Cytokinetics Reports Additional Clinical Trials Data for Ispinesib
...ought to result when these drugsinterfere with the dynamics of microtubule filaments that areresponsible for the long-distance transport of important cellularcomponents within nerve cells. Mitotic kinesins are essential to mitosis, and, unlike tubulin,appear to have no role in other cellular functions. Cytok...New Study Reveals Limitations of a Complex and Challenging Global Tuberculosis Drug Marketplace
First comprehensive study of market dynamics offers insights intowhat will be needed to get new...d results from the firstcomprehensive study of the dynamics of the global TB drug marketthat offers a detailed analysis of how today's TB medicines reachpatient...Telomerase Presentations at the AACR 2007 Annual Meeting
...hout the AACR meetingon the regulation of telomere dynamics and telomerase activityelucidates the potential for telomerase-inhibiting molecules in thetreatment of cancer. Cancer Stem Cells Cancer stem cells (CSCs) are a rare sub-population ofself-renewing, immortal tumor cells capable of differentiating i...EntreMed Presents Multi-Mechanism Antitumor Data for ENMD-1420 in Preclinical Models
...l proliferation by interfering with themicrotubule dynamics required for cell division. This interferenceblocks the cell cycle sequence, leading to cell death(apoptosis). About EntreMed EntreMed, Inc. is a clinical-stage pharmaceutical companydeveloping therapeutic candidates primarily for the treatment ofc...Cytokinetics Announces Non-clinical Data to be Presented at the 2007 AACR Annual Meeting
...ought toresult when these drugs interfere with the dynamics of microtubulefilaments that are responsible for the long-distance transport ofimportant cellular components within nerve cells. Mitotic kinesins are essential to mitosis, and, unlike tubulin,appear to have no role in unrelated cellular functions.Cy...EntreMed Presents Mechanism Data for Its Three Lead Oncology Compounds
... demonstrate thatsubtle differences in microtubule dynamics can lead to differentapproaches to the treatment of cancer. Panzem(R), MKC-1 andENMD-1198 are all orally-active yet distinct tubulin bindingagents, and exhibit a different array of antitumor activitypreclinically. Understanding the multiple mechanism...