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Bench-Top Centrifuges--Basic Tools for the Small Lab

...UL/CSA compliant. It includes a 30-minute timer, a double encased, brushless motor and a clear lid with a safety switch. Thermo Electron Corporation, Milford, Mass., characterizes its Medilite microcentrifuge as the ideal choice for routine, low-volume centrifugation of blood and urine. Each Medilite comes...

NIEHS Researchers Identify Enzyme Critical in DNA Replication

...ging, pair with each other to form the nowfamiliar double helix. Shortly thereafter, Kornberg and colleague...y one of two possibledirections. One strand of the double helix must be replicated firstby a dedicated leading strand polymerase, followed slightlythereafter ...

Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea

... thecolon. In the placebo controlled, randomized, double blind trial 120patients in 8 sites in South Africa were treated with a 200mgtablet, 4 times per day for 3 days. The trial assessednon-inferiority versus Normix® (rifaximin) and the primaryendpoint was the time from first ingestion of tablet to th...

Avexa's Apricitabine Clinical Trial Update

... today thecompletion of apricitabine's controlled, double blinded phase whichrepresents the first 24 week segment of its Phase IIb trial.Patients have now progressed into the open-label section of thetrial (weeks 24 to 48) and will continue to receive 800mgapricitabine twice a day as part of their daily tre...

Tranzyme Pharma Presents Initial Phase IIa Data for its Novel Ghrelin Agonist, TZP-101, in Patients with Diabetic Gastroparesis

.... Using scintigraphy and a standardized meal, this double blind,randomized, four-way crossover study assessed the efficacy of threedifferent dose levels of TZP-101 on gastric emptying in patientswith long standing Type 1 diabetes and severe gastroparesis. Thedata showed that TZP-101 significantly accelerate...

Novagali Pharma Presents at AACO the Results of its Pivotal Phase III Clinical Trial of Vekacia in Children Suffering From Vernal Keratoconjunctivitis

...ase II/III, multicenter,randomized parallel group, double masked, dose ranging, controlledstudy divided in two treatment periods: (I) a four-weekprospective, randomized, multicenter, double-masked, threeparallel-group, vehicle-controlled treatment period; and (II) athree-month prospective, multicenter, doub...

Positive Clinical Results for DG041 Lead Product Development Highlights at deCODE R&D Event

...tor forprostaglandins E2 (PGE2) that approximately double the risk of PAD,a common and debilitating atherosclerotic condition in which theflow of blood to the legs is progressively constricted. Themechanism through which EP3 modulates platelet aggregation isdistinct from those targeted by aspirin and Plavix...

Arisaph Pharmaceuticals Announces Results of its Potent Smart DPP-4 Inhibitor, ARI-2243, at the ADA

...rldwith the prevalence of the disease projected to double to 300million cases worldwide by the year 2025 according to the WorldHealth Organization. Certain statements in this press release, including statementsregarding the Company's research and development effort, theCompany's expectation to complete IND...

Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Extension Trial with Tovaxin for Multiple Sclerosis

... include 150 patientsin a multicenter, randomized, double blind, placebo-controlledtrial designed primarily to evaluate the efficacy, safety andtolerability of the Tovaxin T-cell vaccination with clinicallyisolated syndrome (CIS) and relapsing-remitting MS (RR-MS)patients. A total of 100 patients will recei...

Vical Licensee AnGes MG Announces Positive Results of Phase 3 Angiogenesis Trial in Japan

...s This trial is a randomized, placebo-controlled, double blindstudy for CLI subjects using AMG 0001. In this efficacy evaluation, 40 subjects with CLI wereevaluated. 27 subjects received AMG0001, and were compared with 13placebo subjects. (The AMG0001 group received 8mg (4mg x 2) ofAMG0001.) The primary ...

Geron Corp. Licensee TA Sciences Announces Landmark 7/07/07 Teleconference to Answer Questions About TA-65, Their Telomerase Activator With Proven Age Management Benefits

...ell being The Pivotal 2005 Anti-Aging Trial was a double blind,placebo-controlled, 24 week study conducted in the USA involving 36male subjects aged 60-85. The most compelling result of the Trial was the profound andpositive impact of TA-65 on the immune system, which normallydeclines with age, leading to...

Indevus Announces Presentation of Pagoclone Data at 47th Annual New Clinical Drug Evaluation Unit Meeting

...cy measures compared to baseline that was at least double themagnitude seen in the initial 8 weeks of double...reatment. For patients receiving placeboduring the double blind phase, 36% were rated as improved, whilefollowing three months of open label treatment, 80% we...

Repros Reports That Proellex Has Demonstrated Superior Efficacy and Safety in Endometriosis When Compared to Standard of Drug Care

...nt of endometriosis. Proellex was administeredin a double blinded fashion as a daily oral dose of either 12.5mg,25mg, or 50mg capsules. Data from this study demonstrate thattreatment with the 50mg Proellex dose reduces both the duration andintensity of pain more effectively than 12.5mg or 25mg and issignifi...

NCI Researchers Discover Genes That Are Turned on at High Levels in Tumor-associated Blood Vessels of Mice and Humans

...ableinhibitory molecule might be able to deliver a double blow -- oneto the tumor cells themselves and the other to the blood vesselsthat feed them. "These studies demonstrate that CD276 is overexpressed in theblood vessels of a variety of human cancers," says St. Croix."Therefore, it may be an important t...

Karo Bio Announces Sucessfule Phase II Results of KB2115

... body. The completed 12 week, placebo controlled, double blind,randomised, clinical phase II study in 99 patients with highcholesterol levels was designed to explore whether a clinicallyrelevant LDL-cholesterol lowering effect can be achieved withoutaffecting the heart, bone, muscle and thyroid function. ...

Opexa Presents Tovaxin Research at Federation of Clinical Immunology Societies Annual Meeting

... include 150 patientsin a multicenter, randomized, double blind, placebo-controlledtrial designed primarily to evaluate the efficacy, safety andtolerability of the Tovaxin T Cell vaccination with clinicallyisolated syndrome (CIS) and relapsing-remitting MS (RR-MS)patients. A total of 100 patients will recei...

Clinical Update - Debio 9902 (ZT-1) for Alzheimer's Disease

...er's patients withImplaNts of ZT-1) is a phase II, double blind, double dummyclinical trial with Debio 9902 SR. The study will measure thesafety and efficacy of Debio 9902 ...

Promising Data on Cognitive Effects of Safinamide in Early Parkinson's Disease

...he data are from a 6-month (24 weeks), randomized, double blind,placebo-controlled, international Phase III trial. Some resultsfrom this trial were presented last month at the American Academyof Neurology 59th Annual Meeting and showed that safinamidesignificantly improved motor symptoms and activities of d...

Merck at ASCO 2007: Spectrum of Studies Reinforces Promise of Erbitux for Colorectal and Head and Neck Cancer Patients

...ubgroup who had liver metastases only was morethan double with Erbitux plus FOLFIRI vs. control arm (9.8% versus4.5%). The number of complete resections in the overall populationwas three times higher in the Erbitux plus FOLFIRI arm. “These encouraging results indicate that we have a newfirst-line ...

Repros' Androxal Shows Highly Statistically Significant Positive Effects in Men with Secondary Hypogonadism

...erone level was maintainedfor the entire six month double blind period and the proportions ofsubjects achieving testosterone levels greater than 300 ng/dl were70.5%, 84%, 53.2% and 31.9% for 12.5mg, 25mg, Androgel and placeboarms, respectively. The improvement in total testosterone in the Androxal arms was...

Antidepressant Use May Boost Fracture Risk, From Harvard Women's Health Watch

...selective serotonin reuptake inhibitors(SSRIs) had double the rate of fractures as people not using suchmedications. Other research points to depression itself as a sourceof endocrine changes that can damage bone. Whether the danger comes from depression, the drugs used totreat it, or something else, docto...

DP-b99 Phase IIb Trial Results to be Presented at the European Stroke Conference

...brains of stroke patients. A Phase IIbmulticenter, double blind, placebo controlled, randomized trial toassess DP-b99's effect on stroke outcomes was completed in December2006. The study enrolled 150 ischemic stroke patients with signs ofcortical involvement and NIH Stroke Scale (NIHSS) score of 7-20.DP-b99...

BioLineRx Presents Data From Successful Phase I Trial for BL-1020 in Schizophrenia at American Psychiatric Association Conference

...al The Phase 1 trial of BL-1020 was a randomized, double blind,placebo-controlled, dose-escalation, single center study in healthyadult males (ages 21-45). The primary objective was to evaluate thesafety and tolerability of escalating doses of BL-1020. Thesecondary objectives were to determine the pharmaco...

Positive Clinical Data on CC-10004 Confirms Potential as Novel Oral Approach to Treating Inflammatory Diseases

... trial in psoriasis. The multicenter, randomized, double blind, placebo-controlledPhase II study achieved t...This Phase II study was a multicenter, randomized, double blind,placebo- controlled, parallel-group, dose comparison efficacy studyin 260 patients with modera...

FDA approves MyocondaR IND for MAP in Crohn's Disease

...ny is continuingpreparations for the multi-centre, double blind, placebocontrolled, Phase II/III trial. Before the trial commences theCompany will conduct pharmacokinetics investigations, test the drugmanufacturing for the trial and make ethics submissions to thevarious clinical trial centres. It is anticip...

New Data Highlights Potential of SPP100 (Tekturna) as Gold Standard Therapy in Treatment of Hypertension

...e daily werecomparable to Losartan 100mg, which is double the usual startingdose of this ARB (Stanton, Jensen, Nussberger, O'Brien,Hypertension.2003; 42: 1137-1143). About Speedel Speedel is a public biopharmaceutical company thatseeks to create value for patients, partners and investors bydeveloping innov...

BioLineRx Presents Phase I Clinical Data of BL-1020 at Upcoming Clinical Conferences

...esults of a Phase I, randomized,placebo-controlled double blinded, single dose-escalation study toevaluate the safety and determine the pharmacokinetic profile ofBL-1020, first in class GABA-enhanced antipsychotic for thetreatment of schizophrenia. "We are very pleased that these important data regarding...

Revolutionary Immunologic Data Explains Function of Diamyd Diabetes Vaccine

...thclinical results in August 2006. The study was a double blind,randomized and placebo controlled trial that included 70 young type1 diabetes patients. The patients received two injections, fourweeks apart, of either 20 µg Diamyd® or placebo. Sincethis was a double-blinded study, the code containi...

Immediate Treatment of Early MS Patients with Betaferon Significantly Delayed Permanent Disability

...her day or placebo as asubcutaneous injection in a double blind fashion. Theplacebo-controlled treatment period lasted up to 24 months or up tothe time when patients were diagnosed with clinically definite MS.All study participants were then invited to participate in afollow-up study with Betaferon® to ...

Phase III Data on Safinamide in Parkinson’s Disease Presented at American Academy of Neurology 59th Annual Meeting

...ese data are from a6-month (24 weeks), randomized, double blind, placebo-controlled,international trial. "These data are promising for patients withParkinson’s disease," said Fabrizio Stocchi, Professor ofNeurology and Honorary Consultant at the IRCCS San Raffaele Rome,University La Sapienza, and pri...

First of Its Kind Data Show: Immediate Treatment of Early MS Patients with Betaseron Significantly Delayed Permanent Disability

...her day or placebo as asubcutaneous injection in a double blind fashion. Theplacebo-controlled treatment period lasted up to 24 months or up tothe time when patients were diagnosed with clinically definite MS.All study participants were then invited to participate in afollow-up study with Betaseron to prosp...

BDSI Announces Positive Phase III Clinical Trial Results for BEMA Fentanyl

...portantly, we believethat the dose linearity (i.e. double the dose and double the plasmaconcentration of the drug) demonstrated in our previously announcedpharmacokinetic studies...

Prospective Model Outlined Potential Time and Cost Savings of Once-Monthly Anemia Treatment

...tes and cardiovascular disease frequently playthis double role. About Roche Hoffmann-La Roche Inc. (Roche), based in Nutley, N.J., is theU.S. pharmaceuticals headquarters of the Roche Group, one of theworld's leading research-oriented healthcare groups with corebusinesses in pharmaceuticals and diagnostic...

Data Show SuperGen's Multi-Targeted Tyrosine Kinase Inhibitor Suppresses Critical Double-Stranded DNA Repair Protein, Rad51

...ommonly used to treattumors. It acts to repair the double stranded DNA breaks that arecaused by therapies, thus limiting their efficacy and increasingdosage requirements. Data indicate that SuperGen's novel compound,MP470, blocks the induction of Rad51 by anticancer platinum agents.MP470, in combination wit...

Antares Pharma Announces Positive Results from Application Site Study for Anturol

...uct.The ANTUROL Phase III protocol, will include a double blind,randomized, parallel, placebo controlled, multi-center studyevaluating the effect of 12 weeks of treatment with ANTUROL(R)administered topically once daily to patients with urge and mixedurinary incontinence. We are diligently working on the AN...

AVEO Presents Preclinical Efficacy Data on AV-412, a Novel Oral Tyrosine Kinase Inhibitor of EGFR/HER2 for EGFR Mutant and Drug-Resistant Lung Cancer

...nd gefitinibhave no effect on the EGFR L858R/T790M double mutant, which isestimated to account for approximately 50 percent of all drugresistance in EGFR mutant non-small cell lung cancer - representinga key unmet medical need. "AV-412 showed potent inhibition of the EGFR L858R mutationsand, in two well-...

AVAX Technologies Presents Results of Phase I-II M-Vax Trial at Annual Meeting of American Association for Cancer Research

...ned for vaccine production. They wereassigned in a double blind fashion to one of four dosage arms ofM-Vax(TM), including a placebo arm that contained no vaccine cells.The results of the first 54 evaluable patients are being presented,and the blinding of the dosage arm assignments has been preserved.As dete...

Data Analyses Outline Efficacy and Safety of Mircera for the Treatment of Renal Anemia Associated With Chronic Kidney Disease

...tes and cardiovascular disease frequently playthis double role. About MIRCERA The initial registration clinical program for MIRCERA consistedof 10 global studies involving more than 2,700 patients from 29countries. The Phase III program for MIRCERA consisted of twocorrection and four maintenance studies e...

DNA Therapeutics Reports a Novel Mechanism of Action and a Biomarker of its Lead Molecule Dbait That Open an Innovative Pathway-Targeting in Molecular Cancer Therapy

... cancer therapies induce directly orindirectly DNA double strand breaks (DSBs), but unfortunately cellspossess DNA repair complexes specialized in repairing these lethallesions, which are responsible of lessened efficacy, orrefractoriness of classical therapies. A new family of anticancer drugs, named shor...

New Clinical Study Results Indicate Higher Early Virologic Response with Celgosivir Combination Therapy in HCV Non-Responders

...stent with the originallyreported results: (a) the double combination did not show ameaningful difference in...ination arm for anyconclusions to be drawn and the double combination showed lesseffect than the control treatment. Celgosivir combination therapy was well t...

GSK and Adolor Announce Preliminary Results from Phase 3 Safety Study of Alvimopan (Entereg/Entrareg)

...mopan (Entereg/Entrareg(R)). Study 014, a Phase 3, double blind, placebo-controlled (12month) study, was designed to evaluate the long-term safety andtolerability of alvimopan 0.5 mg twice daily in patients takingopioids for chronic non-cancer pain and experiencing opioid-inducedbowel dysfunction (OBD). A t...

New Cardioprotective Drug Could Provide Boost For Post-Bypass Surgery Heart Health

...ntinue to take blood thinners, theycould more than double their risk of heart attack or death. This emerging safety controversy around drug-coated stents hassome experts predicting a resurgence in heart bypass operations.The bypass operations, although more invasive and dangerous, arebelieved to have longe...

Opexa Therapeutics Reports Positive Top-line Data in Phase I/II Dose Escalation Trial with Tovaxin for Multiple Sclerosis

... include 150 patientsin a multicenter, randomized, double blind, placebo-controlledtrial designed primarily to evaluate the efficacy, safety andtolerability of the Tovaxin T- cell vaccination with clinicallyisolated syndrome (CIS) and relapsing-remitting MS (RR-MS)patients. A total of 100 patients will rece...

Data on Telavancin and Micafungin Hold Promise of New Therapeutic Options in Fight Against Serious Infectious Disease

...cus aureus(MRSA).(6),(7) The results of the two double blind parallel studies, in which1,867 patients were treated, showed that telavancin comparedfavorably to standard therapy in clinical cure, microbiologicaleradication, and overall therapeutic response rates. The safetyprofile of telavancin in these s...

Protein Found to Shield Pancreatic Cancer Cells from Self-Destruction

...cavities calledvacuoles. When autophagy occurs, a double membrane forms around a cellorgan, or organelle. This autophagosome then merges with adigestive organelle called a lysosome and everything inside isconsumed, leaving the vacuole and a residue of digested material.If enough of this happens, the cell d...

Avexa Reports Positive Phase IIb Result

...nical Data Trial Design AVX-201 is a randomised, double blind study of two doses of ATCcompared to lamivudine (3TC) in treatment-experienced HIV-1infected patients with the M184V mutation. Patients were randomisedto receive 600mg or 800mg ATC twice daily, or 3TC twice daily, for21 days, in a blinded fashi...

Researchers Use Poliovirus to Destroy Neuroblastoma Tumors in Mice

...tony Brook,this engineering feat is like putting a double failsafe into thevirus. “The engineered poliovirus cannot produce neurovirulentcopies of itself if the spacer region remains interrupted,”said Cello. “And in the unlikely event that the regulatorygene element is deleted, the virus ...

Actelion Announces Positive Study with Bosentan (Tracleer) in CTEPH

...oembolic PulmonaryHypertension) study is the first double blind, randomized,placebo-controlled, parallel-group study in CTEPH patients. BENEFiTenrolled 157 patients in 26 centers in 13 countries. The mean ageof patients enrolled in the study was 63 years and 65% of patientswere female. Patients had either i...

CeNeS Pharmaceuticals plc: Update on Successful Phase III results announced on Lead Product M6G

...to control their pain. Thestudy was randomised and double blind so that neither patient norcarer was aware of which treatment was being administered. The mainpurpose of the study was to demonstrate statistically that: - Treatment with either M6G or morphine, particularly duringPCA, results in similar level...

Replidyne Phase II Pediatric Trial Meets Primary Objective

...r doseeffect to tolerability. The trial included a double tap designwhere middle ear fluid is obtained both prior to and duringtreatment then submitted for culture. These cultures providemicrobiologic documentation of faropenem's effectiveness ineradicating bacteria from the middle ear fluid. "We are ple...