Bowel in Medical Technology

Procter & Gamble Pharmaceuticals Launches Asacol(R) HD (mesalamine) Delayed-Release Tablets

... ulcerative colitis (UC), a form of inflammatory bowel disease. UC involves inflammation of the lining ... reduce their UC symptoms, including number of bowel movements and rectal bleeding, for some as early ... number of trips to the bathroom (i.e., number of bowel movements) in approximately three out of four of ...

Advance in Bowel Cancer Test Research

... improved screening/diagnostic test for detecting bowel cancer and significant pre-cancer lesions. ... new diagnostic weapon in the fight against bowel cancer," says CSIRO's Preventative Health ... Prevention and Control, regular screening for bowel cancer in people aged 50 years and over is a ...

PROTECT-1 Phase II/III Induction-Stage Results for ChemoCentryx's Traficet-EN(TM) Presented in Oral Session at DDW 2009 Conference

... dose (QD) of Traficet-EN in patients with small bowel and/or colonic Crohn's disease was consistently ... ChemoCentryx. "No cure exists for inflammatory bowel diseases and many patients do not respond to or ... therapeutics for the treatment of inflammatory bowel diseases." The randomized, ...

Ironwood and Forest Present Additional Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

... Early Onset of Abdominal Pain Relief and Improved bowel Habits -- CAMBRIDGE, Mass. and NEW YORK, May ... agent linaclotide in 419 patients with irritable bowel syndrome with constipation (IBS-C). Previous ... doses, significantly improved abdominal symptoms, bowel habits, and global assessments over the 12-week ...

Ironwood Announces Linaclotide European Licensing Agreement with Almirall

... linaclotide for the treatment of irritable bowel syndrome with constipation (IBS-C) and other ... reduced abdominal pain and bloating and improved bowel function throughout the 12-week treatment period. ... in United States. About Irritable bowel Syndrome with Constipation (IBS-C) IBS-C is a ...

New Study Shows Probiotic Strain Effective in Improving Irritable Bowel Syndrome Symptoms

... pain and bloating in subjects with irritable bowel syndrome ( IBS ). As many as 25 percent of the ... product, Digestive Advantage Irritable bowel Syndrome, experienced statistically significant ... that people who try Digestive Advantage Irritable bowel Syndrome are more likely to become repeat ...

Nektar Announces Positive Results from Phase 2 Study of Oral NKTR-118 in Patients with Opioid-Induced Constipation (OIC)

... dose-dependent increase in spontaneous bowel movements (SBMs) from baseline after the first ... mg and 50 mg dose levels dramatically increased bowel movements within the first week of treatment for ... associated with other symptoms of opiate-induced bowel dysfunction as a result of the opiate binding to ...

ASGE Urges Patients to Seek a Qualified Endoscopist Before Undergoing a Colonoscopy for Colorectal Cancer

... colonoscopy and that patients must take the bowel prep as directed by their physician allowing for ... ever in encouraging their patients to take their bowel prep as directed before the colonoscopy. A proper bowel prep allows the physician to clearly see the ...

Ironwood and Forest Present Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

... and efficacy in 420 patients with irritable bowel syndrome with constipation (IBS-C). Analysis of ... vs. placebo for complete spontaneous bowel movement (CSBM) frequency-the study's primary ... p = 0.0236 to <0.0001). Results for spontaneous bowel movement (SBM) frequency, stool consistency, ...

Ironwood and Collaborators Present Preclinical Data Demonstrating That Cyclic GMP Alleviates Intestinal Pain

... for its potential to treat irritable bowel syndrome with constipation (IBS-C) and other ... linaclotide reduced abdominal pain and improved bowel habits. The detailed Phase 2b IBS-C study results ... of North America. About Irritable bowel Syndrome (IBS) One out of six adults in ...

'Friendly' Bacteria Can Benefit Health Throughout the Lifecycle

... and for health conditions such as Inflammatory bowel Disease (IBD). Probiotics are used worldwide ... newest research on probiotics and inflammatory bowel disease. "Inflammatory bowel disease is a condition that affects approximately ...

Ironwood Raises $50 Million to Advance Linaclotide Through Phase 3

... outside of North America. About Irritable bowel Syndrome (IBS) One out of six adults in ... condition marked by abdominal pain and disturbed bowel function. IBS accounts for 12% of adult visits to ... incomplete evacuation, and fewer than three bowel movements per week. The discomfort of CC ...

Ironwood and Forest to Present Positive Data From Linaclotide Phase 2b IBS-C Study at ACG Annual Scientific Conference

... and efficacy in 419 patients with irritable bowel syndrome with constipation (IBS-C) in a plenary ... experienced a significant improvement in bowel function as well. Linaclotide was well tolerated ... outside of North America. About Irritable bowel Syndrome (IBS) One out of six adults in ...

ASGE Encourages Patients to Speak to Their Doctor About Colorectal Cancer Screening Options

... if they had lower abdominal pain, inflammatory bowel disease or familial polyposis syndrome among ... day and the patient would require a second bowel prep before undergoing the colonoscopy. The ... its limitations: -- Requires the same bowel prep as colonoscopy. -- Does not detect small ...

New England Journal of Medicine Publishes Results From a RELISTOR Phase 3 Clinical Study

... OIC patients with advanced illness experienced bowel movements (laxation) within four hours of ... the proportion of patients with a rescue-free bowel movement within four hours of the first dose, and ... the study, 48 percent of patients experienced a bowel movement within four hours of receiving the first ...

First Patient Enrolled in Global Phase III Study of Bevacizumab and Trastuzumab in Early Breast Cancer

... the NSABP (National Surgical Adjuvant Breast and bowel Project) and CIRG (Cancer International Research ... ABOUT THE NATIONAL SURGICAL ADJUVANT BREAST AND bowel PROJECT (NSABP) Headquartered in Pittsburgh, ... USA, the National Surgical Adjuvant Breast and bowel Project (NSABP) is a clinical trials ...

Research Team Clones Genes Responsible for Amino Acid Absorption

... of nutrients in patients with inflammatory bowel disease (IBD), according to Uma Sundaram, M.D., ... "In the majority of cases of inflammatory bowel disease, patients are unable to properly ... be to find specific treatments for inflammatory bowel disease that avoid all the complications of ...

Tioga Pharmaceuticals' Asimadoline Demonstrates Positive Results in a Phase 2b Clinical Trial for the Treatment of Irritable Bowel Syndrome

... significant results in the treatment of Irritable bowel Syndrome (IBS). Asimadoline produced significant ... were also collected. About Irritable bowel Syndrome Irritable bowel syndrome is a common, chronic gastrointestinal ...

Ironwood Pharmaceuticals and Forest Laboratories Announce Presentation of Linaclotide Phase 2b Chronic Constipation Study Results

... change from pre-treatment in weekly spontaneous bowel movement (SBM) frequency. During the two-week ... significant improvements in complete spontaneous bowel movement (CSBM) frequency, stool consistency, ... treatment on patients with CC and irritable bowel syndrome with constipation (IBS-C). Ironwood and ...

New AMITIZA 8 mcg Phase III Studies Demonstrated Overall Symptom Improvement in Adult Women with Irritable Bowel Syndrome with Constipation (IBS-C)

... relief of overall symptoms of Irritable bowel Syndrome with Constipation (IBS-C). These results ... Approximately 58 million Americans have Irritable bowel Syndrome (IBS), and IBS-C accounts for ... by abdominal discomfort or pain and changes in bowel habits including symptoms of constipation. ...

Microbia and Forest Laboratories Announce Preliminary Results of Linaclotide Phase 2b Studies

... examined its effects in patients with irritable bowel syndrome with constipation (IBS-C). Preliminary ... change from pre-treatment in weekly spontaneous bowel movement (SBM) frequency rate. During the ... top-line efficacy endpoints-complete spontaneous bowel movement (CSBM) frequency, stool consistency, ...

Lexicon Reports Initial Clinical Trial Results for LX1031, an Investigational New Drug for Irritable Bowel Syndrome

... potential treatment for irritable bowel syndrome (IBS) and other gastrointestinal (GI) ... trials in 2008." About LX1031 and Irritable bowel Syndrome Based on findings from Lexicon's ... GI disorders, including IBS. IBS is a functional bowel disorder of the GI tract characterized by changes ...

Clinical Benefits Demonstrated with Low-Dose GATTEX(TM) in Phase 3 Short Bowel Syndrome Study

... greatest potential for effectively treating short bowel syndrome by improving nutrient absorption, while ... with parenteral nutrition (PN)-dependent short bowel syndrome. Eighty three (83) patients who were ... surgical removal of significant portions of the bowel following injury or illness. There are 16,000 ...

Sucampo Pharmaceuticals, Inc. Begins Pivotal Phase III Studies of Oral Lubiprostone to Treat Opioid-Induced Bowel Dysfunction (OBD)

... twice daily) for the treatment of Opioid-Induced bowel Dysfunction (OBD). The OBD Pivotal Assessment of ... daily) and is under FDA review for Irritable bowel Syndrome with constipation. AMITIZA is marketed ... these studies are positive. About Opioid-Induced bowel Dysfunction (OBD) ...

Lexicon to Present Research Results at American Chemical Society Meeting Regarding Target of LX1031 Drug Candidate

... for the potential treatment of irritable bowel syndrome (IBS)," will reveal the target of ... LX1031, a potential treatment for irritable bowel syndrome (IBS), which is currently being ... areas of major unmet medical need as irritable bowel syndrome and cognitive disorders. The company ...

Lexicon's Drug Candidate LX1032 for Carcinoid Syndrome Receives Orphan Drug Designation From EMEA

... progressing through clinical development, including LX1031 for irritable bowel syndrome, LX2931 for rheumatoid arthritis, and LX4211 for diabetes. For ... autoimmune disease, carcinoid syndrome, diabetes, glaucoma and irritable bowel syndrome, all of which were discovered by the company's research team. ...

New One-Year Data from REMICADE(R) SONIC Trial Show Sustained Efficacy Compared with Azathioprine in Treatment of Crohn's Disease

... between weeks 30 and 54. Dr. William J. Sandborn, Inflammatory bowel Disease Clinic, Mayo Clinic, and principal investigator for the SONIC ... an inadequate response to conventional therapy, a related inflammatory bowel disease. REMICADE is also approved for the treatment of pediatric ...

Spirus Medical Announces Complete Examinations of the Small Intestine by Physicians Using Endo-Ease(TM)

... upper and lower GI disorders. Spiral enteroscopy allows for rapid small bowel access which can give the physician the ability to diagnosis and treat ... enteroscopy technique, the medical team was able to traverse the small bowel and reach the ileo-cecal valve in 44 minutes. A second ...

Lexicon Pharmaceuticals Provides Clinical Pipeline Update and Reports 2009 First Quarter Results

... trial of its LX1031 drug candidate for non-constipating irritable bowel syndrome (IBS). Enrollment is on track to be completed by year-end. ... autoimmune disease, carcinoid syndrome, diabetes, glaucoma and irritable bowel syndrome, all of which were discovered by Lexicon's research team. ...

Pharmos Issues Business Update on Dextofisopam Trial and Financing

... Pharmos modified the size of the Dextofisopam Phase 2b trial for Irritable bowel Syndrome IBS D+A to a minimum 300 patient trial. The trial is now ... targeting pain, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease and other disorders. These are available for licensing / ...

Virtual Colonoscopies Show Value for Some Patients, But Polyps Will Be Missed

... cancer screening. Both procedures involve the same patient bowel preparations. However, no sedative is administered for CT colonography. CT ... same day as the colonography was performed, the patient must repeat the bowel preparation procedure for the follow-up colonoscopy. For more ...

Takeda Initiates Two Phase III Studies with Vedolizumab (MLN0002) in Patients with Inflammatory Bowel Disease

... for vedolizumab (MLN0002), an investigational compound for inflammatory bowel disease (IBD). The trials, known as the GEMINI(TM) program, will study ... removal of the colon in the case of ulcerative colitis, and multiple bowel resections in the case of Crohn's disease. If approved by the U.S. ...

Pharmos Announces Clinical Results from Phase 2a Trial of Topical Diclofenac NanoEmulsion Cream

... all its resources on its Dextofisopam clinical trial for Irritable bowel Syndrome (IBS) currently enrolling in a 480 patient Phase 2b trial. ... targeting pain, multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease and other disorders. These are available for licensing / ...

Alba Therapeutics Presents New Data for Larazotide Acetate at the 2008 American College of Gastroenterology Annual Scientific Meeting

... Disease Additional Data Indicates Potential in Treating Inflammatory bowel Disease ORLANDO, Fla., Oct. 7 /PRNewswire/ -- Alba Therapeutics ... The GSRS is a validated measure used in clinical trials for irritable bowel syndrome and peptic ulcer disease. GSRS has been utilized in studies to ...

New Findings Show Efficacy of REMICADE(R) Compared With Azathioprine in Treatment of Crohn's Disease According to First-of-its Kind Study

... inflammatory bowel disease." Dr. William J. Sandborn, Inflammatory bowel Disease Clinic, Mayo Clinic, and principal investigator for the SONIC ... approved for the treatment of ulcerative colitis, a related inflammatory bowel disease, and pediatric Crohn's disease. Crohn's disease is a chronic ...

New Genes Found for Inflammatory Bowel Disease in Children

... N. Baldassano, M.D., director of the Center for Pediatric Inflammatory bowel Disease at The Children's Hospital of Philadelphia. "We will resequence ... therapies to their patients. The Center for Pediatric Inflammatory bowel Disease at Children's Hospital currently treats 1,400 children annually ...

Omega-3 Fatty Acids Critical to Infants, Mothers and the Seriously Ill

... current U.S. regulations. In infants with severe liver disease and short bowel syndrome, a fish oil-based preparation significantly reversed the disease ... oil-based TPN saves lives and hastens the recovery of infants with short bowel syndrome," Nettleton said. "Evidence from these studies may help ease U.S. ...

Abbott Presents Long-Term Data From Extension Study Showing Adult Crohn's Patients Treated With HUMIRA(R) (Adalimumab) Maintained Remission

... from baseline. Crohn's disease is a serious, chronic, inflammatory bowel disease that affects more than 500,000 Americans. It affects people of all ... Panaccione, M.D., Associate Professor, and Director of the Inflammatory bowel Disease Clinic at the University of Calgary and study author. "In this ...

Ardea Biosciences Presents Preclinical Data on RDEA119 Demonstrating Favorable Anti-Inflammatory Profile for Potential Use in Ulcerative Colitis

... The MEK1/2 pathway is important in cell cycle regulation in inflammatory bowel disease, including ulcerative colitis and Crohn's disease. RDEA119 was ... there are still significant unmet medical needs for inflammatory bowel disease. Blocking the MEK1/2 pathway appears to be a promising strategy in ...

New Analysis Shows Efficacy of REMICADE(R) in Treatment of Ulcerative Colitis in Patients with Recent Disease Onset or Long-Standing Disease

... on Absenteeism Among Employees with Inflammatory bowel Disease SAN DIEGO, May 20 /PRNewswire/ -- Data from a new analysis of ... About Ulcerative Colitis Ulcerative colitis (UC), a chronic inflammatory bowel disease affecting nearly 500,000 people in the U.S., is marked by the ...