Activity in Medical Technology

Regular Yoga Practice Is Associated With Mindful Eating

... to hunger and satiety than the physical activity of yoga practice itself. The follow-up ... who did not. This was independent of physical activity and dietary patterns. We hypothesized that ... gain over time, independent of the physical activity aspect of yoga practice," said Kristal, who is ...

Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C

... The secondary objective was to assess antiviral activity by measuring the change in HCV RNA. Patients were ... QD) were evaluated. PSI-7851 Antiviral activity Summary Preliminary Antiviral ... PSI-7851 demonstrated potent antiviral activity with a mean HCV RNA decrease of -0.49 log(10) ...

FDA Approves Tekturna HCT(R) as Initial Treatment in Patients Unlikely to Achieve Their Blood Pressure Goals With a Single Agent

... by directly targeting renin and decreasing the activity of the renin angiotensin aldosterone system ... by directly targeting renin and decreasing the activity of the RAAS. Renin is an enzyme produced by the ... to high blood pressure. Tekturna reduces renin activity and helps blood vessels relax and widen so blood ...

Cytokine PharmaSciences Initiates Phase I Study of Oral Anti-Inflammatory Agent, CPSI-2364

... to generate antibodies that could neutralize its activity and result in loss of efficacy over time." ... IL-1, IL-6, and IL-8. Semapimod has demonstrated activity in multiple animal models of inflammation and ... was shown to have significant anti-inflammatory activity in Phase II clinical trials in Crohn's disease, ...

Human Genome Sciences and GlaxoSmithKline Announce Positive Phase 3 Study Results for BENLYSTA(TM) in Systemic Lupus Erythematosus

... BENLYSTA also significantly reduced SLE disease activity versus placebo based on a number of other ... of at least 4 points on the SELENA SLEDAI disease activity scale (which indicates a clinically important ... recognizes and inhibits the biological activity of B-lymphocyte stimulator, or BLyS(R). BLyS is a ...

Oncolytics Biotech(R) Inc. Announces Publication of Research on Synergistic Activity of Reovirus and Chemotherapy in NSCLC

... The paper, entitled "Synergistic Antitumor activity of Oncolytic Reovirus and Chemotherapeutic Agents ... used alone, it demonstrated significant cytolytic activity in 7 of 9 NSCLC cell lines examined. The ... The investigators concluded that the oncolytic activity of reovirus can be potentiated by taxanes and ...

Results From Drug Trials and New Risk Factors Announced at International Alzheimer's Conference

... Two studies from ICAD 2009 looked at physical activity and mental performance as we age. One study found that maintaining or increasing physical activity throughout life may slow cognitive decline as we ... women found that moderate long-term physical activity may improve late life cognition; while long-term ...

Data Demonstrated ACTEMRA(R) (tocilizumab) Significantly Inhibited Progression of Structural Joint Damage in Rheumatoid Arthritis Patients

... of RA. Studies demonstrate that reducing the activity of IL-6, one of several key cytokines involved in ... www.RocheExchange.com . (1) The Disease activity Score (DAS)28 is a combined index that measures disease activity in patients with RA. It combines information from ...

Trius Announces Positive Results From Phase 2 Clinical Trial of Torezolid in Patients With Complicated Skin and Skin Structure Infections

... in vitro and in vivo In vivo bactericidal activity activity against all clinically important, gram-positive, ... including those resistant to linezolid activity against clinically important atypical and ...

Access Pharmaceuticals Announces Publication of Thiarabine Combination Data

... clofarabine provides much greater antitumor activity than achieved by either agent alone. In one ... entitled "Enhancement of the in vivo antitumor activity of clofarabine by ... has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on ...

CuraGen Updates CR011-vcMMAE Data at ASCO

... - activity Demonstrated in Advanced Breast Cancer and ... "We are very encouraged by the early evidence of activity demonstrated in this trial and look forward to ... The study successfully met its primary activity endpoint, with 5 objective responses (1 ...

Proteolix Presents Positive Clinical Data for Carfilzomib in Multiple Myeloma at the 2009 ASCO Annual Meeting

... carfilzomib demonstrating anti-cancer activity and progression-free survival in patients with ... tolerated and demonstrates clear single-agent activity in a heavily pre-treated multiple myeloma patient ... trials, carfilzomib has demonstrated single-agent activity in hematologic malignancies and solid tumors, ...

Trubion Announces Positive Data From a Phase 1 / 2 Study of TRU-016 for the Treatment of Chronic Lymphocytic Leukemia (CLL)

... and Refractory CLL -- Early Promising Clinical activity The clinical data presented at the American ... with the 0.1 mg/kg dose, evidence of biologic activity was observed. The median reduction in peripheral ... . "These results show promising single agent activity of TRU-016, even at surprisingly low doses, in a ...

Proteolix Presents Phase 1b/2 Clinical Data for Carfilzomib in Advanced Solid Tumor Patients at the 2009 ASCO Annual Meeting

... Promising Anti-cancer activity Observed in Relapsed Patients ORLANDO, Fla., ... studies, carfilzomib demonstrated promising activity as a highly selective and potent inhibitor of the ... In the Phase 1b trial, carfilzomib demonstrated activity in advanced solid tumors, with partial responses ...

Keryx Biopharmaceuticals Reports Single Agent Phase 2 Data of KRX-0401 (Perifosine) Further Demonstrating KRX-0401's Activity in the Treatment of Advanced Metastatic Renal Cell Cancer

... KERX ) today announced data on the clinical activity of KRX-0401 (perifosine), the Company's ... "perifosine demonstrated impressive single agent activity with an overall partial response rate of greater ... commented, "We believe that this single agent activity for perifosine once again demonstrates that ...

Celladon Provides MYDICAR(R) Program Update of First-In-Human Trial for Advanced Heart Failure at American Society of Gene Therapy Annual Meeting

... Demonstrate Safety and Evidence of Biological activity in 9 of 12 Patients; Phase 2 Study ... quality of life questionnaire, biomarker activity and left ventricular size and function. ... biological effects of restoring SERCA2a enzyme activity in heart muscle cells. The enzyme levels are ...

Cardiovascular Fitness Not Affected by Cancer Treatment

... Medicine in Seattle. "We know physical activity is a critical component of cancer survivorship, ... The data included demographics, physical activity levels and cancer treatment type, duration and ... me, who are interested in prescribing physical activity for this population." LeMoine and Furth ...

Carbapenems and Other Agents that Provide Broad-Spectrum Activity are Preferred by Surveyed Physicians for the Treatment of Intra-Abdominal Infections

... A Drug's activity Against Anaerobes is the Leading Attribute in ... infections because of their potent broad-spectrum activity and efficacy against gram-negative and anaerobic ... a drug to treat intra-abdominal infections is its activity against anaerobes." The new report entitled ...

Video: UCB Launches Vimpat(R) in the U.S. for Add-On Treatment of Epilepsy in Adults

... shown to involve the modulation of sodium channel activity in the nervous system. Sodium channels play a crucial role in regulating the activity of the nervous system to help nerve cells ... blocking drugs. This action then regulates the activity of over-excited nerve cells, which may contribute ...

Two-Year Data Reinforce Effect of ACTEMRA(R) (tocilizumab) in Inhibiting Progression of Joint Damage and Improving Physical Function in Rheumatoid Arthritis Patients

... to DAS28 criteria, which measures disease activity in RA patients(2). The study also showed that a ... of RA. Studies demonstrate that reducing the activity of IL-6, one of several key cytokines involved in ... assistance, and 3 = unable). (2) The Disease activity Score (DAS)28 is a combined index that measures ...

Agennix Receives Fast Track Designation From FDA for Talactoferrin in Combination With Sunitinib for Renal Cell Carcinoma

... NSCLC. Talactoferrin mediates its anti-cancer activity by targeting dendritic cells which play an ... Track designations were based upon the clinical activity and tolerability data from two randomized ... a first-in-class molecule with immunological activity for the treatment of cancer and other unmet ...

Boehringer Ingelheim to Present New Phase II Clinical Data on Two Lead Oncology Compounds at ASCO 2009

... EGFR / HER2 Tyrosine Kinase Inhibitor, Suggests activity in Second-line Treatment of NSCLC Patients with ... LUX-Lung 2 study suggest BIBW 2992 has anti-tumor activity in advanced, second-line, non-small cell lung ... LUX-Lung 2 study suggests that BIBW 2992 may have activity in the second-line setting among NSCLC patients ...

Trius Therapeutics Announces Presentations Featuring Torezolid Antibiotic at the 19th European Congress of Clinical Microbiology and Infectious Diseases

... Phase 2 clinical development with potent activity against gram-positive bacteria, including ... within human macrophages cells and shows activity towards intraphagocytic linezolid-sensitive and ... oral and IV oxazolidinone antibiotic with potent activity against drug-resistant Gram-positive bacterial ...

Doctors Urge Precaution to Shield Against Swine Flu

... defenses, and specifically on the strength and activity of white blood cells called Natural Killer (NK) ... shown that AHCC reliably helps to support NK cell activity in people with low NK cell function, improving ... reduction in deaths. In the AHCC group, NK cell activity was markedly increased immediately, achieving ...

Ground-Breaking Combination of All-Oral Agents Demonstrates Potential as Hepatitis C Treatment Regimen

... Pharmasset. Further studies will test the activity and safety of the combination of R7227 and R7128 ... HCV infection. R7128 has shown potent in vivo activity against all of the most common HCV genotypes (1, ... "First-In-Man Demonstration Of Potent Antiviral activity with a Nucleoside Polymerase (R7128) and Protease ...

Roche and Pharmasset Initiate Phase IIb Clinical Trial of R7128, Most Advanced Nucleoside Polymerase Inhibitor in Development for Chronic Hepatitis C

... including a higher barrier to resistance and activity across multiple genotypes, as well as a high ... chronic HCV infection. R7128 has shown in vitro activity against all of the most common HCV genotypes. ... demonstrated significant short-term antiviral activity with safety and tolerability comparable to ...

ANA598 Demonstrates Potent Antiviral Activity at all Dose Levels in Completed Phase Ib Study in Hepatitis C Patients

... inhibitor, demonstrated potent antiviral activity at all dose levels and was well tolerated in a ... and CEO, commented that "The potent antiviral activity demonstrated at all three doses in this study is ... evaluate the safety, tolerability and antiviral activity of orally administered ANA598 in treatment-naive ...

Expert Insights in Acute Lymphoblastic Leukemia: Current Challenges and Future Directions

... Complimentary Continuing Education Online activity and Podcast for Nurses and Pharmacists ... a complimentary continuing education online activity and podcast titled Expert Insights in Acute ... in this free continuing education online activity and podcast. "Robert Michael Educational ...

Genes Identified That Enhance Tumor Cell Sensitivity to CTI's Cancer Drug Brostallicin

... genetic targets were tested for synergistic activity in combination with brostallicin. The outcome of ... groove binder, has shown potent cancer killing activity and has demonstrated synergism in combination ... and predominantly hematologic toxicities. activity was demonstrated in a number of solid tumor ....

Pharmasset Initiates First Time in Human Study of PSI-7851 for the Treatment of Hepatitis C (HCV)

... their higher barrier to resistance and antiviral activity across multiple HCV genotypes, characteristics ... PSI-7851 has demonstrated in vitro anti-HCV activity with EC(50) values of 90 +/- 60 nM, which is ... Like R7128, PSI-7851 has demonstrated in vitro activity against all of the most common HCV genotypes. ...

Access Pharmaceuticals Announces Positive ProLindac(TM) Phase 2 Ovarian Cancer Clinical Trial Results

... therapies. We saw significant DACH platinum activity and efficacy in patients at the highest dose ... Senior Vice President R&D. "The DACH platinum activity level seen benchmarked favorably with published ... has demonstrated both pre-clinical and clinical activity in certain cancers. For additional information on ...

American Academy Of Orthopaedic Surgeons 2009 Annual Meeting 'Highlights and Hot Topics'

... Using a common mechanism to score activity levels after hip surgery, researchers found that ... bone paste injections, are shown to add improved activity for osteoporosis patients People ... Patients reported 60 days of improved daily activity compared with untreated peers. Driving ...

EntreMed Presents Initial Clinical Results for ENMD-2076

... Data show preliminary evidence of antitumor activity as determined by reduction in tumor markers in ... by tumor regression. The enhanced antitumor activity observed with the combination of ENMD-2076 and ... include MKC-1, an oral cell-cycle regulator with activity against the mTOR pathway currently in multiple ...

Cylene Pharmaceuticals Initiates Phase I Trial With CX-4945 -Breakthrough First-in Class Inhibitor of CK2

... CX-4945 demonstrates potent tumor regression activity in murine xenograft models, as well as favorable ... as well as observe for signs of anti-tumor activity via pharmacodynamic as well as radiographic ... demonstrates broad spectrum anti-proliferative activity against diverse cancer cell lines, and the data ...

Synvista Therapeutics Announces First Dosing of SYI-2074 in Clinical Trial for Psoriasis

... design of oral and topical drugs that mimic the activity of glutathione peroxidase (GPx), the only enzyme ... Animal models have shown that elevated activity of GPx protects animals from experiencing heart ... disease varies inversely with levels of GPx activity (i.e., higher levels of oxidized lipids promote ...

Positive Phase II Study of Pacira's EXPAREL(TM) (DepoBupivacaine) in Hernia Repair Presented at the Postgraduate Assembly in Anesthesiology (PGA)

... resulted in significantly reduced pain with activity in the first 8 to 24 hours following surgery, ... -- Significant reductions in pain with activity in EXPAREL treated patients compared to active ... to significantly lowering pain scores with activity during the 8 to 24 hours after administration, ...

K-State Researcher Finds Correlation Between Childhood Obesity and Asthma

... levels of body fat and lower levels of physical activity had greater amounts of airway narrowing after ... higher the body fat and the lower the level of activity of the child, the more likely they were to have ... about the role body composition and physical activity have in airway health in children, Rosenkranz ...

Three Studies Presented at the American Society of Hematology Annual Meeting Showed Response to Treatment with Campath(R) in Patients with High-Risk CLL

... treatment with Campath(R) (alemtuzumab) showed activity in high-risk chronic lymphocytic leukemia (CLL) ... Hospital, Natters, Austria. "This analysis showed activity in patients across all cytogenetic categories -- ... in combination with the FCR regimen showed activity in previously untreated patients with 17p ...

Rib-X Pharmaceuticals Reports Positive Top-Line Results from Phase 2 Study of Delafloxacin

... - Fluoroquinolone Compound Demonstrates Potent activity Against Antibiotic Resistant Gram-Positive ... the more active compound overall, including its activity against Staphylococcus aureus and ... fluoroquinolone, which has demonstrated more activity than other quinolones against Gram-positive ...

Research Highlights New Approaches to Prevent Blood Clots in Several High-Risk Patient Populations Including Largest Study Ever to Examine Use of Blood-Thinning Medication in Patients With Cancer

... with biotin to reverse the Factor Xa inhibiting activity of idrabiotaparinux. At the end of the initial ... idrabiotaparinux or idraparinux. Anti-Factor Xa activity was measured just prior to the infusion, just ... and idraparinux. Levels of Factor Xa activity were identical in both treatment groups ...