Airway in Medical Technology

K-State Researcher Finds Correlation Between Childhood Obesity and Asthma

... of physical activity had greater amounts of airway narrowing after exercise. "Kids who are ... important that the child remain active to prevent airway problems. Before the study, little was ... body composition and physical activity have in airway health in children, Rosenkranz said. When ...

New Studies Highlight Benefits of Coblation(R)-Assisted Procedures in Airway Fire Prevention and Endoscopic Sinus Surgery

... procedures eliminated the risk of airway fires, and Coblation(R)-Assisted Sinus Surgery ... ArthroCare and entitled, "Device-Related Risk of airway Fire in Oropharyngeal Surgery," presented today ... division, and Lee Smith, MD, compared the risk of airway fire for an electrosurgical device (Bovie) and a ...

Hope for Emphysema Sufferers: Clinical Trial That May Help Patients Breathe Easier Begins at Central DuPage Hospital

... Patient enrollment begins for trial of airway bypass procedure to treat advanced widespread ... recently announced the start of the EASE (Exhale airway Stents for Emphysema) Trial to explore an ... widespread emphysema. The trial focuses on airway bypass, a minimally invasive bronchoscopic ...

Genaera Announces MedImmune Initiation of Phase 2a Trial of Antibody Targeting Interleukin-9 in Patients with Asthma

... in many features of asthma, including increased airway inflammation and hyperreactivity. Blocking ... of IL- 9 has been shown to reduce the increased airway inflammation and airway hyperresponsiveness seen in animal models of ...

MedImmune Advances Clinical Development of Antibody Targeting Interleukin-9 in Patients with Asthma

... in many features of asthma, including increased airway inflammation and hyperreactivity. Blocking ... of IL-9 has been shown to reduce the increased airway inflammation and airway hyperresponsiveness seen in animal models of ...

The New England Journal of Medicine Publishes First Clinical Results for MedImmune's Chitinase-like Protein YKL-40 in Patients With Asthma

... that chitinases are effector models in asthmatic airway inflammation. As the first clinical experience in ... were correlated with asthma severity, airway expression of the molecule and parameters of airway remodeling. Additionally, the expression of ...

Mayo Clinic Physicians Report Findings from Research on Sleep Disorders

... impact that treatment with continuous positive airway pressure (CPAP)and other treatment modalities has ... elevates the air pressure in the upper airway passages slightly to keep these passages open, ... introduction of continuous positive airway pressure (CPAP) therapy in these patients?' and ...

MedImmune Initiates Phase 2a Multi-Dose Study in Patients with Asthma

... in the airways and allergen-induced airway modeling. These data further support our ... in many features of asthma, including increased airway inflammation and hyperreactivity. Blocking the ... to reduce the airway inflammation and increased airway inflammation and increased ...

CareFirst BCBS Covers eNO Measurement for Diagnosis, Asthma Treatment

... a well established indicator of asthma severity and steroid responsive airway inflammation. Measuring eNO and determining the level of airway inflammation can help clinicians more closely manage their patients' ...

New Phase 3 Study of Tapentadol Immediate Release Tablets Published in Current Medical Research and Opinion Journal

... suffering from conditions accompanied by hypoxia, hypercapnia, or upper airway obstruction, in whom even moderate therapeutic doses may significantly ... In such patients, even usual therapeutic doses of NUCYNTA(TM) may increase airway resistance and decrease respiratory drive to the point of apnea. ...

Pivotal Data Show Bronchial Thermoplasty Can Improve Quality of Life and Reduce Asthma Attacks and Emergency Room Visits for Adults with Severe Asthma

... of targeted airways. Controlled thermal energy is then delivered to the airway walls to reduce the presence of airway smooth muscle that narrows the airways in patients with asthma. The ...

Pharmaxis Announces Positive Results of Phase 3 Cystic Fibrosis Trial

... European Medicines Agency. Bronchitol is designed to hydrate the airway surface of the lungs, and promote normal lung mucus clearance. No new ... membrane within cells. In the lungs, this leads to a depletion of the airway surface liquid that normally bathes the cilia, and a resultant reduction ...

Pharmaxis Announces New Drug Application Submission for Aridol(TM)

... rely upon older tests that are often inaccurate and cumbersome to assess airway inflammation in patients with asthma. The easy to administer test uses a ... the more severe the patient's asthma diagnosis. People without airway inflammation do not respond to an Aridol challenge test. ...

FDA Approves LUSEDRA(TM) (fospropofol disodium) Injection for Monitored Anesthesia Care (MAC) Sedation

... and through the recovery process for early signs of hypotension, apnea, airway obstruction, and/or oxygen desaturation. Facilities for providing ... of supplemental oxygen is recommended in all patients receiving LUSEDRA. airway assistance maneuvers may be required. As with other sedative-hypnotic ...

Patients With Asthma and Seasonal Allergies Respond Better to Advair(R) for Their Asthma Than Singulair(TM)

... asthma symptoms. Asthma causes inflammation (swelling in the airways) and airway constriction (the tightening of muscles that surround the airways), and ... inhaled long-acting bronchodilator, salmeterol, to help prevent and reduce airway constriction. Advair is for people who still have symptoms on another ...

N30 Pharma Announces Completion of Phase 1 Clinical Studies With N30-201

... intends to develop N30-201 for the treatment of reactive and obstructive airway diseases, including Cystic Fibrosis and asthma. "We are pleased to have ... which store and transduce nitric oxide, and are critical modulators of airway and vascular smooth muscle tone. N30's drug development strategy focuses ...

Apieron, Inc. Begins Customer Shipments of the Insight(TM) eNO System

... (eNO). Exhaled nitric oxide is a well established clinical indicator of airway inflammation and asthma control. With the use of eNO measurements, ... and CEO of Apieron, Inc. "As current methods for monitoring asthma airway inflammation are subjective, the Insight eNO System provides quantifiable ...

MedImmune Advances Asthma Program with Start of a Phase 2 Trial in Europe and Australia and First U.S.-Based Clinical Trial for Antibody Targeting IL-13

... The Phase 2 clinical trial is designed to assess the effects of CAT-354 on airway hyperresponsiveness in patients with uncontrolled asthma. This randomized, ... a relevant target for treating asthma, considering its potential role in airway obstruction and in chronic airways remodeling, as seen in animal models. ...

Inverseon Announces Positive Phase IIa Asthma Study

... subjects experienced a clinically meaningful, dose-related, reduction in airway hyper-responsiveness. "To our knowledge, this is the first peer-reviewed ... in up-regulation of lung beta receptors, while reducing inflammation and airway hyper-responsiveness. The fact that we are seeing some of these same ...

N30 Pharma Announces Successful Initiation of Human Studies With N30-201

... intends to develop N30-201 for the treatment of reactive and obstructive airway diseases, including Cystic Fibrosis and asthma. "We are pleased to have ... that store and transduce nitric oxide, and are critical modulators of airway and vascular smooth muscle tone. N30 is a privately held company ...

Rigel Announces Initiation of Phase 1 Clinical Trial of R343 for Allergic Asthma by its Partner Pfizer

... address an important pathway in the allergic response causing asthmatic airway obstruction and tissue damage gives new hope to millions of asthma ... asthma is a chronic inflammatory disorder of the airways resulting in airway obstruction. In some patients, allergens, such as pollen, trigger the ...

Phase 2a Multi-Dose Study Initiated by MedImmune in Patients With Asthma to Further Expand Anti-Interleukin-9 Program

... has been shown to result in many features of asthma, including increased airway inflammation and hyperreactivity. Blocking the actions of IL-9 has been shown to reduce the airway inflammation and increased airway inflammation and increased airway hyperresponsiveness seen in animal ...

Genetic Source of Rare Childhood Cancer Found; Gene is Implicated in Other Cancers

... to result from a novel cancer induction mechanism not previously demonstrated. They discovered that loss of DICER1 protein specifically in lung airway cells appears to deregulate signals to nearby cells in which DICER1 itself still functions and somehow causes those cells to transform into malignant ...

Pharmaxis Announces Milestone in Phase III Trial for Cystic Fibrosis

... and Orphan Drug Designation from the European Medicines Agency for Bronchitol in cystic fibrosis. Bronchitol is designed to hydrate the airway surface of the lungs, and promote normal lung mucus clearance in order to improve lung function, break the cycle of repeated respiratory infections ...

New Study Suggests Cholesterol-Lowering Statins Reduce Severe Asthma Attacks that Result in Hospitalizations and Emergency Room Visits

... the bronchial passages. Currently, the recommended drug therapies for treating asthma include the long-term use of inhaled corticosteroids to reduce airway inflammation and mucus production. Statins are medications used to lower cholesterol levels in the blood and to reduce the risk of heart attack ...

Oridion Announces Significant Medical Studies Presented at STA

... the enhancement of patient safety through the monitoring of the carbon dioxide (CO2) in a patient's breath. These products provide effective, proven airway management and are used in various clinical environments, including procedural sedation, pain management, operating rooms, critical care units, ...

Ikaria(R) Named Private Company of the Year by New Jersey Technology Council

... side effect of inhaled nitric oxide therapy. Nitrogen dioxide (NO2) forms rapidly in gas mixtures containing nitric oxide and oxygen, thus may cause airway inflammation and damage. Methemoglobin, NO2, and Fi2 should be monitored during nitric oxide administration. For more information on INOmax, ...

Study Shows Potential Benefits of Xolair(R) in Treating Children Suffering from Moderate or Severe Persistent Allergic Asthma Inadequately Controlled With Inhaled Corticosteroids

... children under the age of 18; of these children, 2.5 million suffer from allergic asthma, the most common type overall. Allergic asthma causes airway obstruction and inflammation, and can be triggered by allergens such as dust mites, pet dander, mold and cockroaches. Among children aged five to ...

Pivotal Data Showed SYMBICORT(R) Improved Lung Function in Adults with COPD

... COPD is a disorder encompassing two serious lung diseases -- emphysema and chronic bronchitis -- which result in decreased quality of life, chronic airway inflammation and progressive loss of lung function, making it difficult to breathe normally.(8) Common symptoms include shortness of breath, chronic ...

New Data Show In Vitro Potency of Doripenem Against Resistant Bacteria

... treatment with epinephrine and other emergency measures, including oxygen, IV fluids, IV antihistamines, corticosteroids, pressor amines and airway management, as clinically indicated. Carbapenems may reduce serum valproic acid concentrations to subtherapeutic levels, resulting in loss of ...

Inhaled Nitric Oxide Data Presented at European Academy of Pediatrics Meeting

... from 24 weeks to 28 weeks, 6 days. All patients required the use of surfactant within 24 hours of birth or the use of CPAP, or continuous positive airway pressure, to maintain an oxygen saturation value of greater than or equal to 85 percent. Upon informed consent of the parent or guardian, patients ...

In Vivo Data on Taligen Therapeutics' Pipeline Candidates Presented at the XXII International Complement Workshop

... and lectin complement pathways whereas TT30 inhibits only the alternative pathway. The study showed that both TT30 and CR2-Crry significantly reduced airway hyper-responsiveness. This suggests that targeting the alternative complement pathway, while keeping the classical and lectin complement pathways ...

ASX/NASDAQ Media Release: Pharmaxis Files First Marketing Application for Bronchitol in Australia

... for people living with the incurable lung condition bronchiectasis. Pharmaxis is dedicated to the development of safe and effective treatments for airway diseases, and we continue to work closely with regulatory authorities worldwide to bring Bronchitol to patients as quickly as possible." It is ...

Data from In Vivo Disease Models on Taligen Therapeutics' Pipeline Candidates to be Presented at the XXII International Complement Workshop

... - 10:30 a.m. - noon, Session 2, Poster 202 TT30 and TT32 Targeted complement-inhibitory proteins CR2-Crry and CR2-fH ameliorate allergen-induced airway hyperresponsiveness and inflammation Joshua Thurman*, Katsuyuki Takeda, Stephen Tomlinson, Erwin Gelfand, V. Michael Holers Oct. 1, 2008, Posters ...

Second Pivotal Phase 3 Trial In Cystic Fibrosis Begins

... developing Bronchitol as a treatment to improve mucus clearance in the lungs of patients with cystic fibrosis, bronchiectasis and chronic obstructive airway diseases. Bronchitol is a patented, inhalable dry powder formulation of mannitol that can be administered by a convenient, hand- held pocket sized ...

FDA Requires Additional Information on DORIBAX for Treatment of Hospital-Acquired Pneumonia

... treatment with epinephrine and other emergency measures, including oxygen, IV fluids, IV antihistamines, corticosteroids, pressor amines and airway management, as clinically indicated. Carbapenems may reduce serum valproic acid concentrations to subtherapeutic levels, resulting in loss of ...

Bronchitol Phase 3 Cystic Fibrosis Trial Completes Recruitment

... and Orphan Drug Designation from the European Medicines Agency for Bronchitol in cystic fibrosis. Bronchitol is designed to hydrate the airway surface of the lungs, improve lung hygiene and promote normal lung clearance. Approximately 75,000 people in the major pharmaceutical markets ...

Bronchitol Cystic Fibrosis Dose Trial Results Positive

... and fast track status from the Food and Drug Administration (FDA) for Bronchitol in cystic fibrosis. Bronchitol is designed to hydrate the airway surface, improve lung hygiene and promote normal lung clearance. Additional data from this trial will be presented at a forthcoming scientific ...

Results From One-Year Study Suggest Advair(R) Provides Important Benefits for African American Patients With Asthma

... on an ICS alone. Taken in combination, an ICS and LABA fight the two main components of asthma -- inflammation (swelling in the airways) and airway constriction (the tightening of muscles that surround the airways). Inhaled corticosteroids treat the inflammation, while LABAs treat the ...

Shire Announces Approval of ELAPRASE(R) (idursulfase) in Brazil

... People with Hunter syndrome may also experience hearing loss, thickening of the heart valves leading to a decline in cardiac function, obstructive airway disease, sleep apnea, and enlargement of the liver and spleen. In some cases, central nervous system involvement leads to progressive neurologic ...