New Advances in Gastric Diagnostics: Smaller is Better
... attached to the esophageal wall at 5 cm above the lower esophageal sphincter, using a proprietary endoscopic delivery system. Normally patients are unaware of the capsule, although some may feel a mild sensation in the esophagus or chest while eating. Data on pH levels can be collected without any interfe...Digital vs. Analog Mammography
... from dense parenchyma to skin. Because there is a lower level of intrinsic noise, a lower dose of x-ray may be used than is currently used in conventional mammography with no loss in accurac...Fast, Accurate Influenza A/B Antigen Detection
...ash, nasopharyngeal aspirate, nasopharyngeal swab, lower nasal swab, throat swab and bronchoalveolar lavage... in particular, the sensitivity of rapid tests are lower than for viral culture and vary by test. Because of the lower sensitivity of the rapid tests, physic...Rapid Flu Tests May Prove Especially Helpful This Season
...ash, nasopharyngeal aspirate, nasopharyngeal swab, lower nasal swab, throat swab and bronchoalveolar lavage. Test results time is 15 minutes. Thermo Electron Corp., Waltham, Mass., produces the FLU OIA test, a high-performance assay for the undifferentiated diagnosis of Influenza A and B. in just over 15 m...Analyzers Offer Point-of-Care Lipid Panels
...re accurate and more comprehensive devices at even lower costs....Tight Glycemic Control in the ICU
...hether the benefits to patients result solely from lower blood glucose, or from the broad physiological effects of insulin, or from both, glycemic control protocols are being instituted in hospital ICUs. Concerns that arise during protocol implementation include worry about hypoglycemia, accuracy of gluco...Appendicitis: Evolving Tools to Diagnose a Classic Disease
...after physical exam. The classic finding of right lower quadrant tenderness is present in some 96% of appendicitis patients but also in many other conditions. No feature on physical exam has been proven to rule out appendicitis definitively. Fortunately, a number of laboratory and imaging modalities, so...Low-Density Cholesterol Subfractions: Not all LDL-C Particles are Created Equal
...e NCEP recommends the following drug treatments to lower LDL-C and raise HDL-C; HMG CoA reductase inhibitor...ids and Fibric acids. All of these treatments also lower triglyceride levels, with the exception of bile acid sequestrants. New evidence illustrates that sma...Antibiotics Don't Prevent Future Urinary Tract Infections, May Cause Resistance in Future Infections
...of preventive antibiotics was not associatedwith a lower risk of recurrent UTI. "The majority of childre.... Conway summarized, "The majority ofchildren have lower grade VUR and this lower grade VUR was notassociated with an increased risk of recurrent UTI in ours...BioSante Pharmaceuticals Announces New Findings for Potential Bird Flu Vaccine
... a vaccine using our BioVant that wouldbe given at lower doses per injection yet still confer a higherlevel of immunity than the currently approved vaccine," saidStephen M. Simes, president and chief executive officer ofBioSante. "These HAI study results confirm the BioVant antibodyresults previously repor......nt of this study wasnon-inferiority (95 percent CI lower limit for the difference intreatment response -12 percent or greater) for HIV RNA of less than400 copies per mL in plasma at week 48 (per-protocol analysis). "This is exciting new information that adds to the body ofknowledge on PREZISTA in a much...NIEHS Researchers Identify Enzyme Critical in DNA Replication
...f the lagging strand by a differentpolymerase. In lower organisms like the E. coli bacteria that Kornbergstudied, one DNA polymerase can accomplish both tasks. However,humans and related higher organisms, such as bakers yeast, are muchmore complicated. Recent discoveries, several of which emerged fromthe ...Skin Rash Actually Signifies Better Outcomes for Pancreatic and Lung Cancer Patients
...th the additionof gemcitabine with Tarceva, or the lower dose of Tarceva in thisstudy, but we just don’t know,” he said. Wacker points out that lack of a rash doesn’t necessarilymean that patients will not benefit from Tarceva. “A smallpercentage of patients who didn’t devel......get, angiopoietin-like protein 4 (ANGPTL4),rapidly lower triglycerides and cholesterol. Research suggests thata monoclonal antibody (mAb) targeting ANGPTL4 may have therapeuticapplication in the treatment of cardiovascular disease. The resultsappeared in an article, entitled "Lipid-lowering effects ofanti-...Beike Biotechnology Study Suggests Adult Stem Cells Show Promise for Peripheral Vascular Disease
...or patients with peripheral vasculardisease of the lower extremities. Beike is best known for its research...e same period comparingthe relative improvement of lower limb ischemia (lack of bloodsupply) between transplantation of autologous peripheral blood stemcells......hen: -- The delta value is 10% or less on the lower bound and includes zero on the upper bound w...eater. -- The delta value is 15% or less on the lower bound and includes zero on the upper bound when the higher clinical cure rate of either ......The incidence of recurrent wheezing was 49 percent lower amongchildren who received Synagis compared to those who did not (13percent vs. 26 percent, p=0.001). There was also significantly lessphysician-diagnosed recurrent wheezing in the group that receivedSynagis (8 percent vs. 16 percent, p=0.011). In a...Genetics Journal Thimerosal/Autism Study the 'Best Science Drug Company Money Can Buy'
...ects including autism. The data was manipulated to lower therelative risk factor before publication in the journal Pediatricsin 2004. Lead investigator Dr. Thomas Verstraeten left the CDC towork for vaccine maker Glaxo-Smith-Kline in 2001 while the dataalterations were ongoing, but his employment was not d...Insmed Inc. Welcomes Studies Linking IGFBP-3 to Prevention of Blindness in Premature Infants
...udy showing IGFBP-3 levels ininfants with ROP were lower than those of healthy babies. Theresearchers said these results suggest that IGFBP-3, actingindependently of IGF-I, helps prevent oxygen-induced loss ofblood-vessels and helps promote vascular re-growth. Insmed Chairman and CEO Geoffrey Allan, Ph.D.......ar to those inpatients with normal renal function, lower dosages are recommendedin patients with moderate a...n with the decrease in glucagon wasassociated with lower fasting glucose concentrations and reducedglucose excursion following an oral glucose load or a meal......r is usedalong with a low-fat diet and exercise to lower cholesterol.Lipitor is not for everyone. It is not for those with liverproblems. And it is not for women who are nursing, pregnant or maybecome pregnant. Patients taking Lipitor should tell their doctors if they feelany new muscle pain or weakness. ...New Poll Shows Men, Women Incorrectly Blame Symptoms of Low Testosterone on Normal Aging
...As many asfive million men over the age of 18 have lower than normal levelsof testosterone.(1) "Most people don't realize that low testosterone is a seriousmedical condition, and one that can have an impact on the entirefamily," said Tanya Abreu, President and National Program Director,Spirit of Women Hea......n or heighten insulin sensitivity, isthat they can lower blood glucose levels, resulting inhypoglycemia, wh...nce in diabetes treatment." Liraglutide acts to lower blood glucose when levels areelevated, and previous studies have shown it is associated with alow ri......<0.0077) and the mean sum of improvementof all lower extremity motor NCVs was 1.9 Meters/sec with SB-50... well as evaluation of pain and clinical effectson lower limb diabetic neuropathy at one, two, three and six monthspost-treatment. Phase 2 Sangamo has two ......de levels (-44.4 +/- 12.1mg/dL or 12 percent), and lower systolic and diastolic bloodpressure (-3.5 +/- 1.2 mmHg or 2 percent and -3.3 +/- 0.8 mmHg or 4percent, respectively). Results also showed an increase in HDL, or"good" cholesterol levels after three and a half years (+8.5 +/-0.6 mg/dL or 24 percent) ......n with the decrease in glucagon wasassociated with lower fasting glucose concentrations and reducedglucose ... In studies with healthy subjects, JANUVIA did not lower bloodglucose or cause hypoglycemia. Cardiac Electrophysiology In a randomized, placebo-control...Positive Clinical Results for DG041 Lead Product Development Highlights at deCODE R&D Event
...ed effect on VASPappears to be achievable at doses lower than previouslyanticipated. deCODE is thus very encouraged that in targeting EP3,the company is advancing a potentially major new approach toanti-platelet therapy - one that acts specifically to preventarterial thrombi, targets a pathway not addresse...Arisaph Pharmaceuticals Announces Results of its Potent Smart DPP-4 Inhibitor, ARI-2243, at the ADA
...erior HbA1c lowering in humans using significantly lower dosesof ARI-2243, thereby supporting our goal of d...diabetes and inhibitors ofDPP-4 have been shown to lower post-prandial glucose and HbA1clevels. Diabetes is a major healthcare problem throughout the worldwi...CytRx Announces Clinical Results from Its Rising Multiple Dose Trial with Arimoclomol for ALS
...fully, with safety andtolerability demonstrated at lower dose levels prior to testinghigher doses. The study indicated that all four doses were safe andwell-tolerated. Based on these results and additional data, CytRxplans to proceed with a 400 mg dose of arimoclomol three timesdaily in its planned Phase I......ortantly, the knockout mice also had significantly lower bloodglucose, insulin and HbA1c levels. These results illustrate theknockout mice resist the development of type 2 diabetes. In the first poster Elixir presents data in which scientistscompared the results of the GhrR knockout mice to those obtained...Apollo's human proteins boost stem cell research
...ologies are expected to lead to more effective and lower costtherapeutics, compared to first generation protein-based drugs. <a target="_blank" href="http://www.apollolifesciences.com/">www.apollolifesciences.com......ministered more quickly and to provide efficacy at lower dosesthan conventional nebulized budesonide, which...asthma. Potential faster deliveryand efficacy at a lower dose together may offer improved safety,compliance and convenience for young patients who suffer fro......roved for use fortype 2 diabetes as monotherapy to lower blood glucose and incombination therapy with insulin, sulfonylureas or metformin. Additional Information ACTOS is not for everyone. ACTOS can cause fluid retention thatmay lead to or worsen heart failure, so tell your doctor if youhave a history of...Research on New Treatment for Neglected Disease Published in The New England Journal of Medicine
...ecost of Paromomycin IM Injection is significantly lower than othercurrently approved VL therapies. About the Institute for OneWorld Health The Institute for OneWorld Health, the first US non-profitpharmaceutical company, develops safe, effective and affordablemedicines for people with neglected diseases......f having mild-to-moderateCAC were 20 to 30 percent lower and the risks of severe CAC were 40percent lower in the group of women assigned to the active HT groupcompared to those receiving placebo. Even more ......hexia. Mice responding to QR-443treatment had much lower levels of serum IL-6 which correlated withreduced ...e severity of cachexia and levels ofIFN-gamma were lower than the detectable assay level. The Quigley Corporation makes no representation that the U.S.Food ...Eurand's Zentase Effective in Treating Exocrine Pancreatic Insufficiency, Studies Show
...reater than 65 percent and half had a baseline CFA lower than 65percent (median CFA levels were 65.8 percent). Patients enrolled inthe pivotal study had a wide range of baseline CFA levels with onepatient as low as 28.7 percent (very severe disease) and fivepatients with CFA levels above 80 percent. The m...Genzyme Announces Results of Clinical Trials Investigating Powder Form of Sevelamer Carbonate
...sphorus levels in the Renagel arm (4.6 mg/dL) were lower thanthose in the Renvela arm (5.3 mg/dL), and this trial did notachieve its primary endpoint of demonstrating non-inferiority ofRenvela powder dosed once per day to Renagel tablets dosed threetimes per day. In both trials, the safety profile of Renv...Genzyme Announces Results of Clinical Trials Investigating Powder Form of Sevelamer Carbonate
...sphorus levels in the Renagel arm (4.6 mg/dL) were lower thanthose in the Renvela arm (5.3 mg/dL), and this trial did notachieve its primary endpoint of demonstrating non-inferiority ofRenvela powder dosed once per day to Renagel tablets dosed threetimes per day. In both trials, the safety profile of Renv......t leastpossibly causally related to HUMIRA include lower respiratoryinfections (including pneumonia, bronchitis), viral infections(including influenza, herpes infections), candidiasis, bacterialinfection (including urinary tract infections), upper respiratoryinfection, lymphopenia, dizziness (including ver...... treatment before you start REMICADE. REMICADE can lower yourability to fight infections, so if you are prone to or have ahistory of infections, or develop any signs of an infection such asfever, fatigue, cough, flu or warm, red or painful skin whiletaking REMICADE, tell your doctor right away. Also, tell ...Anti-TNF Golimumab Continues to Show Promise in Phase II Rheumatoid Arthritis Study
...disease activity. Remission is achieved by A DAS28 lower than 2.6indicates remission has been achieved American College of Rheumatology 20 (ACR20) is utilized todetermine improvement in arthritis signs symptoms. ACR20represents an improvement of at least 20 percent in tender jointcount and swollen joint ......eatyour disease. But, in doing so, ENBREL can also lower the abilityof your immune system to fight infections. All medicines have side effects, including ENBREL. Possible sideeffects of ENBREL include: -0- -- Serious infections -- Many occurred in people prone to infection, such as those with ad......ic within two weeks of diagnosis had a much lower cost burden that those who were not treated for their insomnia. Demonstrating that treating insomnia was cost-effective relative to non-treatment, or delayed treatment. Study Shows that Existing Next Day Impairment Measures May NotCapt......ts treated with GRNOPC1 would requiresignificantly lower doses and/or shorter courses ofimmunosuppression than what are required for patients who undergosolid organ transplants. "The results imply that our cell-based therapeutic, unliketraditional solid organ transplants, is minimally recognized by thehum...Treating Heart Disease Risk Factors May Slow Alzheimer's Disease Progression
...sk of developingdementia. Lower initial weight and lower final weight before deathwere significantly associ...inal weight also weresignificantly associated with lower final MMSE score before death.However, when Braak stage was added to the latter model, theassociatio......W-3902 showed higherrates of treatment success and lower rates of treatment failurecompared to the placebo group. The pilot study also showed that 24-hours after treatment,self-reported marked or moderate improvement in dyspnea wasobserved in 66 percent of the patients who received the 30milligram dose of......latelet count of >50,000/microliter there is a lower risk ofbleeding and bruising. This is consistent with products previouslyapproved to treat ITP and is considered as a target platelet countin ITP treatment guidelines.(8) Other Forms of Thrombocytopenia Thrombocytopenia can occur as a consequence o...... surgery and reduces their quality of life. M6G's lower propensity to cause nausea and vomiting in thepost... assistance and the improved patientcomfort due to lower PONV supports CeNeS' justification of asubstantial price premium for M6G compared to morphine. 5. D...... higher dose. -- Both active treatment groups had lower pain ratings thanplacebo patients (p less than 0.0... averaged over the study periods weresignificantly lower than placebo in the DM/Q 45 arm for comparisonsat days 30, 60 and 90 (p less than 0.0001 for each co......ted. Across allsubjects, zonisamide SR exhibited a lower Cmax than the legacy IRformulation, while retaining a similar overall exposure or areaunder the curve. Results from a Phase II proof-of-concept trial evaluatingEmpatic formulated with zonisamide IR in combination with bupropionSR for the treatment...Human Genome Sciences Announces Positive Final Results Of Phase 2b Trial of Albuferon
...hematologic adverse events was significantly lower in the Albuferon 1200 Q4w treatment group (10.3%, vs. 23.7% for Pegasys, p=0.006). "We are encouraged that more than half of the patients achievedsustained virologic response in the treatment group receivingAlbuferon 1200-mcg once every month,......ing a normal injection needle andapplies pulses of lower voltage than those delivered by presentlyused devices, thus reducing the electrical sensation experienced bythe patient. "We are pleased with the performance of our DNA deliverytechnology in advanced preclinical studies. Together with ourcontinuing ...Santaris Pharma Presents Positive Clinical Data on SPC2996 in Chronic Lymphocytic Leukaemia
...he life of malignant white bloodcells. Drugs which lower the concentration of Bcl-2 or inhibit itsfunction may therefore have therapeutic benefit by inducing cancercell death and removal without resorting to chemotherapy. About SPC2966 SPC2996 is the first of a portfolio of novel experimental drugsblocki......ies the rangethat covers the mean via an upper and lower limit for the actualvalue Patient year - the cumulative amount of timethat a patient has taken a particular medicine as measured inyears. Enquiries: UK Media enquiries: Philip Thomson (020) 8047 5502 Joss Mathieson (0......duct candidatesdiscovered by Metabasis designed to lower serum cholesterol, serumtriglycerides and liver fat," stated Dr. Mark Erion, executive vicepresident of research and development and chief scientific officerof Metabasis. "MB07811 combines a novel agonist selective for thebeta isoform of the thyroid ......e control mice. Additionally, the knockoutmice had lower blood glucose, insulin and HbA1c levels. Theseresults indicate the knockout mice are less prone to thedevelopment of diabetes. The scientists then compared the results of the GhrR knockoutmice to those obtained with mice treated twice a day for up t......assuring for physicians who need effective drugsto lower blood sugar levels -- the main cornerstone of trea...ow blood sugar. Askyour doctor whether you need to lower the dose of your otherdiabetes medicine. Avandia may increase your risk of pregnancy. Talk to your ...Theratechnologies: TH9507 Phase 3 Clinical Update
...easing factor will reduceabdominal obesity and may lower cardiovascular risk in HIVpatients. Since the initiation of the trial in January, Theratechnologies hasobtained regulatory approval in five European countries for itssecond Phase 3 clinical study testing TH9507 in HIV-associatedlipodystrophy. Patien...Cogane Data Presented at ‘11th International Congress of Parkinson’s Disease and Disorders’
...lities whilst maintaininglow fixed overheads and a lower development cost structure. Cogane(tm) Cogane(tm) (PYM50028) is a novel non-peptide, orallybioavailable neurotrophic factor inducer that readily crosses theblood brain barrier. In pre-clinical studies, Cogane(tm) stimulatesthe release of neuronal ...