arrest

Data Available From Erbitux Phase III Study in First-Line Treatment of Advanced Lung Cancer

...ho experience infusion reactions. Cardiopulmonary arrest and/or sudden death occurred in 2%(4/208) of patients with squamous cell carcinoma of the head andneck treated with radiation therapy and ERBITUX as compared to noneof 212 patients treated with radiation therapy alone. Fatal eventsoccurred within 1 t...

Common Preterm Labor Drug Has More Side Effects Than Alternative, Finds Study from Packard Children's Hospital and Stanford

...IRE)--Jun 29, 2007 - The drug mostcommonly used to arrest preterm labor, magnesium sulfate, is morelikely than another common treatment to cause mild to serious sideeffects in pregnant women, according to a study from researchers atLucile Packard Children's Hospital and Stanford University Schoolof Medicine...

New Research Demonstrates Broad Efficacy of Azixa (MPC-6827) Against Multiple Tumor Types and in Drug Resistant Cell Lines

...inhibitingpolymerization and leading to cell cycle arrest and apoptosis.Unlike other tubulin-disrupting cancer treatments, MPC-6827 hadefficacy against tumor cells that over-expressed the three mainprotein transporters responsible for multidrug resistance,indicating that MPC-6827 may prove effective against...

Extensive Clinical Data on Erbitux Presented at the 2007 ASCO Annual Meeting

...ho experience infusion reactions. Cardiopulmonary arrest and/or sudden death occurred in 2%(4/208) of patients with squamous cell carcinoma of the head andneck treated with radiation therapy and ERBITUX as compared to noneof 212 patients treated with radiation therapy alone. Fatal eventsoccurred within 1 t...

EntreMed's Aurora Kinase Inhibitor Induces Tumor Regression in Preclinical Models

...d was also shown toinduce apoptosis and cell cycle arrest in a broad range of celllines. ENMD-981693 exhibited antiangiogenic activity in in vivo animalmodels by preventing the formation of new blood vessels andinducing regression of formed vessels at well-tolerated doses.Orally-administered ENMD-981693 ...

Antidepressant Use May Boost Fracture Risk, From Harvard Women's Health Watch

...ing safety and aging -- Simpler CPR for cardiac arrest -- By the way doctor: Tamoxifen versus aromatase inhibitors for breast cancer Harvard Women's Health Watch is available from Harvard HealthPublications, the publishing division of Harvard Medical School,for $24 per year. Subscribe at <...

Telomerase Presentations at the AACR 2007 Annual Meeting

...ntact. Telomere shortening inthis setting triggers arrest of abnormally dividing cells. However,when certain mutations occur in growth control genes over time dueto environmental events or genetic predisposition, criticaltelomere loss can lead to genomic instability, further mutations,and cancer initiation....

CuraGen and TopoTarget Announce New Clinical Results With Belinostat to be Reported at Upcoming Major Medical Meetings

...cs that target HDACenzymes and have been shown to: arrest growth of cancer cells(including drug resistant subtypes); induce apoptosis, orprogrammed cell death; promote differentiation; inhibit angiogenesis; and sensitize cancercells to overcome drug resistance when used in combination withother anti-cancer...

EntreMed Presents Preclinical Data for MKC-1 in Hematological Cancers

...ient samples through a complex mechanism involving arrest of thecell cycle and disruption of multiple oncoge.... Our results indicatethat MKC-1 causes cell cycle arrest and induces apoptosis both inleukemia cell lines and in leukemia patient samples." Dr. Bray also co...

Pharmacyclics Identifies Functional Biomarkers for its Novel HDAC Inhibitor and Demonstrates Preclinical Anti-Tumor Activity with Bruton's Tyrosine Kinase Inhibitors

...phoma lines are sensitiveto PCI-31523, with growth arrest and apoptosis occurring atconcentrations as low as 0.5uM. In other studies, oral dosing of PCI-31523 (10mg/kg qd) resultedin almost complete inhibition of inflammation in an animal model ofarthritis, indicating that this compound may be effective in...

Alnylam Announces Advancement of a New RNAi Therapeutic Development Program for the Treatment of Liver Cancer

...r cell division that,when inhibited, leads to cell arrest and cell death in dividingcells. ALN-VSP01 is formulated using Alnylam's novel liposomalformulation technology, which has been used to achieve delivery ofsiRNAs to cells of the liver and efficient silencing of genesexpressed in that organ. Liposomal ...

ZIOPHARM Presents Data Highlighting Oral ZIO-101 at AACR

...exasA&M University. ZIO-101 induces cell cycle arrest and celldeath by targeting several cellular pathways essential for cellsurvival. Exposure to ZIO-101 has a direct as well as indirecteffect on mitochondrial functions, resulting in depletion of energysupply to the cell and induction of apoptosis (pro...

Randomized Phase III Trial Showed Erbitux Significantly Improved Secondary Endpoints of Progression-Free Survival and Disease Control in Metastatic Colorectal Cancer Patients

...ho experience infusion reactions. Cardiopulmonary arrest and/or sudden death occurred in 2%(4/208) of patients with squamous cell carcinoma of the head andneck treated with radiation therapy and ERBITUX as compared to noneof 212 patients treated with radiation therapy alone. Fatal eventsoccurred within 1 t...

AEterna Zentaris Discloses In Vivo Data for its GHRH Antagonist JMR-132 at the AACR Annual Meeting in Los Angeles

...1 human breast cancers - JMR-132 induces growth arrest or total regression when combined with docetaxel chemotherapy - JMR-132 could provide a new therapeutic approach to the treatment of early and metastatic breast cancer "We are very pleased and encouraged with these results we haveseen t...

Vion Presents Data on Cloretazine (VNP40101M) at the 100th Annual Meeting of the American Association of Cancer Research (AACR)

...ed "Triapine(R) binds with iron andcauses S- phase arrest and activation of the apoptotic pathway inadvanced cancer patients" will be presented on Monday, April 16from 8 a.m. to 12 p.m. Vion Pharmaceuticals, Inc. is committed to extending the livesand improving the quality of life of cancer patients worldw...

AEterna Zentaris To Present First In Vitro Data for PI3K Inhibitors and In Vivo Results for a GHRH Antagonist at the AACR Annual Meeting in Los Angeles

...1 human breast cancers and induces growth arrest or total regression when combined with docetaxel chemotherapy. Consequently, JMR-132 could provide a new therapeutic approach for the treatment of early and metastatic breast cancer. Copies of these abstracts are current...

Cyclacel Pharmaceuticals to Present Preclinical Data on Sapacitabine and Seliciclib at AACR

...is by causing single-strand DNA breaks and induces arrest ofthe cell division cycle. Both sapacitabine and its majormetabolite, CNDAC, have demonstrated in preclinical studies potentanti-tumor activity in both hematological and solid tumors.Sapacitabine has been administered to approximately 150 patientsenr...

Data Available from Erbitux Phase III Study in First-Line Treatment of Advanced Pancreatic Cancer

...ho experience infusion reactions. Cardiopulmonary arrest and/or sudden death occurred in 2%(4/208) of patients with squamous cell carcinoma of the head andneck treated with radiation therapy and ERBITUX as compared to noneof 212 patients treated with radiation therapy alone. Fatal eventsoccurred within 1 t...

Survival Data Available From Erbitux Study in First-Line Treatment of Advanced Head and Neck Cancer

...ho experience infusion reactions. Cardiopulmonary arrest and/or sudden death occurred in 2%(4/208) of patients with squamous cell carcinoma of the head andneck treated with radiation therapy and ERBITUX as compared to noneof 212 patients treated with radiation therapy alone. Fatal eventsoccurred within 1 t...

Survival Data Available from Erbitux Study in First-Line Treatment of Advanced Head and Neck Cancer

...ho experience infusion reactions. Cardiopulmonary arrest and/or sudden death occurred in 2%(4/208) of patients with squamous cell carcinoma of the head andneck treated with radiation therapy and ERBITUX as compared to noneof 212 patients treated with radiation therapy alone. Fatal eventsoccurred within 1 t...