Fat Kills Cancer: Turning Stem Cells from Fat Tissue into Personalized, Cancer-Targeted Therapeutics
...iles. This gene therapy approach is a novel way to attack smalltumor metastases that evade current detection techniques andtreatments, the researchers conclude in the July 1 issue of CancerResearch, a journal of the American Association for CancerResearch. “These fat-derived stem cells could be expl...Biotec Pharmacon Announces Preliminary Results from the Sloan-Kettering Clinical Study
...ms that enhance the ability of the immunesystem to attack and destroy cancer cells, repair wounds, and fightinfections. Immunotherapy of cancer is one of the prioritytherapeutic areas for Biotec Pharmacon. In addition to the study atMemorial Sloan-Kettering Cancer Center i New York, the company isalso about......chronic autoimmune disease that causes the body to attack its owntissues and joints. Lupus nephritis, considered life-threatening,but rare, is the most serious manifestation of SLE. If leftuntreated, it can lead to kidney failure, need of dialysis, andpotentially death. It is a complicated disease as patien...Positive Clinical Results for DG041 Lead Product Development Highlights at deCODE R&D Event
...normal platelet function. DG031 and DG051 - Heart attack In its drug development programs targeting the leukotrienepathway for the prevention of heart attack, deCODE is advancing thereformulation of its FLAP inhibitor DG031 for re-entry intoclinical trials. A lead formulation has been identified and a3-mo......ossibly related to Hematide (onetransient ischemic attack in a patient with history of atrialfibrillation, and one moderate infusion reaction in a patient whoresponded to outpatient intervention). About Hematide Hematide is a novel synthetic, pegylated peptidic compound thatbinds to and activates the eryt...Array BioPharma Reports New Clinical Data on Its Anti-Inflammatory Drugs
...a natural biologic response to injury orinfectious attack to the human body. Unregulated inflammationresults in a broad range of conditions, most of which areclassified by the tissue or organ where the inflammation occurs.These conditions include rheumatoid arthritis (RA) in the joint,psoriasis in the skin,......theproduction of autoantibodies -- antibodies that attack and destroythe body's own healthy tissues. The presence of autoantibodiesappears to correlate with disease severity. Pre-clinical andclinical studies demonstrate that B-cell antagonists can reduceautoantibody levels and help control autoimmune diseas......he treatment ofspinal cord injury, evades a direct attack by the human immunesystem. Presented by Geron scientist Ross Okamura at the Federation ofClinical Immunology Societies meeting in San Diego, the findingscould mean that patients treated with GRNOPC1 would requiresignificantly lower doses and/or short...Treating Heart Disease Risk Factors May Slow Alzheimer's Disease Progression
...hat increase the risk ofvascular events like heart attack or stroke also increase the riskof cognitive decli...or avery mild stroke known as a transient ischemic attack (TIA). Rosebud O. Roberts, MB, ChB, and colleagues at the Mayo Clinicin Rochester, Minn., investiga......atient's own white blood cells,pathogenic T cells, attack myelin, a fatty tissue in the centralnervous system, which surrounds and protects nerve fibers. Thispathologic process creates multiple areas of inflammation thatultimately lead to scarring (sclerosis) and that interfere withnormal transmission of ne...ProEthic Pharmaceuticals Presents Positive Data for PRO-513 at American Headache Society Meeting
...es, reduced the associated symptoms of themigraine attack and that its benefits persisted up to 24 hours. The first poster presentation provided efficacy and tolerabilityresults from a Phase III clinical study for PRO-513, a randomized,double-blind, placebo-controlled trial that enrolled 690 adultpatients. ...To Stent or Not: Is That the Question?
...gioplasty as involving patients undergoing a heart attack andin dire need of either angioplasty or clot-busting medications. Butthis wasn't the case. The COURAGE study looked at only ratherlow-risk patients who are in a stable condition. The real message is that the study reinforces long-standingclinical......The study was designed tocompare the risk of heart attack and coronary revascularization intype 2 diabetes p...was no difference in the overallincidence of heart attack and coronary revascularization withAvandia-containing therapies (1.75 events per 100 person-years)ve......ficantdifference in cardiovascular death and heart attack between Avandiaand the control groups, and therefore do not confirm the hypothesisgenerated by the recently published meta-analysis in the NewEngland Journal of Medicine that raised concerns about these eventswith Avandia," said Moncef Slaoui, chairm...Data Demonstrated Metastatic Melanoma Response to Investigational Immunotherapy Ipilimumab
...hereby sustaining an active immune response in its attack oncancer cells. Ipilimumab is being developed through a joint partnershipbetween Bristol-Myers Squibb and Medarex. Ipilimumab is currentlyin Phase III development (under Special Protocol Assessments [SPA]with the U.S. Food and Drug Administration [F......e the patient's own immune responseto identify and attack cancer cells in a highly specific manner.This novel cancer immunotherapy is developed using tumor specificantigens, delivered as highly purified recombinant proteins, andGSK's own proprietary Adjuvant Systems, which are specificallydesigned to enhanc...Phase 2 Results for EntreMed's Panzem NCD Brain Cancer Study Presented at ASCO
...By these mechanisms, Panzem(R) has thepotential to attack cancer cells through multiple pathways thataffect the formation and replication of tumor cells, and caninterrupt the formation of blood vessels that nourish tumor cellsand sustain tumor growth. To view the poster presentation of this Phase 2 trial, ......ls. It then recruits the body's natural defencesto attack and kill the marked B-cells. Stem cells (B-cellprogenitors) in bone marrow lack the CD20 antigen, allowing healthyB-cells to regenerate after treatment and return to normal levelswithin several months. MabThera is indicated for the treatment of indo......etic drugs from within our portfolio tocombine and attack these silencing systems simultaneously, withencouraging clinical data emerging in the context of acute myeloidleukemia." Pharmion has three epigenetic products in its portfolio,including Vidaza(R) (azacitidine for injection), MGCD0103 and oralAzacit...... of Betaseron treatment in patients with a firstMS attack was associated with a 40 percent reduced risk ofconfirmed disability progression over three years. This studyconfirms that early treatment is desirable in MS to avoid ordiminish long-term disability. Betaseron is approved for thetreatment of relapsin...FDA Issues Safety Alert on Avandia
...entially significant increase in the risk of heart attack andheart-related deaths in patients taking Avandia...w conflictingresults, related to the risk of heart attack and heart-relateddeaths in patients treated with Avandia," said Steven Galson, M.D.,M.P.H., director......ctly) associate HBP with an increased risk ofheart attack (94%) and stroke (93%). In addition, many surveyrespondents are aware that HBP increases the risk of otherlife-threatening conditions such as failure of the kidney tofunction properly (61%), hardening of the arteries (65%) orenlarged heart (61%). Thi...Innovative Cancer Drug MabThera Again Shown To Improve Survival Rates In Patients With Lymphoma
...s. It then recruits the body's natural defences to attack andkill the marked B-cells. Stem cells (B-cell progenitors) in bonemarrow lack the CD20 antigen, allowing healthy B-cells toregenerate after treatment and return to normal levels withinseveral months. MabThera is indicated for the treatment of indol......ine Treatments Are Equal Triptans stop a migraine attack after the attack begins bystimulating serotonin, which reduces inflammation and constrictsblood vessels, thereby alle...New Study Reveals Limitations of a Complex and Challenging Global Tuberculosis Drug Marketplace
... in the humanbody for many years, but once active, attack the respiratorysystem, and are easily spread through the air like the common cold-- by coughing and sneezing. The WHO estimates that one third ofthe world is infected with M.tb. The last class of TB drugs was developed and approved in the1960s, and ...Global Rabies Treatment May be Possible with NanoViricides Drugs
...d-spectrum, highlyeffective anti-viral agents that attack unrelated viruses withdistinct pathologies, can be created when they share commonmechanisms of binding to human cells. These achievementsessentially are enabling elements for the President's FlexibleDefense BioSecurity Enterprise," said Anil R. Diwan...Data Show FluMist May Reduce Seasonal Influenza Burden Among Children in School, Daycare Settings
...seems to make economicsense. By reducing influenza attack rates, there is less burden onthe healthcare system and fewer days missed from school and work,which drive the societal cost savings," said Parthiv Mahadevia,M.D., MPH, senior director of health outcomes andpharmacoeconomics. Reduction of Disease Bu......ons in motavizumab-treatedinfants. The overall RSV attack rate was low in both treatmentgroups: 1.4 percent for infants who received motavizumab, comparedwith 1.9 percent for those who received Synagis [RR: 0.740, 95percent CI: (0.503, 1.083)]. The p-value for non-inferiority wasp Analysis of the data also...Conor Medsystems, LLC Reports COSTAR II Pivotal Drug-Eluting Stent Trial Conclusions
...cally driven target vesselrevascularization, heart attack (new myocardial infarction) relatedto the target vessel and cardiac death related to an intervenedvessel. "While we are disappointed in these results, we remainoptimistic about the ability of the novel Conor Medsystemsreservoir platform to provide p......chnology,trains the immune system to recognize and attack the disease.Argos' scientific leadership in RNA-loaded dendritic cells andadvanced manufacturing processes provide a platform to tacklevirtually all forms of cancers and infectious diseases.www.argostherapeutics.com Argos is a private biotechnology ...Revolutionary Immunologic Data Explains Function of Diamyd Diabetes Vaccine
...hatthe clinical effect of arresting the autoimmune attack thatdestroys beta cells close to disease onset is superior to a laterintervention when the patient’s beta cells have been almosttotally destroyed. “This may be a breakthrough in diabetes research”,says Professor Johnny Ludvigsson. ......ervous system (CNS) in which the immune system may attack thebrain and spinal cord. MS affects approximately 2.5 million peopleworldwide and approximately twice as many women as men. Theclinical course of MS is highly variable, but is typicallycharacterized by an initial relapsing and remitting phase wheree...Trexima (Sumatriptan/Naproxen Sodium) Demonstrated Efficacy Across Multiple Migraine Attacks
...ademy of Neurology. "The anticipation of the next attack can be quite stressful forpatients," said Richard ...hree of four attacks with Trexima and theremaining attack with placebo; the remaining patients treated allfour attacks with Trexima. In both studies, Trexima...MabThera Significantly Increases Survival of Lymphoma Patients Regardless of Chemotherapy Regimen
...s. It then recruits the body's natural defences to attack andkill the marked B-cells. Stem cells (B-cell progenitors) in bonemarrow lack the CD20 antigen, allowing healthy B-cells toregenerate after treatment and return to normal levels withinseveral months. MabThera is indicated for the treatment of in......stem(CNS) in which the immune system is thought to attack the body'sown myelin, a fatty substance that surrounds and protects the nervefibers of the brain, spinal cord and optic nerves. There are fourtypes of MS with a wide variety of symptoms and different coursesof disease progression. RRMS is the most co......stem(CNS) in which the immune system is thought to attack the body'sown myelin, a fatty substance that surrounds and protects the nervefibers of the brain, spinal cord and optic nerves. There are fourtypes of MS with a wide variety of symptoms and different coursesof disease progression. RRMS is the most co......sionsof these genes confer increased risk of heart attack by increasingthe production of the pro-inflammator...LTB4). DG051 is designed to decrease risk of heart attack bydecreasing the production of LTB4. About deCODE deCODE genetics is a global leader in applying h......ethe potential of AMT-020 to protect against acute attack induced byphenobarbital (Pb) in a mouse model of AIP. The model reproduceskey features of AIP attack after Pb induction, including increasedurinary excretion of haem precursors and decreased motorfunct......hronicinflammatory disease that causes the body to attack its own tissuesand organs, including the skin, joints, blood and kidneys.Treatments for lupus include anti-inflammatory drugs,antimalarials, corticosteroids and drugs approved for otherpurposes, such as immunosuppressive agents given to cancer patien...Critical Therapeutics Announces the Publication of New Preclincial HMGB1 Data in Nature Immunology
...autoimmune disease that causesthe immune system to attack the body's tissue and organs, includingthe joints, kidneys, heart, lungs, brain, blood, or skin.Approximately 1.5 million Americans have a form of the disease,which has no known cause. About Critical Therapeutics Critical Therapeutics, headquartere...MedImmune and Micromet Publish Data on Novel Anti-Cancer BiTE Molecule
...oenable the body's killer T cells to recognize and attack tumor andtarget cells, leaving normal cells unharmed. bscEphA2xCD3 is a BiTEmolecule targeting the tyrosine kinase receptor EphA2, which isfrequently overexpressed on a wide variety of solid tumors. "The results of this study show that a receptor ...Micromet and MedImmune Present Data From Preclinical Study of New BiTE Molecule Targeting CEA
...oenable the body's killer T cells to recognize and attack tumor andtarget cells, leaving normal cells unharmed. In addition todemonstrating in vitro and in vivo anti- tumor activity, certainCEA-specific BiTE molecules also showed resistance to inhibition bysoluble CEA. Because a soluble form of CEA is relea......xic T cells enabling the animals' immunesystems to attack the tumor cells directly. These results are keysig...els, bavituximab alerts the body's immunesystem to attack the tumor's blood supply, stopping the flow ofoxygen and nutrients to the tumor cells and resulting ......roved for patients whohave their first clinical MS attack and have a brain MRI scanconsistent with MS; this use was approved in Europe in 2002 and inthe U.S. in 2003. The most common side effects associated withAVONEX multiple sclerosis treatment are flu-like symptoms,including myalgia, fever, fatigue, head...Newest Adult Stem Therapy Treats Diabetes
...oimmune disorder where the body's own immune cells attack theinsulin producing cell in the pancreas. These researchers used anadult stem cell transplant protocol that has previously been usedwith success in treating other autoimmune disorders such as lupusand MS (multiple sclerosis), crohns disease, sclerod...... 1.1 percent of people without diabetes - Heart attack occurs in 9.8 percent of people with diabetes vs. ...thcare costs for people with type 2diabetes, heart attack is the most costly complication, at $14,150per person, followed by chronic kidney disease(3) ($9,002...The Sturdier Sex?: Study by Pittsburgh Scientists Finds Female Stem Cells Work Better
...ge from therepair of heart muscle damaged by heart attack to the repair ofsports-related bone, cartilage and muscle injuries. For more information about Dr. Huard's research, please visit<a target="_blank" href="http://www.chp.edu/">http://www.chp.edu . Pittsburgh of UPMC CONTACT: Marc Lukasiak, ...New Cardioprotective Drug Could Provide Boost For Post-Bypass Surgery Heart Health
...rs, theycould more than double their risk of heart attack or death. This emerging safety controversy around drug-coated stents hassome experts predicting a resurgence in heart bypass operations.The bypass operations, although more invasive and dangerous, arebelieved to have longer lasting benefits compared...Trexima (Sumatriptan/Naproxen Sodium) Superior Efficacy Data Published in JAMA
...a were reported from 2,911patients who treated one attack each. There were two objectives of these studies. The first was toevaluate the efficacy of Trexima at two hours post-dose versusplacebo on the following variables: -- Headache relief -- Absence of phonophobia (sensitivity to sound) -- ......ncer of the breast or uterus, had astroke or heart attack in the past year, have or had blood clots,have liver problems, are allergic to any of the ingredients inPREMARIN or PREMPRO, or think you may be pregnant. In general, theaddition of a progestin is recommended for women with a uterus toreduce the chan...Presentations at American College of Cardiology Meeting Highlight New Opportunities for HDL Therapy
...w approach in reducingthe residual risk of a heart attack or stroke in high-risk patientstaking statin drugs. The results obtained with the imagingtechniques, including IVUS, clearly indicate that imaging trialscan be an effective way to obtain and assess data which can beuseful in determining the potential...... primaryendpoints -- rates of death, stroke, heart attack and kidneydysfunction -- were similar for Cleviprex compared to the otherthree agents. About Perioperative Hypertension Perioperative hypertension affects patients in the operatingroom, post- anesthesia care unit and intensive care unit. It isthoug......rial of 8,888 patients who had had aprevious heart attack comparing Lipitor 80 mg with simvastatin 20mg-40 m...dpoint, Lipitor reduced therisk of non-fatal heart attack by a significant 17 percent and therisk of any cardiovascular events by 16 percent compared withpati......nois Site in Trial CHICAGO, March 27, 2007--Heart attack patients who received annew intravenous adult stem cell therapy, Provacel™,experienced a lower number of adverse events, such as cardiacarrhythmias, and had significant improvements in heart, lung andglobal function compared to those who receiv......ie from, and three times as likely to have,a heart attack or stroke compared with people without thesyndrome. New Analysis of the Stroke Prevention by Aggressive Reduction inCholesterol Levels (SPARCL) study A new SPARCL analysis was conducted to evaluate if treatmentwith Lipitor 80 mg was associated with...... The primary endpoint of death, stroke and heart attack at 30days was 4.6 percent in EXACT and 5.2 percent... not yet experienced stroke or a transientischemic attack would, for the first time, have access to carotidartery stenting. To date, more than 60,000 patient......ts. Composite ischemia was defined as death, heart attack or unplanned revascularization for ischemia. ...f death for patients whohad a major bleed or heart attack within 30 days followingtreatment was 2.89 and 2.47 times greater, respectively, than therisk for pa......s withdiabetes (33.8 percent), or history of heart attack (33.4 percent),balloon angioplasty (44.6 percent) ...ficant differences in the rates of mortality,heart attack or stent thrombosis after one year compared to theoutcomes of patients who stopped dual anti-platele......Events (MACE), such as cardiac death, heart attack or target lesion revascularization (artery ...hof these trials, the risk of cardiac death, heart attack orre-treatment in the diseased artery area in patients wasapproximately two to three times lower wit......more than 100 countries, for thetreatment of heart attack survivors in more than 70 countries andin more than 90 countries for the treatment of people with heartfailure. DIOVAN is contraindicated in patients who are hypersensitive toany component of this product. Volume and or salt depletion should be cor...