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Appendicitis: Evolving Tools to Diagnose a Classic Disease

... lives. The condition occurs when the appendix, a blind pouch of intestine at the proximal colon, becomes obstructed by mucus, stool, or lymphatic tissue. Infection ensues, which can rapidly evolve to perforation and sepsis. The risk of these complications, already elevated for children and those over 5...

Optimizing Quality Control Data Management

...ratories additional confidence that they will pass blind proficiency surveys offered by external quality assessment programs. References Fraser Callum, Biological Variation: From Principles to Practice, AACC Press, Washington DC, 2001 (available at www.aacc.org) Ricos Carmen et al., Current databases o...

Cosmo Pharmaceuticals Reports Positive Preliminary Phase II/III Data with Rifamycin MMX in Infectious Diarrhea

...on. In the placebo controlled, randomized, double blind trial 120patients in 8 sites in South Africa were treated with a 200mgtablet, 4 times per day for 3 days. The trial assessednon-inferiority versus Normix® (rifaximin) and the primaryendpoint was the time from first ingestion of tablet to the last...

HepaLife's PBS-1 Cells for Influenza Vaccine Production Prove Superior at International Conference

...c testing. According to researchfindings, nineteen blind influenza virus received from humanrespiratory samples were successfully identified as type-Ainfluenza using PBS-1 cells. Entitled "High titer growth of human and avian influenza virusesin an immortalized chick embryo cell line without the need fore...

Indevus Announces Presentation of Pagoclone Data at 47th Annual New Clinical Drug Evaluation Unit Meeting

...ose patients randomizedto pagoclone in the double- blind phase, the mean reduction inpercent syllables stut...t. For patients receiving placeboduring the double blind phase, 36% were rated as improved, whilefollowing three months of open label treatment, 80% were rat...

Repros' Androxal Shows Highly Statistically Significant Positive Effects in Men with Secondary Hypogonadism

...evel was maintainedfor the entire six month double blind period and the proportions ofsubjects achieving testosterone levels greater than 300 ng/dl were70.5%, 84%, 53.2% and 31.9% for 12.5mg, 25mg, Androgel and placeboarms, respectively. The improvement in total testosterone in the Androxal arms wasthe re...

Long-Term Extension of Ulcerative Colitis Study Shows Remicade Responders Maintained Improvement Through Two Years of Follow-Up

...cebo also enrolled in theextension to maintain the blind and continued to receive placeboevery 8 weeks, but were discontinued upon unblinding. Over the course of the extension trials subjects were allowed toadjust corticosteroid use as required. When corticosteroid useduring the extension in all participa...

VEGF Trap-Eye Phase 2 Wet AMD Results Reported at ARVO Annual Meeting

...s disruption anddysfunction of the retina creating blind spots in central vision,and it can account for blindness in wet AMD patients. About DME Diabetic Macular Edema (DME) is the most prevalent cause ofmoderate vision loss in patients with diabetes. DME is a commoncomplication of Diabetic Retinopathy (...

NanoViricides Drugs Found To Be Highly Effective Against Most Recent Strain of the H5N1 Avian Flu Virus

...ore effective than oseltamivir(Tamiflu(R)) in this blind study performed by the NationalInstitute of Hygiene and Epidemiology (NIHE) scientists inVietnam. In addition, the antibody-fragment-based H5N1 specific (Clade 1,Vietnam, 2004-2005 strains) AviFluCide(TM) drug candidate wasdemonstrated conclusivel...

Immediate Treatment of Early MS Patients with Betaferon Significantly Delayed Permanent Disability

... or placebo as asubcutaneous injection in a double blind fashion. Theplacebo-controlled treatment period lasted up to 24 months or up tothe time when patients were diagnosed with clinically definite MS.All study participants were then invited to participate in afollow-up study with Betaferon® to prospe...

First of Its Kind Data Show: Immediate Treatment of Early MS Patients with Betaseron Significantly Delayed Permanent Disability

... or placebo as asubcutaneous injection in a double blind fashion. Theplacebo-controlled treatment period lasted up to 24 months or up tothe time when patients were diagnosed with clinically definite MS.All study participants were then invited to participate in afollow-up study with Betaseron to prospective...

AVAX Technologies Presents Results of Phase I-II M-Vax Trial at Annual Meeting of American Association for Cancer Research

... vaccine production. They wereassigned in a double blind fashion to one of four dosage arms ofM-Vax(TM), including a placebo arm that contained no vaccine cells.The results of the first 54 evaluable patients are being presented,and the blinding of the dosage arm assignments has been preserved.As determined...

Data on Telavancin and Micafungin Hold Promise of New Therapeutic Options in Fight Against Serious Infectious Disease

...eus(MRSA).(6),(7) The results of the two double blind parallel studies, in which1,867 patients were treated, showed that telavancin comparedfavorably to standard therapy in clinical cure, microbiologicaleradication, and overall therapeutic response rates. The safetyprofile of telavancin in these studies...

Positive Interim Phase 2 Data Reported for VEGF Trap-Eye in Age-Related Macular Degeneration

...s disruption anddysfunction of the retina creating blind spots in central visionand can account for blindness in wet AMD patients. About Regeneron Pharmaceuticals Regeneron is a biopharmaceutical company that discovers,develops, and intends to commercialize therapeutic medicines forthe treatment of serio...

Avexa Reports Positive Phase IIb Result

...ata Trial Design AVX-201 is a randomised, double blind study of two doses of ATCcompared to lamivudine (3TC) in treatment-experienced HIV-1infected patients with the M184V mutation. Patients were randomisedto receive 600mg or 800mg ATC twice daily, or 3TC twice daily, for21 days, in a blinded fashion. Th...

CeNeS Pharmaceuticals plc: Update on Successful Phase III results announced on Lead Product M6G

...rol their pain. Thestudy was randomised and double blind so that neither patient norcarer was aware of which treatment was being administered. The mainpurpose of the study was to demonstrate statistically that: - Treatment with either M6G or morphine, particularly duringPCA, results in similar levels of p...