Paclitaxel Poliglumex (OPAXIO(TM)) Added to Cisplatin and Radiation Produces 45% Pathologic Complete Remissions in Patients With Esophageal Cancer
... ("CR") rate when given OPAXIO, a biologically
enhanced paclitaxel, in addition to cisplatin and ... data suggest paclitaxel poliglumex may provide
enhanced radiation sensitization as compared to standard ... be influenced by estrogen, which could lead to
enhanced release of paclitaxel and efficacy in women with ...
Data Reported at ICAAC Indicates Selzentry(TM) Phase III Treatment-Naive Trial Shows Increased Efficacy When Used With Enhanced Trofile(TM) Assay
... of the
patient population by use of the
enhanced version of Monogram's Trofile(TM)
Assay.
The ... the trial.
In June 2008 Monogram introduced an
enhanced sensitivity version of the
Trofile Assay, with ... original samples
from the MERIT trial using the
enhanced Trofile assay. These samples had
been previously ...
Medarex Highlights Strength in Antibody Development and Underlying Pipeline Strategy at R&D Day Event in New York City
... MDX-1401 is a second-generation antibody
enhanced for improved
antibody effector function over the ... -- MDX-1342 is a fully human antibody with
enhanced antibody effector
function that selectively binds ... -- MDX-1411 is a fully human antibody with
enhanced antibody effector
function that targets CD70, a ...
Spectrum Pharmaceuticals Announces Presentation of SPI-1620 Data at the AACR-NCI-EORTC International Conference
... tumor
blood perfusion, and significantly
enhanced the uptake and delivery of
paclitaxel to the ... in
drug delivery to tumors, which in turn
enhanced the efficacy of the
chemotherapeutic drugs. ... shown in animal models.
Furthermore, SPI-1620
enhanced the efficacy of chemotherapeutic drugs ...
Medarex Announces Preclinical Data from Multiple Research Programs Demonstrating Anti-Tumor Activity in Cancer
... MDX-1110 also demonstrated potent anti-tumor activity as a monotherapy and
enhanced efficacy and improved control of tumor cell growth in combination with ... model with no evidence of toxicity. Targeting glypican-3 with antibodies
enhanced for antibody-dependent cell-mediated cytotoxicity properties, as ...
Sequoia Pharmaceuticals Presents Proof of Clinical Concept of SPI-452, a Novel Pharmacokinetic Enhancer
... conducted in
healthy volunteers demonstrated that SPI-452 substantially
enhanced the
exposures of three currently approved HIV protease inhibitors (PIs). ... single-dose in vivo animal studies. SPI-452 consistently and
significantly
enhanced the systemic exposure of the co-administered HIV PIs
comparable with ...
Medarex Announces Enhanced Activity Data with Second Generation Anti-CD30 Antibody for Malignant Lymphoma
... potency and efficacy of MDX-1401 in in vivo
xenograft models indicates
enhanced antibody-dependent cellular cytotoxicity
(ADCC) activity, an important ... are excited with the growing body of scientific evidence that
indicates
enhanced ADCC and improved anti-tumor efficacy with the second
generation anti-CD30 ...
Perceptive Informatics Improves Clinical Trial Management With Enhanced TrialWorks(R) Solution
... International Corporation (Nasdaq: PRXL ), announced today that
it has
enhanced its TrialWorks(R) solution, a specialized Clinical Trial
Management System (CTMS) designed specifically for small and mid-size
companies. The
enhanced 2.1 version of the TrialWorks solution has updated
functionality for ...
Halozyme Therapeutics Announces Positive Findings With Pegylated Enzyme in Prostate Cancer Models
... treatment with chemotherapy and pegylated enzyme produces significantly
enhanced survival compared to chemotherapy alone - - Pegylated ... activity. The docetaxel combination treatment demonstrated
significantly
enhanced survival compared to treatment with the
chemotherapeutic agent alone. The ...
Interleukin Genetics Launches Enhanced Heart Health Genetic Test Report Format
... Interleukin Genetics,
Inc. (Amex: ILI ), today announced the launch of an
enhanced test report
format and information package for the company's Heart Health ... studies and conducted by the company. The company believes that
this
enhanced report format will provide individuals and their physicians
more complete ...
Seven Presentations by Two Independent Research Groups Highlight Advantages of Pressure Cycling Technology (PCT) at Scientific Symposia in Philadelphia, Boston, and New York City
... by PCT may result in new therapeutic strategies,
diagnostic paradigms, and
enhanced analysis of samples.
About Pressure BioSciences, Inc.
Pressure ... PCT may result in new
therapeutic strategies, diagnostic paradigms, and
enhanced analysis of
samples. These statements are based upon the Company's ...
Additive Anti-Tumor Activity of NKTR-102 in Combination With Bevacizumab Highlighted in Positive Preclinical Data Presented at AACR Meeting
... Annual Meeting 2008 in San Diego,
California, the data also featured the
enhanced pharmacokinetic profile and
tolerability of NKTR-102, as compared to ... tumors"
#5741: "NKTR-102, a novel PEGylated-irinotecan, has an
enhanced pharmacokinetic profile with reduced gastrointestinal and hematopoietic ...
Alegent Health Sees Positive Results From Recent Clinician Usability Study Collaboration With Siemens and Motion Computing
... Include Increased Productivity and End-User Satisfaction,
enhanced Workflow and Quality of Care Improvements
ORLANDO, Fla., Feb. 25 ... can use computing technology in new ways and places.
The company's
enhanced line of tablet PCs, mobile clinical assistants and
accessories are ...
Insmed Launches National Awareness Campaign Surrounding Follow-On Biologics
... FOBs market would provide to patients and healthcare providers; -- An
enhanced Insmed website containing
enhanced FOB resources and updates; -- Interactive advocacy program utilizing ...
Siemens Showcases Its Most Comprehensive and Advanced Breast Care Portfolio
... the mechanical properties of tissue providing additional
information for
enhanced diagnostic decision-making. Clinical studies
indicate that elasticity ... as a biomarker, syngo GRACE provides improved
differential diagnosis and
enhanced confidence in therapy monitoring.
Advances in Immunodiagnostics
New ...
MedicAlert Foundation Joins The Alzheimer's Association to Offer MedicAlert(R) + Alzheimer's Association Safe Return(R) - Live 24-Hour Emergency Response for Wandering and Medical Emergencies
... ) MedicAlert + Safe Return will provide
enhanced services including
assistance when a person wanders or is lost and access ... and family contacts,
insurance information, and advance directives. "Our
enhanced service offerings in collaboration with the Alzheimer's
Association will ...
Rx for Africa, Inc. Now Trading Under New Symbol (RXAF.PK)
... including the failure to complete successfully the
development of new or
enhanced products, the Company's future capital
needs, the lack of market demand for any new or
enhanced products the
Company may develop, any actions by the Company's partners or ...
New Study: Pine Bark Extract Boosts Nitric Oxide (NO) Production
... seems to allow people
to move faster when exercising by satisfying the
enhanced muscle oxygen
demand and increasing the blood flow to active muscles. When ... supplying muscles, which makes them expand, a
process that requires
enhanced production of NO." A multitude of studies about Pycnogenol(R) and sports ...
Lilly Files for European Approval of ALIMTA(R) (pemetrexed for injection) for First-Line Treatment of Non-Small Cell Lung Cancer
... toxicity (see SPC). Sequential radiotherapy (given >7 days apart):
enhanced toxicity has
not occurred when gemcitabine was started after the resolution of acute
radiation effects or at least one week after radiation.
enhanced toxicity
from radiation therapy following gemcitabine exposure has not ...
OPAXIO(TM) Combined with Alimta(R) Well Tolerated in Dose-Ranging Study of Patients with Advanced Non-Small Cell Lung Cancer
... chemotherapy. Preclinical and clinical studies support that OPAXIO metabolism by lung cancer cells may be influenced by estrogen, which could lead to
enhanced release of paclitaxel and efficacy in women with lung cancer compared to standard therapies.
About Cell Therapeutics, Inc.
Headquartered ...
VisEn Molecular Imaging Technology Enables Key Insights Into Newly Discovered Biologic Pathway Published in SCIENCE
... of the heart to identify and quantify biomarkers of monocyte activity in vivo . These results enabled an important data correlation that further
enhanced the integrated array of in vitro assays and microscopy-based readouts of this important pathway."
About VisEn Medical Inc.
...
National Cancer Institute Research Identifies Unique Mechanism of Brostallicin's Anti-Tumor Effectiveness
... Unlike other chemotherapy agents, including trabectedin, the NCI research indicates that the tumor cell DNA damaging effects of brostallicin are
enhanced by high tumor glutathione levels, a hallmark of drug-resistant tumors. Brostallicin was shown to affect DNA in both dividing and quiescent cells. ...
Prospective Clinical Advantages of Trabecular Metal(TM) Technology Highlighted in Comparative Study
... risks and uncertainties include, but are not limited to, our compliance with the Corporate Integrity Agreement through 2012; the impact of our
enhanced healthcare compliance global initiatives and business practices on our relationships with customers and consultants, our market share and our overall ...
New Study Shows that Prebiotics, as Used by Jackson GI Medical, Increases Lifespan by 33%
... clinical research demonstrating strong health benefits. Plain inulin is a far cheaper prebiotic which is used in most prebiotic supplements and
enhanced foods.
"The implications of this study are somewhat staggering," says Jackson GI Chairman and Founder Frank W. Jackson, M.D. "While the research ...
Brain Fitness Makes Boomers Age Younger
... a journal for doctors who are board certified in Geriatrics. It confirms earlier studies showing similar effects and imaging research showing
enhanced brain activity.
Posit Science
Posit Science is the leading provider of scientifically proven brain fitness programs. The company works with ...
CeNeRx BioPharma Obtains Rights to Novel Drug Candidate for Prevention and Treatment of Neurodegeneration Disorders
... in the peripheral neuropathies associated with diabetes, kidney disease, cancer chemotherapy and other conditions. In preclinical studies, CXB909
enhanced the action of NGF in vitro , amplifying its activity almost seven-fold. CXB909 was neuroprotective in a variety of cellular assays and in animal ...
Published Study Shows VNUS ClosureFAST(TM) System Significantly Superior to Laser for Varicose Vein Treatment
...
"The study confirms what many of us who have used both laser and radiofrequency devices have felt subjectively - that there is significantly
enhanced patient comfort with the radiofrequency technology," said Raymond G. Makhoul, M.D., of Richmond, Virginia, a researcher for the study. "The ...
ThermoGenesis Announces National Institute of Health Grant
... Company's research is based upon the growing body of evidence which shows that the efficacy of stem cells for tissue regeneration and repair can be
enhanced if the cells are presented to the body within bioengineered materials.
The AXP is used for the processing of stem cells from umbilical cord ...
Tolerx Presents Data at 69th Scientific Sessions of the American Diabetes Association
... assessing more than 10 dosing regimens, have led to the identification of a dosing regimen that is expected to result in optimal TCR modulation,
enhanced tolerability, no immunogenicity, beneficial clinical activity, and an improved safety profile. This regimen is currently being evaluated in the ...
Pixantrone in Combination with Chemotherapy Regimens Produces Overall Response Rates of 58-74% with Complete Remission Rates of 37-57% in Relapsed/Refractory Aggressive or Indolent NHL
... in hematologic cancers over standard anthracyclines and the rational design modifications to the chemical compound believed to be responsible for
enhanced DNA damage and binding to topoisomerase II enzyme, a key target for anthracycline mediated tumor death. These modifications are also hypothesized by ...
Boston Scientific Begins Clinical Trial for Next-Generation Nitinol Stent to Treat Iliac Artery Disease
... for treating iliac disease."
The EPIC Stent is a self-expanding nitinol stent designed to sustain vessel patency (openness), while providing
enhanced visibility during placement. The ORION trial incorporates stent diameter ranges from 6-12 mm and lengths up to 120 mm. All stent sizes are ...
Boston Scientific Launches Third-Generation Platinum Chromium Drug-Eluting Stent
... and a lower profile, designed to improve radial strength, recoil and angiographic visibility. Deliverability to complex lesions is further
enhanced through the incorporation of a new highly deliverable dilatation catheter technology.
"It is particularly important to have a range of options ...
Ongoing Landmark ROADMAP Study Demonstrates Significant Improvement in Blood Pressure Control at One Year, According to Blinded Results
... which results in constriction and increasing blood pressure. In addition, angiotensin II stimulates the release of another hormone that causes
enhanced sodium and chloride (salt) retention, with a resultant increase in vascular water retention and blood volume that also contributes to an elevation in ...
New Data Shows Blood Pressure Reduction Therapy with BENICAR(R) and BENICAR HCT(R) Effectively Reduces Blood Pressure in Elderly Patients to Target Blood Pressure
... which results in constriction and increasing blood pressure. In addition, angiotensin II stimulates the release of another hormone that causes
enhanced sodium and chloride (salt) retention, with a resultant increase in vascular water retention and blood volume that also contributes to an elevation in ...
InspireMD Announces the Enrollment of the 1st Patient in the MGuard iMOS Registry, the Registry Will Enroll 1000 Patients
... delivered and the patient was released
from the hospital after a few days with no complications. Dr. Horak stated:
"I feel MGuard(TM) offers
enhanced safety during the procedure by preventing
defragmentation of the thrombus. I look forward to seeing good clinical
results for both the one-month and ...
Affitech-Discovered Anti-PS Antibodies in Development by Peregrine Pharmaceuticals Show Excellent Functionality in Preclinical Studies
... and the tumor
microenvironment, showing that the anti-PS antibody induced a sequential
release of cytokines and beta-chemokines and stimulated
enhanced macrophage
recruitment to tumors. Furthermore, the researchers showed that in vitro,
PGN635 induced antibody-dependent death of endothelial cells, ...
Intarcia Therapeutics, Inc. Announces Completion of Enrollment of ITCA 650 Phase 1b Study for the Treatment of Type 2 Diabetes
... more convenient treatment option."
About Intarcia
Intarcia Therapeutics, Inc. is a biopharmaceutical company developing therapies to ensure
enhanced treatment outcome by optimizing patient adherence and improving the convenience and tolerability of drug therapies. Intarcia's drug development ...
Karmanos Cancer Institute Researchers Study New Drug Combinations to Treat Childhood Leukemia
... for a new use," Dr. Ge said. "It looks like the increased drug activity or synergy is not due to the transport or delivery of clofarabine, but to
enhanced cell death. We were so pleased with the results."
AML afflicts mostly adults -- about 10,000 new cases each year -- and strikes older children. ...
Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies
... and the tumor microenvironment, showing that the anti-PS antibody induced a sequential release of cytokines and beta-chemokines and stimulated
enhanced macrophage recruitment to tumors. Furthermore, the researchers showed that in vitro , PGN635 induced antibody-dependent death of endothelial cells, ...
Pivotal Clinical Data Published for the Only Laser Phototherapy Device Cleared by the FDA for Hair Growth
... has the building blocks and energy to transform from a weakened follicle to one that is healthy and capable of producing thick terminal hair. The
enhanced environment in turn invigorates the hair follicle which produces healthier hair, prevents further hair loss and stimulates the re-growth of thicker ...