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Vitro in Medical Technology

Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C

... infection. PSI-7851 has demonstrated potent in vitro anti-HCV activity with EC(90) values of 31 +/- ... inhibitor, RG7128 (formerly known as R7128). In vitro studies of PSI-7851 have not shown evidence of ... has demonstrated pan genotype activity in vitro . About Pharmasset Pharmasset is a ...

VisEn Molecular Imaging Technology Enables Key Insights Into Newly Discovered Biologic Pathway Published in SCIENCE

... using an integrated and innovative array of in vitro readouts and advanced in vivo imaging ... use of a series of advanced and integrated in vitro assays, microscopic readouts, and in vivo ... the heart." "We see the integration of in vitro and in vivo readouts becoming increasingly ...

Cordex Signs European Development Partnership for ATPotent(TM) Sperm Motility Drug

... Outcome of Intrauterine Insemination and In vitro Fertilization Procedures LA JOLLA, Calif., ... a novel ATP-based drug candidate designed for in vitro (outside of the human body) treatment of sperm ... with intrauterine insemination (IUI) and in vitro fertilization (IVF) procedures. ATPotent(TM) is ...

An Independent Study Reports on the Utility of ImmuKnow(R), the Cylex(TM) Immune Cell Function Assay, for Monitoring Heart Transplant Recipients

... 24 /PRNewswire/ -- Since it was cleared as an in vitro assessment of cell-mediated immunity in ... leader in the development and manufacture of in vitro diagnostic products that are intended to illuminate immunity. ImmuKnow is the in vitro diagnostic utilized to detect cell-mediated ...

First Candidate from Esperance's Targeted Anti-cancer Platform, EP-100, Establishes Preclinical Proof of Concept

... range of cancers. Results from preclinical in vitro and in vivo studies of EP-100 in ovarian ... called CLIP 71. The drug candidate was tested in vitro and in vivo for activity in LHRH receptor ... negative SKOV-3 ovarian cancer cells. In in vitro studies designed to test the cytotoxicity of ...

Studies Presented at AACR Annual Meeting Highlight Multiple Immunomodulatory Mechanisms of Peregrine's PS-Targeting Antibodies

... PGN635, to confirm previous observations that in vitro , anti-PS antibodies stimulate the tumor ... Furthermore, the researchers showed that in vitro , PGN635 induced antibody-dependent death of ... the anti-tumor potential of PGN635 in vitro and in a number of animal cancer models. ...

Novel Valortim(R) Mechanism of Action Data Presented at the Keystone Symposia on Molecular and Cellular Biology

... ability to kill anthrax bacilli. In an in vitro mouse macrophage model, Valortim(R) enhanced the ... "As is the case with mouse macrophages, our in vitro data suggest that human dendritic cells also ... similar potency for neutralizing anthrax toxin in vitro as was seen with serum obtained from subjects who ...

Pharmasset Initiates First Time in Human Study of PSI-7851 for the Treatment of Hepatitis C (HCV)

... HCV infection. PSI-7851 has demonstrated in vitro anti-HCV activity with EC(50) values of 90 +/- ... nucleoside polymerase inhibitor, R7128. In vitro studies of PSI-7851 have not shown evidence of ... dosing. Like R7128, PSI-7851 has demonstrated in vitro activity against all of the most common HCV ...

ViroPharma Submits Comments on Vancocin(R) Draft Bioequivalence Guidance

... standard from testing in humans to an in vitro dissolution test because it concluded that ... OGD's new method nonetheless retains in vitro dissolution testing as the means to determine ... determine bioequivalence to Vancocin through in vitro dissolution testing will be successful. We ...

New Study Proves Multiple Births From IVF Can Be Avoided

... elective Single Embryo Transfer (eSET) for In vitro Fertilization (IVF) can almost eliminate triplet ... exceed the expense of single-embryo transfer in vitro fertilization (IVF)," said Robert J. Stillman, ... progressive, performing more than 4,000 in vitro fertilization (IVF) cycles annually, including ...

Sequella Presents Data on Synergy Between Investigational New TB Drugs SQ109 and TMC207

... inhibitory concentration (MIC) resulting from in vitro combination studies of Sequella lead TB drug ... and Tibotec was designed to investigate in vitro interactions of SQ109 for synergistic, additive, ... and drug resistant M. tuberculosis (MTB). In vitro interactions investigated included ...

Sequoia Pharmaceuticals Presents In Vitro and First-in-Human Data Supporting Further Development of SPI-256, a Novel Investigational Protease Inhibitor

... protease inhibitor (PI). One study based on an in vitro analysis demonstrates that the mode of ... on SPI-256 at this conference Discovery and in vitro activity of SPI-256 Scientists from Sequoia ... and was advanced to clinical studies. In vitro activity data were also presented in this poster. ...

Mpex Pharmaceuticals Presents New Data on MP-376 in Cystic Fibrosis

... than for these other antibiotics. Previous in vitro work has also shown superior potency of ... found in CF patients. -- Resistance: in an in vitro model of resistance development in P. ... in biofilms: studies in an established in vitro biofilm system showed that levofloxacin ...

Trius Antibiotics to be Highlighted in 18 Presentations at ICAAC/IDSA

... Methionyl-tRNA Synthase (MetRS) -- F1-335: In vitro Activity of Rx100472 Against Clinically Important ... Resistance Mechanisms -- F1-2062: In vitro Pharmacodynamics of TR-700, the Active Moiety of ... a Novel Oxazolidinone Antibiotic -- F1-2065: In vitro and In Vivo Efficacy of TR-701 and TR-700 Versus ...

MatTek's EpiDerm In Vitro Tissues Headed for Validation in Europe

... validation study on MatTek's EpiDerm in vitro human skin tissue equivalent. The test results ... that it would be helpful in promoting the new in vitro skin irritation test in Europe if these catch-up ... review the new Draft OECD Test Guideline on "In vitro Skin Irritation: Human Skin Model." Inclusion ...

Idenix Pharmaceuticals Advances HCV Discovery Program to Clinic

... demonstrated HCV antiviral activity in both in vitro and in vivo preclinical models. Pre-clinical ... of 2.3 log10 after four days of dosing. "The in vitro antiviral activity of IDX184 combined with the ... IDX375 has exhibited single nanomolar in vitro potency against HCV genotype 1b replicon (EC50 = ...

Wyeth Receives Approvable Letter from FDA for TYGACIL for the Treatment of Patients with Community-Acquired Pneumonia

... antibiotic with an expanded broad spectrum of in vitro activity against gram positives, gram negatives, ... In addition, TYGACIL has been shown to have in vitro activity against the following organisms: ... multocida. The clinical significance of in vitro activity is unknown. TYGACIL provides ...

Idenix Pharmaceuticals Presents Positive Preclinical Data on HCV Programs at The Annual Meeting of The European Association for the Study of the Liver (EASL)

... liver- targeting technology. Results from in vitro and in vivo preclinical studies confirm that this ... ribavirin. IDX184 also remained fully active in vitro against HCV containing known protease and ... compounds also displayed high selectivity in vitro with no inhibition of selected human ...

Independent Studies Report on Possible Roles for Cylex's Immune Cell Function Assay in Monitoring of Heart and Lung Transplant Recipients

... -- Since it was initially cleared as an in vitro diagnostic technique to detect cell-mediated ... development and manufacture of research and in vitro diagnostic products intended to assist in ... in the development and manufacture of in vitro diagnostic products that are intended to ...

Anadys Pharmaceuticals Announces Positive Results for ANA598 in Animal Model of Chronic Hepatitis C Virus Infection

... 1a and 1b replicons. It exhibits good in vitro metabolic stability properties and does not ... The EC95 is the concentration required in vitro to suppress hepatitis C viral RNA levels by 95% ... Anadys' Chief Medical Officer. "Based on the in vitro and in vivo potency, pharmacokinetic and ...

Data Presented at 2007 ASH Meeting Demonstrate Activity of Forodesine HCl as a Single Agent or in Combination With Bendamustine in Certain Types of Leukemia and Lymphoma

... of Barcelona presented a poster detailing the in vitro activity of forodesine HCl and the synergistic in vitro activity of forodesine HCl with bendamustine in ... of forodesine HCl and bendamustine in these in vitro experiments. "We believe the encouraging ...

Caliper Life Sciences Introduces Drug Combination Services to Identify Synergistic Response of Compounds

... cell lines create a relationship between in vitro screening and profiling, and in vivo animal ... "The exact same cell lines used in the in vitro drug combination testing can be used to create in ... and market adoption. Testing combinations in vitro and in vivo also ensures that new clinical ...

FDA Accepts Wyeth's Supplemental New Drug Application for Tygacil for the Treatment of Patients with Community-Acquired Pneumonia

... antibiotic with an expanded broad spectrum of in vitro activity against gram positives, gram negatives, ... In addition, Tygacil has been shown to have in vitro activity against the following organisms: ... multocida. The clinical significance of in vitro activity is unknown. Tygacil provides clinicians ...

Further Data on Safety and Efficacy of Cethromycin Presented at 47th Interscience Conference on Antimicrobial Agents and Chemotherapy

... to other treatments is known: "Assessment of In vitro Activity of Cethromycin ... cethromycin MIC. Cethromycin maintained good in vitro potency against a collection ... pneumoniae of this phenotype. "Assessment of In vitro Activity of Cethromycin Against Strains ...

Further Data on Safety and Efficacy of Cethromycin Presented at 47th Interscience Conference on Antimicrobial Agents and Chemotherapy

... to other treatments is known: "Assessment of In vitro Activity of Cethromycin ... cethromycin MIC. Cethromycin maintained good in vitro potency against a collection ... pneumoniae of this phenotype. "Assessment of In vitro Activity of Cethromycin Against Strains ...

Oritavancin Demonstrates Potent and Rapid In Vitro Activity Against MRSA, VRE and Other Strains of Resistant Bacteria

... at 12:15 pm CDT. Poster E-1617 is entitled "In vitro Activity Profile of Oritavancin (ORI) Against ... study demonstrated that oritavancin had potent in vitro activity against a wide spectrum of staphylococci ... clinical settings. Poster E-1613, entitled "In vitro Activity Profile of Oritavancin (ORI) Against ...

Advanced Life Sciences to Present Data on Selected Cethromycin Therapeutic Studies at the 47th Interscience Conference on Antimicrobial Agents and Chemotherapy

... Quinolones -- Poster E-1633: Assessment of In vitro Activity of Cethromycin Against ... pneumoniae -- Poster E-1632: Assessment of In vitro Activity of Cethromycin Against Strains of ... pneumoniae -- Poster E-1631: Assessment of In vitro Activity of Cethromycin Against Strains of ...

Alfacell Provides Shareholder Update

... to platinum increased tumor growth inhibition from 37% to 73%. These in vitro and in vivo data, which are presently being prepared for publication ... independent study in vivo is underway that may confirm Dr. Pass' in vitro study. After much thought, consideration, and input from highly ...

Advanced Life Sciences Announces Outcome of FDA's Anti-Infective Drugs Advisory Committee Review of Restanza(TM) (cethromycin)

... for approval by the FDA for the treatment of CAP. It has shown higher in vitro potency and a broader range of activity than macrolides against ... bacteria associated with respiratory tract infections, and, again in in vitro tests, it appears to be effective against penicillin-, macrolide-, and ...

Three Independent Studies Include the ImmuKnow(R) Assay to Manage and Optimize Immunosuppression Therapy in Transplant Patients

... company that is the leader in the development and manufacture of in vitro diagnostic products that are intended to illuminate immunity. ImmuKnow is the in vitro diagnostic utilized to detect cell-mediated immunity (CMI) in an ...

Living Donor Kidney Transplants Using Alemtuzumab Pre-Conditioning and Tacrolimus Monotherapy: Long-Term Safety and Efficacy

... company that is the leader in the development and manufacture of in vitro diagnostic products that are intended to illuminate immunity. ImmuKnow is the in vitro diagnostic utilized to detect cell-mediated immunity (CMI) in an ...

Newly Published Article Details How PGS Techniques Directly Effect Successful Pregnancy Outcomes

... When done correctly, PGS can be used to improve the success of in vitro fertilization (IVF) for women of advanced maternal age and recurrent ... shows that many times IVF fails because a majority of embryos created in vitro are chromosomally abnormal. When done correctly, PGS screens the most ...

Novexel to Present Four Posters at the 19th European Congress of Clinical Microbiology and Infectious Diseases in Helsinki

... with NXL104 in combination with ceftazidime. The poster provides in vitro data showing that a ceftazidime/NXL104 combination is rapidly bactericidal ... community acquired pneumonia. The first of the three posters provides in vitro data showing that NXL103 was active against methicillin resistant ...

Midwest Research Institute Launches Clinical Molecular Diagnostics Laboratory

... molecular diagnostics is one of the fastest growing segments of the in vitro diagnostics industry. Growth in this sector, coupled with increasing FDA guidance for labeling in vitro diagnostic devices requiring clinical validation or clinical trials, has ...

Calixa Therapeutics Announces Positive Phase 1 Results for CXA-101, a Novel Intravenous Cephalosporin Antibiotic with Excellent Anti-Pseudomonal Activity

... intravenous CXA-101, a novel cephalosporin antibiotic with excellent in vitro anti-pseudomonal activity. The results from this first Phase 1 ... (FR264205) from Astellas Pharma Inc. in 2007. CXA-101's potent in vitro activity against Pseudomonas aeruginosa has the potential to address ...

Blue Light Destroys Antibiotic-Resistant Staph Infection - Results Reported in Photomedicine and Laser Surgery Journal

... Light Kills Methicillin-Resistant Staphylococcus aureus (MRSA) in vitro ," the authors exposed bacterial colonies of MRSA to various doses of ... colonies and the IS-853 colonies. The effectiveness of blue light in vitro suggests that it should also be effective in human cases of MRSA ...

EpiDerm's Skin Irritation Test Fully Validated in European Union

... model. The new exposure time provides an improved sensitivity of the in vitro EpiDerm SIT and better correlation with in vivo Draize rabbit skin ... Corp., founded in 1985, is the world's largest independent producer of in vitro human epithelial tissue equivalents. MatTek maintains a database that ...

SuperGen's PIM Kinase Inhibitor, SGI-1776, Effective in Pre-Clinical Models of Acute Lymphoblastic Leukemia

... that its oral PIM kinase inhibitor, SGI-1776, is effective both in vitro and in vivo in preclinical models of acute lymphoblastic leukemia (ALL) ... In a poster presentation entitled " Inhibiting PIM-1 is effective in vitro and in vivo against ALL: A novel mechanistic and potentially clinically ...

Roche, InterMune and Pharmasset Announce Initiation of INFORM-1, the First Dual-Combination Clinical Trial with Oral Antivirals in Hepatitis C

... distribution and metabolic properties of that molecule. R7128 has shown in vitro activity against all of the most common HCV genotypes (1, 2, 3 and 4). ... the INFORM-1 study, InterMune, Roche and Pharmasset have investigated in vitro the combined antiviral effect of these compounds. About InterMune ...

Study Shows Potential Benefits of Xolair(R) in Treating Children Suffering from Moderate or Severe Persistent Allergic Asthma Inadequately Controlled With Inhaled Corticosteroids

... moderate-to-severe persistent asthma who have a positive skin test or in vitro reactivity to a perennial aeroallergen and whose symptoms are inadequately ... moderate-to-severe persistent asthma who have a positive skin test or in vitro reactivity to a perennial aeroallergen and whose symptoms are inadequately ...
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(Date:11/6/2014)... 2014 - Insilico Medicine, Inc, a Baltimore-based bioinformatics ... related diseases announced a research collaboration with the ... Oncology, Inc (OTC: CSBR). , "There are many ... but Champions Oncology,s TumorGraft technology is unique in ... regimen experimentally generating vast amounts of valuable data. ...
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