Markers in Medical Technology

Prometheus Announces New Findings Regarding Patients at Risk for Celiac Disease at DDW

... of Crohn's disease and particular genetic markers in patients at risk for celiac disease. In an ... cohort further confirmed that using multiple markers combined with Prometheus' Smart Diagnostic ... cutoff value analysis of the individual markers alone. PROMETHEUS IBD Serology 7 combines ...

Phase III Trial Showed Investigational Compound Arzoxifene Was Superior to Evista(R) (raloxifene HCl) in Increasing BMD in Postmenopausal Women with Osteoporosis

... Arzoxifene Significantly Suppressed Bone Turnover markers versus Raloxifene in Postmenopausal Women with ... at suppressing bone turnover as assessed by serum markers of bone metabolism. In this study of 320 ... significant increases in BMD and suppression of markers of bone turnover seen in these data show the ...

Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL

... of 64 years) stratified according to cytogenetic markers that were identified by fluorescent in situ ... GCLLSG and Comprehensive Analysis of Prognostic markers The multicenter trial evaluated ... risk of infection. About Cytogenetic markers In some cases of CLL, at least one of the 23 ...

Exiqon Forms Research Collaboration With M. D. Anderson Cancer Center

... agreement with the Kleberg Center for Molecular markers at The University of Texas M. D. Anderson Cancer ... in understanding and developing molecular markers for treatment changes and our effort in ... of M. D. Anderson's Kleberg Center for Molecular markers and chair of the Department of Systems Biology. ...

Data Presented at the American Psychiatric Association (APA) Annual Meeting Demonstrate Iloperidone's Efficacy and Safety, With Low Rates of Movement and Metabolic Adverse Events

... data were presented identifying genetic markers that may help predict response to iloperidone, ... and haloperidol, respectively. Study of Genetic markers to Predict Likelihood of Response to Iloperidone ... to ziprasidone The combination of six markers defined several groups of patients with different ...

Imaging Results From the ADAGIO-LIPIDS Reveal That Effects of Rimonabant on Cardiometabolic Risk Profile Include Loss of Visceral Fat and Mobilization of Liver Fat

... consistent effects of rimonabant on several markers of cardiometabolic risk. For instance, ... (increase of 4.8% vs placebo). Several markers of HDL concentration and quality were also ... on lipid metabolism" mentioned Dr Despres. "All markers of cardiometabolic risk improved in the right ...

Virogenomics, Inc. Awarded $2 Million National Institute of Standards and Technology (NIST) Advanced Technology Program Grant to Develop Integrated Diagnostic Biosensors

... (SSOP) that tests for many different biological markers in a single assay. Successful development of the ... have multiple contributing factors and surrogate markers of interest. For that reason a single test can ... ability to rapidly screen for multiple disease markers and antibodies in real time on a microchip will ...

School of Dentistry Studies Link Between Oral Health and Memory

... level of inflammatory byproducts," Crout explained. "We're looking for markers in the blood that show inflammation to see if there is a link to memory ... up some of the problems in the mouth and then see if the inflammatory markers go down." Researchers don't yet understand whether microorganisms in ...

Arena Pharmaceuticals Announces Lorcaserin Data Demonstrating Highly Significant Categorical and Absolute Weight Loss and Improvements in Secondary Endpoints Associated with Cardiovascular Risk

... glucose, fasting insulin and insulin resistance Inflammatory markers of Cardiovascular Risk: high-sensitivity CRP and fibrinogen ... several key secondary endpoints, including changes in serum lipids, markers of inflammation and insulin resistance, and in the BLOOM-DM trial, other ...

Mayo Researchers Help Discover Genetic Cause for Primary Biliary Cirrhosis

... the illness, researchers designed a three-phase study to identify genetic markers associated with the disease. In phase one, researchers conducted a ... given that the researchers started by looking at 300,000 genetic markers across approximately three billion base pairs that comprise our entire ...

Moffitt Cancer Center Signs Licensing Agreement with Frantz BioMarkers, LLC

... on ovarian cancer biomarker research, combining use of these licensed markers with lipid markers developed independently by Frantz BioMarkers. Each year, 26,000 women ...

Anthera's Varespladib Meets Primary Endpoint in Phase 2 FRANCIS Trial for the Treatment of Acute Coronary Syndrome

... was designed to assess the impact of oral varespladib on known biological markers of cardiovascular risk. It enrolled 625 patients who will be treated for ... A2 (sPLA2), has demonstrated marked improvements in independent markers of cardiovascular risk including, a near complete suppression of sPLA2 ...

YM BIOSCIENCES ANNOUNCES NIMOTUZUMAB PRESENTATIONS TO BE MADE AT THE 100TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH AND EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY

... The authors conclude that toxicities of Erbitux(R) should not be viewed as markers for clinical benefit of EGFR-targeting antibodies in general, but only as markers of indiscriminate targeting of that particular antibody, with the EGFR ...

Molecular Marker Identifies Normal Stem Cells as Intestinal Tumor Source

... and other tissues. The researchers are also exploring the use of stem cell markers in diseases other than cancer. "As we develop these kinds of characteristic markers for stem cells, we might be able to use them to isolate stem cells capable ...

Concord Grape Juice Has No Significant Impact on Body Weight

... consumption of 100% Concord grape juice on body weight, diet quality, and markers of metabolic syndrome. The study included 76 men and women between the ... in waist circumference, demonstrating a beneficial effect on one of the markers of metabolic syndrome. There were no changes in other markers of metabolic ...

Experts Assert That Varian Technologies Deliver Speed and Clinical Accuracy in Treating Cancer Patients

... structures, such as the tumor and surrounding organs, making fiducial markers unnecessary. "It's often not possible to place fiducial markers into lung tumors without risking the possibility of a collapsed lung or ...

Anthera Completes Special Protocol Assessment With FDA and Receives EMEA Scientific Advice on Development Path Toward Varespladib Approval

... A2 (sPLA2), has demonstrated marked improvements in independent markers of cardiovascular risk including, a near complete suppression of the ... Suppression) to assess the impact of oral varespladib on known biological markers of cardiovascular risk in ACS patients with elevated LDL and CRP. FRANCIS ...

Vion Pharmaceuticals Enters into Agreement to Conduct a Phase I/II Clinical Trial of Cloretazine(R) in Combination with Induction Therapy in Poor Prognosis AML Patients

... or more than 60 years of age). The prognostic value of various molecular markers will also be studied. The trial is expected to start this fall and will ... biologists in order to facilitate the use of new technologies and biologic markers in a multi-center setting, as well as a centralized cell repository. The ...

Interleukin Genetics to Present Important New Findings at 2008 World Congress on Osteoarthritis

... new findings by Interleukin Genetics and collaborators, titled "Genetic markers Associated with Generalized Osteoarthritis," will be presented during the ... specific gene variations were investigated to determine whether these markers were predictive of which knee OA patients also had hand OA. It was found ...

Anthera Pharmaceuticals Advances Global Development Strategy for Varespladib in Patients With Acute Coronary Syndrome With the Initiation of FRANCIS Trial

... is designed to assess the impact of oral varespladib on known biological markers of cardiovascular risk. It will enroll up to 500 patients that will be ... A2 (sPLA2), has demonstrated marked improvements in independent markers of cardiovascular risk including, a near complete suppression of the ...

Markers in Blood and Spinal Fluid, and a New Imaging Agent, Show Promise for Early Detection of Alzheimer's

... trials, and to direct and monitor therapy. "Discovery of measurable markers that track with the presence of Alzheimer's pathology and that predict the ... at the Alzheimer's Association. "It is greatly preferable that these markers be easy to obtain, such as in samples of blood or urine, or through ...

Synvista Therapeutics Reports Results of Three Phase 2 Clinical Trials of SYI-2074 in Diabetic Patients with Cardiovascular Disease

... acute coronary syndrome at this time, in the absence of stronger surrogate markers of efficacy," said Noah Berkowitz, M.D., Ph.D., President and Chief ... and urinary isoprostanes, CRP, myeloperoxidase, paraoxonase and other markers of inflammation or oxidative stress. Trial 203 was a Phase 2, ...

Exelixis Reports Encouraging Phase 1 Data for XL184 at ASCO

... of the evaluated MTC patients had reductions in the MTC-associated plasma markers calcitonin and carcinoembryonic antigen. Most of the MTC patients in the ... demonstrated statistically significant changes at the MTD in plasma markers including VEGF-A, PlGF, and soluble VEGFR2, similar to the effects of ...

New Data on MAGE-A3 Cancer Immunotherapy Support Potential Novel Options of Treating Non-Small Cell Lung Cancer and Melanoma

... on the melanoma tumors prior to immunization were used to identify genetic markers expressed by the disease. These markers enabled researchers to establish a correlation between the expression of ...

AviaraDx Confirms That Combination of Two Molecular Biomarkers Improves Prediction of Disease Recurrence in Early Stage Breast Cancer Patients

... According to the paper published this month, the combination of these markers provides superior risk stratification as it relates to endocrine benefit ... of a highly proliferating tumor." The authors conclude that these two markers together should enable oncologists to identify a large subgroup of women ...

Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of 'Knock-Out' Cell Lines

... gene of interest with an efficiency that obviates the need for selection markers and other complicated strategies to identify knockout cells -- a dramatic ... process occurred with sufficiently high frequency that selection markers were not required to identify multiple independent knockout cell lines ...

Novel Small Molecule Therapy Shows Benefit for Anemic Patients Via Hydration of Red Blood Cells

... study, senicapoc was evaluated for its effect on hemoglobin level and markers of RBC destruction (hemolysis) in SCD patients. The investigators also ... level from baseline to end of study, and secondary endpoints included markers of hemolysis, changes in RBC count and indices, and frequency of painful ...

Abbott Receives Supplemental FDA Approval for its Best-in-Class in Sensitivity RealTime HIV-1 Viral Load Test

... for use in conjunction with clinical presentation and other laboratory markers as an indicator of disease prognosis and for use as an aid in assessing ... diagnostic markers, and is developing diagnostic products based on these markers as well as other known markers. Celera maintains a strategic alliance with ...

Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis

... The objective of the 221-patient Phase 2 clinical trial was to assess safety and evaluate the effect of three doses of BA058 on bone formation markers and on lumbar spine and femoral neck BMD over six months relative to placebo. The study also included a Forteo(R) reference arm. Forteo(R), a form of ...

Idenix Pharmaceuticals Successfully Completes Proof-of-Concept Study of IDX184 for the Treatment of Hepatitis C Virus (HCV)

... to advance into broader clinical trials." In the 75 and 100 mg/day cohorts, patients receiving IDX184 experienced improvements in two key markers of liver injury, with mean AST and ALT levels decreasing to below the upper limit of normal. These improvements were sustained for up to 6 days ...

deCODE-led Megastudy Finds New Genetic Clues to Causes of Schizophrenia

... Norway, Russia, Finland and Spain. Bringing together the results of different consortia established he association between the the total of seven markers on chromosomes 6, 11, and 18 with increased risk of schizophrenia. Acknowledgments deCODE and all of the authors would like to thank ...

CRi Oosight(TM) Instrument Crucial in IVF Breakthrough Demonstrating a Correlation Between Non-Invasive Egg Metrics and Pregnancy

... spindle density was significantly higher in those oocytes resulting in pregnancy. The work by Dr. Kilani's group, "Are there non-invasive markers in human oocytes that can predict pregnancy outcome?" was published in March by Reproductive BioMedicine Online. Cambridge Research & ...

Trius Announces Positive Results From Phase 2 Clinical Trial of Torezolid in Patients With Complicated Skin and Skin Structure Infections

... the higher doses also provides for a broad safety margin. In our prior 21-day Phase 1 clinical trial, which examined hematological parameters as key markers of oxazolidinone safety, the 200 mg dose of torezolid was comparable to placebo while the labeled dose of linezolid produced the expected depletion ...

Three Independent Studies Include the ImmuKnow(R) Assay to Manage and Optimize Immunosuppression Therapy in Transplant Patients

... of North Carolina at Chapel Hill and Ohio State University prospectively studied the use of the ImmuKnow assay together with various viral markers in 93 renal transplant recipients. Lead study investigator, Dr. Kenneth A. Andreoni, summarized the results of the study by saying, "We collected ...

Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support

... can severely impact patient outcome. An alternative is to use cord blood (CB), which extends the donor pool because as few as four of the six HLA markers need to match. CB has many other logistical and clinical advantages, including faster availability, lower incidence and severity of acute graft ...

Ridge Diagnostics, Inc. Clinical Data on Blood Test for Depression Presented at American Psychiatric Association Annual Meeting

... from other investigators seeking to utilize single or groups of single biomarkers to characterize or identify patients with MDD by use of multiple markers and the construction of a unique diagnostic hyperspace mapping technology. "We are pleased to present this clinically important blood test to ...

HIV/AIDS Research Network Recommends Use of Abbott RealTime Viral Load Test for NIH-Sponsored Clinical Trials

... as group N and O isolates. The Abbott RealTi m e HIV-1 test is intended for use in conjunction with clinical presentation and other laboratory markers as an indicator of disease prognosis and for use as an aid in assessing viral response to antiretroviral treatment as measured by changes in plasma ...

Pistachios Offer Protective Benefits Against Heart Disease, Type II Diabetes and Obesity

... diet intervention, researchers measured the subjects' HbA1c (a marker of blood sugar control over the previous three months) as well as blood lipid markers associated with heart heath. The findings revealed that the full dose nut group had significantly reduced LDL and total cholesterol levels compared ...

Genes Identified That Enhance Tumor Cell Sensitivity to CTI's Cancer Drug Brostallicin

... (CTI) (Nasdaq and MTA: CTIC), presented data from a preclinical study, which utilized RNA interference (RNAi) and bioinformatics to identify genetic markers - "contexts of vulnerability" - that enhance the anti-tumor response to the experimental drug candidate brostallicin, at the 2009 American ...

EAU Position Statement on Screening for Prostate Cancer

... of specificity and lack of selectivity for aggressive cancers which require treatment. The development of novel diagnostic and prognostic markers and imaging modalities is needed urgently to enhance the predictive value of screening tools. - In the absence of population screening, ...