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Digital vs. Analog Mammography

... (LCD), allowing for unlimited manipulation of the contrast and brightness of the image, including image rever... and to process them, i.e., to vary brightness and contrast levels, auto-windowing, image manipulation. Information can also be coupled with patient information...

Appendicitis: Evolving Tools to Diagnose a Classic Disease

...endix is visible on the scan. With oral or rectal contrast (with or without intravenous contrast), sensitivity and specificity can both approach 98%. Helical CT, which has finer resolution and shorter acquisition times, has improved test quality and made it more practical for patients who cannot remain stil...

Breast Cancer and HER-2/neu: Diagnostic Tools for Targeted Therapy

...so available to quantify Her-2/neu expression. In contrast to IHC and FISH, ELISA can detect Her-2/neu as a serum marker. This bypasses the need for a tissue specimen and may allow earlier Her-2/neu detection. The Her-2/neu ELISA (Bayer Diagnostics Oncogene Science) is a sandwich-type immunoassay approved ...

YM BioSciences Announces Secondary Efficacy and Safety Findings in Randomized Phase IIB Aerolef Trial

...moderate to severe pain, including cancer pain. In contrast tofixed-dose approaches to opioid delivery, where a significanttitration period is often required to determine the suitable dosefor the patient, AeroLEF(TM) is being developed as a non-invasivedelivery system designed to enable patients to self-titra...

Reaction to Avandia Warnings Stronger Among Internists Than Endocrinologists, According to Study by GfK Market Measures

...e drug, even though the FDA has notrequired it, in contrast to a smaller percentage ofendocrinologists. Internists are also more likely than theendocrinologists to indicate a reluctance to prescribe any productcontaining Avandia. To a lesser degree, the news of Avandia's effect oncardiovascular risk may have...

Halozyme Therapeutics' Enhanze Technology Large Protein Molecule Therapeutic Clinical Trial Results Presented at the 34th Annual Meeting of the Controlled Release Society

...ing localanesthetics, other co-injected drugs, and contrast agents, and forsubcutaneous fluid replacement. Although a large body of clinicalexperience supports the benefits and safety of using hyaluronidaseas an adjuvant to increase the absorption and dispersion ofco-injected small molecule drugs, to Halozyme...

Cytos Biotechnology Reports Results from Phase IIa Study with CYT003-QbG10 in Patients Suffering from Atopic Dermatitis

...to develop allergicdiseases. Disease-modifying: in contrast to symptomatic treatment, adisease-modifying treat...term refers to treatment with CYT003-QbG10 alonein contrast to a regimen where CYT003-QbG10 is combined to anallergen extract (i.e. CYT005-AllQbG10). Phase IIa:...

An Investigational Study Released at ADA Showed that Initial Combination Therapy with Januvia (sitagliptin) and Metformin Led to Improvement in Markers of Beta Cell Function in Patients with Type 2 Diabetes

...12-fold (plessthan0.001) compared with placebo. In contrast to active GLP-1levels that were increased by both drugs, the levels of total GLP-1(which includes both active and inactive GLP-1) were increased bymetformin only and not by JANUVIA. These observations areconsistent with the effect of JANUVIA to raise...

Liraglutide provides significantly better glucose control than insulin glargine in phase 3 study

...nsulin only when glucoselevels become too high. In contrast to most other antidiabetictreatments liraglutide also leads to weight loss instead of weightincrease. The LEAD(TM) programme (Liraglutide Effect and Action in Diabetes)is comprised of five randomised, controlled, double-blind studiesconducted in mo...

Diabetes drug supported by Mexican Diabetes Federation

...gs, the review notes, have a history ofproblems in contrast with Sucanon which, clinical studies haveindicated, is very safe. The review notes that Sucanon does nothave any of the hepatotoxicity or liver-damage risks of theglitazone drugs. The first glitazone, troglitazone was approved in1998 but was withdraw...

Hypertension Vaccine CYT006-AngQb Achieves Strong Blood Pressure Reduction During Important Early Morning Period When Most Adverse Cardiovascular Events Occur

...ecreasing theefficacy of current drug therapy1. In contrast to small moleculeinhibitors, which display large variations in serum drug levelsthroughout the day, the vaccine-induced anti-angiotensin IIantibodies were found to decline with a half-life of about 4months. This may lead to a practically continuous i...

Barrier Therapeutics Announces Liarozole Phase 2/3 Study Results in Lamellar Ichthyosis

...s essential for optimalfunctioning of the skin. In contrast to current synthetic retinoidtreatments, which introduce man-made forms of vitamin A into thebody, RAMBAs work by slowing the metabolism or degradation of thebody's own retinoic acid. This causes the body to maintain higher,potentially therapeutic le...

Accera, Inc. Announces Open-Label Data from Phase II Study in Alzheimer's Disease at International Conference on Prevention of Dementia

...nly 0.8 points belowbaseline in ADAS-Cog scores in contrast to the 5.4-point declineobserved in placebo subjects extrapolated to nine months. "The significant and rapid cognitive improvements observed inApoE4(-) patients support the efficacy observed in our Phase IIastudy," said Dr. Lauren Costantini, Accera...

Archemix Announces Completion of Phase 1 Trial of ARC1779

... ability to targetprotein-protein interactions. In contrast to monoclonal antibodies,aptamers are chemically synthesized rather than biologicallyexpressed. About Archemix Archemix Corp. is a privately-held biopharmaceutical companydeveloping aptamers as a class of directed therapeutics for theprevention and...

Extensive Clinical Data on Erbitux Presented at the 2007 ASCO Annual Meeting

... antibody-dependent cellular cytotoxicity (ADCC)in contrast to the lack of such activity in IgG2 monoclonalantibodies. -- Erbitux plus radiation is currently a standard of care forpatients with locally advanced Head and Neck cancer. The EasternCooperative Oncology Group reported promising results of a Phase ...

Vaxfectin-formulated Measles DNA Vaccine Elicits Long-term Protection and Sterilizing Immunity in Nonhuman Primates

...evels ofmeasles virus at any time point tested, in contrast to negativecontrol animals which all had detectable virus. Measles-specificT-cell responses were also detected after vaccination. The vaccineswere well-tolerated in all animals. The study in infant rhesus macaques tested only intradermalneedle-and- ...

Preclinical Study Finds Protease Inhibitor-Resistant HIV May Have Reduced Potential to Develop Resistance to Panacos' Bevirimat

...esistance tobevirimat does not develop rapidly, in contrast to some currentlymarketed HIV drugs, possibly because there is selective pressure tomaintain the integrity of the capsid-SP1 cleavage site sequence,which is highly conserved among HIV strains. While resistance tendsto develop eventually to all HIV in...

Positive results from placebo-controlled phase IIa study in patients suffering from house dust mite allergy

...ase status of an individual. Disease-modifying: in contrast to symptomatic treatment, adisease-modifying treat...term refers to treatment with CYT003-QbG10 alonein contrast to a regimen where CYT003-QbG10 is combined to an allergenextract (i.e. CYT005-AllQbG10). Open-label...

2007 ASCO Annual Meeting: Clinical Results on Phase IIb-study with AP 12009 in Anaplastic Astrocytoma selected for Poster Discussion

...ot yet been reached inboth AP 12009 dose groups in contrast to 91 weeks in thechemotherapy treatment group. Overall response rates demonstrate abenefit of AP 12009 over chemotherapy. The duration of long-termtumor responses until now exceeds the active treatment period byfar. “The significance of our c...

Indivumed Study Provides Sound Scientific Basis for a Predictive Drug Test- Platform

...ivated colorectalcancer primary cells show that in contrast to long-term cultivation(>1 month) primary cells cultivated for up to 72h do not changethe molecular expression level of most cancer relevant genes. Someof the genes that play a role in cell to cell contact and tissueorganization changed expressi...

Progenics Announces Positive Results in Clinical Trial of Novel HIV Therapy

...ered harmless and rapidlycleared from the body. In contrast to PRO 140's mechanism of actionas a viral-entry inhibitor, most antiretroviral drugs are designedto slow viral replication inside already-infected immune cells. Clinical trial design and study results This multi-center, double-blind, randomized, p...

Innovive Pharmaceuticals Announces Preclinical Data from INNO-206 Oncology Program

...diomyopathy scores of one and three on average, in contrast tothe doxorubicin group having a high cardiomyopathy score ofseven These data suggest that the proposed Phase II dose of 200 mg/m2should demonstrate mild to no cardiotoxicity in patients. Innoviveintends to initiate a Phase II study in Small Cell Lu...

Poster on Cyclosert Drug Delivery Presented at AACR Meeting

...ubulysin-Cyclosert conjugate was welltolerated, in contrast to tubulysin A alone, which was highly toxicand caused 50% mortality. The conjugate was also compared tovinblastine, an agent with a similar mechanism of action totubulysin A. Vinblastine was found to be significantly lesseffective as an antitumor ag...

GSK and Adolor Announce Preliminary Results from Phase 3 Safety Study of Alvimopan (Entereg/Entrareg)

...ed inpatients receiving alvimopan. This data is in contrast topreviously conducted studies that showed a similar or lowerincidence of fractures in patients receiving alvimopan relative toplacebo. Preliminary Conclusions and Next Steps As the findings outlined were observed during the preliminaryevaluation o...

CombinatoRx Provides Topline Results from Phase 2 RA Study with CRx-139 and Very Low Dose Prednisolone

...f prednisolone alone (a very low dose)in RA and to contrast this effect with the activity previouslyreported with CRx-102, a synergistic combination of very low doseprednisolone and dipyridamole. The results with 3mg prednisoloneconfirm that the anti-inflammatory benefits previously observed inthree phase 2a ...

Everest Data on Short- and Long-Term Use of Otsuka's Investigational Novel Treatment, Tolvaptan, Published in Journal of the American Medical Association and Featured in ACC's Late Breaking Clinical Trials

... is treated with diuretics to excrete the fluid.In contrast to diuretics, tolvaptan is designed to promoteaquaresis, the excretion of electrolyte-free water.(1) OtsukaPharmaceutical Co., Ltd. (Japan) and Otsuka PharmaceuticalDevelopment & Commercialization, Inc., are developingtolvaptan, which has the pot...

Two New Imaging Studies Show Higher Dose Lipitor Stopped the Progression of Atherosclerosis

...n the most diseased part of thecoronary artery. In contrast in the Lipitor arm of RADIANCE 2patients took a low average Lipitor dose of 13 mg and progressionof atherosclerosis was observed. "From a clinical perspective, what is remarkable in thesestudies is that Lipitor was able to stop the progression ofdis...

REACH Registry Demonstrates That Multiple Arterial Disease Locations Sharply Increase the Risk of Major CV Events in Outpatients With Atherothrombosis

...t rates that accruedalmost linearly over time - in contrast to the sharp rise followedby a leveling off of event rates that is usually seen in patientsdischarged from hospital after acute events. REACH is the firstinternational outpatient registry to characterize the real-worldburden of atherothrombotic disea...

Avid Announces Results of AV-1 Molecular Imaging Agent for Alzheimer's Disease Presented at AD/PD Meeting

...s of thebrain known to contain amyloid plaques. In contrast there was noretention of AV-1 in the cerebellar cortex, an area where amyloidplaques do not accumulate. This is the first scientific report of a clinical trial with an18F-compound designed for specifically imaging amyloid plaques inAD. The wide av...

Placebo-controlled Phase IIa Study with the Immunotherapeutic CYT003-QbG10 Shows Significant Improvement of Allergy Symptoms in Hay Fever Patients

...ase status of anindividual. Disease-modifying: in contrast to symptomatictreatment, a disease-modifying treat...term refers to treatment withCYT003-QbG10 alone in contrast to a regimen where CYT003-QbG10 iscombined to an allergen extract. Open-label: a set-up used in cli...

CeNeRx BioPharma Announces Positive Phase I Results in First Human Trial of Third Generation RIMA Antidepressant

...rine and dopamine) thataffect mood and anxiety, in contrast to the leading antidepressantsavailable today that...arry Brand, chief executive officer of CeNeRx. "In contrast toother MAO inhibitors, our third generation RIMA series is designedto bind selectively and reversib...