Monitoring Patient Glucose Levels: New Advances in software make it easier
... The data is sent to physicians via the Orange GSM cellular network to a secure server that contains patient files. Doctors in France can then easily check files, and communicate with patients and offer recommendations via SMS text messages.2 Tracking Glucose Trends Glucose meter manufacturers provide innova...Stanford Researchers Find Brain Pathway of Depression in Rats
...duate student and co-firstauthor, searched for the cellular basis of these changes incircuitry. An obvious place to start, she said, was to look at theformation of new neurons in the hippocampus, a process thatneuroscientists have suggested is at the root of howantidepressants work. What they found was that t...Rosetta Genomics and Weizmann Institute Scientists Identify Role of microRNA in Cancer Suppression
...likelihood that miR-34a coulditself play a role in cellular apoptosis, researchers introducedmiR-34a directly into human cancer cell lines to determine itsimpact on tumor cell behavior. The results clearly demonstratedthat overexpression of miR-34a led to increased cancer cell deathas well as promoted other i...Chi-Med Announces Positive Phase II Proof-of-Concept Data for HMPL-004 in Ulcerative Colitis
...h HMPL-004 has shown that HMPL-004acts on multiple cellular targets in the inflammatory signaltransduction pathways resulting in suppressed inflammation cytokineexpression including TNF-?, IL-1? and IL-6. HMPL-004 wasdemonstrated to inhibit TNF-? and IL-1? production in cell-basedassays and is also able to i...Cytokinetics Reports Additional Clinical Trials Data for Ispinesib
...nd, unlike tubulin,appear to have no role in other cellular functions. Cytokinetics believes that drugs that inhibit KSP and CENP-E andother mitotic kinesins may represent the next generation ofanti-mitotic cancer drugs by arresting mitosis and cellproliferation without impacting unrelated, normal cellularfun...... SL, Hanon E, et al. Enhanced humoral and memory B cellular immunity using HPV16/18 L1 VLP vaccine formulated with the MPL/aluminium salt combination (AS04)compared to aluminium salt only. Vaccine 2006 6. Viscidi R, Schiffman M, Hildesheim A, et al. Seroreactivity to Human Papi......ll cyclearrest and cell death by targeting several cellular pathwaysessential for cell survival. Exposure to darinaparsin has a directas well as indirect effect on mitochondrial functions, resulting indepletion of energy supply to the cell and induction of apoptosis(programmed cell death). Increase in intra-c......roblastoma cells called autophagy(the digestion of cellular constituents by enzymes of the samecell), which leads to apoptosis (programmed cell death). Anti-tumoractivity of ONCONASE against drug-sensitive and chemoresistantneuroblastoma xenografts was confirmed in animals. "The data speak to the broad pot......tilizedat FHCRC. Shelly Heimfeld, director of the cellular therapy laboratory atthe Fred Hutchinson Cancer Research Center, commented: "We wereimpressed by how much better the CryoStor patented mediaformulations improved the post-preservation recovery of CD34+ andcolony-forming cells. We will continue our ev...PromegaExpress Expands Easy Access to Products with New Cabinet
...to advancetheir knowledge in genomics, proteomics, cellular analysis,molecular diagnostics and human identification. Founded in 1978,the company is headquartered in Madison, WI, USA with branches in12 countries and 54 global distributors. For more information aboutPromega, visit www.promega.com. Contact Pro...... anddiabetes. The Company is focused on autologous cellular therapyapplications of its proprietary T-cell and stem cell therapies. TheCompany's lead product, Tovaxin(TM), a T-cell therapy for multiplesclerosis is in a Phase IIb trial. The Company holds the exclusiveworldwide license for adult multipotent stem...Neoprobe Phase 2 Lymphoseek Trial Meets Primary Endpoint
...ciences, Inc., is alsoadvancing a patient-specific cellular therapy technology platformcalled ACT. Neoprobe's strategy is to deliver superior growth andshareholder return by maximizing its strong position in gammadetection technologies and diversifying into new, synergisticbiomedical markets through continued...Avalon Pharmaceuticals Announces Positive Interim Results For AVN944 Phase I Trial
...te (GTP), a molecule required forDNA synthesis and cellular signaling. IMPDH is over expressed inmany cancer cells. Pre-clinical studies showed that AVN944 is ahighly specific inhibitor of IMPDH, suppresses pools of GTP, and incultured cells has a selective growth inhibition effect on cancercells vs. normal c...Array BioPharma Reports New Clinical Data on Its Anti-Inflammatory Drugs
...TNF, IL-6 and IL-1.These cytokines can also act as cellular growth factors and areoften up-regulated in certain cancers including prostate, ovarianand multiple myeloma. Additionally, p38 may play a role in certainresistance mechanisms or metastatic progression in cancer. About Array BioPharma: Array BioPhar......ects, and (3) show thatMPC-6827 is not affected by cellular proteins known to be involvedin cancer drug resist...the effect of small moleculedrug candidates on the cellular activity of a protein, enablingresearchers to determine the protein's function. Using thisapproach w...Pluristem's PLX Cells Demonstrate Potential to Treat Parkinson's Disease
...other disorders of the centralnervous system. As a cellular therapy for PD and otherneurodegenerative diseases...pproximate $30 billion therapeutic andregenerative cellular market. The in vitro assay demonstrated that Pluristem's PLX cells canbe differentiated into dopa...Cimzia Effective in Reducing Signs and Symptoms of Rheumatoid Arthritis
... is this region that hasoften been associated with cellular cytotoxicity," commentedProfessor Edward Keystone, Professor of Medicine, University ofToronto, Canada. "The consistency of the RAPID data confirmthat certolizumab pegol may provide a valuable new treatment option forpatients with this condition." T......ecificity for telomerase. The molecule hassuperior cellular and tissue penetration properties due to itsproprietary manufacturing chemistry and its 5' lipid chain. GRN163L has been demonstrated to have anti-tumor effects in awide range of hematological and solid tumor models and appears tobe unique in its ob......ents (SALAs). Flurizan lowered levels ofAbeta42 in cellular assays and animal models. Abeta42 is theprimary constituent of senile plaque that accumulates in the brainof patients with Alzheimer's disease. It is thought to be the keyinitiator of Alzheimer's disease, since Abeta42 has the greatesttendency to agg......monstrated that SNS-032 has greater selectivityand cellular potency to other CDK-targeting agents, such asflavopiridol and seliciclib. SNS-032 was analyzed againstflavopiridol in a cancer cell line in bovine and human serum toassess mechanism of action and target modulation. SNS-032 wasobserved to be a more p...Lexicon Pharmaceuticals and Fox Chase Publish Findings on Immune Deficiency
...comprise the large subunitof eukaryotic ribosomes, cellular complexes that are responsiblefor translating messenger RNA and assembling proteins. Althoughnot-required for translation, Rpl22 may play a role in proteinsynthesis or macromolecular assembly that is important for somecell types, but not others. "Th......sesbrief, controlled electrical pulses to increase cellular uptake ofa useful biopharmaceutical. In the case of DNA vaccines, Inovio'stechnology has shown it can significantly increase levels of geneexpression and immune response. Inovio's immunotherapy partnersinclude Merck, Wyeth, Vical, University of South......site-specific antigen notonly enhanced humoral and cellular immune responses, but moreimportantly caused a sig...sesbrief, controlled electrical pulses to increase cellular uptake ofa useful biopharmaceutical. In the case of DNA vaccines, Inovio'stechnology has shown it ca...Extensive Clinical Data on Erbitux Presented at the 2007 ASCO Annual Meeting
...gGI monoclonalantibody, induces antibody-dependent cellular cytotoxicity (ADCC)in contrast to the lack of such activity in IgG2 monoclonalantibodies. -- Erbitux plus radiation is currently a standard of care forpatients with locally advanced Head and Neck cancer. The EasternCooperative Oncology Group reporte...Phase I Results for ImClone Pipeline Anti-IGF-1R Monoclonal Antibody IMC-A12 Presented at ASCO
...In vitro, IgG1 antibodies elicitantibody-dependent cellular cytotoxicity (ADCC), which can killcancer cells an...tion of IgG1 monoclonalantibodies targeted against cellular pathways that are emerging ascritical drivers of cancer growth, proliferation, and survival,"said Er...Infinity and MedImmune Present Updated Phase I Results of IPI-504 in GIST at ASCO Annual Meeting
...n the majority of GIST cases,specific mutations in cellular signaling enzymes ("kinases") calledKIT or PDGFRA cause the growth and survival signal of the cell tobecome permanently active, leading to cancer. Both KIT and PDGFRAare client proteins of Hsp90, suggesting that inhibition of Hsp90in GIST is an attra...Stanford Researchers Track Human Stem Cells Transplanted Into Rat Brain
...scule particles of iron insidestem cells to act as cellular beacons detected by magneticresonance imaging. With the ability to monitor where the human stemcells go in real time, researchers will have an easier timelearning the best way of using the cells to treat human neuraldisorders, such as stroke, traumat...Diatos Announces Positive Clinical Results for its DTS-201 Doxorubicin Prodrug Program
... coupling of a tetrapeptidicsequence that prevents cellular uptake. DTS-201 is stable in bloodbut cleavable by some specific peptidases present in the tumorenvironment. Preclinical studies have demonstrated that DTS-201 wasless toxic in rodents and dogs than free doxorubicin andsignificantly more effective in...Infinity and MedImmune Announce Updated Data On Ipi-504 to be Presented At ASCO
...n the majority of GIST cases,specific mutations in cellular signaling enzymes ("kinases") calledKIT or PDGFRA cause the growth and survival signal of the cell tobecome permanently active, leading to cancer. Both KIT and PDGFRAare client proteins of Hsp90, suggesting that inhibition of Hsp90in GIST is an attra......sesbrief, controlled electrical pulses to increase cellular uptake ofa useful biopharmaceutical and, in the case of DNA-basedtreatments, levels of gene expression. Inovio's immunotherapypartners include Merck, Wyeth, Vical, University of Southampton,Moffitt Cancer Center, and the U.S. Army, with four DNA-base...Inovio: DNA delivery technology shows positive human results
...tory Agency,is assessing safety, tolerability, and cellular (T-cell) andhumoral (antibody) immune responses to...ses brief, controlledelectrical pulses to increase cellular uptake of a usefulbiopharmaceutical and, in the case of DNA-based treatments, levelsof gene expressi...Dendreon Announces Presentation of Data at American Urological Association Annual Meeting
...sis conducted to assess theinfluence of the active cellular immunotherapy PROVENGE on theclinical outcome of p..., engineering and cellprocessing to produce active cellular immunotherapy productcandidates designed to stimulate an immune response. Activecellular immunothera...Inovio Biomedical's Partners to Present New Data from Two Cancer Immunotherapy Clinical Trials
...rief, controlledelectrical pulses to increase both cellular uptake of a usefulbiopharmaceutical and, in the case of gene-based treatments, levelsof gene expression. Inovio's technology is protected by anextensive patent portfolio covering in vivo electroporation. Moreinformation is available at www.inovio.com......cid that hasbeen used in topical applications. The cellular receptor andtransporter for EGT, OCTN-1 has recently been identified and isresponsible for the intracellular accumulation of this naturallyoccurring antioxidant. However, there have been questions of therole of EGT and its receptor/transport, OCTN-1.......de photodamage, finelines and wrinkles. Natural cellular repair of the oxidative damage entails completeremoval of 8-oxo-G from DNA via the enzyme OGGI. For the test, OOGIencapsulated in liposomes showed that the delivery of this enzymeinto fibroblasts increases the rate of repair of 8-oxo-G, andreduces mi...Pacgen Announces Positive Results from Phase I/II Trial of Novel Antifungal Drug
...iation therapy to the head and neck,and those with cellular immune deficiency states, such as HIV andAIDS. Patients with xerostomia and those treated with inhaledcorticosteroids for asthma or rhinitis are also at risk.Oropharyngeal candidiasis infection can cause great discomfort, andif not treated, can sprea...Pluristem to Present Two Scientific Posters at the International Society for Cellular Therapy
...siness colleagues, all working orinterested in the cellular therapy sector." About Pluristem Pluristem Life ...pproximate $30 billion therapeutic andregenerative cellular market. Factors that could prevent ourforward looking statements from being achieved include that we......he EGF receptors,which, in turn, triggers internal cellular signals that stimulatetumor cell growth. Vectibix binds to EGF receptors, preventing thenatural ligands such as EGF and TGF-alpha from binding to thereceptors and interfering with the signals that might otherwisestimulate growth and survival of the c...Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer
...rf2, which activates the phase 2 genes and reduces cellular levelsof reactive oxygen and nitrogen species. In addition, thetriterpenoids directly regulate activation of NF-kB by binding toIKKB, the kinase that inhibits NF-kB activation. The triterpenoidsblock the activation of STAT3 and STAT5 in cancer cells ......edfrom DNA. These processes are critical to proper cellular functionand provide an opportunity for therapeutic...as previouslyabsent, to be delivered to the proper cellular location, and toinduce restoration of muscle function. In addition to the studiesdescribed in the Na...Mode of Action of EpiCept-Licensed Cancer Compound Profiled at AACR
...the effect of small moleculedrug candidates on the cellular activity of a protein, enablingresearchers to determine the protein's function. Using thisapproach with its proprietary caspase-3 screening technology,EpiCept researchers can focus their investigation on the cellularactivity of small molecule drug ca...ImClone Systems Showcases Extensive Research and Development Program at the AACR Annual Meeting
...In vitro, IgG1antibodies elicit antibody-dependent cellular cytotoxicity (ADCC),which can kill cancer cells an...tion of IgG1 monoclonalantibodies targeted against cellular pathways that are emerging ascritical drivers of cancer growth, proliferation, and survival,"said Er......tor, PCI-24781 inhibits homologousrecombination, a cellular mechanism of DNA repair, by bothdown-regulating RAD51 gene expression, and by affecting the abilityof the cell to form RAD51 foci at the site of the lesion. The RAD51gene provides instructions for making a protein that is essentialfor the repair of d...ZIOPHARM Presents Data Highlighting Oral ZIO-101 at AACR
...ll cycle arrest and celldeath by targeting several cellular pathways essential for cellsurvival. Exposure to ZIO-101 has a direct as well as indirecteffect on mitochondrial functions, resulting in depletion of energysupply to the cell and induction of apoptosis (programmed celldeath). Increase in intra-cellul......c elementsin addition to carrying out more routine cellular tasks essentialto development and growth. In mammalian cells siRNAs have beenshown to be the most effective tools for RNAi, allowing for thedevelopment of clean and easily regulated methods for disruption ofgene expression. siRNA technology allows fo...EntreMed Presents Multi-Mechanism Antitumor Data for ENMD-1420 in Preclinical Models
... form microtubules, which are keycomponents of the cellular cytoskeleton (structural network).Microtubules are necessary for cell division (mitosis), cellstructure, transport, signaling and motility. Given their primaryrole in cell division, microtubules have been an important targetfor anticancer drugs -- of......n the communication and relay of signals topromote cellular growth and function. CDK2 is involved in cellularproliferation by regulating the initiation of and progressionthrough the DNA-synthesis phase of the cell cycle. CDK7 and CDK9are involved in transcriptional regulation of certain proteinsinvolved in ce...Novelos Therapeutics and MUSC Present Two Posters at AACR 2007 Annual Meeting
...ue toadd to our understanding of its molecular and cellular mechanismsof action as they may relate to therapeutic activity," saidChristopher Pazoles, Ph.D., Vice President of Research &Development of Novelos. "Our ongoing and broad-ranging researchcollaboration with Drs. Tew and Townsend at MUSC is an imp......ighly-selective PI3Kinhibition as well as improved cellular efficacy and betterdrug-like properties, were iden...ies targeting theinhibition of PI3K and functional cellular assays of tumor cellproliferation have been performed. In addition, physicochemical andinitial ADMET......ases ATM/ATR and DNA-PK are involved inthe general cellular response to DNA damage by signaling proteinsthat control cell cycle, apoptosis and DNA repair. In particular,ATM and DNA-PK both phosphorylate the H2AX, an isoform of thehistone H2A, after exposure to ionizing radiation. The appearanceof the phosphor...Fragile X, Down Syndromes Linked to Faulty Brain Communication, Stanford Researcher Finds
... Madison,PhD, associate professor of molecular and cellular physiology."It's as if you had every light in your house wired to just one ortwo switches, rather than having many switches that can be flippedon or off in complex combinations to control the lighting in oneroom," he said. Madison is the senior auth......nce release ofapoptosis-inducing factor (AIF) from cellular mitochondria, and theauthors suggest that this is the mechanism of Atiprimod's apoptotic(programmed cellular death) activity. Atiprimod is an orally bio-available small molecule drug thatdisplays multiple m...Infinity and MedImmune to Present Preclinical Data From Study of Oral Formulation of IPI-504 At AACR
... specific mutations havebeen identified in EGFR, a cellular signaling enzyme. Thesemutations allow the survival signal of the mutated cancer cell tobe switched "on" all the time. NSCLC patients with mutations inEGFR have been found to benefit from drugs such as Tarceva(r) andIressa(r) that block EGFR signalin...Cytokinetics Announces Non-clinical Data to be Presented at the 2007 AACR Annual Meeting
...and cellproliferation, but also in other important cellular functions.Inhibition of these other cellular functions produces dose-limiting toxicities such as peripheral neuropathy, an impairment ofperiphera...CytRx Announces Positive Results of Arimoclomol in Preclinical Stroke Recovery Studies
...mol is believed to function by stimulating anormal cellular protein repair pathway through the activation of"molecular chaperones." Since damaged proteins called aggregatesare thought to play a role in many diseases, CytRx believes thatactivation of molecular chaperones could have therapeutic efficacyfor a br...Calando Pharmaceuticals Publishes Study Showing Anti-Cancer Effect with Lead RNAi Candidate
...iginal articles describingclinical research on the cellular and molecular characterization,prevention, diagnosis, and therapy of human cancer. Its focus is oninnovative clinical research and translational research whichbridges the laboratory and the clinic. Clinical Cancer Research isespecially interested in ...... anddiabetes. The Company is focused on autologous cellular therapyapplications of its proprietary T-cell and stem cell therapies. TheCompany's lead product, Tovaxin(TM), a T-cell therapy for multiplesclerosis is in Phase IIb trials. The Company holds the exclusiveworldwide license for adult multipotent stem ...Curecumin May Be an Effective Treatment for Lung Cancer
...ti-cancer activities... This study investigatedthe cellular and molecular changes induced by curcumin leading tothe induction of apoptosis in human lung cancer cell lines -- A549and H1299... Curcumin inhibited the growth of both the cell linesin a concentration dependent manner... Curcumin induced apoptosisin...EntreMed Presents Mechanism Data for Its Three Lead Oncology Compounds
...re and areessential for maintenance of cell shape, cellular functions andcell division (growth). These highly dynamic filaments are composedof dimeric tubulin proteins. Microtubule targeting drugs are one ofthe most successful classes of chemotherapy agents and are used forboth solid and liquid tumors. There ...Inovio Biomedical's DNA Delivery Technology Significantly Enhances Potency of HIV DNA Vaccine
...tincrease in both the breadth and magnitude of the cellular immuneresponse to selected HIV antigens. This is t... example,DNA vaccines may be better in stimulating cellular immunitynecessary to fight chronic infection or diseases such as cancer.Despite this promise, vaccin...