Cells in Medical Technology

Amgen Announces Positive Top-Line Results for Denosumab in Trial for Delay of Skeletal Related Events in Bone Metastases Patients Compared to Zometa(R)

... cancer spreads to the bone, the growing cancer cells weaken and destroy the bone around the tumor. ... the essential regulator of osteoclasts (the cells that break down bone). With more than 19,000 ... Impact and Prevalence Bone metastases, cancer cells that separate from tumors and migrate to bone ...

British Woman Celebrates a Year of Living Cancer-Free

... of tumor-activated natural killer (TaNK) cells as a treatment for leukemia. Her doctors ... failed, sparking hope among oncologists that TaNK cells could be the key to a new type of advanced cancer ... Free injected Ms. Scott with natural killer (NK) cells taken from her daughter, Tara, who was 21 at the ...

Study Shows Cancer Vaccines Led to Long-Term Survival for Patients with Metastatic Melanoma and to Long Periods of Disease Control After Completion of Therapy

... cancer vaccines derived from patients' own cancer cells and immune cells were well tolerated and resulted in impressive ... The study entitled "Phase II Trial of Dendritic cells Loaded with Antigens from Self-Renewing, ...

Unlikely Treatment Identified by BrainCells Neurogenesis Platform Improved Clinical Outcomes in Patients Suffering From Depression

... is the process by which pre-existing stem cells in the hippocampus of the adult brain produce new ... that the brain's ability to grow new brain cells may have an impact on depression, and we now know ... is the process by which endogenous stem cells in the adult human brain produce new brain ...

Cryo-Cell Announces C'elle(SM) Research and Development Collaboration with Cryopraxis Cryobiology Ltd.

... "This research will determine if the stem cells found in menstrual blood can accurately provide a ... Cryopraxis will also utilize C'elle stem cells to develop potential therapies for female stress ... in the muscles that affect urine flow. Since stem cells isolated from menstrual fluid have the ability to ...

Correction to Earlier Release From Jewish Hospital and University of Louisville

... In today's announcement regarding the use of stem cells in the treatment of heart failure, we failed to ... trial using "c-kit-positive" adult cardiac stem cells to treat heart disease. The clinical trial is ... cells: the c-kit-positive cardiac stem cells are self-renewing, clonogenic and multipotent, ...

World's First Cardiac Adult Stem Cell Patient Receives Infusion

... the world's first recipient of adult cardiac stem cells to treat congestive heart failure. Jones' ... clinical trial using adult cardiac stem cells to treat heart disease. The clinical trial is ... was directly injected with his own cardiac stem cells into heart scar tissue using a minimally-invasive ...

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

... nuclear transfer (cloning) or embryonic stem cells and allows rapid creation of new animal models." ... genes in fruit flies, worms, cultured human cells and zebrafish embryos and are now in human ... to the challenge of making gene knockouts in cells and in whole organisms. We believe that this ...

Injection Reverses Heart-Attack Damage

... heart function without need for cardiac stem cells BOSTON, July 23 ... heart attack. After birth, heart-muscle cells (cardiomyocytes) normally withdraw from the cell ... based strategies, our work suggests that stem cells aren't required and that stimulating ...

Denosumab Demonstrates Superiority Over Zometa(R) in Pivotal Phase 3 Head-to-Head Trial in Breast Cancer Patients With Bone Metastases

... cancer spreads to the bone, the growing cancer cells weaken and destroy the bone around the tumor. ... the essential regulator of osteoclasts (the cells that break down bone). With more than 19,000 ... Impact and Prevalence Bone metastases, cancer cells that separate from tumors and migrate to bone ...

Leading Experts Endorse Bioheart's Muscle Stem Cell MyoCell Therapy

... tissue (not living tissue) has shown that the cells survive, engraft and form new muscle and they do ... tissue within a patient's heart with new living cells for the purpose of improving cardiac function in ... MyoCell(R) SDF-1, a therapy utilizing autologous cells that are genetically modified to express ...

Amicus Therapeutics Commences Phase 3 Trial Evaluating Amigal(TM) for the Treatment of Fabry Disease

... GL-3, the substrate that accumulates in the cells of Fabry patients. In addition, the FDA is in ... enzyme (a-Gal A), as measured in white blood cells and in the kidney, and reduced levels of the ... as measured in renal interstitial capillary cells from kidney biopsies and in urine. About ...

Urologist and Allergist Explore Link Between Allergies and Interstitial Cystitis

... and sending it to a pathologist to look for mast cells because, when mast cells reach a certain density, patients seem to benefit from allergy testing and treatment. Mast cells elsewhere in the body are key players in allergic ...

Alfacell Provides Shareholder Update

... function may allow more drug to come into the cells and cause death of the cancer. Another major ... as nfkB is also known to be elevated when normal cells turn into mesothelioma cells, and high levels of ... in the laboratory and clinic to target cancer cells while sparing normal cells. ONCONASE triggers ...

Cancer Treatment Centers of America(R) Studies Treatment That Aims Chemotherapy Directly at Ovarian Cancer Cells

... Therapy targets folate receptors found on cancer cells otherwise resistant to standard chemo ZION, ... a treatment designed to target ovarian cancer cells otherwise resistant to standard chemotherapy. ... a powerful chemotherapy drug directly to cancer cells while sparing the healthy cells," says Dr. ...

HEALTHPOINT-Sponsored Venous Leg Ulcer Clinical Trial Enrolls First Subject for Second Phase II Study

... Trial to Test Unique Delivery System Using Living cells to Enhance Wound Healing Marks Milestone for Fort ... wound healing by using metabolically active donor cells to support the patient's own skin cells' healing ... utilizes allogeneic cells, which are living human cells derived from an individual donor that are ...

MacroGenics and Lilly Achieve Targeted Patient Enrollment in PROTEGE, a Global Phase 2/3 Clinical Trial of Teplizumab in Type 1 Diabetes

... the destruction of the insulin-producing beta cells of the islets of the pancreas. Teplizumab binds ... of the CD3-epsilon chain expressed on mature T cells and by doing so, may modulate the immunologic ... and has the ability to preserve or protect beta cells of the pancreas, patients may require less ...

UPCI Joins ExCell Research Study Using Stem Cells for Leukemia and Lymphoma Patients

... StemEx is a graft of expanded stem/progenitor cells taken from a single unit of umbilical cord blood ... transplanted in combination with non-expanded cells from the same unit. "I am extremely ... Program. "Using umbilical cord blood stem cells instead of a traditional bone marrow transplant ...

ThermoGenesis Announces National Institute of Health Grant

... that can be used to deploy placental stem cells in bone repair and regenerative medicine ... to identify the best methods of combining stem cells with biomaterials," noted Mel Engle, Chief ... Res-Q(TM) cell separation technologies as well as cells derived from the placenta. The goal of this ...

Tolerx Presents Data at 69th Scientific Sessions of the American Diabetes Association

... attacks and destroys the insulin-producing beta cells in the pancreas. As a result of the decrease in ... with type 1 diabetes who have residual beta cells by blocking the function of effector T cells that mistakenly attack and destroy ...

Micromet's Blinatumomab Achieves Primary Endpoint in Phase 2 Study with Acute Lymphoblastic Leukemia Patients

... therapeutic antibody that activates a patient's T cells to seek out and destroy cancer cells. The ... but retained a detectable level of ALL cancer cells in their bone marrow -- so called minimal ... is defined as the elimination of ALL cancer cells in patients with MRD below the limit of ....

Three Surgeons in East Texas Are Successfully Integrating a Novel Stem Cell Procedure for Spine Surgeries

... their industry by utilizing concentrated stem cells for spine surgery. The innovative technique is ... harnesses the healing potential of adult stem cells from a patient's own body. During surgeries for ... by an FDA-approved device and the living cells are delivered back to the surgeon in a ...

CEL SCI Collaborators Demonstrate Novel L.E.A.P.S. Vaccines Immunize Mice Against Tuberculosis Antigens and Suggest Potential to Treat Swine and Other Influenzas

... presented data that showed that blood cells from immunized mice produced gamma interferon in response to the vaccine, while the blood cells from mice in the various control groups did not. ... at the Microbiology Conference that mouse blood cells taken from L.E.A.P.S. TB immunized mice made ...

PROTECT-1 Phase II/III Induction-Stage Results for ChemoCentryx's Traficet-EN(TM) Presented in Oral Session at DDW 2009 Conference

... which is selectively expressed by inflammatory T cells to migrate to the digestive tract in a process ... CCR9 is a highly specific receptor expressed by T cells that migrate selectively to the digestive tract. The trafficking of T cells to the small and large intestine causes ...

In Rare Disorder, a Familiar Protein Disrupts Gene Function

... in biology has been, "What does cohesin do when cells are not dividing?" His team's paper provides part of the answer, as the first study in human cells to identify genes that are dysregulated when ... lines from 16 patients with severe CdLS. All the cells had mutations in the NIPBL gene, which plays a ...

Fate Therapeutics Announces First Patient Treated in Phase 1b Clinical Trial of FT1050 for Hematopoietic Stem Cell Support

... molecules and biologics that modulate adult stem cells within the body for regenerative medicine," said ... in our approach - using a small molecule to treat cells ex vivo but creating an in vivo regenerative ... and biologics that seek to modulate adult stem cells within the body to guide a desired outcome such ...

Bethesda-Based NHSi Wins $2M Grant for Blood Technology

... to deliver oxygen and more deformable red blood cells for better capillary perfusion, and extend by 50 ... device to evaluate the quality of red blood cells stored for transfusion. Red blood cells' ... evaluates the "fitness" of stored red blood cells by passing it through an artificial capillary ...

Mutant Genes in High-Risk Childhood Leukemias Identified

... previous genetic analysis of the leukemic cells from pediatric ALL patients. "The findings ... the uncontrolled proliferation of white blood cells that is seen in leukemia." Thus, the ... white blood cells. The team analyzed the leukemic cells from 187 patients with high-risk ALL. That ...

Agennix Receives Fast Track Designation From FDA for Talactoferrin in Combination With Sunitinib for Renal Cell Carcinoma

... its anti-cancer activity by targeting dendritic cells which play an important role in activating innate ... induces the recruitment of immature dendritic cells to the GALT and promotes their maturation. This ... its function results in recruitment of dendritic cells that have captured tumor antigens while in the ...

Novel Vaccine Approach Offers Hope in Fight Against HIV

... immune system to produce antibodies or killer cells that would eliminate the virus before or after it infected cells in the body. However, clinical trials have been ... it is a very effective way to insert DNA into the cells of a monkey or human. In the second part of ...

Creighton Medical Laboratories First to Offer New Cancer Test

... patient care for decades. DNA is bundled inside cells as chromosomes; a karyotype is a representation of all of the chromosomes in a cell. Normal human cells have two copies of each chromosome. Cancer cells will often duplicate or lose pieces of ...

Glivec(R) is the First Adjuvant Treatment Approved in the UK to Delay Return of Gastrointestinal Cancer After Surgery

... normal role of KIT is to provide the 'signal' to cells in the body to grow and divide: this signal is ... activated. Left 'on' all the time, KIT signals to cells to constantly grow and divide, driving the growth ... it from sending continuous signals to the cancer cells to grow and divide.(14) Glivec has been available ...

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology 2009 Meeting

... related to the death of photoreceptor cells, the cells responsible for capturing light in the retina. We ... Palomid 529 also reduces the activation of glial cells and subsequently slows the formation of ... and can prevent the recovery of photoreceptor cells even though the retina is reattached. When ...

Lack of Food Variety Puts Kids With Autism at Risk for Poor Nutrition

... autism, the second one showing that the red blood cells of children with autism have low levels of a ... acids were significantly lower in the red blood cells of autistic children than in normally developing ... whether there are functional issues in neural cells involving a deficiency of essential fatty acids," ...

BioInformatics, LLC New Report - Capitalizing on New Opportunities for Stem Cell Products, Now Available

... to obtain a better understanding of how stem cells are used in the lab and in particular, what ... majority of respondents differentiate their stem cells into hematopoeitic and epithelial cells, other ... the next couple of years. By 2011, osteogenic cells in particular, but also endothelial, ...

Doctors Urge Precaution to Shield Against Swine Flu

... on the strength and activity of white blood cells called Natural Killer (NK) cells. NK cells identify and kill any non-self cell, foreign ... exposure. Research shows that the strength of NK cells can fluctuate from individual to individual. ...

Micromet Presents Update on BiTE Antibody Pipeline and Reviews Key AACR Presentations at R&D Day

... Research (AACR) demonstrated MT110 can direct T cells to eliminate EpCAM-expressing human colorectal cancer stem cells in cell culture and in animal models. EpCAM is a ... studies have shown that patients with tumor cells harboring mutations in KRAS and BRAF oncogenes do ...

Micromet Presents Preclinical Data Showing Activity of Erbitux and Vectibix Based BiTE Antibodies against KRAS- and BRAF-mutated Human Colorectal Cancer Cells

... active in colorectal cancer patients with tumor cells harboring mutations in KRAS and BRAF oncogenes. ... EGFR BiTE antibodies were able to direct T cells against cetuximab/panitumumab-resistant human colorectal cancer cells harboring KRAS and BRAF mutations, resulting in ...

First Candidate from Esperance's Targeted Anti-cancer Platform, EP-100, Establishes Preclinical Proof of Concept

... oncolytic peptides to selectively destroy cancer cells that express target receptors. In addition to ... bind specifically and exclusively to cancer cells that express the target receptors on their ... and multi-drug resistant ovarian cancer cells (OVCAR-3). As a negative control, the study ...

Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies

... encourages multiple types of immune system cells to mount anti-tumor responses." In a ... to recruit monocytes and other immune cells to the tumor with resulting anti-tumor effects, ... present confirms that PGN635 also triggers immune cells to produce other chemokines and cytokines that ...