Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C
... of hepatitis C (HCV). PSI-7851 is a second
generation nucleotide polymerase inhibitor of HCV.
... and safety data with PSI-7851, our second
generation nucleotide analog," said Michelle Berrey, MD, ... 15-fold more potent than Pharmasset's first
generation nucleoside polymerase inhibitor, RG7128 (formerly ...
VivoMetrics(R) Introduces Next Generation LifeShirt Prototype, a Smart Garment That Delivers Real-time Vital Signs Remotely to Healthcare Providers
... today the first complete prototype of their next
generation LifeShirt for the remote monitoring of patients' ... realization of telemedicine.
The next
generation LifeShirt incorporates cutting-edge sensor ... intent is to address these needs with the next
generation LifeShirt and help make the full promise of RPM a ...
CardioVascularCS.Org, a division of EndoVascular Forum, Inc., Partners with Complex Interventional Cardiovascular Therapy (CICT) to Extend Electronic Medical Care Advancement
... Forum's commitment to developing a new
generation of tools for physicians to learn from peer ... a complementary, accelerated path to knowledge
generation and dissemination. "The end goal of this ... ( www.ICSciences.com ). The EVF NGHI (next
generation health Internet) community comes together to ...
PharmAthene Submits SparVax(TM) Regulatory Strategy to FDA
... plans for licensure of SparVax(TM), a next
generation recombinant protective antigen anthrax vaccine.
... to develop and procure 25 million doses of a next
generation rPA anthrax vaccine for the country's civilian ... the advanced development and procurement of next
generation rPA anthrax vaccines."
About SparVax(TM)
...
Pharmasset Initiates First Time in Human Study of PSI-7851 for the Treatment of Hepatitis C (HCV)
... in healthy volunteers with PSI-7851, a second
generation nucleotide analog polymerase inhibitor of ... Pharmasset. PSI-7851 is a wholly owned, second
generation nucleotide analog that was discovered by ... than the active metabolite of Pharmasset's first
generation nucleoside polymerase inhibitor, R7128. In vitro ...
Sangamo BioSciences Provides Update on Company's 2008 Progress and 2009 Objectives
... our technology platform, which is unique in its
generation of novel,
highly differentiated therapies and ... establishing the utility of ZFNs in
the
generation of transgenic animals and the potential ... ZFN technology as a new approach for
rapid
generation of "knock-out" cell lines (Santiago et al., 2008, ...
Stem Cell Sciences Announces the Creation of the World's First Authentic Rat Embryonic Stem Cells from its Exclusively Licensed Technology
... important new technology is that it allows
the
generation of both knock-out rat models, in which the effect of gene
deletion is studied, as well as the
generation of knock-in models, which
involves the insertion ... "This remarkable breakthrough will enable the
generation of transgenic
rat models for drug discovery in a ...
Ardea Biosciences Appoints John W. Beck Chief Financial Officer, Announces Clinical Development Progress and Reports First Quarter 2008 Financial Results
... a first-in-human micro-dosing study of our second
generation NNRTI, RDEA427, and selected it as a ... a first-in-human micro-dosing study of our second
generation MEK inhibitor, RDEA436, and selected it as a ... favorable resistance profiles for our next
generation NNRTI family of compounds against HIV at the ...
Sangamo BioSciences and Sigma-Aldrich Announce Publication of Study Demonstrating Zinc Finger Technology for Rapid Generation of 'Knock-Out' Cell Lines
... nucleases (ZFNs(TM)) in a
new approach for rapid
generation of "knock-out" cell lines, important
tools in ... advance in the specificity and
efficiency of the
generation of cell lines in which an individual gene ... vice president of research. "The
generation of knockouts in basic
research and industrial ...
Poniard Pharmaceuticals Provides Year-End Clinical Update at 2007 Lazard Capital Markets Healthcare Conference
... to
advance our development of picoplatin, a new
generation chemotherapy agent
with the potential to become a ... .
About Picoplatin
Picoplatin is a new
generation platinum chemotherapy agent with the
potential to ... lead
platform product candidate, is a new
generation platinum therapy with an
improved safety profile. ...
Sangamo BioSciences and Sigma-Aldrich Announce Nature Biotechnology Study Demonstrating Zinc Finger Technology for Modification of Human Stem Cells
... in stem cells
potentially enabling the efficient
generation of stem cell lines for use as
models of human ... for drug testing. In
addition to its use in the
generation of valuable research reagents, the
technology has ... has revolutionized biology and enabled the
generation of mouse
cell-lines and transgenic mouse models ...
Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology
... modified animal models of human disease. ZFN technology will make the
generation of such animals faster and will create new opportunities in species other ... transgenic rats using DNA or lentiviral vector microinjection. The
generation of transgenic rats also is open to the scientific community through an ...
Poniard Pharmaceuticals Announces Positive Cardiac Safety Data From Picoplatin Phase 1 Trial Supporting NDA Filing
... announced results from a Phase 1 cardiac safety study of picoplatin, a new
generation platinum-based chemotherapy agent and the Company's lead product ... later this year.
About Picoplatin
Picoplatin is a new
generation platinum-based chemotherapy agent that is in clinical development for ...
Thiarabine Demonstrates a Reduction of Both Inflammatory and Erosive Disease Parameters in Rheumatoid Arthritis
... be developed for rheumatoid arthritis as well."
Thiarabine is a next
generation nucleoside analogue that Access has licensed from Southern Research. It ... factor and is targeted to breast cancer; and Thiarabine , a new
generation nucleoside analog which has demonstrated both pre-clinical and clinical ...
Sangamo BioSciences Announces Achievement of Key Milestone in Cell Engineering Agreement With Genentech
... with Genentech, Inc., a wholly-owned member of the Roche Group, for the
generation of cell lines with novel characteristics for pharmaceutical protein ... obviates the need for selection markers, thereby enabling the rapid
generation of cell lines in which multiple genes have been knocked out. Our proven ...
Trius Announces Positive Results From Phase 2 Clinical Trial of Torezolid in Patients With Complicated Skin and Skin Structure Infections
... Second
generation Oxazolidinone Demonstrates Safety and Efficacy with Once-Daily, 200 ... pathogens. The company's lead drug candidate, torezolid, is a second
generation oral and IV oxazolidinone antibiotic with potent activity against ...
Access Pharmaceuticals Announces Publication of Thiarabine Combination Data
... for download from the journal's website.
"Thiarabine is a next
generation nucleoside analogue, licensed by Access from Southern Research Institute ... factor and is targeted to breast cancer. Thiarabine is a new
generation nucleoside analog which has demonstrated both pre-clinical and clinical ...
PharmAthene Submits Proposal to BARDA in Response to Broad Agency Announcement for Advanced Research and Development for Valortim(R)
... development programs include:
SparVax(TM) - a second
generation recombinant protective antigen (rPA) anthrax vaccine
Valortim(R) - ... RypVax(TM) - a recombinant dual antigen vaccine for plague
A third
generation rPA anthrax vaccine.
For more information about ...
First Jatropha Genome Completed by Synthetic Genomics Inc. and Asiatic Centre for Genome Technology
... it can be grown on marginal, non-food producing lands; has a very short
generation time; can be productive for 30 to 40 years; and its seed oil and biomass ... of the genome, using both traditional Sanger sequencing and next
generation sequencing, has revealed that the jatropha genome is approximately 400 ...
BioVex to Report Phase I/II Clinical Trial Results for the Front Line Treatment of Head and Neck Cancer With OncoVEX GM-CSF at the 2009 American Society of Clinical Oncology Meeting
... Mass., May 15 /PRNewswire/ -- BioVex Inc, a company developing next
generation biologics for the treatment and prevention of cancer and infectious ... recently commenced a Phase III study in metastatic melanoma following the
generation of an unprecedented number of durable complete remissions in a Phase II ...
PharmAthene to Host a Conference Call and Webcast on Wednesday, April 29th at 4:30 PM to Provide an Update on the SparVax(TM) rPA Anthrax Vaccine Program
... development programs include:
SparVax(TM) - a second
generation recombinant protective antigen (rPA) anthrax vaccine
Third
generation rPA anthrax vaccine
Valortim(R) - a fully human monoclonal ...
Facet Solutions, Inc. Expands U.S. Pivotal Study With Next Generation Implant System
... Study for the treatment of lumbar spinal stenosis utilizes the second
generation design technology from Facet Solutions, Inc. This technology enables the ... stability to the lumbar spine. Average implantation times with the second
generation design are equivalent to implantation times for standard postero-lateral ...
Pharmasset Voluntarily Halts Clinical Studies with Clevudine in Hepatitis B Infected Patients
... trial at the upcoming EASL meeting. Pharmasset's unpartnered second
generation HCV nucleoside, PSI-7851, is progressing well in a phase I trial and we ... has completed a Phase 2 clinical trial. PSI-7851, an unpartnered second
generation HCV nucleotide analogue recently entered phase 1 studies.
Pegasys(R) ...
AACR Data Highlights InNexus Preclinical Antibody Candidate
... ), a drug development company commercializing the next
generation of monoclonal antibodies based on its technology, Dynamic Cross Linking ...
InNexus is a drug development company commercializing the next
generation of monoclonal antibodies based on its DXL technology, which improves the ...
Study Data Show Positive European Experience With DuraHeart Left Ventricular Assist Device for Advanced Stage Heart Failure Patients
... rates during DuraHeart support were acceptable in comparison to first
generation pulsatile and second
generation axial flow LVADs. The event rate of bleeding requiring surgery (0.22 per ...
Novel Valortim(R) Mechanism of Action Data Presented at the Keystone Symposia on Molecular and Cellular Biology
... development programs include:
SparVax(TM) - a second
generation recombinant protective antigen (rPA) anthrax vaccine
Valortim(R) - ... RypVax(TM) - a recombinant dual antigen vaccine for plague
A third
generation rPA anthrax vaccine.
For more information about ...
DSM Obtains Exclusive World-Wide License for Innovative Drug Delivery Technology
... platform, this will open up a broad range of opportunities for next
generation drug delivery. DSM's activities in this field are a perfect illustration ... technology for the delivery of biologics and drugs is based on a next
generation set of polymers exclusively licensed from Cornell University . Generated ...
Research Teams at J. Craig Venter Institute and Ludwig Institute for Cancer Research Uncover New Chromosomal Alterations in Cancer Using Transcriptome Sequencing Approach
... changes in certain cells. Continued advances and cost efficiencies of next
generation DNA sequencing technologies are enabling this more precise and detailed ... in cancer.
The team concluded that transcriptome sequencing with next
generation sequencing technologies such as the 454 Life Sciences platform is very ...
Trius Completes Enrollment in Phase 2 Clinical Trial Evaluating Torezolid (TR-701) in Patients With Complicated Skin and Skin Structure Infections
... 180 Patient Trial of 2nd
generation Oxazolidinone Enrolls in Four Months
SAN DIEGO, Jan. 26 /PRNewswire/ ... pathogens. The company's lead drug candidate, torezolid, is a second
generation oral and IV oxazolidinone antibiotic with potent activity against ...
Gene Therapy Corrects Sickle Cell Disease in Laboratory Study
... altered blood-forming cells from the original treated mice into a second
generation of sickle cell mice to show that the gamma-globin gene had incorporated ... blood-forming cells. Five months after that transplantation, the second
generation of mice also showed production of fetal hemoglobin and correction of their ...
The Government of Canada Procures IMVAMUNE(R) Smallpox Vaccine for the Country's Biological Preparedness
... for Proposal issued in 2007 with the intent to procure an MVA-based,
third
generation smallpox vaccine, Public Works and Government Services
Canada, on behalf ... 25 % of the population.
IMVAMUNE(R), Bavarian Nordic's new, third
generation smallpox vaccine,
offers a number of unique advantages compared to the old ...
PharmAthene Initiates Phase I Clinical Trial of Nerve Agent Bioscavenger Protexia(R)
... lead product
development programs include:
-- SparVax(TM) - a second
generation recombinant protective antigen (rPA) anthrax vaccine -- Third
generation rPA anthrax vaccine -- Valortim(R) - a fully human monoclonal antibody ...
Texas Cardiac Arrhythmia Institute at St. David's Medical Center Selected to Conduct Clinical Trial for Device to Treat Atrial Fibrillation
... the pathway for the abnormal heart rhythm. The new study
involves second
generation software (Gen II) that uses a catheter believed
to result in the formation ... temperature at the catheter's tip,
overheating may occur, resulting in the
generation of a less effective
lesion.
"While many studies involve less complex ...
PharmAthene Presents Data for Protexia(R) and Valortim(R) at 2008 BARDA Industry Conference / PHEMCE Stakeholders Workshop
... lead product
development programs include:
-- SparVax(TM) -- a second
generation recombinant protective antigen (rPA) anthrax vaccine -- Third
generation rPA anthrax vaccine -- Valortim(R) -- a fully human monoclonal antibody ...
Southern Research Institute Wins $14.7 Million NIH Award to Participate in Molecular Libraries Probe Production Center Network
... Libraries Program (MLP) is a full-scale production
program emphasizing the
generation of high quality probes and
biological-chemical data for high-value ... abilities that will
enable screening of diverse types of assays and
generation of chemical
probes to address a wide range of biological opportunities. ...
febit and TGen Collaborate to Study New DNA Capture Method
... conversation on the future direction of
genomic research centers on next
generation sequencing," said Matthew
Huentelman, Ph.D., TGen associate investigator ... for TGen researchers to make a
difference in research utilizing next
generation sequencing."
TGen has been a user of the Geniom One device for the ...
First DuraHeart(TM) Left Ventricular Assist System Implanted in the U.S. Pivotal Trial
... readily available for the increasing need of heart
failure patients. Third
generation systems are anticipated to demonstrate
improved outcomes and long term reliability. DuraHeart is the most advanced
third
generation centrifugal pump by virtue of the magnetically levitated
impeller, ...
New CyberKnife Technologies Demonstrate Dramatic Reduction in Treatment Times
... First Patients Treated Using Next
generation CyberKnife System at Oklahoma CyberKnife Center
... Oklahoma CyberKnife, LLC purchased its CyberKnife System with all
the next
generation upgrades included, those same upgrades were made
available to existing ...
Aegera Initiates a Fifth Phase 1 and 2 Clinical Trial for AEG35156
... in a fifth phase 1 and 2
clinical oncology study of AEG35156, a second
generation antisense
therapeutic targeting XIAP, a key member of the Inhibitor of ... disable their normal
response to apoptotic triggers. AEG35156, a second
generation antisense
which targets XIAP, is designed to lower the apoptotic threshold ...
Start of Phase I Study for Intranasal Pandemic Influenza Vaccine deltaFLU
... its intranasal vaccine deltaFLU
against pandemic influenza. This novel
generation of a live-attenuated
vaccine based on the deletion of the NS1 gene has ... has
optimized the method of reverse genetics, which permits the
generation of a
vaccine against any potential influenza virus within a very short ...