New Data Shows Blood Pressure Reduction Therapy with BENICAR(R) and BENICAR HCT(R) Effectively Reduces Blood Pressure in Elderly Patients to Target Blood Pressure
... (3.4 percent), hypotension (2.2 percent), and/or
headache (1.1 percent).
High blood pressure can cause ... respiratory tract infection (4 patients, 2.2%),
headache (4 patients, 2.2%), and hypotension (4 patients, 2.2%). Among individual treatment regimens,
headache (4 patients, 2.4%) and dizziness (4 patients, ...
CHMP Recommends Approval in the European Union (EU) for New Options for Patients With Certain Primary Brain Tumors
... 36%, 49%; vomiting 20%, 29%; anorexia 19%, 27%;
headache 19%, 23%; constipation 18%, 22%; with the ... 1%, 1%; vomiting <1%, 2%; anorexia 1%, 1%;
headache 2%, 4%; constipation 1%, 0%; convulsions 3%, 3%; ... were: nausea 10%, 53%; vomiting 6%, 42%;
headache 6%, 41%; fatigue 4%, 34%; constipation 1%, 33%; ...
Minster Pharmaceuticals Plc Announces Positive Results from Phase II Trial of Migraine with Aura
... sufferers and
is a type of migraine in which the
headache is preceded by symptoms such as
visual ... Phase II trial, which was
conducted at the Danish
headache Center at Copenhagen's Glostrup ... in the trial was Professor Jes Olesen,
the Danish
headache Center's Director and one of the world's ...
Phase II Results of COL-144 Presented at European Headache and Migraine Trust International Congress 2008
... presented in poster presentations at the European
headache and
Migraine Trust International Congress 2008 in ... was headache
response, defined as a reduction in
headache severity from moderate to
severe at baseline to mild or no
headache at two hours after initiation of
infusion of ...
Data Presented at American Headache Society's Annual Scientific Meeting Show Primary Endpoint Met as Well as Improvement on Important Secondary Endpoints in Phase IIb Acute Migraine Trial of TorreyPines Therapeutics' Tezampanel
... 50th Annual
Scientific Meeting of the American
headache Society showed that, in
addition to meeting the primary endpoint of
headache pain relief at two
hours, the company's lead ... in the following
secondary endpoints: sustained
headache response, absence of nausea or
vomiting, absence ...
TorreyPines Therapeutics to Host Webinar at 11 a.m. EDT Today on the Opportunity for Treating Chronic Pain, Migraine and Muscle Spasticity Through Inhibition of Neurotransmitter Glutamate
... therapy. He is a member of the American
headache Society, The International
headache Society and The National
headache Foundation. Dr. Goldstein is a Board ...
Alexza Pharmaceuticals to Present AZ-104 Phase 2a Clinical Data at the American Headache Society Annual Scientific Meeting
... loxapine (AZ-104) for
the treatment of migraine
headache at the 50th Annual Scientific Meeting of
the American
headache Society, which being held at the Marriott ... Loxapine, a Dopamine Antagonist, Reduces
headache Pain in Patients
Having an Acute Migraine ...
Treximet(TM) (Sumatriptan and Naproxen Sodium) Tablets Approved by FDA for Acute Treatment of Migraine
... of neurology
and director of the Jefferson
headache Center at Thomas Jefferson
University and an ... are undiagnosed.
According to the International
headache Society's diagnostic criteria,
migraine is ... only be used
where a clear diagnosis of migraine
headache has been established. Treximet
may cause an ...
Alexza's AZ-104 (Staccato(R) Loxapine) Phase 2a Trial Meets Primary Endpoint of 2-Hour Pain Relief in Patients with Migraine Headache
... onset of a migraine and were treated once their
headache was
considered to be of moderate or severe ... in the placebo dose group.
Patients rated their
headache pain using the International Headache
Society ... Migraine Headaches
According to the National
headache Foundation, approximately 13 million
people in ...
Tezampanel Meets Primary Endpoint in Phase IIb Clinical Trial in Acute Migraine Headache
... significant improvement on
headache pain response at two
hours post-dose compared to ... at three and four hours
post-dose, sustained
headache response at 24 hours, functional disability
and a ... four hours
post-dose that included measures of
headache severity, nausea, vomiting,
photophobia, ...
TorreyPines Therapeutics Completes Patient Enrollment in Phase IIb Clinical Trial of Tezampanel for the Treatment of Acute Migraine Headache
... The primary efficacy endpoint for
the trial is
headache pain relief at two hours post-dose. ... and sustained pain free at 24 hours, and
headache recurrence and
relapse. Additional measures ... in the U.S. suffer from
migraines. In addition to
headache pain, migraine attacks are frequently
accompanied ...
Alexza Initiates AZ-104 (Staccato(R) Loxapine) Phase 2b Clinical Trial in Patients With Migraine Headaches
... 2 hours post-dose, using the standard 4-point rating scale
(International
headache Society). Secondary efficacy endpoints for the trial
include pain relief ...
About Acute Migraine Headaches
According to the National
headache Foundation, approximately 13 million
people in the United States have been ...
Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma
... anemia (29%), edema (23%), headache, paresthesia and dysesthesia and
headache (each 22%), dyspnea (21%), cough and insomnia (each 20%), rash (18%), ... pneumonia (16% vs 11%), dizziness (16% vs 11%), dyspnea (15% vs 13%),
headache (14% vs 10%), pain in extremity (14% vs 9%), abdominal pain (14% vs 7%), ...
Prolonged Progression-Free Survival Demonstrated by VELCADE(R) (Bortezomib) for Injection Based Induction Regimens in Transplant-Eligible Previously Untreated Multiple Myeloma Patients
... anemia (29%), edema (23%), headache,
paresthesia and dysesthesia and
headache (each 22%), dyspnea (21%), cough and
insomnia (each 20%), rash (18%), ... pneumonia (16% vs 11%),
dizziness (16% vs 11%), dyspnea (15% vs 13%),
headache (14% vs 10%), pain in
extremity (14% vs 9%), abdominal pain (14% vs 7%), ...
Long-term Follow Up Interim Data Show Nplate(TM) Increased and Sustained Platelet Counts in Adult Chronic ITP Patients
... of patients, with most mild to moderate in severity.
The most common were
headache (34 percent), contusion (32 percent), and
fatigue (31 percent). ...
General Safety
-- In the placebo-controlled studies,
headache was the most commonly
reported adverse drug reaction, occurring in 35 ...
Novel VELCADE(R) (Bortezomib) for Injection Based Four-Drug Combination Was Well Tolerated In Previously Untreated Multiple Myeloma Patients
... anemia (29%), edema (23%), headache,
paresthesia and dysesthesia and
headache (each 22%), dyspnea (21%), cough and
insomnia (each 20%), rash (18%), ... pneumonia (16% vs 11%),
dizziness (16% vs 11%), dyspnea (15% vs 13%),
headache (14% vs 10%), pain in
extremity (14% vs 9%), abdominal pain (14% vs 7%), ...
More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies
... (>10%) were rash (33%), pruritus (29%), nausea (31%), fatigue (28%),
headache (31%), constipation (21%), diarrhea (22%) and vomiting (21%). The most ... (21%), lower-limb edema (21%), malignant neoplasm aggravated (20%),
headache (19%), dizziness (excluding vertigo) (18%), insomnia (16%), decreased ...
Head-to-Head Study Demonstrates Focalin(R) XR Offers Faster and Better Symptom Control than Concerta(R)1 in Early Part of ADHD Patients' Day
... adverse events seen with Focalin XR were dyspepsia,
decreased appetite,
headache and anxiety in pediatric studies; and dry
mouth, dyspepsia, feeling jittery, dizziness,
headache and anxiety in adult
studies.
Focalin XR is contraindicated in patients ...
Headache Specialists Convene in Boston For 50th Annual American Headache Society Meeting
... BOSTON, June 26 /PRNewswire-USNewswire/ --
headache specialists meet
today in Boston for the 50th annual meeting of the American Headache
Society. Learn more about
headache and face pain developments of the last
50 years -- including the top five ...
ACTEMRA(R) (tocilizumab) Significantly Reduces Rheumatoid Arthritis Signs and Symptoms Regardless of Previous Therapy in Two New Global Studies
... ACTEMRA arm of the AMBITION trial were
upper respiratory tract infections,
headache and nasopharyngitis.
About RADIATE Study
The RADIATE (RheumAtoiD ... clinical studies were upper
respiratory tract infection, nasopharyngitis,
headache and hypertension.
Increases in liver function tests (ALT and AST) were ...
New Study Demonstrates ACTEMRA(R) (tocilizumab) Inhibits Progression of Joint Damage in Rheumatoid Arthritis Patients
... were upper
respiratory tract infections, nasopharyngitis, hypertension,
headache and
an increase in transaminases.
"At one year, the results from the ... clinical studies were upper
respiratory tract infection, nasopharyngitis,
headache and hypertension.
Increases in liver function tests (ALT and AST) were ...
TorreyPines Therapeutics Announces Strategic Plan with Focus on Clinical Development Activities to Maximize Value of Versatile Lead Compounds
... As reported last October, tezampanel met its primary endpoint of
headache pain relief in a double-blind, placebo-controlled, Phase IIb trial ... opportunities for tezampanel and
NGX426 as treatments for migraine
headache and other chronic pain and
non-pain indications. This will be in addition ...
Alexza Completes Target Enrollment in AZ-104 Phase 2a Clinical Trial in Migraine Patients
... against placebo in the clinical
trial. Using the IHS (International
headache Society) 4-point rating scale,
the primary efficacy endpoint was ... of 2008."
About Acute Migraine Headaches
According to the National
headache Foundation, approximately 13 million
people in the United States have been ...
SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia
... placebo group in
the randomized phase were insomnia (8.5% vs 17.5%) and
headache (7.4% vs
4.9%).(3,6) Launched in 1997, SEROQUEL has been prescribed to ... 2%), sedation
(13% vs 7%), somnolence (12% vs 4%), dizziness (10% vs 4%),
headache (7% vs
5%), and orthostatic hypotension (7% vs 5%). In long-term clinical ...
Cethromycin Achieves All Endpoints in Second Pivotal Phase III Trial for Treatment of Pneumonia
... were mild-to-moderate diarrhea (cethromycin 4.5%,
Biaxin 4.1%),
headache (cethromycin 2.4%, Biaxin 3.1%), nausea (cethromycin
4.5%, Biaxin 1.4%), ... (13/288) (12/291) (13/260) (12/257) (26/548) (24/548)
headache 2.4% 3.1% 3.1% 6.2% 2.7% 4.6% ...
Rotigotine Transdermal System Shows Significant Symptom Reduction and Tolerability in Patients with Restless Legs Syndrome
... to be drug-related were application site reactions, nausea,
headache and dizziness
SP 792
* In a multi-center, double-blind, ... adverse events were application site reactions (27.2%), nausea (21.5%),
headache (17.6%) and somnolence (12.6%)
24-Month, Open-Label Extension Trial in ...
Aptivus(R) (tipranavir) Capsules Granted Full Approval by the U.S. FDA
... patients taking APTIVUS/r
are diarrhea, nausea, fever, vomiting, fatigue,
headache and abdominal
pain. The most common laboratory abnormalities are elevated ... with APTIVUS/r were diarrhea, nausea, fever, vomiting, fatigue,
headache and abdominal pain. Please see full Prescribing Information (PI), ...
FDA Issues Complete Response Letter for INTUNIV(TM) (guanfacine) Extended Release for the Treatment of ADHD in Children and Adolescents
... usually transient and mild to
moderate in severity.(1,2) Treatment-related adverse events greater than 10
percent included somnolence (32 percent),
headache (26 percent), fatigue (18
percent), upper abdominal pain (14 percent), and sedation (13 percent).(11)
Small to modest changes in blood pressure, ...
July 2009 Mayo Clinic Health Letter Highlights a Positive Outlook, Bell's Palsy and Heart Valve Repair
...
A dry, irritated eye with tears dripping from the corner
Pain around the ear or jaw, ringing in the ears, sensitivity to noise
headache
Loss of taste or a decrease in saliva production
Bell's palsy can affect anyone, at any age. The risk rises until about age 40 ...
Data Demonstrated ACTEMRA(R) (tocilizumab) Significantly Inhibited Progression of Structural Joint Damage in Rheumatoid Arthritis Patients
... tolerated. The adverse events reported most frequently in the ACTEMRA arms of the studies were upper respiratory tract infection, nasopharyngitis,
headache and hypertension.
About the AMBITION Study
AMBITION, a two-arm, randomized, double-blind, placebo-controlled study, was designed to ...
Study Results Present Efficacy and Safety Findings from the PHIRST-1 Study of Patients with Pulmonary Arterial Hypertension Taking Tadalafil Tablets Once Daily
... the SF-36 health survey and for all sections of the EQ-5D questionnaire(6).
The most commonly reported adverse events for tadalafil 40 mg were
headache (42 percent for tadalafil 40 mg, versus 15 percent with placebo), myalgia (14 percent for tadalafil 40 mg, versus 4 percent with placebo) and ...
Study Demonstrating Lurasidone Is Effective in Patients With Schizophrenia Published in The Journal of Clinical Psychiatry
... adverse events (reported frequency greater than or equal to 10% among lurasidone subjects) for lurasidone versus placebo were nausea (16% vs. 3%),
headache (11.1% vs. 10%), constipation (11.1% vs. 5.6%), vomiting (11.1% vs. 5.6%), dyspepsia (11.1% vs. 3.3%), somnolence (11.1% vs. 3.3%), insomnia (10.0% ...
Horizon Therapeutics' HZT-501 Significantly Reduces Incidence of NSAID-Induced Upper Gastrointestinal Ulcers in Patients With Mild-to-Moderate Pain
... with HZT-501 was well-tolerated. The most commonly reported adverse events in these two studies were dyspepsia, nausea, diarrhea, constipation,
headache and upper respiratory tract infection. The majority were mild to moderate in severity. There were no significant differences in adverse event or ...
Shire Presented Results of a New Database Analysis on Lialda(R) (Mesalamine) and Other 5-ASAs for Ulcerative Colitis at Digestive Disease Week
... moderate in severity. In clinical trials (N=535), the most common treatment-related adverse events with Lialda 2.4 g/day, 4.8 g/day and placebo were
headache (5.6%, 3.4% and 0.6%, respectively) and flatulence (4%, 2.8% and 2.8%, respectively). Pancreatitis occurred in less than 1% of patients during ...
Shire Announces Study Results of the Effects of INTUNIV(TM) (Guanfacine) Extended Release on Secondary Measures in Children with ADHD and Oppositional Symptoms
... were usually transient and mild or moderate in severity. Treatment-related adverse events greater than 10 percent included somnolence (32 percent),
headache (26 percent), fatigue (18 percent), upper abdominal pain (14 percent) and sedation (13 percent). Syncope occurred in approximately 1 percent of ...
Video: Partnership Unites UCB with Consumer Product Innovator OXO(R)
... (n=640) and more frequently than with placebo with concomitant methotrexate (n=324) were upper respiratory tract infection (6% CIMZIA, 2% placebo),
headache (5% CIMZIA, 4% placebo), hypertension (5% CIMZIA, 2% placebo), nasopharyngitis (5% CIMZIA, 1% placebo), back pain (4% CIMZIA, 1% placebo), pyrexia ...
Alexza Reports 2009 First Quarter Financial Results and Updates Clinical Pipeline Status
... aura. Two dose levels of AZ-104 are being evaluated in the clinical trial, 1.25 mg and 2.5 mg. The primary efficacy endpoint for the trial is
headache pain relief at 2 hours post-dose, using the standard IHS 4-point rating scale. Secondary efficacy endpoints for the trial include pain relief and ...
Results From Phase 3 EQUATE Trial of VIVUS' Qnexa Highlighted at European Congress on Obesity
... study. The most common adverse events reported for the full-dose, mid-dose and placebo group were tingling (23%, 16%, 3%), dry mouth (18%, 13%, 0%),
headache (16%, 15%, 13%), and constipation (15%, 7%, 8%). The completion rate for the study overall was 70 percent.
"The weight loss seen across our ...
Schering-Plough Highlights Hepatitis C Clinical Data Presentations at the European Association for the Study of the Liver (EASL) Annual Meeting
... attempts and suicides) occurred in 2% of all patients during treatment or during follow-up after treatment cessation. PEGINTRON induced fatigue or
headache in approximately two-thirds of patients, with fever or rigors in approximately half of the patients. The severity of some of these systemic symptoms ...
Ground-Breaking Combination of All-Oral Agents Demonstrates Potential as Hepatitis C Treatment Regimen
...
The most common adverse events reported for PEGASYS and COPEGUS combination therapy observed in clinical trials were fatigue/asthenia (65 percent),
headache (43 percent), pyrexia (41 percent), myalgia (40 percent), irritability/anxiety/nervousness (33 percent), insomnia (30 percent), alopecia (28 ...