Cellular in Medical Technology

Injection Reverses Heart-Attack Damage

... the researchers also stimulated production of a cellular receptor for NRG1, known as ErbB4, cardiomyocyte ... reveals how both periostin and NRG1 work at the cellular and molecular level, an essential step in ... Both compounds ultimately act on the same cellular pathway, Kuhn found. "We applied ...

Data Presented at AUA Demonstrate PROVENGE Significantly Prolongs Survival for Men With Advanced Prostate Cancer in Pivotal Phase 3 IMPACT Study

... Percent Compared to Placebo - - First Active cellular Immunotherapy for Cancer to Prolong Survival - ... and represents the first in a new class of active cellular immunotherapies (ACI) specifically designed to ... validate the potential of our pipeline of active cellular immunotherapy product candidates that may help ...

Genes Identified That Enhance Tumor Cell Sensitivity to CTI's Cancer Drug Brostallicin

... double helix. To identify genes associated with cellular response to brostallicin, a high-throughput RNA ... ovarian cancer cell lines. RNA interference is a cellular process that results in the targeted knockdown of ... of vulnerability to brostallicin, converged on cellular concepts relating to DNA repair and chromosome ...

Dendreon Presents Integrated Analysis of Clinical Data from NEUVENGE Trials at Chemotherapy Foundation Symposium

... an investigational active cellular immunotherapy, at the Chemotherapy Foundation ... further evidence of the promise of our active cellular immunotherapy platform which also includes ... investigational product in a new class of active cellular immunotherapies (ACIs) that are uniquely designed ...

Wild Blueberries Take Top Spot in New Antioxidant Research Study

... University Food Scientists Expand Testing Using cellular Antioxidant Activity Assay ... and strawberries in an expanded test using the cellular Antioxidant Activity (CAA) assay. New ... shows that Wild Blueberries have the highest cellular antioxidant activity of the 25 fruits tested, as ...

Seahorse Bioscience Announces the XF96 Extracellular Flux Analyzer for Cellular Bioenergetics

... For the past 75 years tools for measuring cellular bioenergetics have been relatively unchanged ... greatly expanding our ability to investigate cellular bioenergetics." "Seahorse provides a ... of RNAi knockdown of mitochondrial genes on cellular bioenergetics," added Vamsi Mootha, from the ...

Dendreon Announces Interim Data From Phase 3 PROVENGE IMPACT Trial

... safety and efficacy of the investigational active cellular immunotherapy PROVENGE(R) (sipuleucel-T) in men ... reported in our previous trials). About Active cellular Immunotherapy with PROVENGE PROVENGE may ... engineering and cell processing to produce active cellular immunotherapy product candidates designed to ...

Idenix Pharmaceuticals Advances HCV Discovery Program to Clinic

... HCV genotype 1a and 1b polymerases. Additionally, cellular cytotoxicity testing in Huh-7 cells demonstrated ... in vitro studies, IDX375 did not inhibit human cellular DNA polymerases alpha, beta and gamma (IC50 >100 ... and demonstrating no activity against eight human cellular proteases. Both drug candidates appear to have ...

Dendreon Expects Interim Data Analysis for Phase 3 PROVENGE IMPACT Trial in October

... PROVENGE is the Company's investigational active cellular immunotherapy for the treatment of advanced ... metastatic prostate cancer. About Active cellular Immunotherapy with PROVENGE PROVENGE may ... engineering and cell processing to produce active cellular immunotherapy product candidates designed to ...

VIRxSYS to Host a Web Conference to Announce Clinical Trial Update

... to direct CD4 T cell traffic to GALT and enhance cellular interaction through forming synapses between T ... delivered antigens that induced long-lasting cellular and humoral immune responses, better than those ... of CD4 T cells that ensues. Activation of both cellular and humoral immunity can also halt the slow ...

University of Miami Team Confirms Value of Monitoring Cell-Mediated Immunity Pre- and Post-Transplant in Management of Kidney Transplant Recipients

... rejection. Several patients showed evidence of cellular (n = 8) or humoral (n = 2) rejection while under monitoring. The patients demonstrating cellular rejection all had increases in CMI > 200 ng ... are predictive of either infection or onset of cellular transplant rejection." The clinical research ...

Gene Therapy Improves Vision in Patients with Congenital Retinal Disease

... The current study is sponsored by the Center for cellular and Molecular Therapeutics at The Children's ... was manufactured at the hospital's Center for cellular and Molecular Therapeutics (CCMT). Starting ... http://www.chop.edu . About the Center for cellular and Molecular Therapeutics at The Children's ...

Cardium's Innercool Therapies Unit Announces Publication of Positive Effects of Early and Rapid Hypothermia Following Heart Attack

... oxygen within cells that damages cellular proteins, DNA, and the cell's plasma membrane. ... of biochemical events that lead to a variety of cellular changes, including cell shrinkage, ... events, by lowering metabolism and preserving cellular energy stores, thereby potentially ...

Dendreon Presents Data Correlating the Cumulative Potency of PROVENGE(R) to Overall Survival

... (sipuleucel-T), an investigational active cellular immunotherapy for hormone-refractory prostate ... metastatic prostate cancer. About Active cellular Immunotherapy with PROVENGE PROVENGE may ... and cell processing to produce active cellular immunotherapy product candidates designed to ...

New Clinical Studies Confirm Mauna Kea Technologies' Cellvizio(R) GI in Range of Procedures

... (MKT), the leader in the field of in vivo cellular imaging, announced that leading ... to evaluate the entire small bowel at the cellular level without the need for taking biopsy ... be introduced in all patients, and imaging of the cellular structures of the bile duct epithelium was ...

Dendreon Completes Target Enrollment of 500 Patients in Phase 3 IMPACT Study of Provenge(R) For Advanced Prostate Cancer

... the Company's investigational active cellular immunotherapy for the treatment of advanced ... advanced, metastatic prostate cancer. Active cellular Immunotherapy with PROVENGE PROVENGE may ... and cell processing to produce active cellular immunotherapy product candidates designed to ...

Interim Safety Data Favorable for Vical's Phase 2 Trial of DNA Vaccine Against CMV

... attenuated viruses can induce both antibody and cellular immune responses, but pose a potential safety ... is designed to induce both antibody and cellular immune responses against specific features of the ... whether the vaccine will induce both antibody and cellular immune responses; whether the vaccine ...

Dendreon Announces Publication of Phase 1 Study Highlighting Immunologic and Clinical Activity of Lapuleucel-T (Neuvenge(R)) in Advanced Breast Cancer Patients

... 1 study of NEUVENGE, an investigational active cellular immunotherapy, in the August 20 issue of the ... further substantiate the promise of active cellular immunotherapies as new treatments for ... investigational product in a new class of active cellular immunotherapies (ACIs) that are uniquely designed ...

Cordex Signs European Development Partnership for ATPotent(TM) Sperm Motility Drug

... found in every cell of the human body where it plays a critical role in cellular metabolism and constitutes the source of energy for all bodily functions. ... (ATP) and nitric oxide (NO). These two molecules play critical roles in cellular metabolism and signal transduction, the manipulation of which constitute ...

Living Donor Kidney Transplants Using Alemtuzumab Pre-Conditioning and Tacrolimus Monotherapy: Long-Term Safety and Efficacy

... and 57.6 (+/-24.6), respectively. The cumulative incidence of acute cellular rejection (ACR) at 1, 3, 6, 12, 18, 24, 30, 36, 42, and 48 months were ... ImmuKnow is a noninvasive biomarker of immune function that assesses cellular immune status by detecting cell-mediated immunity (CMI) in adult ...

Theranostics Health Announces Involvement with Major Academic Medical Center in Study Funded by Susan G. Komen for the Cure(R)

... are developed to both preserve cell morphology and fix the state of cellular activities for molecular analysis. LCM is used to isolate specific cell ... RPMA enables sensitive, quantitative, calibrated, multiplexed analysis of cellular proteins from a limited amount of starting materials, such as clinical ...

Pivotal Clinical Data Published for the Only Laser Phototherapy Device Cleared by the FDA for Hair Growth

... to increase the biological molecule ATP which in turn increases cellular metabolism and cellular activity. The hair follicle then has the building blocks and energy to ...

Dendreon to Hold a Conference Call Tomorrow at 9:00 AM ET to Discuss Final Results of Phase 3 PROVENGE IMPACT Trial

... trial of PROVENGE(R) (sipuleucel-T), the Company's investigational active cellular immunotherapy for the treatment of advanced prostate cancer. Those ... antigen identification, engineering and cell processing to produce active cellular immunotherapy product candidates designed to stimulate an immune response. ...

Key Protein May Lead to Faster Acting Anti-Depression Drugs

... even months required by current drugs. This study, Role of p11 in cellular and Behavior Effects of 5-HT4 Receptor Stimulation , solidifies the ... faster-acting antidepressants," says Greengard. "An understanding of the cellular mechanisms underlying the therapeutic actions of these drugs may lead to ...

Cloned Human Embryos Successfully Reprogrammed Using Human - But Not Animal - Eggs

... Officer at ACT, and senior author of the study. "At the center of cellular reprogramming lies the activation of the transcription factors Oct4, Sox2, ... Advanced Cell Technology, Inc. is a biotechnology company applying cellular technology in the field of regenerative medicine. For more information, ...

Medarex Announces Enhanced Activity Data with Second Generation Anti-CD30 Antibody for Malignant Lymphoma

... MDX-1401 in in vivo xenograft models indicates enhanced antibody-dependent cellular cytotoxicity (ADCC) activity, an important mechanism of action of ... of the MDX-060 antibody and is enhanced for greater antibody-dependent cellular cytotoxicity (ADCC) activity, an important function of the human immune ...

Vical Completes Enrollment and Reports Positive Interim Data in CMV Vaccine Phase 2 Trial

... approaches using live, attenuated viruses can induce both antibody and cellular immune responses, but pose a potential safety concern, particularly for ... Vical's novel DNA vaccine approach is designed to induce both antibody and cellular immune responses against specific features of the CMV virus without the ...

Dendreon to Hold a Conference Call Today at 9:00 AM ET to Provide an Update on Interim Results of Phase 3 PROVENGE IMPACT Trial

... trial of PROVENGE(R) (sipuleucel-T), the Company's investigational active cellular immunotherapy for the treatment of advanced prostate cancer. Those ... antigen identification, engineering and cell processing to produce active cellular immunotherapy product candidates designed to stimulate an immune response. ...

Novel Photoconductive Life Science Research Innovation Enables Rapid, Reproducible, and Non-Invasive Cellular Excitation

... researchers with the means to dynamically study excitation dependent cellular responses without the requirement for a direct physical link to the cell ... cells will serve to further our understanding of the mechanisms underlying cellular structure/function relationships. Additionally, it will enable scientists ...

Diffusion Pharmaceuticals Announces Initiation of a Phase I/II Clinical Trial in Patients with Peripheral Arterial Disease (PAD)

... also help demonstrate TSC's potential to treat other diseases related to cellular oxygen deprivation," says David G. Kalergis, JD/MBA, Chief Executive ... of conditions characterized by oxygen deprivation (hypoxia) at the cellular level. Using a novel mechanism of action, TSC enhances the diffusion of ...

Dendreon Initiates Phase 2 Trial of PROVENGE in Patients With Localized Prostate Cancer Prior to Surgery

... for men with advanced, metastatic prostate cancer. About Active cellular Immunotherapy with PROVENGE PROVENGE may represent the first product in ... antigen identification, engineering and cell processing to produce active cellular immunotherapy product candidates designed to stimulate an immune response. ...

Promise of Vical's CMV Vaccine Noted by Independent Experts

... approaches using live, attenuated viruses can induce both antibody and cellular immune responses, but pose a potential safety concern, particularly for ... Vical's novel DNA vaccine approach is designed to induce both antibody and cellular immune responses against specific features of the CMV virus without the ...

New Data Offers Insights Into the Potential Role for TYKERB(R) (Lapatinib) in Non-Cytotoxic Chemotherapy-Based Treatment Regimens

... Oncology (ASCO) meeting in Chicago, May 30 - June 3, 2008. Multiple cellular pathways influence the growth and metastatic potential of tumors, which is ... and survival in breast carcinoma: A 15-year follow-up study. Journal of cellular Physiology. 2005; 206;702-708. (7) McMahon G. VEGF receptor signaling in ...

CellCyte Genetics Signs Collaborative Agreement With Northwestern University's Feinberg School of Medicine to Perform Disease Model Outcome Study of CellCyte's CCG-TH30 Product Candidate

... is dedicated to pursuing an understanding of the fundamental molecular and cellular processes underlying cardiovascular disease, the largest contributor to ... complex problems in modern cardiovascular research, including basic cellular signaling pathways and their contributions to disease, the use of stem ...

Dendreon Presents Preclinical Data Demonstrating Activity of Trp-p8 agonist, D-3263, in Benign Prostatic Hyperplasia

... antigen identification, engineering and cell processing to produce active cellular immunotherapy product candidates designed to stimulate an immune response. Active cellular immunotherapy holds promise because it may provide patients with a ...

Biomoda to Present Paper on Enhanced Technology for Early Detection of Lung Cancer at Annual SWARM Meeting

... "New Non-Invasive Technology for the Early Detection of Cancer at the cellular Level" at the 83rd Annual Multidisciplinary Meeting of the American ... in in-vitro diagnostics for non-invasive testing for cancer at the cellular level." Biomoda is seeking international partners interested in ...

VIRxSYS Presents Data on HIV Vaccine at Keystone HIV Vaccine Symposia

... seen significant long term response against HIV proteins both in terms of cellular immunity, which is mediated by T Lymphocytes, and humoral immunity, which ... In small animals, the VRX1023 lentivector has induced long-lasting cellular and humoral response against HIV. Using a DNA prime/vector boost strategy, ...

Nventa Enrolls and Initiates Dosing of Final Cohort in HspE7 Phase 1 Cervical Dysplasia Trial

... and are being evaluated for cytokine responses, anti-HspE7 antibodies and cellular (T-cell) immunology. Affiliations and investigators in this trial ... to covalently fuse stress proteins to target antigens, thereby stimulating cellular immune system responses. Nventa is developing new HspE7 for multiple ...

Nventa Evaluation Complete for First Three Cohorts in HspE7 Phase 1 Cervical Dysplasia Trial

... and are being evaluated for cytokine responses, anti-HspE7 antibodies and cellular (T-cell) immunology. The trial is expected to dose up to 5 cohorts ... to covalently fuse stress proteins to target antigens, thereby stimulating cellular immune system responses. Nventa is developing HspE7 + Poly-ICLC for ...

VioQuest Pharmaceuticals Announces Dosing of First Patient in Phase IIa Solid Tumor Study for Lenocta(TM), a Novel Protein Tyrosine Phosphatase Inhibitor

... targets. The PTPases SHP-1 and SHP-2 modulate progenitor cell development, cellular growth, tissue inflammation, cellular chemotaxis, and directly control cell survival involving oxidative stress ...