Video: Femara(R) First Aromatase Inhibitor to Indicate Survival Benefit Versus Tamoxifen When Taken for Five Years After Breast Cancer Surgery
... censored analysis excluding patients after they
crossed over to Femara, reduction in risk of death was ... 25% of patients in the tamoxifen arm selectively
crossed over to Femara therapy after the tamoxifen arm ... one quarter of those patients selectively
crossed over to Femara treatment. The other three ...
Diverse Approaches to Alzheimer's Therapies Continue to Show Progress at ICAD
... the study. Patients originally
on placebo for 12 months who were then
crossed over to Dimebon on the OLE
phase also stabilized across all key measures ... depressed mood/sadness.
"People initially treated with placebo and then
crossed over to Dimebon
did not show the same level of benefit as those people who ...
REMICADE-Treated Patients Experienced Rapid and Substantial Improvement in Psoriasis in Critical Regions of Body
... maintenance treatments every 8
weeks. Patients in the placebo group were
crossed over at week 24 to
receive REMICADE 5 mg/kg at weeks 24, 26 and 30, then ... during the induction phase. Patients in the
placebo group were
crossed over at week 16 to receive REMICADE 5 mg/kg at
weeks 16, 18 and 22, then ...
Schering-Plough Announces Results of the Early ACS Trial
... not administered pre-PCI, the initial infusion was continued unchanged for 18-24 hours post-PCI. If a thrombotic complication occurred after the wire
crossed the lesion, investigators could request a bailout PCI kit containing bolus therapy opposite to initial treatment assignment.
For patients ...
Prescient Medical Achieves Milestones in Clinical Studies of vProtect(TM) Luminal Shield
... first-in-human clinical trial for the vProtect(TM) Luminal Shield, conducted at the Corbic Research Institute in Colombia. The Shield successfully
crossed all target lesions and was safely implanted in all 30 patients, with a technical success rate of 100%. No procedural or in-hospital complications ...
Poniard Pharmaceuticals Announces Final Top-Line Results from Phase 1 Trial Demonstrating Positive Bioavailability with Oral Picoplatin
... were randomized to a single dose of
either intravenous (120 mg/m squared) or oral picoplatin (200, 300 or 400
mg). Four weeks later, they were
crossed over to a second single picoplatin
dose administered via the alternative route. In the second part of the
trial, patients received only a single oral ...
Medivation Presents Positive New Data on Dimebon's Long-Term Efficacy and Novel Mechanism of Action at the International Conference on Alzheimer's Disease
... support for its potential as a promising
therapeutic to treat this devastating disease."
Patients originally on placebo for 12 months who were then
crossed over
to Dimebon in the open-label extension phase stabilized across all key
measures tested. Since these patients had declined over the previous ...
Genaera Releases Phase 1 Data and New Preclinical Data on the CNS Function of Trodusquemine (MSI-1436) at CBI Obesity Summit
... planned to begin later this year.
Data were also presented from preclinical studies which demonstrated
that systemically administered MSI-1436
crossed the blood-brain barrier and
functionally inhibited PTP1B in the hypothalamus. In this study, rats were
administered a single dose of MSI-1436 one day ...
Human Genome Sciences Reports Positive Long-Term Data for LymphoStat-B in Patients With Active Systemic Lupus Erythematosus
... Health System, Lake Success, NY, and Associate Professor of
Medicine, New York University School of Medicine. "We observe that patients
who
crossed over from placebo to belimumab after Week 52 have also shown
improvement across multiple clinical measures. The durability of clinical
effect and the ...
Kosan's Lead Hsp90 Inhibitor, Tanespimycin, Shows High Level of Activity in Trastuzumab Resistant/Refractory HER2-Positive Breast Cancer in a Phase 2 Trial
... Injectable Suspension product (contains no Cremophor). In addition, 4 of the patients treated initially with the Injection formulation
crossed over to receive the Injectable Suspension formulation. -- For the Injection product: 18 were evaluable and 11 responded (4 PR, 4 ...
Ustekinumab (CNTO 1275) Phase 3 Data Show Long-Term Improvement Of Chronic Plaque Psoriasis
... to receive ustekinumab received 45 mg or 90 mg doses at
weeks 0 and 4 followed by the same dose every 12 weeks. Patients in the
placebo group
crossed over to receive either 45 mg or 90 mg doses of
ustekinumab at weeks 12 and 16 and every 12 weeks thereafter. The primary
endpoint of the study was ...
Promising Phase 3 Trial Results Show Novel Biologic Therapy Ustekinumab (CNTO 1275) Significantly Improved Psoriasis
... to
receive ustekinumab received 45 mg or 90 mg doses at weeks 0 and 4 followed
by the same dose every 12 weeks. Patients in the placebo group
crossed over
to receive either 45 mg or 90 mg doses of ustekinumab at weeks 12 and 16
and every subsequent 12 weeks. The primary end point of the study was ...
Final Vectibix Positive Pivotal Phase 3 Trial Results In Metastatic
Colorectal Cancer Patients Published
... of response was 17
weeks.
In the BSC group 174 (75 percent) patients received Vectibix
under the crossover protocol. In those patients that
crossed over,
the objective response rate was 10 percent. The median time to
crossover was 7.0 (6.6, 7.3) weeks. The median follow-up after
crossover was 27 ...
Catalyst Pharmaceutical Partners, Inc. Announces Top-Line Results
of Its Bioequivalence Study of CPP-109 (Vigabatrin), the Company's
Investigational Drug to Treat Cocaine and Methamphetamine Addiction
... additional 21 blood plasma samples were collected after dosing
over a period of 36 hours. After a washout period of eight days,
each participant was
crossed over to receive the alternate tablet,
and plasma samples were collected according to the same schedule. A
total of 28 subjects completed both arms of ...
Remicade Two Year Data in Ankylosing Spondylitis Show Improvement
in Spinal Mobility and Spinal Inflammation
... in disease activity score on the Assessment in
Ankylosing Spondylitis Response Criteria (ASAS 20) at week 24.
At week 24, placebo patients were
crossed over to receive
treatment with REMICADE 5 mg/kg at weeks 0, 2 and 6 and every six
weeks thereafter and continued on REMICADE through the remainder ...
Eurand's Zentase Effective in Treating Exocrine Pancreatic
Insufficiency, Studies Show
... dose titration, patients were randomized to receive
Zentase or placebo over a week-long period. Following open-label
normalization, all patients were
crossed over to the alternative
treatment arm. A determination of CFA and CNA on a 72-hour sample
and under controlled diet in a hospital environment was ...
Avian (Bird) Flu: Is There a Role for Rapid Tests?
... First in 1997 and now recently, some humans in close contact with infected birds have contracted the virus. Now that the H5N1 subtype has
crossed the species barrier to humans, there is concern for human-to-human transmission. Given the presumed paucity of human resistance to the H5N1 subtype, ...