Nebulized Perforomist(TM) Inhalation Solution Provided Prolonged Bronchodilation and Increased Patient Satisfaction Compared to Albuterol/Ipratropium MDI
... perception that medication
went into the
lungs (p<0.028). Overall, subjects perceived more ... lung disorders in which the airways
in the
lungs become narrowed and breathing becomes ... method of delivering medicine directly into the
lungs for
patients, particularly as their symptoms ...
Amikacin Inhale Shows Promising Results in Phase II Study
... reach effective concentrations in infected
lungs at tolerable doses.
The new study data shows that ... 43 percent of the dose
was delivered to the
lungs using the hand-held system with a comparable low
systemic exposure. The dose delivered to the
lungs with the proprietary
nebulizer is comparable ...
NicOx Announces TOPIGEN Initiates Phase 2 Proof of Concept Study in COPD for TPI 1020
... disease
caused by chronic inflammation of the
lungs and bronchi and represents the
third-leading ... of
air that can be forcibly expelled from the
lungs after breathing in as
deeply as possible and ... of air that can be
forcibly expelled from the
lungs after breathing in as deeply as possible
and ...
Study Shows Need to Test More COPD and Asthma Patients for Underdiagnosed Pulmonary Disease
... roles is to shield the
delicate tissues of the
lungs by binding to neutrophil elastase, an ... the neutrophil elastase
released to protect the
lungs is uncontrolled and can injure healthy lung
tissue. Repeated injury to the normal structure of the
lungs can eventually
result in emphysema, a condition ...
PARI Pharma's Nebulized DSCG Shows Results Similar to Inhaled Steroids in Asthma Studies Presented at ATS
... that chymase-positive mast cells primarily located in the distal
lungs play a crucial role in asthma. This requires delivery of DSCG via small droplets to the target site in the
lungs and can be best achieved by a highly efficient nebulizer, such as the ...
Pharmaxis Announces Positive Results of Phase 3 Cystic Fibrosis Trial
... proprietary dry-powder mannitol, precision formulated for
delivery to the
lungs through an easy-to-use, pocket-size, portable inhaler.
Once inhaled its ... particular, Bronchitol has been shown to
increase mucus clearance from the
lungs and significantly improve quality of
life for people with bronchiectasis. ...
Nanoemulsion Kills Highly Resistant Bacteria Found in Patients With Cystic Fibrosis
... and panresistant
(completely resistant) bacteria obtained from the
lungs of patients with
cystic fibrosis. All strains of bacteria except two were ... can nebulize our
nanoemulsion so that it is deposited directly into the
lungs to kill these
highly resistant infections that cannot be effectively ...
The Ocean Becomes a Pipeline To A Cure for Cystic Fibrosis
... that
causes the body to produce thick, sticky mucus, which clogs the
lungs and
leads to life-threatening lung infections.
Several years ago, ... saltwater mist has a powerful effect on rehydrating the
lining of the
lungs and allowing CF patients to more easily eliminate
bacteria-contaminated ...
Pulmo BioTech Inc. Completes Bio-Distribution Studies
... vivo studies have shown that the molecule is predominantly
retained in the
lungs 30 minutes after injection with only minor retention
(~ 1/10th) in the ... allows an image of
the integrity of the blood vessels throughout the
lungs to be seen by a
diagnostic clinician. PulmoScience is currently ...
Mpex Initiates a Phase 2 Clinical Trial of Aerosol MP-376 in the Treatment of Chronic Bacterial Infections in Cystic Fibrosis Patients
... including Pseudomonas
aeruginosa. Delivery of levofloxacin directly to the
lungs of CF patients
by the aerosol route can potentially provide a number of ... Administration of MP-376 with a high
efficiency nebulizer to the
lungs allows for the delivery of high
concentrations of active drug directly to ...
Concomitant Treatment With Nebulized Formoterol Fumarate and Tiotropium Provides Clinically Significant Improvements for COPD Patients
... refers to a number of chronic lung disorders in which the airways
to the
lungs become narrowed and breathing becomes increasingly difficult.
The most ... is an easy and
effective method of delivering medicine directly into the
lungs for
patients, particularly as their symptoms worsen.(3)
With ...
Concomitant Use of Nebulized Formoterol Fumarate and Tiotropium Provides Significant Improvement in Dyspnea, COPD Symptoms and Rescue Medication Use over Tiotropium Alone
... refers to a number of chronic lung disorders in which the airways
to the
lungs become narrowed and breathing becomes increasingly difficult.
The most ... is an easy and
effective method of delivering medicine directly into the
lungs for
patients, particularly as their symptoms worsen.(3)
With ...
Lung Transplants in Cystic Fibrosis Patients With Life-Threatening Bacteria Sparks Debate at ISHLT Meeting
... of patients with CF, bacteria called Burkholderia
cenocepacia infects the
lungs before transplant. This infection is very
resistant to antibiotics and if ... debate within the transplant community is whether
or not to allocate donor
lungs to patients with Burkholderia cenocepacia
knowing that the success rate is ...
Research Presented at ISHLT Shows Promise of Addressing Critical Organ Shortage and Better Organ Preservation
... results suggest the potential to immediately
increase the number of
lungs available for transplantation. Although
thousands of patients are on lung ... of individuals identified as organ donors actually have
suitable
lungs for transplantation.
During the ISHLT mini-oral session I: The Non-Heart ...
Harris Methodist Fort Worth Hospital Using Bubbles to Help Babies Breathe
... system commonly used to
deliver airflow and pressure to an infant's
lungs via short prongs in the
nose. This air pressure helps to keep the
lungs open at the end of
exhalation while allowing the baby to initiate his/her ...
Schering-Plough Announces U.S. Filing of Mometasone Furoate/Formoterol Fumarate Combination for the Maintenance Treatment of Asthma
... should be monitored by their health care provider.
Use ASMANEX as directed by your health care provider, since its ability to work in your
lungs depends on regular use. Maximum benefit may take 1 to 2 weeks or longer. If your asthma symptoms do not improve, or get worse, contact your health ...
ASMANEX(R) (Mometasone Furoate Dry Powder Inhaler) Now Approved in Japan for the Treatment of Bronchial Asthma in Adult Patients
... should be monitored by their health care provider.
Use ASMANEX as directed by your health care provider, since its ability to work in your
lungs depends on regular use. Maximum benefit may take 1 to 2 weeks or longer. If your asthma symptoms do not improve, or get worse, contact your health ...
Transave Receives $2.2 Million Cystic Fibrosis Foundation Award for Development of ARIKACE(TM)
... encloses the drug in nanocapsules of lipid called liposomes. This advanced pulmonary liposome technology prolongs the release of amikacin in the
lungs while minimizing systemic exposure. The treatment uses biocompatible lipids endogenous to the lung that are formulated into small (0.3 micron), ...
Results and Additional Analyses From Study Show That Corthera's Relaxin for Acute Heart Failure is the Strongest Predictor of Improved Longer-Term Outcomes Following Hospital Discharge When Compared to Other Variables
... accounting for more than $13 billion in hospitalization costs. The great majority of acute heart failure patients have fluid accumulation in the
lungs (congestion) that causes shortness of breath (dyspnea) and other complications. For these patients, the current standard of care includes diuretics ...
Alexza Reports 2009 First Quarter Financial Results and Updates Clinical Pipeline Status
... aerosol that, when inhaled, allows for rapid systemic drug delivery through deep lung inhalation. The drug is quickly absorbed through the
lungs into the bloodstream, providing speed of therapeutic onset that is comparable to intravenous administration, but with greater ease, patient comfort ...
Doctors Urge Precaution to Shield Against Swine Flu
... and published in Journal of Nutrition, November 2006. Compared with animals exposed to the H1N1 virus without consuming AHCC, the viral load in the
lungs of those fed AHCC was 96% lower, their weight was maintained, whereas control group experienced a 19% weight loss, and the AHCC group showed a 27% ...
Prometheus and Rosetta Genomics Announce License and Collaboration Agreement
... or non-squamous NSCLC, have demonstrated histologic-specific response patterns ranging from a high incidence of severe or fatal bleeding in the
lungs to poor response to treatment. Current methods for differentiating squamous from non-squamous NSCLC are not standardized, are difficult to reproduce ...
CRESTOR(R) Reduced Risk of Blood Clots in the Veins
... in the 'deep veins' usually in the legs or
pelvis. An embolism is created if the clot travels through the venous system.
Blood clots lodging in the
lungs are known as a pulmonary embolism (PE).
Estimates suggest that at least 350,000 and as many as 600,000 Americans
annually develop DVT/PE, and at ...
Results From Study Show Promising Efficacy and Safety Results for Corthera's Relaxin in Acute Heart Failure
... accounting for a total of $13 billion in hospitalization costs. The great majority of acute heart failure patients have fluid accumulation in the
lungs (congestion) that causes shortness of breath and other complications. For these patients, the current standard of care includes diuretics and ...
Alexza Initiates AZ-104 (Staccato(R) Loxapine) Phase 2b Clinical Trial in Patients With Migraine Headaches
... drug to form
a condensation aerosol that allows rapid systemic drug delivery through deep
lung inhalation. The drug is quickly absorbed through the
lungs into the
bloodstream, providing speed of therapeutic onset that is comparable to
intravenous administration, but with greater ease, patient comfort ...
Pulmo BioTech Inc. Announces Dual Listing on Frankfurt Borse
... circulatory system in the lungs, and, by the use of an external Gamma Camera, allows an image of the integrity of the blood vessels throughout the
lungs to be seen by a diagnostic clinician. PulmoScience is currently undertaking Regulatory Approval for Phase I Human Trials, and while subsequent ...
Alexza's AZ-004 (Staccato(R) Loxapine) Meets Primary Endpoint of Treating Acute Agitation in Patients with Bipolar Disorder in Phase 3 Trial
... drug to
form a condensation aerosol that allows rapid systemic drug delivery through
deep lung inhalation. The drug is quickly absorbed through the
lungs into the
bloodstream, providing speed of therapeutic onset that is comparable to
intravenous administration, but with greater ease, patient comfort ...
Research Highlights New Approaches to Prevent Blood Clots in Several High-Risk Patient Populations Including Largest Study Ever to Examine Use of Blood-Thinning Medication in Patients With Cancer
... forms in a major vein of the leg, and pulmonary embolism, which occurs when a blood clot detaches from its point of origin and travels to the
lungs where it becomes wedged and prevents adequate blood flow, are known collectively as venous thromboembolism.
"Venous thromboembolism is a ...
Mpex Pharmaceuticals Announces Initiation of a Phase 2 Clinical Trial of Aerosol MP-376 in COPD
... exacerbations in COPD patients.
By delivering the novel MP-376 formulation via the aerosol route,
levofloxacin can be delivered directly to the
lungs at much higher
concentrations than can be achieved through usual oral and intravenous
routes of administration. High concentrations are important to ...
Mpex Pharmaceuticals Presents New Data on MP-376 in Cystic Fibrosis
... orally or intravenously against many bacterial pathogens,
including P. aeruginosa. Administration of MP-376 with a high efficiency
nebulizer to the
lungs allows for the delivery of high concentrations of
active drug directly to the site of infection, while minimizing systemic
exposure. Mpex believes ...
Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease
... stage research with imatinib mesylate in another non-oncology disease called idiopathic pulmonary fibrosis (IPF), a condition in which the
lungs become scarred over time, making it more and more difficult to breathe(6). Early clinical trial results in IPF did not show a significant ...
NVA237 Phase II Results Presented at the European Respiratory Society Annual Meeting Show Promising Efficacy and Tolerability With Potentially Faster Onset Than Tiotropium
... from $23 billion in 2007 to $46 billion by 2017. Vectura also
develops products for non-respiratory diseases where optimised delivery via
the
lungs could provide significant benefits, such as a rapid onset of
action, improved efficacy and improved tolerability compared with current
therapies.
...
Second Pivotal Phase 3 Trial In Cystic Fibrosis Begins
... .
Pharmaxis is developing Bronchitol as a treatment to improve mucus
clearance in the
lungs of patients with cystic fibrosis, bronchiectasis and
chronic obstructive airway diseases. Bronchitol is a patented, inhalable
dry powder formulation ...
Dallas Researchers Find Compression Stockings Improperly Used
... risk for blood clots after surgery
because blood tends to pool and coagulate in stationary extremities. These
deep vein clots can travel to the
lungs and block the pulmonary artery,
resulting in a serious and sometimes-fatal complication called a pulmonary
embolism.
Despite the importance of ...
New Implant Device Remotely Monitors Heart Failure Patients at Northwestern Memorial's Bluhm Cardiovascular Institute
... heart rate -- all of which are symptoms often seen in HF
patients, but in many cases, can be managed with medication. The back
pressure in the
lungs due to the inability of the heart to pump the blood
effectively can be measured and transmitted by this device.
With this system, pressure data is ...
MAP Pharmaceuticals Announces Publication of MAP0004 Study in Current Medical Research and Opinion
... tolerated by subjects with
compromised lung function, and that the pharmacokinetics of MAP0004 was
similar to that experienced by adults with healthy
lungs as shown in an
earlier Phase 1 study. No serious adverse events were reported. In
addition, no clinically significant changes were observed in ...
Pharmaxis Concludes Special Protocol Assessment with FDA for Bronchitol Phase 3 Trial
... phase 3
clinical trial is expected to soon close recruitment.''
Pharmaxis is developing Bronchitol as a treatment to improve mucus
clearance in the
lungs of patients with cystic fibrosis, bronchiectasis and
other acute and chronic pulmonary conditions. The U.S. FDA has granted
Bronchitol fast track ...
Synapse Biomedical Receives FDA Approval of NeuRx Diaphragm Pacing System (DPS)(TM) For Spinal Cord Injury Breathing Applications
... When stimulated by the NeuRx DPS(TM), the diaphragm contracts,
mimicking natural breathing, and allows air to fill the upper and lower
parts of the
lungs rather than forcing air in with a mechanical ventilator.
The NeuRx DPS(TM) received the CE Mark (CE Registration #518356) on
November 20, 2007 and ...
Transave Announces Positive Phase II Results for Once-Daily Arikace(TM) in the Treatment of Cystic Fibrosis Patients Who Have Pseudomonas Lung Infections
... the potential value of delivering amikacin through
Transave's next-generation liposomal technology."
The biofilm is a gel-like matrix in the
lungs formed by colonies of the
common and often chronic bacterium Pseudomonas aeruginosa, which creates a
protective barrier for the bacteria. This ...
Duska Therapeutics Licenses Portfolio of Heart Failure Drugs From Duke and Johns Hopkins
... from congestive
heart failure, a condition characterized by the inability of the heart to
efficiently pump blood and by fluid accumulation in the
lungs and other
tissues. An estimated 300,000 deaths each year result from heart failure.
"The licensing of these novel heart failure drugs greatly ...