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clots in Medical Technology

Value of Genetic Testing for Preventing Blood Clots Unproven, According to New AHRQ Study

... gene mutations in adults with a history of blood clots helps to prevent a condition known as deep-vein ... each year may have deep-vein thrombosis -- blood clots that form in the legs or pelvis. The condition ... who have a genetic tendency to develop blood clots on blood-thinning drugs such as warfarin reduces ...

Portola Pharmaceuticals Initiates Phase II Trial of Novel IV and Oral Anti-Platelet Drug in Non-Urgent Percutaneous Coronary Intervention

... Thrombosis, or the development of harmful blood clots within the arteries or the veins, obstructs the ... by the World Health Organization. Arterial clots are the major cause of heart attack and stroke while venous clots can cause deep-vein thrombosis and pulmonary ...

Research Highlights New Approaches to Prevent Blood Clots in Several High-Risk Patient Populations Including Largest Study Ever to Examine Use of Blood-Thinning Medication in Patients With Cancer

... medication to help prevent deadly blood clots in patients with cancer undergoing chemotherapy ... consists of anticoagulants that help prevent clots from forming, medications that dissolve blood ... change the way physicians prevent serious blood clots in patients undergoing major orthopedic surgery. ...

Pivotal National Trial Uses Newest Interventional Radiology Treatment to Bust Blood Clots in Legs

... can -- unlike standard DVT therapy -- remove clots and have strong potential to prevent PTS. ... preventable if we are able to dissolve the clots early, before permanent damage to the vein ... which remains in the leg. While many patients' clots will slowly dissolve over time, often the vein ...

New Deep Vein Thrombosis (DVT) Registry Data Show Clot Quickly Removed, Blood Flow Restored in Large Patient Registry

... by anticoagulation medication to prevent blood clots in the future. Patients experience dramatic ... (blood thinners), which prevents future clots but does not break up the existing clot. DVT ... not treat the existing clot. Removing these clots is important because about 50 percent of the ...

ImaRx Therapeutics Transitions Business Strategy

... of acute massive pulmonary embolism, or blood clots in the lungs. Following a comprehensive review ... of acute massive pulmonary embolism, or blood clots in the lungs. The product has been commercialized ... microbubbles and ultrasound to break up blood clots and restore blood flow to oxygen deprived ....

PNH Patients Treated with Soliris(TM) Experienced Dramatic Reduction in Blood Clots During Clinical Trials

... in the incidence of life-threatening blood clots (thromboses) following treatment with Soliris(TM) ... symptoms, including the threat of blood clots and their complications," said Leonard Bell, MD, ... risk for developing life-threatening blood clots as a result of their disease," said John Huber, ...

Beating Blood Clots after Joint Replacement

... A previous blood clot A family history of blood clots A genetic predisposition to blood clots, such as protein-deficient ... This topic will be the focus of a Media Briefing entitled: "Beating Blood clots and Deciphering DVT Prophylaxis: What the Patient Needs to Know" on ...

Dallas Researchers Find Compression Stockings Improperly Used

... Journal of Nursing. Immobile patients are at increased risk for blood clots after surgery because blood tends to pool and coagulate in stationary extremities. These deep vein clots can travel to the lungs and block the pulmonary artery, resulting in a ...

Stroke Study Reveals a Key Target For Improving Treatment

... barrier appears to be unrelated to tPA's main job, which is to break down clots that have lodged in the brain's blood vessels, cutting off blood supply to the area and starving brain tissue until it begins to die. Such clots cause 80 percent of the 15 million strokes that occur each year worldwide. ...

Schering-Plough Announces Imperfect Contraceptive Use Impacts Women's Emotional Well-Being

... certain cancers or those who may be pregnant. The risk of getting blood clots may be greater with the type of progestin in NUVARING(R) than with some ... certain low-dose birth control pills. It is unknown if the risk of blood clots is different with NUVARING(R) use than with the use of certain birth ...

Nuvelo Begins Phase 2 Trial and Receives Fast Track Status for Alfimeprase in Patients With Acute Ischemic Stroke

... that holds the potential to directly and rapidly dissolve blood clots while keeping its activity localized to the site of delivery. We look ... fibrinolytic (rDAF) that has the potential to rapidly dissolve blood clots through a unique mechanism of action -- it directly degrades fibrin, a ...

Plavix(R) Indications Expanded in Japan to Include Patients with Acute Coronary Syndrome for Whom Percutaneous Coronary Intervention Is Being Planned

... agent which prevents platelets from sticking together and forming clots in the arteries. Plavix(R) was first authorized in the United States in ... and anticoagulants to prevent blood clotting. Anticoagulants prevent clots from growing and new ones from forming, but they do not dissolve clots. ...

FDA Approves Lilly's Osteoporosis Drug EVISTA(R) (raloxifene HCl) to Reduce The Risk of Invasive Breast Cancer in Two Populations of Postmenopausal Women

... If you are or still can become pregnant, are nursing, or have had blood clots that required a doctor's treatment, you cannot take EVISTA. An infrequent but serious side effect of EVISTA is blood clots in the veins - being immobile for a long time may add to the risk. EVISTA ...

Nuvelo Re-Initiates SONOMA-3 Trial of Alfimeprase in Patients With Catheter Occlusion

... alfimeprase is an active thrombolytic which has the potential to dissolve clots quickly and rapidly restore catheter function, however, the dose and ... fibrinolytic (rDAF) that has the potential to rapidly dissolve blood clots through a unique mechanism of action -- it directly degrades fibrin, a ...

New Study Suggests Rx Estrogen Delivery Through the Skin May Show Safety Benefits as Opposed to Oral Delivery

... after oral estrogen therapy, but no significant change after transdermal estrogen therapy. "Venous thromboembolic complications or blood clots represent an established risk factor of estrogen therapy, and evidence is now mounting that the route of estrogen administration influences this ...

CRESTOR(R) Reduced Risk of Blood Clots in the Veins

... (DVT), which occurs in the 'deep veins' usually in the legs or pelvis. An embolism is created if the clot travels through the venous system. Blood clots lodging in the lungs are known as a pulmonary embolism (PE). Estimates suggest that at least 350,000 and as many as 600,000 Americans annually ...

March 2009 Mayo Clinic Health Letter Highlights Knee Repair Surgery, Anxiety Disorder and Preventing Blood Clots

... More ROCHESTER, Minn. -- Long, cramped airline flights aren't the only risk factor for deep vein thrombosis (DVT), the medical term for blood clots in the legs. For those at high risk, hospitalization or surgery is more likely to trigger clot formation than flying. The March issue of Mayo ...

Atritech to Participate in Late-Breaking Clinical Trial Presentation at American College of Cardiology Meeting

... which causes the upper chambers of the heart to beat too rapidly) are at a significantly greater risk of having a stroke due to embolization of clots that may form in the LAA. Typically these patients require blood thinning medications to prevent these clots from forming in the heart. Current ...

New Phase II Data Show Safety of Once-Daily Oral Factor Xa Inhibitor, DU-176b, Comparable to Warfarin in Patients With Non-Valvular Atrial Fibrillation

... atria) beat inconsistently and rapidly. When this happens, blood can become stagnant near the walls of the atria and form blood clots. These blood clots can break off and travel through the blood stream to the brain where they can plug blood vessels possibly causing a stroke. These clots can also ...

Daiichi Sankyo Initiates Phase III Trial of Its Investigational Factor Xa Inhibitor, DU-176b, in Patients With Atrial Fibrillation

... atria) beat inconsistently and rapidly. When this happens, blood can become stagnant near the walls of the atria and form blood clots. These blood clots can break off and travel through the blood stream to the brain where they can block blood vessels possibly causing a stroke. These clots can also ...

First Clinical Experience With Soliris(R) in Treating Patients With Two Rare Complement-Mediated Diseases Presented at ASH Annual Meeting

... usually caused by a genetic mutation in the complement system. In patients with aHUS, this defect results in hemolysis, formation of tiny blood clots (microvascular thrombosis) and inflammation of blood vessels, often causing acute kidney injury and progressing to end-stage kidney disease. Those ...

Schering-Plough Highlights R&D Pipeline Progress, Innovation and Breadth of Research Projects

... Thrombin Receptor Antagonist (TRA), a novel antiplatelet agent that can potentially prevent the formation of deadly blood clots without adding a significant bleeding risk (in Phase III); approximately 13,000 patients have been enrolled in its Phase III program targeted to ...

FDA Approves Bayer HealthCare's Kogenate(R) FS Treatment for Routine Prophylaxis in Children with Hemophilia A

... known as factor VIII deficiency or classic hemophilia, is largely an inherited bleeding disorder in which one of the proteins needed to form blood clots in the body is missing or reduced. Hemophilia A, the most common type of hemophilia, is caused by deficient or defective blood coagulation proteins, ...

American Heart Association Journal Report: Miniaturized Heart Pumps May Be Effective for Children Awaiting Transplant

... condition and likelihood of successful transplantation, researchers said. In this study, complications such as postoperative bleeding and blood clots blocking a blood vessel occurred infrequently, but there was a high incidence of blood clotting in the pumps. Small heart pump devices have been ...

ThromboGenics Announces Promising Results of MITI IV Phase II Trial in the Treatment of Acute Stroke with Microplasmin

... of increased bleeding risk. Moreover, the results also support previous preclinical studies that have shown that microplasmin is able to lyse clots and may also have certain vascular protective properties." Dr. Patrik De Haes, CEO of ThromboGenics, commenting on today's announcement said: "I am ...

Concentric Medical to Sponsor Randomized Trial

... invasive device that is delivered by a neurointerventionalist into the brain to restore blood flow by engaging, capturing and removing blood clots that cause ischemic stroke. The Merci Retrieval System is available in over 250 leading stroke centers around the world, and has been the subject of ...

Surgeon General's 'Call to Action' to Prevent DVT/PE Praised by NATT as Turning Point

... and education (consumers, patients and health professionals), outreach, advocacy and support towards achieving the goals of the CTA. Blood clots are far more frequent than most people understand because they are often secondary to other other underlying illnesses or conditions. For example, ...

Discharge of First U.S. DuraHeart(TM) Patient

... Nojiri, M.D., PhD, Chief Executive Officer for Terumo Heart, Inc. Earlier generation Left Ventricular Assist devices are prone to hemolysis, blood clots and mechanical failure. Significant advances have been made in the DuraHeart LVAS to potentially overcome these problems. Dr. Nojiri explained: "We ...

First U.S. Patient to Receive New Heart-Assist Device Doing Well After Surgery at University of Michigan

... the left side of a severely weakened heart. As a result, DuraHeart may cause less damage to blood cells and be less likely to allow dangerous blood clots to form, compared with other heart-assisting devices that use mechanical pumps. It has already been used in 70 patients in Europe, where it received ...

DG041 Blocks Platelet Aggregation Through a Novel Mechanism and does not Increase Bleeding Time When Given Alone or with Plavix(TM) or Aspirin

... overall bleeding risk. While the current standard of care, clopidogrel and aspirin, has been shown to be effective in decreasing the risk of blood clots leading to heart attack and stroke, they do so in an untargeted manner and thus raise the likelihood of unwanted bleeding. By targeting EP3, which we ...

Bayer HealthCare Celebrates 20th Anniversary of Kogenate(R) Product Line and 8 Billion IU Milestone at 2008 WFH World Congress

... known as factor VIII deficiency or classic hemophilia, is largely an inherited bleeding disorder in which one of the proteins needed to form blood clots in the body is missing or reduced. Hemophilia A, the most common type of hemophilia, is caused by deficient or defective blood coagulation proteins, ...

Neurobiological Technologies, Inc. Presents Dosing Rationale for Viprinex(TM) (ancrod) at the European Stroke Conference

... blood viscosity, which may improve blood flow. Additionally, as the fibrinogen is broken down, natural mechanisms are activated to dissolve blood clots that have already formed. Since Viprinex acts in the blood for a longer period of time than existing therapies for treatment of stroke, the effect of ...

CryoLife Announces First Implant of Combination Aortic-Mitral Allograft Heart Valve at the Cleveland Clinic

... the heart valves, contain some type of infection. This infection can be localized within the heart, or generalized throughout the body. Blood clots can form as a result of this infection. Valve dysfunction is common and can involve the aortic, mitral or tricuspid valves. In patients with ...

Large Study Gives Nod to Drug-Eluting Stents in Heart Attack

... follow-up and reported conflicting results. There have also been concerns that, because heart attack patients are already prone to forming blood clots in the coronary arteries, they might be at high risk for stent thrombosis, or sudden clotting inside the stent, particularly a drug-eluting stent. ...

Trellis(R) Catheter Removes Blood Clots Quickly, Restoring Blood Flow in 771 Deep Vein Thrombosis (DVT) Patients

... (CDT) techniques. It provides an important adjunct to the standard therapy of anti-coagulation alone, which is intended to prevent future clots but does not break up the existing clot. Gerard O'Sullivan, MD, Interventional Radiologist from University Hospital in Galway, Ireland, reported ...

Multi Merci Trial Results Published in Peer Reviewed Journal

... a "corkscrew-type" device that is delivered into the brain and is designed to restore blood flow by engaging, capturing and removing blood clots that cause ischemic stroke. The full, peer reviewed trial results are available now to online subscribers. Stroke is published by the American Heart ...

PNH Patients With Lower Levels of Hemolysis, Mild Anemia and Minimal Transfusion Support Have Significant Disease Burden; Soliris(R) Therapy Provided Clinical Improvements in PNH Patients Regardless of Disease Severity

... time intervals). In the study, patients who might have been considered to have less severe disease were found to have an elevated risk of blood clots prior to therapy and experienced the following reductions in the incidence of blood clots during Soliris therapy: for patients with the lowest ...

Long-Term Soliris(R) Therapy Improved or Stabilized Kidney Function in Patients With PNH

... prior to treatment (2.10 vs. 4.22, P<0.001). "PNH is a progressive disease that damages vital organs, increases the risk of dangerous blood clots and can lead to premature death. Chronic kidney disease is a significant concern in these patients because it often goes undetected, and kidney ...

SCH 530348 (TRA), a Novel Investigational Antiplatelet Agent, Shown to Inhibit Platelet Aggregation in PCI Patients

... coronary intervention (PCI). "The inhibition of platelet aggregation plays a critical role in reducing the formation of deleterious blood clots in patients undergoing PCI," said Lisa K. Jennings, Ph.D., FAHA, Professor, Department of Medicine; Director, Vascular Biology Center of Excellence, ...
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(Date:7/11/2014)... increased risk of kidney injury related to the use ... mass of HES molecules, according to a report in ... International Anesthesia Research Society (IARS). , The "total mass ... on cultured human renal proximal tubule cells (PTCs), concludes ... of University Hospital Wrzburg, Austria. Other factorssuch as ...
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