Gastrointestinal in Medical Technology

Lexicon's Drug Candidate LX1032 for Carcinoid Syndrome Receives Orphan Drug Designation From EMEA

... , the company's oral drug candidate for managing gastrointestinal symptoms associated with carcinoid syndrome . ... Elevated levels of serotonin contribute to the gastrointestinal and possibly other symptoms experienced by these ... tumors that usually originate from the gastrointestinal tract. These tumors secrete large amounts of ...

DOR BioPharma Receives EMEA Agreement on the Design of its Confirmatory Phase 3 Clinical Trial of orBec(R) in GI GVHD

... lead product orBec(R) for the treatment of acute gastrointestinal Graft-versus-Host Disease (GI GVHD). The ... locally acting therapy tailored to treat the gastrointestinal manifestation of GVHD, the organ system where ... patient's (host's) body -- most frequently the gastrointestinal tract, liver and skin. Patients with ...

Definitive Outcomes of Radiofrequency Ablation for Barrett's Esophagus Using the HALO Ablation System Reported at the Digestive Disease Week Meeting for Gastroenterologists and Esophageal Surgeons

... group. In another study (AIM-II) published in gastrointestinal Endoscopy , 98.4% of patients were Barrett's-free ... of gastroenterology, hepatology, endoscopy, and gastrointestinal surgery. Jointly sponsored by the American ... Association (AGA), the American Society for gastrointestinal Endoscopy (ASGE), and the Society for Surgery of ...

Paclitaxel Poliglumex (OPAXIO(TM)) Added to Cisplatin and Radiation Produces 45% Pathologic Complete Remissions in Patients With Esophageal Cancer

... high incidence of Grade 3-4 toxicity to the upper gastrointestinal track necessitating prophylactic insertion of ... cisplatin due to the lower incidence of severe gastrointestinal toxicity. It is likely that this is due to the ... this study combined with the lower than expected gastrointestinal and other severe toxicities. About ...

PROTECT-1 Phase II/III Induction-Stage Results for ChemoCentryx's Traficet-EN(TM) Presented in Oral Session at DDW 2009 Conference

... side effect profile to patients with this chronic gastrointestinal disease. "Targeting the CCR9 chemokine ... disease and other inflammatory disorders of the gastrointestinal system. About Traficet-EN(TM) (CCX282-B) ... is a chronic inflammatory condition of the gastrointestinal tract. It is estimated that the disease affects ...

Researchers Present Safety and Efficacy Results of 429 Patients Treated With Radiofrequency Ablation for Pre-Cancerous Barrett's Esophagus

... session sponsored by the American Society of gastrointestinal Endoscopy. The study's author reported on ... group. In another study (AIM-II) published in gastrointestinal Endoscopy , 98.4 percent of patients were ... of gastroenterology, hepatology, endoscopy, and gastrointestinal surgery. Jointly sponsored by the American ...

Horizon Therapeutics' HZT-501 Significantly Reduces Incidence of NSAID-Induced Upper Gastrointestinal Ulcers in Patients With Mild-to-Moderate Pain

... developed 50 percent less NSAID-induced upper gastrointestinal (GI) ulcers (gastric and/or duodenal ulcers) ... such as bleeding. Patients at increased risk for gastrointestinal ulcers may benefit from protective co- therapy, ... either an endoscopically diagnosed upper gastrointestinal ulcer and/or prohibitive toxicity. Patients ...

Shire Presented Results of a New Database Analysis on Lialda(R) (Mesalamine) and Other 5-ASAs for Ulcerative Colitis at Digestive Disease Week

... (ADHD), human genetic therapies (HGT) and gastrointestinal (GI) diseases as well as opportunities in other ... of gastroenterology, hepatology, endoscopy and gastrointestinal surgery. Jointly sponsored by the American ... (AGA) Institute, the American Society for gastrointestinal Endoscopy and the Society for Surgery of the ...

Ironwood and Forest Present Additional Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

... (IBS-C) IBS-C is a chronic functional gastrointestinal disorder characterized by abdominal pain, ... of gastroenterology, hepatology, endoscopy, and gastrointestinal surgery. Jointly sponsored by the American ... (AGA) Institute, the American Society for gastrointestinal Endoscopy, and the Society for Surgery of the ...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

... from PROMID were presented at the 2009 ASCO gastrointestinal Cancer Symposium(1). Neuroendocrine tumors ... observed serious adverse events affected the gastrointestinal tract, hematopoietic system and other general ... adverse events were biliary disorders (62%), gastrointestinal disorders (14% to 38%), and injection-site pain ...

Logical Therapeutics Appoints Peter A. Lankau as CEO and Director

... treatment is complicated by significant gastrointestinal risks." Mr. Lankau became President and CEO ... has demonstrated significantly less damage to the gastrointestinal tract than equimolar doses of naproxen. ... exceed $4 billion a year. Serious NSAID-induced gastrointestinal (GI) complications, such as hemorrhage and ...

Glivec(R) is the First Adjuvant Treatment Approved in the UK to Delay Return of Gastrointestinal Cancer After Surgery

... Treatment of Patients With KIT (CD117)-Positive gastrointestinal Stromal Tumours (GIST), who are at Significant ... in the UK for the treatment of patients with the gastrointestinal cancer, KIT (CD117)-positive gastrointestinal stromal tumours (GIST), who have had surgery to ...

Ironwood Announces Linaclotide European Licensing Agreement with Almirall

... syndrome with constipation (IBS-C) and other gastrointestinal conditions. This agreement is a continuation of ... (IBS-C) IBS-C is a chronic functional gastrointestinal disorder characterized by abdominal pain and ... in the areas mentioned plus some others including gastrointestinal and neurology. Almirall is currently present ...

AstraZeneca Submits NDA for Low Dose Aspirin/Esomeprazole Combination Product

... is associated with a risk of peptic ulcers and gastrointestinal symptoms.(3B,3C) These gastrointestinal side effects can lead patients to discontinue ... et al. Prevalence and Clinical Impact of Upper gastrointestinal Symptoms in Patients Treated with Low-Dose ...

DOR BioPharma, Inc. Executes $400,000 Equity Investment Agreement With Numoda Corporation

... trial of orBec(R) for the treatment of acute gastrointestinal Graft-versus-Host disease (GI GVHD). "We ... side effects of cancer treatments and serious gastrointestinal diseases, and vaccines for certain bioterrorism ... BDP may also have application in treating other gastrointestinal disorders characterized by severe inflammation. ...

Task Force Recommends Using Aspirin to Prevent Cardiovascular Disease When the Benefits Outweigh the Harms

... pressure, cholesterol levels, smoking and risk of gastrointestinal bleeding -- before deciding whether to use ... the benefits outweigh the harms for potential gastrointestinal bleeding. Women between the ages of 55 and 79 ... the benefits outweigh the harms for potential gastrointestinal bleeding. Ischemic strokes occur as a result of ...

Meritage Pharma Initiates Phase 2b Clinical Trial of Oral Viscous Budesonide for Pediatric Patients With Eosinophilic Esophagitis

... that specialize in the treatment of patients with gastrointestinal diseases. EoE is an emerging disease that ... safe and effective molecules for the treatment of gastrointestinal and atopic diseases. Meritage Pharma's initial ... esophagitis, an allergic inflammation of the gastrointestinal tract and is currently in a Phase 2b study. The ...

ASGE Urges Patients to Seek a Qualified Endoscopist Before Undergoing a Colonoscopy for Colorectal Cancer

... highlights the importance of seeking a qualified gastrointestinal endoscopist to perform a thorough colonoscopy and ... colon to detect lesions. The American Society for gastrointestinal Endoscopy (ASGE), representing the specialists in ... that patients seek out an expertly-trained gastrointestinal endoscopist to perform a colonoscopy and to ask ...

Horizon Therapeutics Announces Two Pivotal HZT-501 Phase 3 Trials Meet Primary Endpoints

... drug (NSAID)-induced upper gastrointestinal (gastric and/or duodenal) ulcers in patients with ... adverse side effects, which primarily affect the gastrointestinal (GI) tract. Up to 30 percent of patients taking NSAIDs experience gastrointestinal ulcers and a greater percent suffer from upper GI ...

ASGE and The Pancreatic Cancer Action Network Partner to Raise Awareness About Pancreatic Cancer

... -- The American Society for gastrointestinal Endoscopy (ASGE) and the Pancreatic Cancer Action ... the stomach. A recent study in GIE: gastrointestinal Endoscopy , the scientific journal of the ASGE, ... cancer. About the American Society for gastrointestinal Endoscopy Founded in 1941, the mission of ...

Prometheus Presents Findings From Development of PROMETHEUS(R) IBS Diagnostic, First Blood Test for IBS, at ACG Annual Scientific Meeting

... exciting advancement in the field of functional gastrointestinal disease," said Dr. Anthony Lembo, M.D., ... abnormality and symptoms often overlap with other gastrointestinal conditions, such as inflammatory bowel disease, ... on the detection, diagnosis and treatment of gastrointestinal diseases and disorders in the United States. ...

National Study Presented at ACG 2008 Confirms New Device Functions Like 'Rear-View Mirror' to Provide Improved View of the Colon

... in the U.S. However, most cancers of the lower gastrointestinal (GI) tract can be completely cured if they are ... detection and prevention of cancers of the gastrointestinal (GI) tract. The seasoned Avantis team is ... in the dietary Polyp Prevention Trial. gastrointestinal Endoscopy 61(3):385-391, 2005. [3] Rex, ....

Consensus Document Outlines Practical Steps for Reducing Gastrointestinal Risks of Antiplatelet and NSAID Use

... drugs (NSAIDs) along with antiplatelet agents. gastrointestinal bleeding is a major and potentially ... NSAIDs have a two- to four-fold increased risk of gastrointestinal bleeding compared with those not taking these ... individual patient risk to be able to prevent gastrointestinal problems as antiplatelet therapy is actually ...

ASGE Encourages Patients to Speak to Their Doctor About Colorectal Cancer Screening Options

... screening options. The American Society for gastrointestinal Endoscopy (ASGE) encourages patients to speak to ... . About the American Society for gastrointestinal Endoscopy Founded in 1941, the mission of the ... digestive health by promoting excellence in gastrointestinal endoscopy. ASGE, with more than 10,000 physician ...

European Enrollment Begins in Pivotal Phase 3 Trial of Novel Combination Medicine Developed by Cogentus Pharmaceuticals

... Expands to Europe; Focus on Reducing gastrointestinal Side Effects of Antiplatelet Therapy MENLO ... benefits while reducing potentially serious gastrointestinal side effects commonly associated with dual ... of clopidogrel and aspirin is associated with gastrointestinal bleeding, which in some cases requires ...

Study Findings Show Infection Control Intervention Helps Keep Kids in School

... Researchers found absenteeism rates for gastrointestinal illnesses were nine percent lower in classrooms ... illness was not affected by this intervention. gastrointestinal illnesses are extremely common for ... fact, the bacteria and viruses that cause these gastrointestinal infections can be easily passed from one person ...

Wyeth and Progenics Announce Preliminary Clinical Trial Results for RELISTOR Oral and Intravenous Formulations

... found outside the CNS, such as those within the gastrointestinal tract, resulting in constipation that can be ... outside the CNS, including those located in the gastrointestinal tract, thereby decreasing their constipating ... patients with known or suspected mechanical gastrointestinal obstruction. -- If severe or persistent diarrhea ...

Alba Therapeutics Announces the Presentation of Results of a Phase IIa Clinical Trial for Larazotide Acetate for the Treatment of Celiac Disease at the Digestive Disease Week Conference

... signs and symptoms and outcomes, measured by the gastrointestinal Symptoms Rating Scale (GSRS; validated in several gastrointestinal diseases) and the Psychological General ... * Larazotide acetate conferred protection from gastrointestinal symptoms as measured by the GSRS as well as ...

Ironwood Pharmaceuticals and Forest Laboratories Announce Presentation of Linaclotide Phase 2b Chronic Constipation Study Results

... stool consistency. BSFS is a surrogate marker of gastrointestinal transit time. About Linaclotide Linaclotide ... for the treatment of IBS-C, CC, and other gastrointestinal disorders. Linaclotide is an agonist of guanylate ... Institute, the American Society for gastrointestinal Endoscopy, and the Society for Surgery of the ...

Pivotal Study Shows Physician/Nurse Teams Using SEDASYS(TM) System Reduced Risk of Over Sedation With Propofol

... cancer (colonoscopy), and disorders of the upper gastrointestinal tract (EGD). The study -- which will be presented ... in general and bariatric surgery, as well as gastrointestinal health, gynecology and surgical oncology. ... Institute, the American Society for gastrointestinal Endoscopy and the Society for Surgery of the ...

New AMITIZA 8 mcg Phase III Studies Demonstrated Overall Symptom Improvement in Adult Women with Irritable Bowel Syndrome with Constipation (IBS-C)

... in patients with known or suspected mechanical gastrointestinal obstruction. Patients with symptoms suggestive of mechanical gastrointestinal obstruction should be thoroughly evaluated by the ... older and is developing the drug for additional gastrointestinal disorders with large potential markets. In ...

Data Show FLECTOR(R) Patch Yields Significant Pain Reduction for Acute Strains, Sprains and Contusions

... 600 patients. In addition, the incidence of gastrointestinal side effects such as nausea and upset stomach ... coronary artery bypass graft (CABG) surgery. gastrointestinal risk -- NSAIDs cause an increased risk of serious gastrointestinal adverse events including bleeding, ...

New Data Show High Frequency of Medical Claims for Gastrointestinal Events by Patients on Antiplatelet Therapy

... at least one insurance claim for ulcer or gastrointestinal bleeding, according to data released by Cogentus ... study reported today tracked insurance claims for gastrointestinal adverse events among more than 368,000 patients ... about the frequency of medical attention for gastrointestinal events required by an insured population on ...

Nuvelo Announces Preclinical Data for NU206 Demonstrating Potent Therapeutic Activity in Oral Mucositis Models

... are important to disease processes, including gastrointestinal disease, bone disorders, wound healing ... that acts as a highly specific regulator of the gastrointestinal epithelial cell function as demonstrated in early ... of radiation or cancer chemotherapy induced gastrointestinal injury, as well as in animal models of ...

Shire Strives to Increase Adherence Among Chronic Kidney Disease Stage 5 Patients

... levels. Such binders "soak up" phosphorus in the gastrointestinal tract, before it can be absorbed into the blood, ... not compromised by pH variations throughout the gastrointestinal tract. FOSRENOL has a high affinity for ... and works by binding to dietary phosphorus in the gastrointestinal tract. Once bound, the FOSRENOL/phosphorus ...

CureHIV Reaches Out to Bill and Melinda Gates to Fund LiSAVIOR

... do not treat the growth of HIV in the gastrointestinal tract. HIV virus multiplies and mutates in the gastrointestinal tract and then is reabsorbed into the blood. This ... needles or during sexual intercourse. The gastrointestinal tract is comprised of the mouth and ...

Microbia and Forest Laboratories Announce Preliminary Results of Linaclotide Phase 2b Studies

... stool consistency and a surrogate marker of gastrointestinal transit time. About Chronic Constipation (CC) ... tested for the treatment of IBS-C, CC, and other gastrointestinal disorders. Linaclotide is an agonist of guanylate ... syndrome with constipation, and other functional gastrointestinal disorders; and novel, next-generation cholesterol ...

Raven Announces Completion of Enrollment in the Phase 1/2a Clinical Trial of RAV12 Therapeutic Antibody for the Treatment of Adenocarcinomas

... express the RAAG12 antigen, particularly those of gastrointestinal origin. All patients in the trial have undergone ... surfaces of tumor cells, particularly those of gastrointestinal origin (gastroesophageal, pancreatic, and ... is in clinical development for the treatment of gastrointestinal and other cancers. Raven's discovery ...

Horizon Therapeutics Completes Enrollment in Phase 3 Trials for Lead Product Candidate HZT-501

... of development of ibuprofen-associated upper gastrointestinal (gastric and/or duodenal) ulcers in patients who ... trials ever conducted regarding NSAID-induced gastrointestinal ulcers," said Loren Laine M.D., professor of medicine in the Division of gastrointestinal and Liver Diseases, University of Southern ...

First Patient Enrolled in Cogentus Pharmaceuticals' Pivotal Phase 3 Trial of Novel Combination Medicine

... of clopidogrel and aspirin is associated with gastrointestinal bleeding, which in some cases requires ... as COGENT-1 (Clopidogrel and the Optimization of gastrointestinal Events Trials) and is part of a clinical ... Patients will be assessed regularly for any gastrointestinal side effects such as bleeding and ulcers as well ...