treat Swine and Other Influenzas

... from blood monocyte cells to become dendritic cells that secrete the IL-12 cytokine. The dendritic cells that result initiate a protective cell mediated and antibody immune response. These results were obtained for L.E.A.P.S. vaccines against HSV and HIV. The use of the L.E.A.P.S. vaccine technology ...

Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, Is Well Tolerated and Demonstrates Activity in Phase I Solid Tumor Patients

... activity as a single agent; synergy with commonly used chemotherapy agents, targeted agents, and radiation; and has been shown to reverse resistance mediated through the PI3K/PTEN pathway. About PI3 Kinase Phosphatidylinositol 3 kinases (PI3K) are involved in one of the major pathways of ...

Clinical Data on Semafore's SF1126, a Vascular Targeted Pan-PI3K/mTOR Inhibitor, to be Presented at the 2009 ASCO Meeting

... activity as a single agent; synergy with commonly used chemotherapy agents, targeted agents, and radiation; and has been shown to reverse resistance mediated through the PI3K/PTEN pathway. About PI3 Kinase Phosphatidylinositol 3 kinases (PI3K) are involved in one of the major pathways of ...

RAPAFLO(TM) (silodosin) Provides Rapid and Sustained Benign Prostatic Hyperplasia (BPH) Symptom Relief in as Little as Three Days

... study period. "The severity of urinary symptoms appears to depend in part on smooth muscle tone in the prostate and bladder neck, which is mediated by alpha 1A adrenoreceptors," said Leonard S. Marks, MD, author of the study and professor of urology at the Geffen School of Medicine, the ...

Bayer and Regeneron Extend Development Program for VEGF Trap-Eye to Include Central Retinal Vein Occlusion

... Bayer HealthCare Executive Committee. "Since the underlying biology of CRVO is related to edema and the growth of abnormal new blood vessels that are mediated by vascular endothelial growth factor (VEGF), we are hopeful that VEGF Trap-Eye may help address this significant unmet medical need." About ...

Processed Tomato Products May Protect Against Inflammation, According to a Study Presented at the Experimental Biology Meeting

... protein level that was lower in response to the high-fat meal. High-tomato intake was also associated with increased mean vessel diameter, but flow mediated vasodilatation was not different, possibly related to the BMI of subjects. The researchers concluded that processed tomatoes provide a protective ...

Pharmacyclics Initiates Phase 1 Clinical Trial of Novel Oral Btk Inhibitor for Refractory B-cell Non-Hodgkin's Lymphoma

... tyrosine kinase is a critical enzyme involved in B-cell activation and function, and inhibition may be useful in the treatment of a number of immune mediated diseases. B-cells are a type of white blood cell that normally play an important role in the body's immune response. However, when B-cells are ...

Novexel's NXL104/ceftazidime Combination Commences Second Phase II Clinical Trial in Hospital Patients With Complicated Intra-Abdominal Infections (cIAIs)

... is being developed to address the increasing problem of microbial resistance to beta lactam antibiotics (penicillins, cephalosporins, carbopenems) mediated by beta-lactamase enzymes. NXL104 is a significant advance, as it is able to inhibit a broader range of beta-lactamases than currently ...

Cordex Pharma Announces Strategic Master Services Equity Agreement With Cato BioVentures

... dose of adenosine in terminating PSVT. While both ATP and adenosine inhibit AV nodal conduction, ATP is believed to have dual inhibitory action, one mediated by adenosine, the product of ATP's rapid enzymatic degradation, and the other a rapid and potent ATP-triggered vagal reflex. Physical vagal maneuvers ...

Jazz Pharmaceuticals, Inc. Completes Enrollment in Second of Two Phase III Clinical Trials of Sodium Oxybate to Treat Fibromyalgia

... gamma-hydroxybutyrate, an endogenous neurotransmitter and metabolite of GABA. While the precise mechanism of action is unknown, the effects may be mediated in part through interaction with GABA(B) and GHB receptors. Sodium oxybate is the active ingredient in XYREM(R), approved by the FDA for the ...

Intra-Cellular Therapies Announces Successful Outcome of a Phase II Clinical Trial with ITI-007 in Patients with Sleep Maintenance Insomnia

... (DPPM) for the treatment of schizophrenia. A low dose formulation of ITI-007 (formerly referred to as ITI-722) whose actions are predominantly mediated by 5HT2A receptor antagonism is being developed for the treatment of SMI. "The results that we have analyzed to date from this study are ...

Cylene Pharmaceuticals Initiates Phase I Trial With CX-4945 -Breakthrough First-in Class Inhibitor of CK2

... cell proliferation as well as in angiogenesis. As such, CX-4945 is a truly novel therapeutic, particularly against cancers and in other indications mediated by IL-6 and IL-8," added Dr. Daniel Von Hoff, Cylene's Co-Founder and Vice President, Medical Affairs. About CX-4945, an oral CK2 protein ...

Jazz Pharmaceuticals and UCB Announce Positive Phase III Results for Sodium Oxybate (JZP-6) in Fibromyalgia

... of gamma-hydroxybutyrate, an endogenous neurotransmitter and metabolite of GABA. While the precise mechanism of action is unknown, the effects may be mediated in part through interaction with GABA(B) and GHB receptors. Sodium oxybate is the active ingredient in XYREM(R), approved by the FDA for the ...

Duska Therapeutics Applies for Phase 3 Special Protocol Assessment

... dose of adenosine in terminating PSVT. While both ATP and adenosine inhibit AV nodal conduction, ATP is believed to have dual inhibitory action, one mediated by adenosine, the product of its ATP's rapid enzymatic degradation, and the other a triggered vagal reflex. Vagal maneuvers, such as Valsalva ...

Novexel's NXL104/ceftazidime Combination Commences Phase II Clinical Trial in Hospital Patients With Complicated Urinary Tract Infections

... is being developed to address the increasing problem of microbial resistance to beta lactam antibiotics (penicillins, cephalosporins, carbopenems) mediated by beta-lactamase enzymes. NXL104 is a significant advance, as it is able to inhibit a broader range of beta-lactamases than currently marketed ...

Micromet Presents Data at the 23rd Annual Meeting of the International Society for Biological Therapy of Cancer on the Activity of Human Antibody Adecatumumab against KRAS-mutated Colon Cancer Cells

... California. The new preclinical data indicated that human colon cancer cells are efficiently eliminated in tested cell lines by adecatumumab, mediated by antibody-dependent cellular cytotoxicity (ADCC), irrespective of their KRAS mutation status. Recent studies suggest that anti-EGFR antibodies ...

Nerviano Medical Sciences Invited by EORTC-NCI-AACR to Present the State-of-the-Art of Aurora

... of Histone H3 in patients treated with PHA 739358 supports this hypothesis whereby the anti-cancer activity exerted by the compound is mediated through inhibition of Aurora kinases. "Results obtained to date in humans reveal that PHA 739358 is a molecule with a good tolerability profile and ...

New Data Support Role for Monitoring of Cell-Mediated Immunity in Adult Patients Following Renal Transplantation

... assay to prospectively monitor intracellular adenosine triphosphate (ATP) concentrations following CD4 cell activation as a measure of cell- mediated immune function in 81 immunosuppressed adults who underwent kidney transplantation. The objective of their study was to examine the association ...

New Data Support Earlier Suggested Guidance for Levels of Cell-Mediated Immunity in Pediatric Liver Transplant Patients

... published in the peer-reviewed journal Liver Transplantation, have further developed our understanding of the clinical potential of monitoring cell- mediated immunity in pediatric liver-transplant patients post-transplantation. Working in a cooperative group involving several institutions in Petach- ...

Nature Publication Reports on Key Role of Bile Acids in Glucose Metabolism and Insulin Signaling

... Ph.D., a group leader at the Ecole Polytechnique Federale de Lausanne commented, "Our research efforts have uncovered a number of endocrine effects mediated by bile acids acting on receptors such as FXR and TGR5. This review is one of the first to provide a comprehensive summary of what is now known about ...

PTC Therapeutics Announces $25 Million Award From Cystic Fibrosis Foundation Therapeutics for Development of PTC124

... physician, patient, advocacy and regulatory communities. We look forward to initiating registration-directed studies of PTC124 for nonsense-mutation- mediated CF within the next few months." In June 2008, PTC announced encouraging new data from recently completed Phase 2a studies in adult and pediatric CF ...

Results Published in the Journal 'Cancer' Demonstrate that Oral Talactoferrin Alfa is Active as Monotherapy in Previously Treated Patients with Metastatic Renal Cell Carcinoma

... maturation. DC maturation in the presence of tumor antigens and lymphoid effector cells induces a strong systemic innate and adaptive immune response mediated by anti-cancer Natural Killer (NK) cells, CD8+ lymphocytes and NK-T cells. This results in the activation of tumor-draining lymph nodes, cellular ...

Genetic Immunity to Present at 2008 BIO International Convention

... encoded antigens. DermaPrep is the topical administration device that delivers NanoComp into a patient's lymph node dendritic cells to induce T cell mediated immune responses that can treat a broad spectrum of diseases. These two components together make up the DermaVir Patch. The plasmid DNA within ...

Preliminary Phase 2 Results of R788 in Lymphoma Show Benefit in Diffuse Large B-Cell and SLL/CLL

... cells, grow uncontrollably and build up in the lymphatic system and bone marrow giving rise to malignant tumors. The uncontrolled growth is, in part, mediated by the Syk enzyme, which signals the growth/survive mechanism of the aberrant cells. By inhibiting Syk, that signal is curtailed and the aberrant ...

University of Miami Team Confirms Value of Monitoring Cell-Mediated Immunity Pre- and Post-Transplant in Management of Kidney Transplant Recipients

... Departments of Surgery and Pathology at the University of Miami - Lawrence Miller School of Medicine have corroborated the value of monitoring cell- mediated immunity (CMI) post transplant in recipients of kidney transplants using a regular laboratory assay of cell function (ImmuKnow(R)/Cylex). Their ...

Naturally Occurring Compounds in Cocoa Tied to Blood Flow Improvements for Adults With Type 2 Diabetes

... hours following consumption. The researchers found a positive correlation between the flavanol dose consumed and immediate improvements in FMD (flow mediated dilation, a measure of vessel health, i.e. the ability of a vessel to relax). In a subsequent controlled 30-day, double-masked clinical trial, ...
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