Paclitaxel Poliglumex (OPAXIO(TM)) Added to Cisplatin and Radiation Produces 45% Pathologic Complete Remissions in Patients With Esophageal Cancer
... with potentially resectable, locally-advanced
esophageal cancer. Although the addition of chemotherapy to radiation is beneficial, the cure rate for
esophageal cancer is low. Standard neoadjuvant treatment for
esophageal cancer uses a regimen of cisplatin, and ...
Study in the New England Journal of Medicine Shows Non-Surgical Treatment for Pre-Cancerous Condition of Esophagus is Effective and Reduces Risk for Cancer Development
... progression to more severe forms of dysplasia and
esophageal cancer. This and data from other recent trials ... reflux disease (GERD), the normal
esophageal lining is replaced with abnormal cells (Barrett's ... the presence of early Barrett's, dysplasia, and
esophageal cancer. Comparison of the biopsy results at one ...
Torax Medical Launches Pivotal Clinical Study of New Acid Reflux Treatment
... therapy.
GERD is caused by a defective lower
esophageal sphincter, a ring-like muscular valve that ... numerous complications including ulcerations and
esophageal cancer. The incidence of
esophageal cancer is rising at a faster rate than any other ...
Early Esophageal Cancer and Pre-Cancer Eliminated With Non-Surgical Treatment Combination
... which report a 100% eradication
rate for early
esophageal cancer and pre-cancerous dysplasia ... (GERD) and is a known risk factor for
esophageal cancer, the
fastest growing cancer in the Western ... in each
trial, all patients were cured of their
esophageal disease.
"This data confirms that early cancer ...
Definitive Outcomes of Radiofrequency Ablation for Barrett's Esophagus Using the HALO Ablation System Reported at the Digestive Disease Week Meeting for Gastroenterologists and Esophageal Surgeons
... ablation using the HALO ablation system for eradicating a pre-cancerous
esophageal condition known as Barrett's esophagus. Among them, reports included ... esophagus places a patient at a significantly higher risk for developing
esophageal adenocarcinoma," commented David S. Utley, M.D., chief medical officer for ...
Schering-Plough Highlights Hepatitis C Clinical Data Presentations at the European Association for the Study of the Liver (EASL) Annual Meeting
... of varices (43 control vs. 16 treatment). In patients with pre-existing
esophageal varices (n=82) there were significantly more events (n=14) in the ... secondary analysis as well as in subjects with pre-existing
esophageal varices.
Extended Treatment Duration in Chronic Hepatitis C ...
It's Only Heartburn...or is it? Chronic Heartburn a Risk Factor for Precursor to Esophageal Cancer
... These abnormal cellular changes
can lead to a type of cancer called
esophageal adenocarcinoma, the fastest
rising malignancy in the United States, ... must be removed. Dr. Korst specializes in the
treatment and research of
esophageal cancer and is highly experienced in
using both laparoscopic and ...
Researchers Present Safety and Efficacy Results of 429 Patients Treated With Radiofrequency Ablation for Pre-Cancerous Barrett's Esophagus
... today reveal that endoscopic radiofrequency ablation performed in a community practice setting is safe and effective for eradicating a pre-cancerous
esophageal condition known as Barrett's esophagus. The study is entitled, "Radiofrequency Ablation of Barrett Esophagus: Outcomes of 429 Patients from a ...
TNFerade(TM) Phase III Data Presented at ASCO
... pancreatic cancer. TNFerade has also been and is currently being evaluated for its potential use in the treatment of several other cancers, including
esophageal cancer, rectal cancer, and head and neck cancer. GenVec also uses its proprietary adenovector technology to develop vaccines for infectious diseases ...
New Preliminary Data from Two Studies Show Clinical Activity of Neratinib in Combination with Trastuzumab and in Combination with Paclitaxel in Advanced HER-2 Positive Breast Cancer
... with IV paclitaxel 80 mg/m2, if tolerable, or 70 mg/m2 on days 1, 8 and 15. Patients with solid tumors (endometrial, cervical, colorectal and
esophageal cancers) were entered in the phase 1 portion (part 1), and only patients with metastatic ErbB-2 positive breast cancer were enrolled in part 2. ...
Ascenta Therapeutics Announces Multiple Presentations on AT-101 at 2009 ASCO Annual Meeting
... B-cell malignancies (with Rituxan(R)), small cell lung cancer (with Hycamtin(R)), glioma (with Temodar(R), +/- chemoradiotherapy [XRT]) and
esophageal cancer (with docetaxel, 5-fluorouracil and XRT).
About Ascenta Therapeutics
Ascenta Therapeutics, Inc. is a privately-held, clinical-stage ...
RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment Delayed the Time to Relapse in Patients with Bipolar I Disorder
... should be used cautiously in patients with a history of seizures or with conditions that potentially lower seizure threshold.
Dysphagia:
esophageal dysmotility and aspiration can occur. Use cautiously in patients at risk for aspiration pneumonia.
Priapism has been reported. Severe priapism ...
CyberKnife Radiosurgery for Lung Cancer Sees Increased Interest and Continued Rapid Growth
... amongst this group of physicians.
Discussions by leading thoracic surgeons, such as James Luketich, M.D., Chief of The Heart, Lung and
esophageal Surgery Institute at the University of Pittsburgh Medical Center highlighted the efficacy and resulting increased demand for CyberKnife treatments ...
Ascenta Therapeutics Announces Positive Preliminary Results with AT-101 in Docetaxel Refractory Prostate Cancer
... [rituximab]), small cell lung cancer (with Hycamtin(R) [topotecan]), glioma (with Temodar(R) [temozolomide], +/- chemoradiotherapy [XRT]) and in
esophageal cancer (with docetaxel, 5-fluorouracil and XRT). Recently, two double-blinded, randomized, controlled trials of the docetaxel + AT-101 combination ...
Sanvar(R) (Debio 8609) for Esophageal Variceal Bleeding
... or Debio 8609 (vapreotide
acetate). The immediate release formulation of Sanvar(R), a somatostatin
analogue, is used in the treatment of acute
esophageal variceal bleeding
(EVB).
"This is an important step towards completing the U.S. registration of
our drug. Sanvar(R) has demonstrated therapeutic ...
Multi-Centre European Clinical Trial Shows Advanced Dysplasia and Early Cancer of Esophagus Cured With Combined Endoscopic Resection and Radiofrequency Ablation With HALO Ablation System
... as in this study. Once dysplasia or cancer occurs,
an esophagectomy (surgical removal of the entire esophagus) has been the
first-line therapy.
esophageal cancer of this type is the fastest growing
cancer in industrialized countries.
Jacques Bergman, M.D., Associate Professor, Department ...
Takeda's Investigational PPI TAK-390MR Demonstrated Higher Healing Rates Compared to Lansoprazole as the Severity of Erosive Esophagitis Grade Increased, a New Integrated Analysis Showed
... GERD is a chronic condition commonly known as acid reflux disease. GERD
can occur when the valve at the lower end of the esophagus, called the
lower
esophageal sphincter (LES), does not close properly. This valve opens
to allow food and liquids to enter the stomach and closes to keep acid and
food in the ...
CryoCath Arctic Front(R) Results Published in JACC
... safety data reported in the article confirms the strong safety
profile Arctic Front has demonstrated to date. There were no observed
reports of atrio
esophageal fistula, stroke, death or peri-interventional
complications. Phrenic nerve palsies were reported in 7.5 percent of
patients treated; in some ...
Ception Therapeutics Initiates Phase II/III Clinical Trial for Its Lead Product Reslizumab in Eosinophilic Esophagitis (EE) in Children
... dose groups or placebo, administered at monthly
intervals for four months. The co-primary endpoints of the study are
changes in clinical symptoms and
esophageal eosinophil levels at the end of
therapy. The clinical study is being conducted at multiple centers and will
enroll approximately 172 patients. For ...
U.S. Food and Drug Administration Approves ABILIFY(R) (aripiprazole) for the Acute Treatment of Manic and Mixed Episodes Associated With Bipolar I Disorder in Pediatric Patients (10 to 17 Years of Age)
... may exercise strenuously, be exposed to extreme heat, receive
concomitant medication with anticholinergic activity, or be subject to
dehydration.
esophageal dysmotility and aspiration have been associated with
antipsychotic drug use, including ABILIFY; use caution in patients at risk
for aspiration ...
Potential Breakthrough Cancer Treatment Emerges from MIPS-Funded Clinical Trial Teaming CSA Medical Inc. and University of Maryland Researchers
... reduce and often eliminate pre-cancerous and cancerous lesions in
patients, including those with Barrett's esophagus, a precursor to cancer
involving
esophageal lesions created by chronic acid reflux.
Trial results will be presented today at the American College of
Gastroenterology's Annual Scientific ...
New Study Shows Once-Monthly Boniva(R) is as Clinically Effective as Once-Weekly Fosamax(R) at Increasing Bone Mineral Density in Postmenopausal Women With Osteoporosis
... of Boniva. Boniva, like other
bisphosphonates administered orally, may cause upper gastrointestinal
disorders such as dysphagia, esophagitis, and
esophageal or gastric ulcer.
Boniva is not recommended in patients with severe renal impairment.
Adequate intake of calcium and Vitamin D is important in all ...
New Phase III Data Presented for Once Monthly Dosing Regimen of Risedronate to Treat Postmenopausal Osteoporosis
... with severe renal impairment
(creatinine clearance Bisphosphonates may cause upper gastrointestinal disorders such as
dysphagia, esophagitis and
esophageal or gastric ulcer. Patients should pay
particular attention to the dosing instructions, as failure to take the
drug according to instructions may ...
Cell Therapeutics, Inc. (CTI) Supports Panel Discussion on Women and Lung Cancer on Capitol Hill
... Jill M. Siegfried, Ph.D., Professor and Vice Chair of Pharmacology at
the University of Pittsburgh School of Medicine and co-Director of the Lung
and
esophageal Cancer Program at the University of Pittsburgh Cancer
Institute (UPCI). Women and Lung Cancer Lung cancer is the number one cancer killer of women ...
Cell Therapeutics, Inc. (CTI) Sponsors Panel Discussion on Women and Lung Cancer on Capitol Hill
... Jill M. Siegfried, Ph.D., Professor and Vice Chair of Pharmacology at
the University of Pittsburgh School of Medicine and co-Director of the Lung
and
esophageal Cancer Program at the University of Pittsburgh Cancer
Institute (UPCI). Women and Lung Cancer Lung cancer is the number one cancer killer of women ...
Kosan's Motilin Receptor Agonist, Licensed to Pfizer, Enters Phase 1 Clinical Trial in Gastroesophageal Reflux Disease
... of disordered upper GI tract motility, resulting in
increased ingress of gastric contents into the lower esophagus, together
with impairments in
esophageal clearance and protection mechanisms.
Increased exposure to gastric contents, coupled with reduced ability to
clear the bolus, appears to precipitate ...
Addex Achieves Statistically Significant Outcome in Phase IIa
Clinical Trial With ADX10059 in Gastro-Esophageal Reflux Disease
... primary objective, the control of 24-hour
esophageal pH, with
statistical significance, and also ... duration of acid reflux episodes,
determined by
esophageal pH measurement, was significantly ... in sleep disturbance and
increased risk of
esophageal damage, was also significantly reduced
by ...
DUSA Pharmaceuticals Receives Orphan Drug Desi gnation for Levulan
PDT to Treat Esophage al Dysplasia
... Barrett's Esophagus, a Leading Cause of
esophageal Cancer
WILMINGTON, MASSACHUSETTS--(CCNMatthews - ... Photodynamic Therapy (PDT)
for the treatment of
esophageal dysplasia. This disease occurs in
some patients ... cause of
esophageal cancer. The incidence of
esophageal cancer is one of the
most rapidly growing in the ...
NCCN Updates Esophageal and Gastric Cancer Guidelines
... Practice Guidelines in Oncology(TM) --
esophageal Cancer
and Gastric Cancer. The NCCN Guidelines ... (Xeloda(R),
Roche) as an option for treatment of
esophageal and gastric cancer.
The REAL 2 study, the largest ... regimens used
for the treatment of advanced
esophageal and gastric cancer.
A new page entitled ...
Dynogen's DDP733 Reduces Reflux in Phase 1b GERD Study
... - DDP733 reduces
esophageal reflux -
Waltham, Mass., June 7, 2007 – ... left
untreated, complications of GERD can include
esophageal erosions or
ulcers and abnormal narrowing of the ... of
chronic heartburn, left untreated, can lead to
esophageal cancer,
currently the fastest growing cancer in ...
Dynogen Reports Positive Results in Phase 1B GERD Study
... after the age of 40. If left untreated,
complications of GERD can include
esophageal erosions or ulcers and
abnormal narrowing of the esophagus. Years of chronic heartburn,
left untreated, can lead to
esophageal cancer, currently the
fastest growing cancer in the United States. NGERD ...
New Advances in Gastric Diagnostics: Smaller is Better
... containing a pH receiver and a small radio transmitter, is attached to the
esophageal wall at 5 cm above the lower
esophageal sphincter, using a proprietary endoscopic delivery system. Normally ...
FDA MedWatch: Avastin (bevacizumab) and Formation of
Tracheoesophageal Fistula in a Recent Clinical Study in Patients
with Limited-stage Small Cell Lung Cancer
... phase of the study in the context of persistent
esophagitis. Additionally, six other cases of TE fistula have also
been reported in other lung and
esophageal cancer studies using
Avastin and chemotherapy alone or with concurrent radiation
treatment.
Avastin is not approved for the treatment of SCLC. ...
Palatin Technologies and King Pharmaceuticals Report Data Showing
Improvements in Sexual Relationship and Self-Esteem in Patients
with Erectile Dysfunction Treated with Bremelanotide
... that was
likely related to bremelanotide. There were two Serious Adverse
Events in Study 17 that were considered likely related to
bremelanotide; an
esophageal tear, secondary to emesis, and an
incident of prolonged erection.
About Bremelanotide
Bremelanotide is the first in a new class of drugs ...
NCI Researchers Discover Genes That Are Turned on at High Levels in
Tumor-associated Blood Vessels of Mice and Humans
... cells derived from cancer patients. They found that the
CD276 protein was overexpressed in tumor-associated blood vessels
from colon, lung, breast,
esophageal and bladder cancers. In
addition, the protein was also found to be frequently overexpressed
by the tumor cells themselves, indicating that a ...