Genes in Medical Technology

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

... for 'knocking out,' or mutating, specific genes to understand their function," said Howard Jacob, ... out an inserted reporter gene and two native rat genes without causing measurable effects on other ... 90 percent of the rat's 25,000-30,000 estimated genes are analogous to those in humans and mice, and ...

Sangamo BioSciences Announces Achievement of Key Milestone in Cell Engineering Agreement With Genentech

... the successful knockout of two preselected genes in a Chinese hamster ovary (CHO) cell line. The ... technology for specifically editing target genes in mammalian cells," stated Philip Gregory, D. ... rapid generation of cell lines in which multiple genes have been knocked out. Our proven ability to ...

More Gene Mutations Linked to Autism Risk

... extra copies of DNA segments - were found in the genes of children with autism spectrum disorders ... Philadelphia. This study also uncovered two novel genes in which variations were found, BZRAP1 and ... Interestingly, key variants of these genes were transmitted in some, but not all, of the ...

ADHD Genes Found; Known to Play Roles in Neurodevelopment

... than in children without ADHD. Many of those genes were already known to be important for learning, ... study in 2003, we expected to find a handful of genes that predispose a child to ADHD," said study ... Hospital. "Instead, there may be hundreds of genes involved, only some of which are changed in each ...

Alfacell Provides Shareholder Update

... that there are specific chemotherapy resistance genes which not only are present in untreated ... reaction, measured the levels of the MDR and nfkB genes after treatment with the drug. Striking decreases in all of these genes in the mesothelioma cell lines were seen after ...

In Rare Disorder, a Familiar Protein Disrupts Gene Function

... also plays an important role in regulating genes in humans. When gene regulation is ... and patients, better knowledge of how those genes perturb normal development may enable researchers ... as the first study in human cells to identify genes that are dysregulated when cohesin doesn't work ...

Getting More From Whole-Transcript Microarrays

... are functionally distinct. Almost 90% of human genes are now considered to exhibit alternative ... The approach can only be used in well-annotated genes and can detect differential splicing involving ... that it should work particularly well for genes containing few exons, since for ...

Autism Genes Discovered; Help Shape Connections Among Brain Cells

... the autism puzzle, with two studies that identify genes with important contributions to the disorder. One ... pathways. Significantly, both studies detected genes implicated in the development of brain circuitry ... compelling to find evidence that mutations in genes involved in brain interconnections increase a ...

Scientists Discover Why Teeth Form in a Single Row

... is the process by which information stored in genes is converted into proteins that make up the ... "It takes the concerted actions of hundreds of genes to build a tooth, so it was amazing to find that ... one of many transcription factors that turn genes on or off. "Knocking out" (deleting) the Osr2 ...

The Children's Hospital of Philadelphia: New Gene-Searching Method Uncovers Possible New Targets for Crohn's Disease Drugs

... -- Discovering the different genes that contribute to a complex disease is like ... that combines a statistical tool that identifies genes interacting on the same biological pathways with ... team of researchers has discovered new genes involved in Crohn's disease. Crohn's disease is a ...

Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs

... Nearly all of the key differentially-expressed genes were activated in the human clones. In distinct contrast, the majority of these genes were down-regulated or silenced in the ... a down-regulation of these critical pluripotency genes effectively silencing them--thus making the ...

Research Teams at J. Craig Venter Institute and Ludwig Institute for Cancer Research Uncover New Chromosomal Alterations in Cancer Using Transcriptome Sequencing Approach

... focused on the transcriptome, a subset of genes in the genome that code for proteins. It has long ... clearer picture is emerging of all the expressed genes some of which present in altered forms in the ... in breast and prostate cancers. Most genes involved in the discovered chromosomal ...

Why Wait for an Anti-Aging Drug? Researchers Interviewed on CBS-TV's 60 MINUTES Discover Longevinex(R) Nutriceutical Matrix Activates 9-Fold More Longevity Genes than Plain Resveratrol

... matrix, activates 9-fold more longevity genes than plain resveratrol at a far lower dose than ... to a limited-calorie diet to activate as many genes as Longevinex(R) did in just a short time. This ... has been shown to significantly alter more genes than calorie restriction," says Bill Sardi, ...

Scientists Unmask Genetic Markers Associated With Psoriasis

... "This discovery highlights the role of several genes in mediating the immune responses that result in ... siblings have a three- to six-fold risk. But the genes responsible for psoriasis haven't yet been ... two of the previously identified psoriasis genes (IL12B and IL23R) encode proteins that bind to ...

Study Shows How Defective DNA Repair Triggers Two Neurological Diseases

... in the Jan.15, 2009, issue of the journal genes & Development . "Besides shedding light ... like their human counterparts, had defective genes that produce a protein called Mre11; while NBS ... lead to understanding how carriers of the disease genes are more prone to cancer. "There is a ...

Infant Blood May Provide Insights into Diseases Present at Birth

... to measure on a large scale the presence of genes in blood spots - the blood drawn from ... were able to detect over 3,000 genes in each sample, and to quantify the levels of ... in RNA technology to measure the expression of genes in blood spots on a larger scale. Using a random ...

A Window Into Parkinson's Disease

... If one views a cell as a computer, then the genes can be viewed as software. Unique programs operate depending on which genes are turned on. When genes are "turned on", they cause the cell to produce ...

Breakthrough Mapping of Alzheimer's Genome Helps ID Four New Suspect Genes

... Oct. 30 /PRNewswire-USNewswire/ -- Four novel genes that may significantly increase the risk of the ... the inheritance of Alzheimer's. The four genes discovered in the family study are described in ... it feasible to identify the complete set of genes influencing risk for Alzheimer's disease, Dr. ...

More Findings on Gene Involved in Childhood Asthma

... is a complex disease in which a variety of genes are thought to interact with each other and with ... additional markers, our data suggest that other genes outside the region occupied by ORMDL3 might have ... asthma is a very heterogeneous disease, the genes involved in childhood-onset asthma may be very ...

Resveratrol Longevity Science Makes Dramatic U-Turn, But Resveratrol Supplements Remain Unchanged

... regulation of SIRT1 by calorie restriction. genes Dev. 2008 Jul 1; 22(13):1753-7; Regulation ... but now outdated news reports about Sirtuin1 genes and mega-doses appear oblivious to the striking ... itself, as once claimed. The Sirtuin family of genes works in tandem with other genes, such as FOXO1 ...

New Genes Found for Inflammatory Bowel Disease in Children

... -- Researchers have discovered two new genes that increase the risk of developing ... in these new genes, the researchers say the genes are particularly strong candidates to be added to the list of genes already known to affect IBD. "As we continue to ...

Video: Resveratrol-based Nutriceutical (Longevinex(R)) Induces Favorable Changes on Gene Expression in Mouse Heart At Doses 17-320 Times Lower Than Prior Studies

... Shown To Affect 9-Fold More Longevity genes Than Resveratrol Or A ... (Longevinex(R)) exhibits striking effects upon genes controlling energy metabolism, nine times broader ... with long-term calorie restriction. Of the 2829 genes significantly affected by any of the three ...

Pediatric Researchers Find Possible 'Master Switch' Gene in Juvenile Arthritis

... of Children's Hospital. "There are only a few genes that may act as master switches like this to ... be an 'ON' gene and when it interacts with other genes and environmental triggers, a child may get ... markedly enhanced our ability to identify disease genes in complex disorders such as JIA, and what is ...

Genomic Health Announces Results of Initial Studies to Develop Predictive Tests for Targeted Therapies

... 226 samples, quantitative expression of 40 genes was significantly associated with disease ... expression of a number of the candidate genes used in conjunction with K-Ras mutation status ... with the expression levels of a small number of genes to select patients for cetuximab," said Joffre ...

NARSAD Researchers Identify Specific Genes and Family Traits Linked to Schizophrenia, Bipolar Disorder and Depression

... scientists are providing important clues into how genes work to impair various aspects of attention, ... studies are shedding new light on how specific genes contribute to the susceptibility to and pathology ... for Schizophrenia: Who Will Benefit? Do genes explain why some people with schizophrenia are ...

Presentation of Data on Progen's Cancer Epigenetic Targets Platform

... cancer target which, if inhibited, may activate genes that protect against tumor development. ... effective re-expression of aberrantly silenced genes by targeting this recently discovered cancer ... this new class of compounds we can reactivate genes that normally suppress cancer and are deactivated ...

Continued Funding to Help Advance 'Exciting Moment' in Diabetes Research

... to study newly discovered human type 2 diabetes genes in mice, and potentially find new drug molecules ... focus on whether mouse models with human diabetes genes will have beneficial effects on glucose control. ... project Cellular Models of Human Type 2 Diabetes genes will study whether markers can be established to ...

St. Jude Gene Study Reveals Basis of Anti-Cancer Drug Resistance in Childhood Leukemia

... methotrexate treatment for ALL to identify genes that governed their response to the drug. In ... analysis to measure the activity levels of 12,357 genes in the patients. In microarray analysis, ... "gene chips" on which samples of thousands of genes are arrayed. Researchers can analyze the ...

In Blood Vessel Stents, Innovative Materials Allow Better Control, Delivery of Gene Therapy

... for controlled local release of therapeutic genes at a disease site. In an animal study, the ... served as a gene therapy vector to carry genes for an enzyme that significantly reduced ... containing adenovirus vectors that delivered genes that successfully inhibited restenosis. However, ...

New Gene Discovery Suggests Which Patients CTI's Brostallicin May Benefit

... gene expression. A systematic evaluation of 7,000 genes was conducted in a cisplatin resistant variant of ... of important molecular concepts and important genes involved in DNA repair. On the basis of these and ... patients with genetic defects in mismatch repair genes such as BRCA1 and 2, which are associated with ...

Molecular Science Could Further Improve Leukemia Survival, Say St. Jude Researchers

... of this form of leukemia, including the role that genes play in therapies, according to Ching-Hon Pui, ... the amount of messenger RNA made by different genes in different cell types; and the other is pharmacogenetics. RNA is the decoded form of genes and is a signal that ...

deCODE Obesity Study Sheds Light on How Genetics Affects Risk and Onset of Common Diseases

... -- in the up-regulation or downregulation of how genes are translated into proteins -- have a major ... have made in our work on the isolation of disease genes is that the genetic risk of common diseases is ... and resources have enabled us to isolate key genes contributing to major public health challenges ...

Pre-Clinical Data Show Intracellular Pathways Affected by ONCONASE(R)

... Selectivity." The data demonstrated that 181 genes were consistently up- and down-regulated by ONCONASE and that the genes involved in triggering apoptosis (programmed cell ... to simultaneously switch on and off numerous genes controlling major regulatory processes in the ...

Genomic Health Announces Identification of Genes Associated With Colon Cancer Recurrence Across Multiple Studies

... Cancers Symposium to be Used in Selecting Final genes for Colon Cancer Test - ... the results of studies that have identified genes that could help predict the likelihood of ... methods developed by Genomic Health can identify genes that may predict the likelihood of colon cancer ...

Steps Toward Stopping Autoimmune Disease: International Consortium Identifies Genes Linked to Lupus

... A landmark genetic study has identified multiple genes linked to systemic lupus erythematosus (SLE), or ... Genetics, initial study results uncovered several genes linked to lupus and underscore the importance of ... "The mechanism of the disease by which these genes cause lupus will be seized upon by scientists who ...

St. Jude Defines Eye Cancer Gene's Role in Retinal Development

... may translate into a deeper understanding of how genes coordinate the complex process of eye formation ... with eye growth during development." genes in the Myc family carry out vital roles during ... size, differentiation and survival of cells. Myc genes are also proto-oncogenes--genes in which ...

Pharmion Submits European Marketing Authorization Application (MAA) for Vidaza(R) in Patients with Higher-Risk Myelodysplastic Syndromes (MDS)

... Hypomethylation may restore normal function to genes that are critical for differentiation and ... involved. The silencing of key cell cycle control genes and tumor suppressor genes through these two mechanisms of epigenetic ...

MDS Patients on Five-Day Vidaza(R) Dosing Schedules Achieve Transfusion Independence Consistent with Seven-day Schedule

... Hypomethylation may restore normal function to genes that are critical for differentiation and ... key cell cycle control genes and tumor suppressor genes through these two mechanisms of ... and in solid tumors. These key growth control genes can be re-expressed in cancer cells when DNA ...

PET Scans Show Gene Therapy Normalizes Brain Function in Parkinson's Patients

... Medical Center in Manhattan and others to deliver genes for glutamic acid decarboxylase (or GAD) into the ... was designed as a phase I safety study, and the genes were delivered to only one side of the brain to ... patients only received the viral vector-carrying genes to the side of the brain that controls movement ...

Groundbreaking Study Proves Personalized Diet Based on Genetics Leads to Significant Advances in Long Term Weight Management and Blood Glucose Levels

... were tailored to individual variations in the genes known to affect nutrient metabolism and ... for (24) separate variants in (19) individual genes specifically know to be related to metabolism. A ... a nutrigenetic test screening 24 variations in 19 genes involved in metabolism. The case histories of 50 ...