Fetal in Medical Technology

Diabetes Gene Raises Odds of Lower Birth Weight

... weight -- a finding that supports the so-called fetal insulin hypothesis. Previous studies by European ... reinforced that association. Under the fetal insulin hypothesis, a slight underproduction of insulin, an important fetal growth factor, during the prenatal period may ...

Video: Data on More Than 15 Novartis Oncology Compounds at ASCO Highlight Progress Toward Targeted Therapies for Diverse Tumor Types

... severe hepatic impairment. Afinitor may cause fetal harm in pregnant women. The most common ... take Femara if you are pregnant as it may cause fetal harm. Some women reported fatigue and dizziness ... Gleevec important safety information fetal harm can occur when administered to a pregnant ...

Lenetix Launches Screening Study of New Down Syndrome Test

... first and second trimester non-invasive fetal diagnostic test to detect Down syndrome. The ... number of unnecessary invasive tests -- and the fetal losses they can cause. "We take deep pride ... the promise of a comprehensive assessment of fetal aneuploidy in the first trimester using a ...

Breakthrough in Prenatal Screening for Down Syndrome

... improved first and second trimester non-invasive fetal chromosomal screening test to detect Down syndrome and other genetic fetal conditions. Lenetix presented preliminary study ... of methylation-sensitive amplification (MSA) of fetal nucleic acid markers. In the preliminary studies, ...

More Than 200 Abstracts at ASH and SABCS Reveal Potential Compelling Patient Benefits From Novartis Oncology Current and Pipeline Therapies

... failure of interferon-alpha therapy. fetal harm can occur when administered to a pregnant ... malabsorption. Pregnancy fetal harm can occur when Tasigna is administered to a ... take Femara if you are pregnant, as it may cause fetal harm. Some women reported fatigue and dizziness ...

Gene Therapy Corrects Sickle Cell Disease in Laboratory Study

... by persistence in the blood of an immature fetal form of hemoglobin in red blood cells. This ... the drug hydroxyurea encourages the formation of fetal hemoglobin and alleviates disease symptoms. ... could use gene transfer to permanently increase fetal hemoglobin levels," said Derek Persons, M.D., ...

Leukemia Therapy With Imatinib During Pregnancy May Cause Infant Abnormalities

... (CML), may be at moderate risk of developing fetal abnormalities. Imatinib was introduced for ... three following the identification of fetal abnormalities. At least 18 pregnancies ... In total, 12 pregnancies resulted in infants with fetal abnormalities (9.6 percent) and of those, there ...

Molecular Biometrics Hires Denny Sakkas, PhD Renowned Yale Embryologist and International Thought-Leader, as Chief Scientific Officer; Opening U.S. Research Facility

... disease and Parkinson's disease), maternal fetal medicine, and drug discovery and development. The ... sperm and oocytes used in IVF), maternal fetal medicine (to monitor the health status of a ... disease and Parkinson's disease), maternal fetal medicine, pulmonary metabolism and edema, ...

Orthopaedic Injury: High Risk to Pregnant Women

... placental abruption poor infant condition at birth fetal death death of the infant soon after birth Dr. ... a high-energy event, and the impact can have a significant influence over fetal outcome," she noted. Dr. Cannada said results of the study clearly ...

Video: Tasigna(R) Demonstrates Rapid Response as Initial Therapy in Life-Threatening Form of Leukemia

... or of glucose-galactose malabsorption. Pregnancy fetal harm can occur when Tasigna is administered to a pregnant woman. Women ... therapy. Gleevec important safety information(3) fetal harm can occur when administered to a pregnant woman; therefore, women of ...

National Study Shows Magnesium Sulfate Reduces Risk of Cerebral Palsy in Premature Births

... in the placebo group. "This is a substantial breakthrough in maternal fetal medicine that could positively impact the health of thousands of babies," said Alan Peaceman, MD, chair of the Division of Maternal fetal Medicine at Northwestern Memorial Hospital, professor of Obstetrics and ...

Thrombosis Guidelines Emphasize Difficult Choices for Pregnant Women

... and are, therefore, advised to stop taking VKAs before 6 weeks of fetal gestation. However, some pregnant women with certain types of mechanical ... to conception. Although the second option eliminates the potential for fetal exposure to VKA, it provides additional challenges. LMWH and UFH are more ...

Injection Reverses Heart-Attack Damage

... capacities that can be reawakened. Kuhn developed a sponge-like patch, soaked in a compound called periostin that is abundant in the developing fetal heart (and in injured skeletal muscle) but scarce in adult hearts. When the patch was placed over the site of cardiac injury in rats, it induced ...

University of Michigan Study Shows SEQUENOM's MassARRAY Technology Identifies HPV Infections Missed by Standard Hybridization Test

... by combining the versatility of the MassARRAY system with the company's SEQureDx(TM) technology, which enables the detection of circulating cell-free fetal nucleic acids in a maternal blood sample. The company is also developing tests for oncology, infectious diseases and other disorders. The company was ...

FDA Accepts sNDA for Alternative Dosing Regimen for Dacogen(R) (decitabine for injection) to Treat Patients with Myelodysplastic Syndromes (MDS)

... leukemia), and Intermediate-1, Intermediate-2 and High-Risk International Prognostic Scoring System (IPSS) groups. Dacogen may cause fetal harm when administered to a pregnant woman. Women of childbearing potential should be advised to avoid becoming pregnant while using Dacogen. Men ...

Gene Findings Unlocking Reasons for Neuroblastoma Risk

... are now working to understand the mechanism by which BARD1 gene variants act on developing nervous system cells to give rise to cancer during fetal or early childhood development. Maris's second study, spearheaded by Dr. Sharon Diskin, also of The Children's Hospital of Philadelphia, found ...

Afinitor(R) Phase II Data Show Positive Results for Patients With Multiple Types of Lymphoma, Leading to Phase III Trial

... vaccines should be avoided by patients taking Afinitor. Afinitor should not be used in patients with severe hepatic impairment. Afinitor may cause fetal harm in pregnant women. The most common adverse reactions irrespective of causality (incidence greater than or equal to 30%) were stomatitis, ...

Taking Folic Acid for a Year Before Pregnancy May Reduce Risk of Preterm Birth

... of folic acid daily." The March of Dimes honored Dr. Bukowski's study in January 2008 during the annual meeting of the Society for Maternal fetal Medicine. "Preconceptional Folate Supplementation and the Risk of Spontaneous Preterm Birth: A Cohort Study" by Bukowski, et al. is available online ...

New Data Shows Blood Pressure Reduction Therapy with BENICAR(R) and BENICAR HCT(R) Effectively Reduces Blood Pressure in Elderly Patients to Target Blood Pressure

... derived drugs Fetal/Neonatal Morbidity and Mortality Thiazides cross the placental barrier and appear in cord blood. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. Hepatic Impairment Thiazides ...

Video: Afinitor(R) Approved in US as First Treatment for Patients With Advanced Kidney Cancer After Failure of Either Sunitinib or Sorafenib

... those who have received live vaccines should be avoided. Afinitor should not be used in patients with severe hepatic impairment. Afinitor may cause fetal harm in pregnant women. The most common adverse reactions (incidence greater than or equal to 30%) were stomatitis, infections, asthenia, ...

Neuralstem's Human Stem Cells Integrate into Nervous System of Rats with Animal Model of ALS

... degenerations." In a study conducted at Johns Hopkins Medical Institutions, laboratory-grown human neural stem cells (hNSCs) isolated from a fetal spinal cord region were grafted into the spinal cord of rats with a genetic mutation (SOD-1 G93A) that gives them a disease like a particularly ...

Study Finds DOXIL(R) Combination Therapy Delays Disease Progression for Patients With Metastatic Breast Cancer

... in discontinuation of therapy * DOXIL is an irritant, not a vesicant; use precautions to avoid extravasation * DOXIL can cause fetal harm when used during pregnancy * Recall reaction has occurred with DOXIL administration after radiotherapy * DOXIL may interact ...

Video: Femara(R) First Aromatase Inhibitor to Indicate Survival Benefit Versus Tamoxifen When Taken for Five Years After Breast Cancer Surgery

... women. Talk to your doctor if you're allergic to Femara or any of its ingredients. You should not take Femara if you are pregnant as it may cause fetal harm. Some women reported fatigue and dizziness with Femara. Until you know how it affects you, use caution before driving or operating machinery. ...

Dacogen(R) (decitabine for injection) Data Presented on a Phase II Clinical Trial in Elderly Patients with Acute Myeloid Leukemia (AML)

... leukemia), and Intermediate-1, Intermediate-2 and High-Risk International Prognostic Scoring System (IPSS) groups. Dacogen(R) may cause fetal harm when administered to a pregnant woman. Women of childbearing potential should be advised to avoid becoming pregnant while using Dacogen(R). Men ...

CHMP Recommends Approval in the European Union (EU) for New Options for Patients With Certain Primary Brain Tumors

... Cases of myelodysplastic syndrome and secondary malignancies, including myeloid leukemia, have also been observed. TEMODAR may cause fetal harm when administered to a pregnant woman. Nursing should be discontinued in women taking TEMODAR. Prophylaxis against Pneumocystis ...

March of Dimes Honors Dr. Susan Carlson for Outstanding Work In Maternal-Fetal Nutrition

... supports healthy brain development, especially in young children. Dr Carlson and her collaborators continue to actively study the role of DHA during fetal and neonatal development. Dr. Carlson, the A.J. Rice Professor of Nutrition in the Department of Dietetics and Nutrition, Professor of Pediatrics ...

Early Data Show Potential for Imatinib Mesylate Tablets to Treat Life-Threatening Form of Pulmonary Artery Disease

... patients demonstrating a clinical benefit, such as improvement in disease-related symptoms or increased survival. Important safety information(7) fetal harm can occur when Gleevec is administered to a pregnant woman; therefore, women of childbearing potential should be advised to not become pregnant ...

TRANSCEND(TM) Trial Results Presented at European Society of Cardiology Congress and Published in The Lancet

... possible (see WARNINGS, Fetal/Neonatal Morbidity and Mortality). Thiazides cross the placental barrier and appear in cord blood. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. MICARDIS is contraindicated in patients ...

Beckman Coulter Buys Out Royalty Obligation for Preeclampsia Markers

... laboratories with the tools that improve patient health and reduce the cost of care. Our expectations for diagnostic testing related to maternal and fetal well-being leads us to believe that buying out our U.S. royalty obligation will create substantial value for our shareholders." Beckman Coulter has ...

Eisai Provides Preliminary Efficacy Update On EORTC Phase III Trial of Dacogen(R) Versus Supportive Care in Patients With Myelodysplastic Syndromes

... myelomonocytic leukemia), and Intermediate-1, Intermediate-2 and High-Risk International Prognostic Scoring System (IPSS) groups. Dacogen may cause fetal harm when administered to a pregnant woman. Women of childbearing potential should be advised to avoid becoming pregnant while using Dacogen. Men ...

FDA Files Application To Convert ONTAK(R) (Denileukin Diftitox) to Full Approval for Use in Cutaneous T-Cell Lymphoma (CTCL)

... infection. Pregnancy Category C Animal reproduction studies have not been conducted with ONTAK. It is also not known whether ONTAK can cause fetal harm when administered to a pregnant woman or affect reproductive capacity. ONTAK should be given to a pregnant woman only if clearly needed. ...

New Subset Analysis of AndroGel(R) Data Highlights Efficacy - Regardless of BMI

... (a rare condition for men). AndroGel must not be used by women who are pregnant, may become pregnant, or breastfeeding, as testosterone may cause fetal harm. The major risks of AndroGel include prostate enlargement, prostate cancer, and transfer of testosterone to others (including women and ...

New Study Shows BENICAR(R) (olmesartan medoxomil) Reverses Blood Vessel Damage Independent of Blood Pressure Lowering

... derived drugs. Fetal/Neonatal Morbidity and Mortality Thiazides cross the placental barrier and appear in cord blood. There is a risk of fetal or neonatal jaundice, thrombocytopenia, and possibly other adverse reactions that have occurred in adults. Hepatic Impairment Thiazides should be ...

CellCept(R) and a Reduced Level of CNI Shows Trend Towards Preservation of Kidney Function Versus a Standard-Dose CNI

... transplant patients, physicians should also consider the risk that reduced immunosuppression represents to the graft. -- CellCept can cause fetal harm when administered to a pregnant woman. A patient who is planning a pregnancy should not use CellCept unless she cannot be successfully ...

Preliminary Analyses from Phase 2 Genzyme Study Highlight Efficacy and Safety of Clofarabine in Older Adult AML Patients

... and/or previous therapy or concurrent illness in patients receiving Clolar makes the etiology of these disorders unclear. Clolar may cause fetal harm when administered to a pregnant woman. Women of childbearing potential should be advised to avoid becoming pregnant and avoid breast feeding ...

Early Data Presented at ASCO Show Potential of RAD001 to Enhance Efficacy of, and Overcome Resistance to, Breast Cancer Treatments

... women. Talk to your doctor if you are allergic to Femara or any of its ingredients. You should not take Femara if you are pregnant as it may cause fetal harm. Some women reported fatigue and dizziness with Femara. Until you know how it affects you, use caution before driving or operating machinery. ...

Final Results of the CellCept(R) Spare the Nephron (STN) Study Show Maintenance Therapy is Associated with Improved Renal Function

... transplant patients, physicians should also consider the risk that reduced immunosuppression represents to the graft. -- CellCept can cause fetal harm when administered to a pregnant woman. A patient who is planning a pregnancy should not use CellCept unless she cannot be successfully ...

New Data Offers Insights Into the Potential Role for TYKERB(R) (Lapatinib) in Non-Cytotoxic Chemotherapy-Based Treatment Regimens

... if patients experience severe pulmonary symptoms. TYKERB prolongs the QT interval in some patients. Consider ECG and electrolyte monitoring. fetal harm can occur when administered to a pregnant woman. Women should be advised not to become pregnant when taking TYKERB. The most common adverse ...

Two DOXIL(R) Studies to be Presented at American Society of Clinical Oncology (ASCO) Annual Meeting

... in discontinuation of therapy -- DOXIL is an irritant, not a vesicant; use precautions to avoid extravasation -- DOXIL can cause fetal harm when used during pregnancy -- Recall reaction has occurred with DOXIL administration after radiotherapy -- DOXIL may interact with ...

Wyeth Receives Approvable Letter from FDA for TYGACIL for the Treatment of Patients with Community-Acquired Pneumonia

... most common treatment-emergent adverse events in patients treated with TYGACIL were nausea (26.4%) and vomiting (18.1%) -- TYGACIL may cause fetal harm when administered to a pregnant woman -- The safety and effectiveness of TYGACIL in patients below age 18 and lactating women have not ...