Intestine in Medical Technology

Molecular Marker Identifies Normal Stem Cells as Intestinal Tumor Source

... and cancer stem cells in solid tissues like the intestine was not known," said Richard Gilbertson, M.D., ... and cancer. The fact that this occurs in the intestine is particularly interesting since human ... cells generate the covering of the entire small intestine and are therefore the stem cell of this tissue. ...

Spirus Medical Announces Complete Examinations of the Small Intestine by Physicians Using Endo-Ease(TM)

... in Chicago, May 30 through June 4. Complete examination of the small intestine has been elusive in regular practice due to the difficulty in maneuvering an endoscope through the long, tortuous path in the body. The small intestine is about 20 to 23 feet long and other methods for reaching and studying ...

Treating Knee Ligament Injuries

... nonsurgical treatments, such as gene therapy, growth factors, and small intestine submucosa, which is a naturally derived biomaterial isolated from the small intestine of pigs. All are currently in their early stages of use, ...

Ironwood and Collaborators Present Preclinical Data Demonstrating That Cyclic GMP Alleviates Intestinal Pain

... this mechanism. Ironwood's first cGMP modulator, linaclotide, acts in the intestine to increase intracellular and extracellular cGMP levels by stimulating ... disorders. Linaclotide was designed to exert its effect on the intestine with minimal systemic exposure. Linaclotide is an agonist of guanylate ...

Ocera Therapeutics, Inc. Completes Enrollment in FHAST1, a Pivotal Phase 3 Clinical Trial in Fistulizing Crohn's Disease

... inflammation of the digestive tract that most commonly affects the small intestine and/or the colon. Some patients may develop tears in the lining of the ... of the inflammatory process, is a tunnel that leads from one loop of intestine to another, or that connects the intestine to the bladder, vagina, or ....

PROTECT-1 Phase II/III Induction-Stage Results for ChemoCentryx's Traficet-EN(TM) Presented in Oral Session at DDW 2009 Conference

... a highly specific receptor expressed by T cells that migrate selectively to the digestive tract. The trafficking of T cells to the small and large intestine causes persistent inflammation that may result in Crohn's disease or ulcerative colitis - the two principal forms of IBD. In preclinical studies, ...

Horizon Therapeutics' HZT-501 Significantly Reduces Incidence of NSAID-Induced Upper Gastrointestinal Ulcers in Patients With Mild-to-Moderate Pain

... University of Southern California . "NSAIDs are effective at treating pain, but they also increase the risk of developing ulcers in the stomach or intestine and the risk of developing ulcer complications, such as bleeding. Patients at increased risk for gastrointestinal ulcers may benefit from protective ...

New Study Evaluating the ADHD Medication VYVANSE(R) (lisdexamfetamine dimesylate) CII Demonstrated No Change in the Pharmacokinetic Profile of VYVANSE When Coadministered with Prilosec OTC(R) 40 mg (20 mg X 2), a Commonly Used Proton Pump Inhibitor (PPI)

... system has one type of bead designed to be released immediately and the other type to be released approximately four hours later in the lower intestine where pH levels are higher. The drug interactions section of the ADDERALL XR product labeling states that coadministration of ADDERALL XR and ...

GeneThera Announces it is Set to Begin Commercial Testing for Johne's Disease as Soon as January, 2009.

... containing M. paratuberculosis microorganisms. Once ingested, M. paratuberculosis survive and replicate within macrophages in the wall of the intestine and in regional lymph nodes. After an incubation period of several years, extensive granulomatous inflammation occurs in the terminal small ...

Alba Therapeutics Announces Enrollment of Its First European Patient in Global Phase IIb Study of Larazotide Acetate for Treatment of Active Celiac Disease

... of gluten causes an immune response which triggers an inflammatory reaction in the small intestine. This then causes damage to the villi in the small intestine and can lead to total villous atrophy in celiac disease. This results in varying symptoms such as fatigue, skin rash, anemia, fertility issues, joint ...

Alba Therapeutics Presents New Data for Larazotide Acetate at the 2008 American College of Gastroenterology Annual Scientific Meeting

... of gluten causes an immune response which triggers an inflammatory reaction in the small intestine. This then causes damage to the villi in the small intestine and can lead to total villous atrophy in CD. This results in varying symptoms such as fatigue, skin rash, anemia, fertility issues, stillborn births, ...

Ironwood and Forest Present Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

... currently being evaluated for the treatment of IBS-C, CC, and other gastrointestinal disorders. Linaclotide was designed to exert its effect on the intestine with minimal systemic exposure. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. Linaclotide ...

CIMZIA(R) (Certolizumab Pegol) Provides Long-Term Benefit Without Dose Escalation in Crohn's Disease Patients

... is a chronic, progressive, destructive disorder that causes inflammation of the gastrointestinal (GI) tract, most commonly at the end of the small intestine (the ileum) and beginning of the large intestine (the colon). If not effectively treated, it may result in the need for surgery and hospitalization. ...

New Findings Show Efficacy of REMICADE(R) Compared With Azathioprine in Treatment of Crohn's Disease According to First-of-its Kind Study

... a related inflammatory bowel disease, and pediatric Crohn's disease. Crohn's disease is a chronic inflammatory disease of the colon and large intestine that affects approximately 500,000 people in the United States. Crohn's disease can lead to frequent hospitalizations, surgery and loss of work ...

CIMZIA(R) (certolizumab pegol) Reduces Intestinal Lesions and Induces Endoscopic Improvement in Crohn's Patients

... is a chronic, progressive, destructive disorder that causes inflammation of the gastrointestinal (GI) tract, most commonly at the end of the small intestine (the ileum) and beginning of the large intestine (the colon). If not effectively treated, it may result in the need for surgery and hospitalization. ...

Ironwood Raises $50 Million to Advance Linaclotide Through Phase 3

... at all doses in both Phase 2b studies, with the most common adverse event being diarrhea. Linaclotide was designed to exert its effect on the intestine with minimal systemic exposure. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. In ...

Ironwood and Forest to Present Positive Data From Linaclotide Phase 2b IBS-C Study at ACG Annual Scientific Conference

... patients with CC were detailed in May 2008 at the Digestive Disease Week conference in San Diego. Linaclotide was designed to exert its effect on the intestine with minimal systemic exposure. Linaclotide is an agonist of guanylate cyclase type-C, a receptor found on the lining of the intestine. In ...

Napo Announces Positive Clinical Data Indicating Crofelemer, Could Effectively Treat Cholera

... therapy, the water loss associated with severe cholera results in death for about half of affected individuals. The cholera toxin causes the intestine to secrete watery fluid in volumes far exceeding the intestinal absorptive capacity. Current standard-of-care therapy focuses on rehydration therapy, ...

ASGE Encourages Patients to Speak to Their Doctor About Colorectal Cancer Screening Options

... limitations." CT colonography, also referred to as virtual colonoscopy, relies on a computer program to generate a 3D picture of the large intestine (colon) using x-ray images. This differs from colonoscopy, which provides actual photos of the colon and rectum via a camera attached to a thin, ...

Nature Publication Reports on Key Role of Bile Acids in Glucose Metabolism and Insulin Signaling

... TGR5. These receptors are key mediators of energy homeostasis and are involved in maintaining integral functions of the liver, intestine and kidney, organs exposed to bile acid flux. The company's chemocentric discovery programs are based on proprietary expertise in the rational design ...

New Research Provides Evidence that Tea May Improve Attention and Focus, Keep Brain Cells Healthy, & Influence Genetics in Cancer

... a more calming, relaxed state, but one that allows the mind to focus and concentrate better at tasks Theanine is known to be absorbed by the small intestine and cross the blood-brain barrier where it affects the brain's neurotransmitters, and increases alpha brain-wave activity. This alpha brain rhythm is ...

ChemoCentryx Completes Enrollment of PROTECT-1, a Phase II/III Clinical Trial of CCR9 Antagonist CCX282-B (Traficet-EN(TM)) in Crohn's Disease

... is a highly specific receptor expressed by T cells that migrate selectively to the digestive tract. The trafficking of T cells to the small and large intestine causes persistent inflammation that may result in Crohn's disease or ulcerative colitis - the two principal forms of IBD. In preclinical studies, the ...

Welchol(TM) Lowered A1C by a Mean 1 Percent or Greater When Added to Metformin-, Insulin-, or Sulfonylurea-Based Therapy in 47 Percent of Patients Evaluated

... for the glucose-lowering effect of Welchol, including reductions in glucose absorption and effects on glucose metabolism via nuclear receptors in the intestine and/or the liver. The exact mechanism(s) is under investigation. About the Analyses For both analyses, data was extracted from three ...

Ironwood Pharmaceuticals and Forest Laboratories Announce Presentation of Linaclotide Phase 2b Chronic Constipation Study Results

... visceral pain, increase fluid secretion into the intestine, and accelerate intestinal transit. Linaclotide was designed to exert its effect on the intestine with minimal systemic exposure. In Phase 2a trials, linaclotide improved bowel function as measured by both CSBMs and SBMs in patients with CC and ...

Cimzia(R) Provides Long-Term Efficacy with Stable Dosing in Crohn's Disease

... is a chronic, progressive, destructive disorder that causes inflammation of the gastrointestinal (GI) tract, most commonly at the end of the small intestine (the ileum) and beginning of the large intestine (the colon). If not effectively treated, it results in the need for surgery. Crohn's disease has ...

New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease

... to compare REMICADE with placebo within each disease duration subgroup. Ulcerative colitis is a chronic inflammatory disease of the colon and large intestine that affects approximately half a million Americans and can lead to frequent hospitalizations, surgery and loss of work productivity. Both UC and ...

NPS Reports Successful GATTEX(TM) Extension Study

... GATTEX (teduglutide) is a proprietary analog of naturally occurring human glucagon-like peptide 2 (GLP-2), a peptide secreted primarily in the distal intestine and involved in the regeneration and repair of the intestinal epithelium. NPS is also pursuing development of GATTEX as a possible treatment for ...

Florastor(R) Receives ConsumerLab.com Certification

... the enteric protection of the product, meaning the microorganisms' ability to survive as they make their way through stomach acid and into the small intestine where bacteria would flourish. "Florastor is the most widely used probiotic in the world and is the product of extensive and ongoing research," ...

Organ Donor Shortage Remains Obstacle for Would-Be Transplant Patients Despite Better Medicine

... Immunosuppressive Markets provides detailed statistics, market size and forecasts, trends and competitive analysis for kidney, liver, lung, heart and intestine transplants. This report can be purchased directly from Kalorama Information by visiting ...

Photo: Welchol(TM) (colesevelam HCl) Receives FDA Approval to Reduce Blood Glucose in Adults with Type 2 Diabetes

... P450 pathway. Systemic medications, which include statins, fibrates and cholesterol absorption inhibitors, are those that are absorbed from the intestine into the bloodstream and travel throughout the body, specifically to the liver and/or kidneys. Additionally, Welchol has demonstrated beneficial ...

Clinical Benefits Demonstrated with Low-Dose GATTEX(TM) in Phase 3 Short Bowel Syndrome Study

... drug, GATTEX is a proprietary analog of naturally occurring human glucagon-like peptide 2 (GLP-2), a peptide secreted primarily in the distal intestine and involved in the regeneration and repair of the intestinal epithelium. A previous Phase 2 proof-of-concept clinical study in patients with SBS ...

Feeling Anxious or Distracted? New Research Shows a Cup of Tea Could Help

... tea plant. After drinking tea, the amino acid theanine, which is present in Green, Black and Oolong varieties, is known to be absorbed by the small intestine and cross the blood-brain barrier where it affects the brain's neurotransmitters, and increases alpha brain-wave activity. This alpha brain rhythm is ...

Sucampo Pharmaceuticals, Inc. Begins Pivotal Phase III Studies of Oral Lubiprostone to Treat Opioid-Induced Bowel Dysfunction (OBD)

... effectiveness, opioids are known to produce gastrointestinal effects that lead to opioid-induced constipation, including inhibition of large intestine motility, decreased gastric emptying and hard stools. About AMITIZA(R) (lubiprostone) 24 mcg Twice Daily for Chronic Idiopathic Constipation ...

FDA approves MyocondaR IND for MAP in Crohn's Disease

... tract. The disease most commonly affects the lower small intestine and the large intestine. Symptoms of Crohn's Disease include abdominal pain, diarrhoea, fever and weight loss. In severe cases, the intestine can become blocked or obstructed, requiring surgery. Young patients ...

UCB Presents Long-Term CImzia Data in Crohn's Disease

... the gastrointestinal (GI) tract, most commonly at the end of the small intestine (the ileum) and in the large intestine (the colon). People with Crohn's disease may suffer all of their ...

British Journal of Cancer Reports Preclinical Evidence of Positive Effect of Rice Bran on Intestinal Cancer

... by consuming a suitable daily dose of stabilized rice bran, an average 51% reduction in the number of precancerous adenomas in the stomach and large intestine of mice was observed. "The results show that the mice that received stabilized rice bran (30%) into their diets had a significant decrease in ...

Emisphere Technologies, Inc. Reports Clinical Data on Oral Delivery of GLP-1 and PYY

... and exocrine pancreatic secretion, indicating that the hormone acts as an enterogastrone -- a hormone released from the distal portion of the small intestine that inhibits proximal gastrointestinal events. Another important action of GLP-1 is to induce satiety. About PYY Peptide YY 3-36 is produced by ...

Mymetics' HIV Vaccine Achieves Research Breakthrough, Eliciting Protective Antibody Response in Mucosal Tissues of Non-Human Primate Model

... allow protection in different anatomical compartments and block the early event of HIV translocation at the genito-reproductive and intestine tracts and subsequent infection of target cells underlying the mucosal tissues, thereby preventing HIV entry and spreading in the ...

Nuvelo Announces Publication of NU206 Study Results in Gastroenterology

... models, NU206 was shown to decrease the severity of chronic colitis by restoring the epithelial lining and alleviating inflammation of the small intestine and colon. In addition, treatment with NU206 reduced the physiological symptoms of colitis, including weight loss, diarrhea, and rectal bleeding." ...