Animals in Medical Technology

Scientists Discover Origin of Malaria

... parasites show that malaria jumped from animals to humans, much the way that HIV, SARS and swine ... that modern pandemics do, namely by jumping from animals to humans" Wolfe said. "We now know that malaria, ... sanctuaries. They were primarily wild-born animals brought to the sanctuaries after being ...

China Animal Welfare Law Under Review While 36,000 Dogs Culled

... is the only way to ensure the humane treatment of animals for the long-term. "Hanzhong county and the ... on improving the welfare of wild and domestic animals by reducing the commercial exploitation of animals, protecting wildlife habitats, and assisting animals in distress. IFAW works both on the ground and in ...

Why Wait for an Anti-Aging Drug? Researchers Interviewed on CBS-TV's 60 MINUTES Discover Longevinex(R) Nutriceutical Matrix Activates 9-Fold More Longevity Genes than Plain Resveratrol

... derived proteins were found in calorie restricted animals because this intervention protected Sirtuin1 ... first study involving warm-blooded animals, the animals fed mega-dose resveratrol did not live as long as animals placed on a normal-calorie diet. Many resveratrol ...

EpiDerm's Skin Irritation Test Fully Validated in European Union

... the EU directive on the protection and welfare of animals used for experimental and other scientific ... This directive (EU 86/609) prohibits the use of animals in experiments if a validated alternative is ... because testing of cosmetic raw materials in animals will be prohibited in the EU beginning March 2009 ...

PharmAthene Presents Data for Protexia(R) and Valortim(R) at 2008 BARDA Industry Conference / PHEMCE Stakeholders Workshop

... was observed in 5 of the 8 Valortim(R)-treated animals that succumbed to inhalational anthrax. An oral ... positive ECL after spore exposure, 56% of the animals survived. "We are very excited about the animal ... showed over 50% of Valortim(R)-treated animals survived inhalational anthrax as compared to no ...

Rabies Vaccination Program Underway in Western Pennsylvania

... annual program that helps control rabies in wild animals is underway in western Pennsylvania, Agriculture ... "Controlling the spread of rabies in wild animals is essential to human and domestic animal ... the primary focus is to vaccinate raccoons, other animals -- including dogs, cats, cattle, horses, skunks ...

Catalyst Pharmaceutical Partners Announces Publication of Animal Data Demonstrating Vigabatrin Effective for Weight Loss

... up to 300 milligrams of vigabatrin per day. All animals received injections for two, 7-13 day periods, ... between. At the end of the 40 day period, all animals receiving vigabatrin weighed significantly less ... 19 percent of their total weight, while non-obese animals lost 12 to 20 percent of their total weight ...

Pew Commission Says Industrial Scale Farm Animal Production Poses 'Unacceptable' Risks to Public Health, Environment

... health, the environment and the welfare of the animals themselves, according to an extensive 2 1/2-year ... past five decades, the number of farms producing animals for food has fallen dramatically, yet the number of food animals produced has remained roughly constant. It is the ...

Preclinical Study Presented at AACR Annual Meeting Shows Peregrine's Anti-PS Immunocytokines Can Generate Protective Immune Responses in a Highly Aggressive Breast Cancer Model

... effect of the PS. This enabled the pre-treated animals to leverage the T-cell activating effects of the ... 270 days post-treatment. Among control animals receiving either 2aG4 alone or IL-2 fused to a ... 20%, remained tumor-free. All of the control animals receiving irradiated breast tumor cells alone ...

Data Presented at AACR Annual Meeting Shows Bavituximab Equivalent Plus Docetaxel Reduces Tumor Growth By Up to 95% and Halts Metastasis in a Model of Hormone-Refractory Prostate Cancer

... Treatment- -Survival Time More Than Doubled in animals Treated with Combination ... reduced the metastatic spread of tumor cells. In animals treated with the combination regimen, none of the ... 5 times. Survival time was more than doubled in animals receiving combination therapy compared to ...

Pixantrone Shows Activity in a Preclinical Study of Experimental Autoimmune Myasthenia Gravis (EAMG)

... in EAMG. EAMG was induced in subject animals using acetylcholine (T-cell) receptor, the autoantigen at the neuromuscular junction. The animals were randomly assigned to four treatment groups ... weeks after immunization, and 4) vehicle-treated animals as control groups. Doses of both pixantrone and ...

Anadys Pharmaceuticals Announces Positive Results for ANA598 in Animal Model of Chronic Hepatitis C Virus Infection

... a primate model of chronic HCV infection. Two animals chronically infected with HCV genotype 1b each ... activity of ANA598, two HCV genotype 1a infected animals received a single oral dose of ANA598 at ... dosing, the mean viral load decline in the two animals was 1.0 log10. ANA598 was well tolerated by all ...

Man's Best Friend May Open Door to Understanding Fibrotic Lung Disease in Human and Animal Populations

... Terriers (Westies) and discuss how science in animals and humans can work together to combat it," said ... "We believe that researching this disease in animals may move the field forward at a much faster pace ... diagnostic guidelines and standards of care for animals and creation of an animal tissue bank to study ...

Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

... program showing antisense drugs reduced fat mass and body weight in animals by reducing levels of targets in peripheral tissues such as liver and fat ... Significant reduction in plasma glucose levels in extremely hyperglycemic animals No harmful effects such as low blood glucose levels (hypoglycemia) ...

Doctors Urge Precaution to Shield Against Swine Flu

... Compound (AHCC), is standardized, has been extensively studied in animals and humans, and is the subject of dozens of articles in peer-reviewed ... and published in Journal of Nutrition, November 2006. Compared with animals exposed to the H1N1 virus without consuming AHCC, the viral load in the ...

Dendreon Presents Preclinical Data Demonstrating Activity of TRPM8 Agonist, D-3263, in Benign Prostatic Hyperplasia

... agent given alone, suggesting a potential additive effect. BPH-induced animals showed increases in dihydrotestosterone (DHT) concentrations in the plasma, levels of which were reduced in animals treated with D-3263, finasteride or a combination of the two. While ...

Elusys' Anthrax Anti-Toxin, Anthim(TM), Enters Second Phase I Clinical Study

... - Anthim Dramatically Improves Survival in animals with Clinical Symptoms of Anthrax disease - PINE BROOK, N.J., April ... life-saving potential even when given in a single dose to symptomatic animals many hours after anthrax exposure. In earlier animal studies, Anthim ...

Anadys Pharmaceuticals Announces Single Dose Safety and Pharmacokinetics Results for ANA598 in Healthy Volunteers

... antiviral effect against both genotype 1a and 1b. In two HCV genotype 1b animals dosed over four days, maximum viral load reductions of 2.2 and 2.6 log10 ... in viral load was seen over days three and four. In two HCV genotype 1a animals that each received a single dose of ANA598, viral load reductions of 0.5 ...

New Study Shows Cloning from Dried Cells Now Possible

... Widespread Use in Improving Medical Care and Saving Endangered animals from Extinction MT. LAUREL, N.J., Sept. 8 /PRNewswire/ -- Core Dynamics ... Loi also noted that the new technology also could assist with conserving animals threatened with extinction by allowing for easy and inexpensive ...

Inverness Medical Innovations Receives USDA Licensure of the BinaxNOW(R) Avian Influenza Virus Type A Antigen Test Kit

... and timely detection of AIV is not only important for the protection of animals and our food supply, but infections with these viruses can occur in ... 1997. Thus, early identification and effective management of infected animals may have important benefits for human health worldwide. By developing ...

Halozyme Therapeutics Announces Positive Findings With Pegylated Enzyme in Prostate Cancer Models

... and PC3-M-luc bone metastases. For the HA-producing xenograft PC3 model, animals received an intramuscular inoculation with PC3 prostate carcinoma cells in ... high IFP. When tumor volume reached 400-500 mm(3), a high tumor burden, animals were randomized to receive one of four possible treatments: PEGPH20 alone, ...

New Research Provides Evidence that Tea May Improve Attention and Focus, Keep Brain Cells Healthy, & Influence Genetics in Cancer

... EGCG equal to about two to four cups of green tea per day was provided to animals with induced Parkinsonism as part of their diet to evaluate how their symptoms improved or progressed. They found that when the animals are fed green tea EGCG, the polyphenol appeared to prevent brain cells ...

Sangamo BioSciences Announces Nature Biotechnology Study Demonstrating the Use of Zinc Finger Nucleases to Generate HIV Resistant T Cells

... of healthy and uninfectable immune cells. Furthermore, we observed that animals given the ZFN-modified cells had increased numbers of CD4 cells and substantially lower levels of HIV in their blood compared to animals given non-modified cells demonstrating statistically significant ...

Animals That Cyclone Survivors Depend on Need Help Now

... An emergency veterinary team from the World Society for the Protection of animals (WSPA) is on stand-by in Thailand awaiting authority to enter cyclone ... complimenting humanitarian efforts in this way we increase the number of animals we protect," said Russell. For more information and updates, visit: ...

Isis Reports Reduction of apoB-100 Levels in a Murine Model Resulting in Up to 92% Reduction of Atherosclerosis

... of normal serum cholesterol levels, has been genetically eliminated. These animals have very high cholesterol levels (1,000 - 2,000 mg/dL on a high fat diet) ... drug was evaluated in the context of two atherogenic high fat diets. animals on these diets had elevated total cholesterol and LDL-cholesterol levels ...

People With Diabetes May Have All-Natural Citrus Supplement To Help Lower Blood Glucose and Cholesterol Levels

... blood glucose, insulin, cholesterol and triglyceride levels. Half of the animals were then given Diabetinol(TM) for 42 days. The other six hamsters were ... treatment. At the end of the study, the Diabetinol(TM)-treated animals showed improvements in each blood glucose, insulin, and cholesterol and ...

New Data Shows Ranexa(R) Increases Glucose-Stimulated Insulin Secretion

... insulin secretion (GSIS) in pancreatic islets isolated from animals and humans. The Company believes that the increase in GSIS seen with ... manner in isolated islets. Acute administration of ranolazine to animals also significantly increased GSIS in the presence of a glucose load ...

Crystal Research Associates, LLC Issues Executive Informational Overview(R) (EIO(R)) on Bioniche Life Sciences Inc.

... that is committed to improving the quality of life in both humans and animals worldwide through innovative research, novel technologies, and ... focuses on providing products that enhance reproductive performance in animals and reduce the industry's reliance on antibiotics. One of the Company's ...

New Patent Awarded for Antigen-Sparing Vaccines that Elicit Robust Immunity

... nanoemulsion technology, have elicited a dramatic immune response in animals vaccinated against influenza, anthrax, hepatitis B and other diseases. In ... surfactant together with antigens from specific pathogens. Studies in animals demonstrate these vaccines easily penetrate the mucous membrane, where ...

New Approach to Treating Anthrax Significantly Improves Survival Rates in Pivotal Efficacy Studies

... monkeys, and acted quickly to provide a significant survival benefit to animals showing clinical symptoms caused by exposure to massively lethal ... significant survival benefit versus placebo. All ABthrax-treated animals that survived in both studies were rapidly cleared of anthrax toxin and ...

Dog Law Officers' Crackdown on Unsatisfactory Kennels Protecting Animals, Consumers

... in Pennsylvania, so consumers will know they are buying healthy and happy animals from licensed kennels." In July, state dog wardens inspected an ... able to prosecute kennel operators who willfully violate the law and put animals in potentially harmful situations." State dog wardens also charged ...

Game Commission Announces EHD Confirmed in Fayette County

... While the disease is not spread through deer to deer contact, congregating animals through feeding does make transmission easier by allowing midges that carry the virus greater access to a larger number of animals in a more confined area. Therefore, such feeding activities should be ...

One Shot of Gene Therapy Spreads Through Brain in Animal Study

... entire brain -- after one injection of gene therapy. If these results in animals can be realized in people, researchers may have a potential method for ... future studies, he will investigate whether this technique is effective in animals larger than mice. Such results might conceivably resemble a 2005 study in ...

Further Data on Safety and Efficacy of Cethromycin Presented at 47th Interscience Conference on Antimicrobial Agents and Chemotherapy

... Inhalation Anthrax Challenge in Rhesus Macaques" All antibiotic treated animals maintained normal hematologic parameters and remained abacteremic throughout the treatment period. All cethromycin- treated animals survived, with only 1/10 demonstrating abnormal hematologic parameters ...

Further Data on Safety and Efficacy of Cethromycin Presented at 47th Interscience Conference on Antimicrobial Agents and Chemotherapy

... Inhalation Anthrax Challenge in Rhesus Macaques" All antibiotic treated animals maintained normal hematologic parameters and remained abacteremic throughout the treatment period. All cethromycin- treated animals survived, with only 1/10 demonstrating abnormal hematologic parameters ...

Feeling Anxious or Distracted? New Research Shows a Cup of Tea Could Help

... how their symptoms improved or progressed. They found that when the animals are fed Green Tea EGCG, the polyphenol appeared to prevent brain cells ... improvements in reducing compounds that lead to lesions in the brains of animals with Alzheimer's disease. According to Dr. Mandel, "not only may the EGCG ...

K-State Researchers Bringing Expertise to Kansas City Symposium on Disease and National Security

... -- Kansas State University's expertise on diseases transmitted between animals and humans is being tapped for a prestigious symposium in Kansas City, Mo. ... recognized as the persistent concern for the health of several companion animals and livestock. During the last two decades, several zoonotic pathogens ...

Upstream Biosciences Acquires Innovative Platform Technology and Drug Candidates for Tropical Parasitic Diseases

... (Trypanosomiasis). Sleeping sickness is a parasitic disease in people and animals caused by protozoa of the Trypanosomiasis genus and transmitted by the ... is caused by the parasite Trypanosoma cruzi, which is transmitted to animals and people by triatomine insects. It is estimated that as many as 8-11 ...

Pennsylvania Agriculture Department Issues Quarantine for Allegheny County Horse Stable

... transmissible disease. Presently, the bureau is testing and monitoring horses at Rolling Hills Ranch. Horse owners who have boarded their animals at the facility since July 7 should contact their local veterinarian if the horse exhibits symptoms of the neurologic form of EHV-1. Owners with ...

Researchers Create First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

... paving the way for the development of novel genetically modified animal models of human disease. ZFN technology will make the generation of such animals faster and will create new opportunities in species other than mice. "Until now, rat geneticists lacked a viable technique for 'knocking ...