Dade Behrings (hsCRP) Tests and BNTM Series Analyzers
C-Reactive Protein (CRP) is an inflammatory marker that has been associated with an increased ...e liver during systemic infection, and is an acute inflammatory marker. While CRP testing has been around for many years, it has only been recently that tests sensi...Near-Patient Testing: The Advantages of C-Reactive Protein in Hematological Testing
...te phase plasma protein, is involved in the innate inflammatory response and is a well known marker of systemic in...arly sensitive and interesting tool for monitoring inflammatory conditions and has numerous clinical applications. CRP measurement is used in the monitoring of adu...Non-Invasive Diagnostic Tests for Celiac Disease
...ting Editor Celiac disease (CD) is an autoimmune inflammatory disease of the small intestine that is triggered in genetically susceptible persons by the ingestion of the gluten-containing grains wheat, rye, barley, and possibly oats. The condition is thought to result from the activation of both a T-cell and B-...Micromet, Inc. to Present at the 3rd Annual C.E. Unterberg, Towbin Emerging Growth Conference
...el, proprietary antibody-based products forcancer, inflammatory and autoimmune diseases. Two productcandidates are currently in clinical trials. MT103/MEDI-538, whichis the first product candidate based on Micromet's novel BiTE(R)product development platform, is being evaluated in a phase 1clinical trial for the ...Array BioPharma to Present at the C.E Unterbeg, Towbin Emerging Growth Conference
... pipeline is focused on thetreatment of cancer and inflammatory disease and includes clinicalcandidates that are designed to regulate therapeutically importanttargets. In addition, leading pharmaceutical and biotechnologycompanies collaborate with Array to discover and develop drugcandidates across a broad range ......veloping novel therapeutics to treatinfectious and inflammatory diseases, today announced the positiveclinical res...unds in the field of severe infectiousdiseases and inflammatory diseases. All its products are based onendogenous molecules which have been optimised to combatdisea......hemotherapy/radiation therapy-inducedmucositis and inflammatory bowel disease. In addition, Nuveloexpects to leverage its expertise in secreted proteins and cancerantibody discovery to further expand its pipeline and createadditional partnering and licensing opportunities. Information about Nuvelo is available a...Chi-Med Announces Positive Phase II Proof-of-Concept Data for HMPL-004 in Ulcerative Colitis
...4 in mild-to-moderate UlcerativeColitis, a form of inflammatory bowel disease. The trial metits objective in that...t HMPL-004acts on multiple cellular targets in the inflammatory signaltransduction pathways resulting in suppressed inflammation cytokineexpression including TNF-?,......sed on the areas of infectiousdiseases, cancer and inflammatory diseases. With more than 2,500employees worldwide, MedImmune is headquartered in Maryland. Formore information, visit the company's Web site at <a target="_blank" href="http://www.medimmune.com/">http://www.medimmune.com . About Abbott Abbo...CombinatoRx Product Candidate CRx-150 Shows Activity on DAS28 and Pain, but Not CRP
...which have been shownin both preclinical and human inflammatory biomarker studies to actsynergistically to modulat...luded DAS28 scores, ACR 20 responses andchanges in inflammatory cytokines from baseline to day 42. 64 subjects with established RA and moderate disease activitywit......el, proprietary antibody-based products forcancer, inflammatory and autoimmune diseases. Two productcandidates are currently in clinical trials. MT103/MEDI-538, whichis the first product candidate based on Micromet's novel BiTE(R)product development platform, is being evaluated in a phase 1clinical trial for the ...MediQuest Concludes Confirmatory Phase III Study of Raynaud’s Therapy
...eutical company focused on developingtherapies for inflammatory and infectious diseases, today announcedthe comple...late-stage clinicaltrials targeting infectious and inflammatory skin diseases andconditions. The Company’s major efforts are focused onprojects targeting Rayn......mmatory score (a measure ofnecro-inflammation - an inflammatory process in the liver includingor leading to death of liver cells) with no concurrent worsening offibrosis (scarring of liver tissue). At 48 weeks, 66.5 percent of patients in the Viread arm (n=176)had a complete response compared to 12.2 percent i......mmatory score (a measure ofnecro-inflammation - an inflammatory process in the liver includingor leading to death of liver cells) with no concurrent worsening offibrosis (scarring of liver tissue). At 48 weeks, 66.5 percent of patients in the Viread arm (n=176)had a complete response compared to 12.2 percent in......company,is developing novel product candidates for inflammatory andinfectious diseases based on its proprietary, small-molecule,boron-based chemistry. AN2690, Anacor's lead product, is in Phase 2trials for onychomycosis, a fungal infection of nails and nailbeds.Anacor has entered into an exclusive, worldwide agre...Array BioPharma Reports New Clinical Data on Its Anti-Inflammatory Drugs
...et(R) - bind to and/ormodulate the activity of the inflammatory cytokines TNF-alpha orIL-1 and are utilized for th... pipeline is focused on thetreatment of cancer and inflammatory disease and includes clinicalcandidates that are designed to regulate therapeutically importanttarge...... QR-443 may have a role in a broadrange of chronic inflammatory diseases. The Company has begundeveloping a human study protocol to evaluate the safety and impactof this compound on specific metabolic processes altered by chronicinflammation and the presence of IL-6. Chronic inflammation is also associated with ......nary and unexpected result was thereduction of the inflammatory symptoms of acne. We plan to amendthe protocol to include patients being treated solely for acne,given the potential of this market," added Elliston. Advanced Viral Research Corp. is a New York basedbiopharmaceutical company dedicated to improving p......thritis patientswith long-standing, highly active, inflammatory disease, whichcomplicates the risk estimation. Dur...hen produced in excess,plays a central role in the inflammatory responses ofimmune-mediated diseases. To date, HUMIRA has been approved in 67countries with more tha...New Positive Pre-clinical Data for Active Biotech's RA Project I-3D
...ative drugwidely used for the treatment of various inflammatory disorders andcancer. The results strengthen further clinical development of I-3D asmonotherapy or in combination with methotrexate. Lund, June 15, 2007 Active Biotech AB (publ) Sven Andréasson President and CEO About I-3D The I-3D compoun......rogressive form of spinal arthritis andsymptoms of inflammatory back pain often first present in peoplebefore age ...in" or undifferentiated arthritis, ASis a systemic inflammatory disease that, in addition to its effecton the spine, can affect internal organs, peripheral joints a...... IL-6, one of several key cytokinesinvolved in the inflammatory process, may reduce inflammation ofthe joints, prevent long-term damage and relieve certain systemiceffects of RA such as decreased hemoglobin, fatigue andosteoporosis. "These study results underscore the potential for ACTEMRA(TM) tobecome a new tre...Additional Data on CombinatoRx Drug Candidates CRx-102 and CRx-139 Presented at EULAR
...r signaling pathways tosynergistically inhibit key inflammatory modulators and mediators(TNF-alpha, MIP-1a, RANTES, MDC, IL-6 and MMP-9) that controldisease progression and contribute directly to diseasepathology. In a poster entitled "Response and State-Attainment Criteria inHand OA: Analysis from a Placebo-Con...Targeted Genetics Reports Inflammatory Arthritis Clinical Data at European Rheumatology Conference
...ase I/II clinical trial oftgAAC94 in patients with inflammatory arthritis. Completion ofenrollment and initial dos...stereddirectly to affected joints of subjects with inflammatory arthritiswith or without concurrent use of systemic TNF antagonisttherapies. "Despite progress in......ammed cell death (apoptosis) andsuppression of the inflammatory process. Can-Fite is using humancells to investiga...-vitro datashowing that CF502 specifically targets inflammatory cells and doesnot affect healthy cells, and will also present the drug'smolecular mechanism of actio...Cimzia Effective in Reducing Signs and Symptoms of Rheumatoid Arthritis
...They work by inhibiting the action ofTNF-alpha, an inflammatory mediator, either directly or indirectly responsiblefor damaging the joint.[6] About CIMZIA(TM) (certolizumab pegol) CIMZIA(TM) (certolizumab pegol) is an investigational drug product.CIMZIA(TM) is the first and only PEGylated Fc-free anti-TNF (Tumou......ommercializinginnovative products for respiratory, inflammatory and critical carediseases. The Company owns worldw... is developingtherapies directed toward the body's inflammatory response.Critical Therapeutics is located in Lexington, Mass. For moreinformation, please visit www.......wing plastic and reconstructivesurgery and chronic inflammatory disorders. Forward-Looking Statements This release contains "forward-looking statements" made pursuantto the safe harbor provisions of the Private Securities LitigationReform Act of 1995, including the statements related to thepreliminary data disc......cesses that arethought to be the main cause of the inflammatory phase of MS" saidArthur A. Vandenbark, M.D., Ph.D., Senior Research Career Scientistat the VA Medical Center, and Professor of Neurology and MolecularMicrobiology and Immunology at Oregon Health & ScienceUniversity in Portland, OR., and lead auth...Promising Data on Cognitive Effects of Safinamide in Early Parkinson's Disease
...neuropathic pain. The drug has potentialbenefit in inflammatory pain, as well. Newron´s clinicalpipeline is supported by a portfolio of early-stage proprietarycompounds generated by its ion channel drug discovery platform.Newron is headquartered in Bresso, near Milan, Italy. The companyis listed at SWX Swis......ernational Pharmaceutical Ltd.for the treatment of inflammatory disease. The Company's firstcommercialized product, Abreva(R), is marketed in North America byGlaxoSmithKline Consumer Healthcare and is the leadingover-the-counter product for the treatment of cold sores. Furtherinformation about AVANIR can be found...Anacor Clinical Study of AN2728, a Novel Anti-Inflammatory Compound, Shows Efficacy in Psoriasis
...linical utility ofthis drug in psoriasis and other inflammatory skin diseases." Psoriatic plaques on each of th...trasound, researchers measured the thickness ofthe inflammatory infiltrate in the psoriatic plaques and alsorecorded the clinical response based on an investigator ...Phase 2 Results for EntreMed's Panzem NCD Brain Cancer Study Presented at ASCO
...lopingtherapeutics for the treatment of cancer and inflammatory diseases,announces the presentation of results of a single-agent Phase 2study for Panzem(R) NCD (2ME2) in patients with glioblastomamultiforme (GBM). The data were presented by David A. Reardon,M.D., Associate Deputy Director at The Preston Robert Ti...EntreMed's Aurora Kinase Inhibitor Induces Tumor Regression in Preclinical Models
...lopingtherapeutics for the treatment of cancer and inflammatory diseases,announced the presentation of preclinical results for its Aurorakinase - angiogenesis inhibitor, ENMD-981693. The data werepresented during oral and poster presentations by EntreMedscientists at the 2nd Protein Kinases in Drug Discovery Conf......nhibitor deficiency, is a rare andlife-threatening inflammatory condition for which there iscurrently no FDA-licensed acute therapy in the United States. "We are pleased to complete the prophylactic portion of thestudy ahead of schedule. The rapid enrollment and commitment ofpatients in the study reflects the ne...MedImmune Highlights Advances in Inflammatory Disease Pipeline With Series of Data Presentations
... White, M.D., vice president, clinicaldevelopment, inflammatory disease. "Additionally, as we expand ourbody of kn...gh Mobility Group Box Protein 1(HMGB1) may play in inflammatory disorders. "As we advance our pipeline of innovative product candidatestargeting inflammatory disea...Cytos Reports Results from Phase I/IIa Study with CYT007-TNFQb for the Treatment of Psoriasis
... candidate for the treatment ofpsoriasis and other inflammatory conditions. The present study wasa first-time-in-m...d to be linked to anoveractive immune system where inflammatory cytokines play anessential role. The inflammatory cytokine tumor necrosis factoralpha (TNF-?) has be......the inappropriate immune system responseunderlying inflammatory bowel disease (IBD) by blocking theactivity of the...bout Crohn's Disease Crohn's disease is a chronic inflammatory condition of thegastrointestinal tract. It is estimated that the disease affectsover 500,000 patient......eristics. About Ulcerative Colitis UC, a chronic inflammatory bowel disease affecting nearly500,000 people in the U.S., is marked by the inflammation andulceration of the colonic mucosa, or innermost lining, which causesbloody stools, severe diarrhea and frequent abdominal pain. Tinyopen sores, or ulcers, form ......or the treatment ofinfectious diseases, cancer and inflammatory diseases. TheCompany's clinical development progra...-150 for thetreatment of Melanoma and VGX-1027 for inflammatory diseases. VGX'sresearch pipelines include new generation of DNA vaccines andtherapeutics as well as ......HAp coatings donot trigger the various adverse and inflammatory reactions that areoften associated with implantation of polymer-coated stents andother foreign substances. HAp coatings are also expected to reduce the risk ofthrombogenic (blood clotting) events attributable in some instancesto polymer-coated stent......d into the gastro-intestinal tract,while its anti- inflammatory and analgesic activity may provide therationale for its significant benefit in abdominal pain. Crofelemeracts locally in the intestines, with limited systemic exposure. CONTACT: Lisa Conte, Chief Executive Officer,(001)+650-616-1902, orCharles Thomp...... processes initiated by unidentifiedantigens. This inflammatory disease of the GI tract affectsapproximately 500,000 people in the United States and at least thatmany in the rest of the world. The disease is characterized byflare-ups of symptoms such as diarrhea, abdominal pain, rectalbleeding and loss of appetit......psoriaticarthritis, rheumatoid arthritis and other inflammatory diseases.The Company is also initiating developmen...s validate the potential of our oral classof anti- inflammatory compounds," said Sol J. Barer, Ph.D.,Chairman and Chief Executive Officer of Celgene Corporation. "W...UCB Presents Long-Term CImzia Data in Crohn's Disease
...therwith ulcerative colitis, Crohn's disease is an inflammatory boweldisease (IBD). (5) About UCB Headquartered in Brussels (Belgium), UCB (<a target="_blank"href="http://www.ucb-group.com/">http://www.ucb-group.com ) is aleading global biopharmaceutical company dedicated to the research,development and...PDL BioPharma Announces Long-Term Nuvion Data Presented at 2007 Digestive Disease Week
...patients with IVSR-UC, the most severe form ofthis inflammatory bowel disease that attacks the colon. Summary of ... support the potential ofNuvion as a treatment for inflammatory bowel diseases: -- On Monday, May 21, Lloyd F. Mayer, M.D., Professor and Chairman of the ......percent; p Crohn's disease is a serious, chronic, inflammatory disease ofthe gastrointestinal (GI) tract that aff...hen produced inexcess, plays a central role in the inflammatory responses ofimmune-mediated diseases. To date, HUMIRA has been approved in 67countries with more tha......http://www.LIALDA.com . About UC UC is a type of inflammatory bowel disease that producesinflammation and sores ...ies andbiotechnological products targeted to treat inflammatory andautoimmune diseases. COSMO Pharmaceuticals SpA Cosmo is a speciality pharma company that aims t...FDA approves MyocondaR IND for MAP in Crohn's Disease
... About Crohn's DiseaseCrohn's Disease is a chronic inflammatory disease of thegastrointestinal tract. The disease most commonly affects the lowersmall intestine and the large intestine. Symptoms of Crohn'sDisease include abdominal pain, diarrhoea, fever and weight loss.In severe cases, the intestine can become bl......DW) conferencetaking place in Washington D.C. The inflammatory response is a key part of the immune system'sbattl... Bifantis has previously been shown tomodulate the inflammatory response in a clinical trial in irritablebowel syndrome. The results announced this week demonstrate...Ulcerative Colitis (UC) Sufferers Find UC Quite Disruptive to Many Aspects of Daily Life
...://www.managinguc.com . About UC UC is a type of inflammatory bowel disease that produces chronicinflammation an...ies andbiotechnological products targeted to treat inflammatory andautoimmune diseases. COSMO Pharmaceuticals SpA Cosmo is a speciality pharma company that aims t...Salix Pharmaceuticals Previews Digestive Disease Week 2007
...n the management of patients with mild to moderate inflammatory bowel diseaseDecreasing rates of colectomy despite M. Issa, M.D. May 23 high rates of hospitalization in C. difficile infected IBD patients: a tertiary referral center experienceMOVIPREPBetter efficacy of a new 2-liter bowel L. Cla...VEGF Trap-Eye Phase 2 Wet AMD Results Reported at ARVO Annual Meeting
...he potential treatment of cancer, eyediseases, and inflammatory diseases and has preclinical programs inother diseases and disorders. This news release discusses historical information and includesforward-looking statements about Regeneron and its products,programs, finances, and business, all of which involve a...Discovery's KL-4 Surfactant Technology Demonstrates Novel Anti-Inflammatory Properties
...el. The authors concludedthat Surfaxin reduced the inflammatory response and thereforeimproved cell survival and f...g diseases. It is well establishedthat respiratory inflammatory mediators damage the cells that makesurfactant. Our research and development strategy is focused ond......ernational Pharmaceutical Ltd.for the treatment of inflammatory disease. The Company's firstcommercialized product, Abreva(R), is marketed in North America byGlaxoSmithKline Consumer Healthcare and is the leadingover-the-counter product for the treatment of cold sores. Furtherinformation about AVANIR can be found......ease modifyingtherapeutics to treat autoimmune and inflammatory diseases basedupon the regulation of tight junctions. Alba's lead compound,AT-1001, is targeted towards the treatment of Celiac Disease,Inflammatory Bowel Disease and Type 1 Diabetes Contact: Stuart Sedlack, SVP, Corporate Development Phone:......ce implicatingT-lymphocytes, key cells involved in inflammatory processes, in thedevelopment of the disease. Uveitis is an under-diagnosed andunder-recognized medical condition that causes vision impairment,ocular pain, and loss of vision. Experts estimate that 10% of newU.S. cases of blindness result from this d...Data to be presented at AAN Meeting -Study results of drug candidate for MS
...phocytes in the lymph nodes,reducing the number of inflammatory T-cells circulating in thebloodstream and in the CNS. One of the preclinical studies presented at AAN evaluatedFTY720's ability to activate S1P receptors on astrocytes in cellculture. Astrocytes are known to play an active role in nervoustissue repa...Abbott's Investigational Treatment ABT-874 Shows Positive Results in Phase II Psoriasis Study
...oach to treating psoriasis,targeting a part of the inflammatory response that is not addressedby any therapy available today. Abbott's biologic drugs indevelopment, including ABT-874, are designed to selectively inhibitproteins that are responsible for inflammation, such aspro-inflammatory interleukins or tumor n......ely 65 percent of all cases. It ischaracterized by inflammatory events leading to loss of myelin(demyelination), variable levels of recovery between events, andirregular periods of remission. When recovery from relapse isincomplete, patients with RRMS gradually accumulate irreversibleneurological damage and disab...