acid in Medical Technology

Results From Trials of DHA in Alzheimer's Disease and Age-Related Cognitive Decline

... amounts, and is the most abundant omega 3 fatty acid in the brain. DHA oil is abundant in some marine ... et al - A clinical trial of docosahexaenoic acid (DHA) for the treatment of Alzheimer's disease. ... of the MIDAS Trial: Effects of Docosahexaenoic acid on Physiological and Safety Parameters in ...

ALP Life Sciences, LLC Announces Nanoveson(TM) Patent Filing and Whitepaper Availability on Proposed Therapy for Non-Alcoholic Fatty Liver Disease (NAFLD) and Comorbid Diseases

... including biliary phospholipids, arachidonic acid metabolites, cholesterol, methyl metabolites, ... research focused on blocking arachidonic acid metabolism along cytochrome P450, leukotriene, ... and thromboxane eicosanoid pathways. Arachidonic acid metabolism is implicated in many inflammatory ...

Shire Presented Results of a New Database Analysis on Lialda(R) (Mesalamine) and Other 5-ASAs for Ulcerative Colitis at Digestive Disease Week

... presented the results of a 5-aminosalicylic acid (5-ASA) persistency analysis entitled, "Twelve-month Persistence with 5-aminosalicylic acid Therapy: Results from a Large Pharmacy Database," ... "Twelve-Month Persistence With 5-Aminosalicylic acid Therapy: Results From A Large Pharmacy Database." ...

New Study Evaluating the ADHD Medication VYVANSE(R) (lisdexamfetamine dimesylate) CII Demonstrated No Change in the Pharmacokinetic Profile of VYVANSE When Coadministered with Prilosec OTC(R) 40 mg (20 mg X 2), a Commonly Used Proton Pump Inhibitor (PPI)

... of adults in the United States who suffer from acid reflux. ADHD is estimated to affect 4.4 percent ... inhibitors tend to decrease the production of acid in the stomach," said Dr. Matthew Brams, a ... these medications act on proton pumps by blocking acid production thereby reducing gastric acidity. ...

Taking Folic Acid for a Year Before Pregnancy May Reduce Risk of Preterm Birth

... Dimes Message: Start Taking a Vitamin with Folic acid Before Pregnancy WHITE PLAINS, N.Y., May 11 /PRNewswire-USNewswire/ -- Women who take folic acid supplements for at least one year before they ... study author. "We already know that folic acid supplementation beginning before pregnancy and ...

Lack of Food Variety Puts Kids With Autism at Risk for Poor Nutrition

... Suggest Food Variety and Cognition-Related Fatty acid are Important to Well Being of Affected Children ... children with autism have low levels of a fatty acid linked to cognitive function. This finding, the ... warrants further research into how the low fatty acid levels may trigger biochemical changes in the ...

Hyperion Therapeutics Receives Orphan Drug Designation for HPN-100 for the Treatment of Urea Cycle Disorders

... ) HPN-100 is a pre-pro-drug of phenylacetic acid which is the active moiety of BUPHENYL(R), the ... ornithine transcarbamylase and argininosuccinic acid synthetase. HPN-100 is dosed orally in liquid ... transcarbamylase (OTC), or argininosuccinic acid synthetase (AS). BUPHENYL should not be ...

Cepheid Announces European Release of First On-Demand Molecular Test for Simultaneous Detection of Mycobacterium tuberculosis (TB) and Resistance to Rifampicin

... find that it requires less hands-on work than the acid fast smear, long a standard method to identify ... for fully integrated and automated nucleic acid analysis. The system is designed to purify, concentrate, detect and identify targeted nucleic acid sequences thereby delivering answers directly ...

American Lung Association Study to be Published in the 'New England Journal of Medicine' Finds Prescription Heartburn Medication Does Not Control Asthma Symptoms as Previously Thought

... and breathlessness were triggered in part by acid reflux. A new study conducted by the American ... who do not exhibit symptoms associated with acid reflux such as heartburn or stomach pain. ... symptoms. These results show that prescription acid controllers were no more effective than placebo ...

Hyperion Therapeutics Announces Results for Phase II Study in Urea Cycle Disorders

... ornithine transcarbamylase and argininosuccinic acid synthetase. HPN-100, which is dosed orally in ... which is formed from phenylacetic acid and glutamine. Hyperion and Ucyclyd Pharma, ... transcarbamylase (OTC), or argininosuccinic acid synthetase (AS). BUPHENYL(R) should not be ...

Another LNA-based RNA Inhibitor Enters Clinical Trials

... inhibitor was developed using the Locked Nucleic acid technology. In preclinical animal studies, ... receptor (AR) down regulation by locked nucleic acid antisense oligonucleotides specifically inhibits ... "EZN-3042, a novel locked nucleic acid oligonucleotide against survivin, inhibits ...

Studies Show Combination Laser Therapy Effective At Clearing Acne, Reducing Oil Production

... pulsed-dye laser and topical 5-aminolevulinic acid provides long-lasting clearance of acne lesions. ... known as topical 5-aminolevulinic acid (ALA) and activated by long-pulse, pulsed dye ... the photosensitizer topical methyl-aminolevulinic acid (MAL) with either PDT or red light. Dr. ...

Mission Pharmacal Launches CitraNatal(R) Assure Prescription Prenatal Vitamin

... a patented, plant-based form of the omega-3 fatty acid DHA, which is consistent with current published ... women(1). DHA is the recommended essential fatty acid for prenatal care. It has been shown to be ... et al. A Randomized Trial of Docosahexaenoic acid Supplementation During the Third Trimester of ...

Phase III Trial Results Show Elitek(R) (rasburicase) Significantly Reduced Plasma Uric Acid Levels versus Allopurinol in Adults with Hematologic Cancers at Risk for Tumor Lysis Syndrome

... (rasburicase) significantly reduced plasma uric acid (PUA) levels compared to allopurinol alone ... alone, which showed a reduction in plasma uric acid levels for the sequential combination versus ... can be eliminated. Elevated levels of plasma uric acid can cause hyperuricemia, a serious condition that ...

Arthritis Advisory Committee Recommends FDA Approval of Febuxostat for the Treatment of Hyperuricemia in Patients With Gout

... for its ability to lower levels of serum uric acid in patients with hyperuricemia associated with gout. Hyperuricemia, elevated uric acid levels in the body, is associated with gout, a ... and diarrhea. About Gout and Uric acid ...

Takeda's Investigational PPI TAK-390MR Demonstrated Higher Healing Rates Compared to Lansoprazole as the Severity of Erosive Esophagitis Grade Increased, a New Integrated Analysis Showed

... GERD is a chronic condition commonly known as acid reflux disease. GERD can occur when the valve at ... liquids to enter the stomach and closes to keep acid and food in the stomach. When the LES does not ... The stomach is better equipped to handle acid than the esophagus. If the esophagus is ...

New Data Shows Prescription Omega-3 Acid Ethyl Esters Reduced the Incidence of Death in Heart Failure Patients

... study, showed that 1 g/d dose of omega-3 acid ethyl esters reduced all cause mortality and ... long term treatment with prescription omega-3 acid ethyl esters was effective in reducing both ... reasons. Treatment with prescription omega-3 acid ethyl esters resulted in a nine percent relative ...

Ardea Biosciences Advances Lead Product Candidate for the Treatment of Gout, RDEA594, Into Phase 1 Clinical Trial

... safety, tolerability, pharmacokinetics and uric acid lowering effects of single ascending oral doses ... caused by abnormally elevated levels of uric acid in the blood stream. These abnormally elevated levels lead to the deposition of uric acid crystals in and around the connective tissue of ...

Nature Publication Reports on Key Role of Bile Acids in Glucose Metabolism and Insulin Signaling

... 7, Number 8, August 2008) describes why bile acid receptors are promising targets for drug ... Highlights of the article, "Targeting bile acid signaling for metabolic diseases," authored by ... metabolism and homeostasis. For example, bile acid activation of FXR results in a decrease in ...

New Discovery of Key Difference in Bile Acid Metabolism in Patients with Type 2 Diabetes May Suggest Underlying Disorder

... First Extensive Report of Bile acid Aberration in Type 2 Diabetes Patients ... have discovered a key difference in bile acid metabolism in people with type 2 diabetes which ... preliminary data suggesting alterations in bile acid metabolism in people with type 2 diabetes. Now ...

FDA Broadens US Indication for Once-Yearly Reclast(R) as Only Osteoporosis Treatment Approved for Prevention of Fractures After a Hip Fracture

... The active ingredient in Reclast is zoledronic acid 5 mg administered once a year(1). Zoledronic acid is also available in a different dosage under the ... HORIZON Recurrent Fracture Trial. Zoledronic acid and clinical fractures and mortality after ...

Video: Major Independent Trial Demonstrates Significant Anticancer Benefit of Zometa(R) in Women With Early-Stage Breast Cancer

... of these studies, AZURE (Adjuvant Zoledronic acid to redUce REcurrence), has completed ... in patients with hypersensitivity to zoledronic acid or other bisphosphonates, or any of the ... 1. Gnant, M. et al. Efficacy of Zoledronic acid in Premenopausal Women With Breast Cancer ...

Ardea Biosciences Identifies Lead Development Candidate for Gout, RDEA594

... is caused by abnormally elevated levels of uric acid in the blood stream. RDEA594 is a major ... to be responsible for essentially all of the uric acid lowering effects seen with RDEA806. Robust uric ... the URAT1 transporter-mediated uptake of uric acid ex vivo and ...

Abbott's Phase III Studies of Investigational TriLipix(TM) (ABT-335), in Combination With Statins, Meets Primary Endpoints on Improving LDL, Triglycerides and HDL

... an investigational new fenofibric acid molecule, will be known as TriLipix(TM). Both ... statins. These studies using fenofibric acid combined with atorvastatin and simvastatin met ... TriLipix is an investigational new fenofibric acid molecule, currently in clinical development for ...

Low Acid Coffee Backed By Scientific Research

... Calif., March 27 /PRNewswire/ -- Puroast(R) Low acid Coffee has conducted both chemistry and consumer ... Davis found Puroast(R) to have less than half the acid of all other commercial coffees. The company now ... symptom relief when drinking Puroast(R) Low acid Coffee. "This is important research for both ...

Mayo Clinic Proceedings Contributors Highlight Research Findings About Cardiovascular Benefits Associated With Omega-3 Fatty Acids

... with cardiovascular benefit, docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA), are found in fish oils. The best source ... randomized to receive omega-3 fatty acid supplements containing DHA and EPA or to act as ...

Phosphagenics Initiates U.S. Clinical Trials for Its Topical Retinoic Acid

... an increase in dermal absorption of retinoic acid when formulated with Phosphagenics' proprietary ... to the American Journal of Dermatology, retinoic acid is prescribed most often as the topical treatment ... Inc., half of the patients who end their retinoic acid treatment cycle prematurely do so because of ...

Folate in Strawberries May Contribute to Healthy Pregnancy

... New Study Links Folic acid to Reduced Premature Births WATSONVILLE, ... reported about a study that shows folic acid supplements greatly reduced the risk of premature ... of the California Strawberry Commission. "Folic acid is the synthetic form of folate, which is ...

Huge Drop in Preterm Birth-Risk Among Women Taking Folic Acid One Year Before Conception

... Largest U.S. Study of Pre-conceptional Folic acid Supplementation Receives March of Dimes Award ... New research suggests that women who take folic acid supplements for at least one year before ... 28 to 32 weeks." "We already knew that folic acid supplementation beginning before pregnancy and ...

Radiesse Provides Greater Patient Satisfaction Than Either Juvederm or Perlane as Reported in a 205-Patient Clinical Trial Published in the Journal of Dermatologic Surgery

... similar safety characteristics as hyaluronic acid fillers. Results from two other studies were ... study of Radiesse against leading hyaluronic acid fillers demonstrates this difference in a ... filler as compared to three leading hyaluronic acid fillers, Perlane and two forms of Juvederm. The ...

Ardea Biosciences, Inc. Announces New Clinical Development Program Directed Toward the Treatment of Gout

... Dose-Dependent Reduction in Serum Uric acid in Phase 1 Clinical Study - Phase 2 Efficacy ... caused by abnormally elevated levels of uric acid in the blood stream. These abnormally elevated levels lead to the deposition of uric acid crystals in and around the connective tissue of ...

Cost-Effectiveness Study Supports Use of EUFLEXXA(TM) by Rheumatologists for Pain Relief in Patients with Knee Osteoarthritis

... hyaluronate) intra-articular hyaluronic acid (HA) for the relief of pain in patients with ... the first and only non-avian derived hyaluronic acid approved in the U.S. for the treatment of ... includes EUFLEXXA(TM), hyaluronic acid for pain from osteoarthritis in the knee. Urology ...

Bayer Issues Additional Guidance to Physicians on Trasylol(R)

... to patients who received either aminocaproic acid or tranexamic acid. Data have not, as yet, been ... to patients who received either aminocaproic acid or tranexamic acid. Patient safety remains ... and safety of the use of aprotinin, aminocaproic acid and ...

Hyperion Therapeutics Announces Enrollment of First Patient in Phase 1/2 Clinical Trial of GT4P in Patients With Urea Cycle Disorders

... including a protein restricted diet, amino acid supplementation, and pharmacological therapy," ... transcarbamylase (OTC), or argininosuccinic acid synthetase (AS)), and a pre-prodrug of ... parts of the urea cycle, essential amino acid supplementation, replacement of urea cycle ...

Studies Show Body Mass Index Has No Effect on Resolution and Healing of GERD Symptoms

... erosive esophagitis, a condition in which stomach acid wears away, or erodes, the inner lining of the ... and stomach does not close properly, allowing acid to leak back into the esophagus. When a person is ... erosive esophagitis, a condition in which stomach acid wears away, or erodes, the inner lining of the ...

FASgen Announces Significant Milestone in Its Cancer Drug Development Program

... BALTIMORE, Oct. 1 /PRNewswire/ -- FASgen's fatty acid synthase inhibitor (FASi) compounds, led by ... of action for the treatment of cancer. The fatty acid biosynthesis pathway is critical to all living ... many compounds that selectively inhibit fatty acid biosynthesis. One group of these compounds holds ...

University of Michigan Study Shows SEQUENOM's MassARRAY Technology Identifies HPV Infections Missed by Standard Hybridization Test

... time-of-flight (MALDI-TOF) mass spectrometry-based nucleic acid analysis platform that quantitatively measures genetic target material and ... manner. SEQUENOM's MassARRAY system facilitates a number of nucleic acid analysis applications including single nucleotide polymorphism (SNP) ...

Cepheid Receives Grant to Develop Ten-Color Real-Time PCR Detection Technology for Use in the GeneXpert(R) System

... and detection functions for fully integrated and automated nucleic acid analysis. The system is designed to purify, concentrate, detect, and identify targeted nucleic acid sequences thereby delivering answers directly from unprocessed samples. ...

Ferring Pharmaceuticals Unveils Six-Month Efficacy Data for EUFLEXXA(R) for the Treatment of Osteoarthritis Knee Pain

... non-pharmacologic therapy and simple analgesics. The goal of hyaluronic acid (HA) therapy is to reduce pain and improve physical function by ... (1% sodium hyaluronate) is the first non-avian derived * hyaluronic acid (HA) approved in the U.S. for treatment of knee pain due to osteoarthritis ...

Pain Relief in Just One Visit with Genzyme's Synvisc-One

... Single-injection products will drive the US Hyaluronic acid Viscosupplementation market to nearly $1 billion by 2013, according to ... Synvisc-One will drive procedural growth in the hyaluronic acid (HA) viscosupplementation market. Released to the market in February ...