affinity

New Assays to Detect Disseminated Fungal Infections

... As opportunistic infections, these fungi show an affinity for the critically ill, for example in the setting of immunosuppression, chemotherapy, transplantation, hyperalimentation, burns, and ulcers. With advances in critical care, oncology, and transplant medicine, more and more patients enter the ranks o...

Arisaph Pharmaceuticals Announces Results of its Potent Smart DPP-4 Inhibitor, ARI-2243, at the ADA

...In vitro kinetic studies show that ARI-2243 has an affinity (Ki) of27 picomolar, binding tightly to DPP-4 and dissociating very slowlyfrom the enzyme. Such binding kinetics confer potency and longactivity. Specifically, during OGTT in normal mice, ARI-2243produced far greater lowering of plasma glucose compar...

Pieris Progresses Development of its Proprietary Biotherapeutics Platform: Successful Demonstration of Dual Targeting With Duocalin(R) Technology

...ic Anticalins(R) selected to havepicomolar binding affinity to distinct determinants on two definedclinically ...binding proteins that retain targetspecificity and affinity regardless of the structural orientationof their binding domains. Furthermore, the high intrinsic st...

Can-Fite Proceeds with Development of Third Drug; Progress in Development of CF502 Will Be Presented at the Annual European Congress of Rheumatology

...ugs CF101 and CF102, and is characterized byhigher affinity and selectivity to the A3 adenosine receptor, whichis targeted by the Can-Fite's drugs. The drug attacks inflammatorycells and leads to programmed cell death (apoptosis) andsuppression of the inflammatory process. Can-Fite is using humancells to inve...

Cimzia Effective in Reducing Signs and Symptoms of Rheumatoid Arthritis

...t inconventional anti-TNFs. CIMZIA(TM) has a high affinity for human TNF-alpha, selectivelytargeting TNF-alpha in inflamed tissue. Over the past decade, TNF-alpha has emerged as a major target of basic research andclinical investigation. This cytokine plays a key role inmediating pathological inflammation, a...

Geron's Telomerase Inhibitor Cancer Drug Demonstrates Good Pharmacokinetics and Tolerability in Phase I/II Trial

...se digestion in blood and tissues and its veryhigh affinity and specificity for telomerase. The molecule hassuperior cellular and tissue penetration properties due to itsproprietary manufacturing chemistry and its 5' lipid chain. GRN163L has been demonstrated to have anti-tumor effects in awide range of hema...

Molecular Insight Pharmaceuticals, Inc. Presents Preclinical Data on Molecular Imaging Pharmaceutical for Prostate Cancer

...earchers demonstratedthat MIP-1072 binds with high affinity to the PSMA protein on thecancer cell surface and that it is internalized into prostatecancer cells. In vivo, human prostate cancer xenograft studiesdemonstrated that MIP-1072 was present in high concentration intissues expressing PSMA, but not in ti...

BioLineRx Presents Data From Successful Phase I Trial for BL-1020 in Schizophrenia at American Psychiatric Association Conference

...or binding studiesindicate that BL-1020 has a high affinity to dopamine and specificGABA-A agonist activity. This unique clinical profile may explainthe reduction in side effects observed in animals and maycontribute to improving cognitive function in schizophrenia. BL-1020 is being developed by BioLineRx, L...

UCB Presents Long-Term CImzia Data in Crohn's Disease

...ential cellularcytotoxicity. CIMZIA(TM) has a high affinity for human TNF-alpha,selectively neutralizing the pathophysiological effects ofTNF-alpha. Over the past decade, TNF-alpha has emerged as a majortarget of basic research and clinical investigation. This cytokineplays a key role in mediating pathologica...

Independent publication supports the profile of CeNeS phase II compound, CNS 5161

...ey have shown thatCNS 5161 is a selective and high affinity NMDA receptor antagonistwith preferential binding ...brain. The profile ofCNS 5161 as a selective, high affinity and brain-penetrating agentnow make this a possibility. These properties of CNS 5161, togetherwith i...

Avanir Pharmaceuticals Presents IEED Prevalence and Updated Zenvia Long-Term Safety Data at AAN Annual Meeting

...sorder(IEED) may be related to the selectivity and affinity ofdextromethorphan at Sigma1 receptor sites concentrated in thebrainstem and cerebellum. All three studies were sponsored by the Company. About Zenvia Zenvia is a combination of two well-characterized compounds, thetherapeutically active ingredien...

Reata's Synthetic Triterpenoids Profiled in Nature Reviews Cancer

...ctorial mode of action,rather than those with high affinity for a single, specificmolecular receptor. While multi-factorial mechanisms are oftenthought to be associated with high drug toxicity, Dr. Sporn notesthat these agents are derived from natural products that have beensafely used for centuries with no a...

Adnexus Therapeutics Announces Presentation at the American Association for Cancer Research (AACR) on Clinical Product Candidate, CT-322

... of VEGFR-2," commentedDr. Furfine. "CT-322's high affinity and selectivity for VEGFR-2achieved comparable anti-tumor effect to molecules that inhibit abroad range of kinases." "As cancer therapy evolves, the importance of efficacy, safetyand tolerability of anti-angiogenic agents are becoming morepronounced...

DX-88 for Hereditary Angioedema Meets Primary and Secondary Endpoints in Phase 3 Trial (EDEMA3)

...which rapidly selectscompounds that bind with high affinity and specificity totherapeutic targets. Dyax leverages this technology broadly withover 70 revenue-generating licenses and collaborations fortherapeutic discovery, as well as in non-core areas such asaffinity separations, diagnostic imaging, and resea...