Function in Medical Technology

Injection Reverses Heart-Attack Damage

... enhances heart regeneration, improves heart function without need for cardiac stem cells ... spur heart-muscle growth and recovery of cardiac function when injected systemically into animals after a ... heart regeneration was increased and pumping function (ejection fraction, assessed on echocardiograms) ...

Data Demonstrated ACTEMRA(R) (tocilizumab) Significantly Inhibited Progression of Structural Joint Damage in Rheumatoid Arthritis Patients

... Most patients also experienced improved physical function following treatment with ACTEMRA, as measured by ... structural joint damage, improvement in physical function and disease signs and symptoms over two years. ... 50 percent of patients can continue to work or function normally on a daily basis. RA affects more than ...

AFRESA(R) Phase 3 Pulmonary Function Safety Data in Patients with Diabetes Presented at ADA

... to standard insulin therapy in pulmonary function tests NEW ORLEANS, June 6 ... rapid acting insulin with changes in pulmonary function tests comparable to usual antidiabetic treatment, ... Key Findings Findings were based on pulmonary function tests (PFTs) over a 2-year period in subjects ...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

... taking Femara(R) experience better cognitive function than those taking tamoxifen - Phase II ... bleeding, cardiac ischemia, elevated liver function tests and infection. Reactivation of Hepatitis B ... Novartis. Femara BIG 1-98 data on cognitive function Impaired cognition is a concern among breast ...

Two-Year Data Reinforce Effect of ACTEMRA(R) (tocilizumab) in Inhibiting Progression of Joint Damage and Improving Physical Function in Rheumatoid Arthritis Patients

... a major cause of disability and loss of physical function for RA patients," said Kenneth Bahrt, M.D., ... study also examined the improvement in physical function and disease signs and symptoms. One-year ... 50 percent of patients can continue to work or function normally on a daily basis. RA affects more than ...

PARI Pharma's Nebulized DSCG Shows Results Similar to Inhaled Steroids in Asthma Studies Presented at ATS

... asthma symptom scores without a change in lung function for both groups. These results were achieved ... chamber. The study compared various lung function parameters, such as forced expiratory volume in 1 ... respectively. No significant change in lung function was observed during the six-month treatment with ...

MitraClip(R) Therapy Data Demonstrate Clinical Benefit in High-Risk Patients With Mitral Regurgitation

... Data Show Improved Symptomatic Status, Cardiac function and Reduced rate of Hospitalization for ... demonstrated improvement in left ventricular function and reduced hospitalization for congestive heart ... functional class was accompanied by improved LV function for both groups. The rate of hospitalization for ...

Study Reported Tadalafil Taken Once Daily Improved Erectile Function in Men with ED and Sexual Quality of Life in Couples

... was generally well-tolerated, improved erectile function for men with erectile dysfunction (ED) and ... questionnaires to assess changes in erectile function and sexual quality of life before and after ... as their female partners who had adequate sexual function as measured by the Female ...

New Analysis Evaluated Impact of Genetic Variation on Response to Prasugrel

... patients who took prasugrel and had a reduced function of the CYP2C19 gene did not have an increased ... Caucasians and 60 percent of Asians have reduced function in the CYP2C19 gene, which is part of the CYP ... one variant in the CYP2C19 gene that reduced its function versus 9.8 percent (N=1048) in patients without a ...

Pharmaxis Announces Positive Results of Phase 3 Cystic Fibrosis Trial

... was to assess whether Bronchitol improves lung function as measured by a change in Forced Expiratory ... a statistically significant improvement in lung function from baseline of 6.6% (p=0.001 versus placebo). Lung function improved at week 6 and was sustained through to ...

Adult Circumcision Reduces Risk of HIV Transmission Without Reducing Sexual Pleasure

... men and that there was no difference in sexual function between circumcised and uncircumcised men. ... show that there was no difference in sexual function between the two groups and that the circumcised ... that circumcision does not interfere with sexual function and that circumcision is an important element of ...

Oh, My Aching Back: Give Me a Shot of Ozone

... Relieves Pain From Herniated Disks; Pain and function Outcomes Similar to Surgery Results but With ... disks. The estimated improvement in pain and function is impressive when we looked at patients who ... explained Murphy. "Equally important, pain and function outcomes are similar to the outcomes for lumbar ...

Cardium's InnerCool Announces Positive Benefits of Cooling During Robotic-Assisted Prostate Surgery Published in Urology

... to demonstrate improved post-operative erectile function for patients as well. A study is underway by Dr. ... control (continence) and possibly erectile function (potency) following surgery. "These ... In many cases, the recovery of sexual function can take up to 24 months. Additional ...

Emerging Therapies Could Help Ease The Chronic Symptoms of Atopic Dermatitis For Adults and Children

... dermatitis, including those in the skin's barrier function -- or its protective outer layer," said Dr. ... and eczema is born with problems with the function of their outer layer of skin, which can cause the ... agents that are designed to improve the barrier function of the skin that is compromised in atopic ...

When to Have That Joint Replacement?

... patients tend to have poorer joint function before undergoing hip or knee replacement ... female patients have less preoperative joint function than male patients across ethnic groups. ... "This means that patients with worse joint function before surgery do not do as well after the ...

Quark Pharmaceuticals Announces Dosing of the First Patient in Phase I/II Clinical Trial for Systemically Delivered siRNA Drug Candidate for Delayed Graft Function

... to as DGFi) for prevention of Delayed Graft function (DGF) in patients undergoing deceased donor ... in the RNAi arena." Delayed graft function (DGF) is one of the most common complications ... major cardiac surgery and of delayed graft function in kidney transplantation. QPI-1007, which is a ...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

... Check serum lipase periodically. Liver function abnormality Serum bilirubin and hepatic ... AST/ALT and alkaline phosphatase. Check hepatic function tests periodically. Electrolyte ... cirrhosis and multi-organ failure. Monitor liver function tests monthly during Exjade treatment and ...

Celladon Announces Presentation of Clinical Data From First-in-Human MYDICAR(R) Trial for Advanced Heart Failure at American Heart Association Scientific Sessions

... properly. Replacing the enzyme may restore function and reverse heart failure. "The CUPID trial is ... of heart failure, but restore physiologic function and reverse the severity of the disease in ... of MYDICAR, and the improvements in cardiac function and overall condition observed in some patients ...

Pivotal Data Showed SYMBICORT(R) Improved Lung Function in Adults with COPD

... Aerosol significantly improved lung function and was well-tolerated in patients with moderate ... trials demonstrated that SYMBICORT improved lung function and was well-tolerated by study patients ... which means people with COPD can expect lung function to worsen over time.(9) When symptoms are severe, ...

New Study Demonstrated ACTEMRA(R) (tocilizumab) Inhibited Progression of Joint Damage in Rheumatoid Arthritis Patients

... - One-year study results showed improved physical function in patients treated with ACTEMRA - NUTLEY, ... a major cause of disability and loss of physical function for RA patients," said Joel Kremer, M.D., ... structural joint damage, improvement in physical function and disease signs and symptoms. Patients received ...

PTC Announces Data Showing That PTC124 Causes Statistically Significant Improvements in Chloride Channel Function in Cystic Fibrosis Patients

... significant improvements in the chloride channel function of children with cystic fibrosis (CF) caused by a ... statistically significant improvements in the function of the cystic fibrosis transmembrane conductance ... a chloride channel which is required for normal function of the lung, pancreas, liver and other organs. ...

Five-Year Data Confirm That Early Treatment with Betaseron(R) at First Sign of Disease Can Delay Progression to MS

... a widely accepted tool that measures intellectual function and cognition. "Changes in cognitive function have important implications for a patient's ... Betaseron fared better in tests of cognitive function compared to those with delayed treatment, which ...

St. Jude Study Gives New Insights Into How Cells Accessorize Their Proteins

... (UBLs) as accessories that adapt their function as needed in the cell. Now St. Jude scientists have discovered how the function of a protein called cullin-RING changes when it ... is critical for the cell's proteins to be able to function as necessary in a given environment. One of the ...

Omeros Announces Publication of Clinical Results for OMS103HP in Arthroscopy: The Journal of Arthroscopic and Related Surgery

... and is designed to improve postoperative knee function and motion, reduce postoperative pain and allow ... "Novel Drug Product to Improve Joint Motion and function and Reduce Pain After Arthroscopic ... period included measurements of knee function and motion, leg muscle strength, pain and return ...

New Data Support Role for Monitoring of Cell-Mediated Immunity in Adult Patients Following Renal Transplantation

... activation as a measure of cell- mediated immune function in 81 immunosuppressed adults who underwent ... About ImmuKnow(R) ImmuKnow is the immune cell function assay cleared by the FDA to detect cell-mediated ... to simply and reproducibly measure immune cell function for the development of new diagnostics, ...

New Data Support Earlier Suggested Guidance for Levels of Cell-Mediated Immunity in Pediatric Liver Transplant Patients

... was no significant difference between the immune function of stable pediatric liver transplant patients who ... About ImmuKnow(R) ImmuKnow is the immune cell function assay cleared by the FDA to detect cell-mediated ... to simply and reproducibly measure immune cell function for the development of new diagnostics, ...

Bronchitol Cystic Fibrosis Dose Trial Results Positive

... Demonstrates Dose-Related Improvements in Lung function of Cystic Fibrosis ... a dose dependent improvement in lung function as measured by FVC (forced vital capacity) and ... Bronchitol treatment periods, changes in lung function were as follows: -- 400 mg treatment group: ...

Diverse Approaches to Alzheimer's Therapies Continue to Show Progress at ICAD

... on placebo, they stabilized at a lower level of function than those treated with Dimebon for the full 18 ... source of all cells and impaired mitochondrial function may play a significant role in the loss of brain cell function in Alzheimer's," Cummings added. First U.S. ...

Medivation Presents Positive New Data on Dimebon's Long-Term Efficacy and Novel Mechanism of Action at the International Conference on Alzheimer's Disease

... After 18 months of treatment, Dimebon preserved function in patients at their original levels upon ... investigational treatment has stabilized function across all facets of Alzheimer's disease for this ... cells and play important roles in mediating cell function and survival. Mitochondrial dysfunction has been ...

Four Alzheimer's Clinical Trials Address a Variety of Treatment Targets - Amyloid, Tau, Synapse Formation

... slow or stop the brain cell death and loss of function caused by Alzheimer's. "We must develop better ... and zinc. MPACs have been shown to restore normal function to beta amyloid-impaired synapses and improve ... compared with placebo, over 24 weeks on cognitive function as measured by the ADAS-cog in patients with mild ...

Bioheart Reports Promising Results From SDF-1 Modified MyoCell(R) Therapy in Heart Failure Study

... remodeling', or return to normal heart function in the same period. Similar results were found in ... contribute to greater improvement in cardiac function after transplantation compared to non-modified ... Study objectives included assessment of cardiac function following onset of MI, assessment of ...

Embryo Viability Studies Support Utility of Novel, Metabolomic Profiling Technology

... medicine to more accurately characterize biologic function in health and disease, presented data from four ... a whole, represent unique biomarkers of biologic function in health and disease. Molecular Biometrics ... personalized medicine to evaluate normal biologic function in health and in disease, and for drug discovery ...

Novel Testosterone Gel Significantly Improves Insulin Sensitivity and Sexual Function in Hypogonadal Men With Type 2 Diabetes and Metabolic Syndrome

... improves insulin sensitivity and sexual function among hypogonadal men with Type 2 diabetes and/or ... Further, measured by the Index of Erectile function (IIEF), patients using the testosterone gel saw ... in hypogonadal males not only improves sexual function but, more importantly, can also have impact on ...

Transave Announces Positive Phase II Results for Once-Daily Arikace(TM) in the Treatment of Cystic Fibrosis Patients Who Have Pseudomonas Lung Infections

... in clinically significant improvement in lung function at the end of treatment. This improvement was ... "The magnitude and sustained improvement in lung function provided by Arikace administered once-daily may ... and achieve a sustained improvement in lung function would be an important advance in this field. ...

PTC Therapeutics Announces Data from Additional Clinical Studies of PTC124 in Cystic Fibrosis Confirming Activity

... statistically significant improvements in the function of the cystic fibrosis transmembrane conductance ... (p< 0.001) improvements in CFTR function as measured by TEPD in both dose groups. The ... in nasal TEPD chloride conductance, pulmonary function and cough -- important markers suggesting the ...

Data From Two Phase 3 Studies Show Anti-TNF Golimumab Significantly Improved Signs and Symptoms of Rheumatoid Arthritis

... Also Experienced Improvements in Physical function and Disease Activity PARIS, June 11 ... arthritis (RA) as well as in physical function and disease activity, with some patients ... clinically relevant improvement in physical function (improvement in HAQ score of at least 0.25 from ...

Sangamo BioSciences Announces Presentation of Phase 1b ZFP Therapeutic Data at American Diabetes Association Meeting

... improvements in measurements of nerve health and function in subjects with diabetic neuropathy. "We are ... were observed in measurements of nerve health and function in subjects with mild to moderate diabetic ... effective in protecting motor and sensory nerve function from disease-induced nerve damage. About the ...

University of Miami Team Confirms Value of Monitoring Cell-Mediated Immunity Pre- and Post-Transplant in Management of Kidney Transplant Recipients

... mean post-transplant CMI level after good immune function was restored. The two patients demonstrating ... About ImmuKnow(R) ImmuKnow is an immune cell function assay that can detect cell-mediated immunity ... used in the detection of cell-mediated immune function in immune-suppressed organ transplant patient ...

Penn State Hershey Transplant Program Uses Assay to Monitor Cell-Mediated Immunity

... of the ability of the Cylex immune cell function assay (ImmuKnow(R)). They compared outcomes of ... Their paper is entitled "Monitoring of immune function for treatment of post-transplant de novo ... State Hershey Medical Center. The ImmuKnow cell function test measures cell-mediated immunity (CMI) by ...

Naturally Occurring Compounds in Cocoa Tied to Blood Flow Improvements for Adults With Type 2 Diabetes

... a 30 percent improvement in measured vessel function at the completion of a 30-day trial. Poor blood vessel function is recognized as an early stage in ... of a flavanol-rich cocoa drink on vascular function in diabetic adults was investigated. In the first ...