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Viral in Medical Technology

Pharmasset Reports Positive Preliminary Antiviral Data With PSI-7851 for the Treatment of Hepatitis C

... and commercializing novel drugs to treat viral infections. Pharmasset's primary focus is on the ... which act as alternative substrates for the viral polymerase thus inhibiting viral replication. We currently have three ...

July 2009 Mayo Clinic Health Letter Highlights a Positive Outlook, Bell's Palsy and Heart Valve Repair

... The disorder is often related to a viral infection. The nerve that controls facial muscles ... becomes inflamed or swollen, typically due to a viral infection, it can become compressed, irritated ... most likely to occur in people who have certain viral infections, such as cold sores or upper ...

Idenix Pharmaceuticals Successfully Completes Proof-of-Concept Study of IDX184 for the Treatment of Hepatitis C Virus (HCV)

... development of drugs for the treatment of human viral diseases, today announced that it has ... between IDX184- and placebo-treated patients. viral load declines were observed in 30 of the 31 ... in one patient in the 25 mg cohort. Significant viral load reductions were observed in the three higher ...

New Results From ARTEN Study of Nevirapine Plus Tenofovir and Emtricitabine (TDF/FTC) Versus Boosted Protease Inhibitor Regimen of Atazanavir/Ritonavir Plus TDF/FTC Revealed

... 48 weeks of treatment, with response defined as a viral load of <50 copies/mL measured at two ... percent achieved the study's primary endpoint of viral load of <50 copies/mL versus 65 percent of ... 48.(1) In patients who began study treatment with viral loads above 100,000 copies/mL, 60 percent of ...

Alcon Commences Phase 2 Clinical Trial of NovaBay's NVC-422 for Viral Conjunctivitis

... patented lead Aganocide(R) compound, NVC-422, for viral conjunctivitis, a type of "pink eye". ... to traditional antibiotics. The Phase 2 viral conjunctivitis study follows a recently completed ... to be entering mid-stage clinical testing for viral conjunctivitis," said Ron Najafi, Ph.D., chairman ...

Three Independent Studies Include the ImmuKnow(R) Assay to Manage and Optimize Immunosuppression Therapy in Transplant Patients

... study to assess the role of the ImmuKnow assay in viral surveillance and immune function monitoring in 35 ... immunosuppressive therapy." For each patient, viral studies and ImmuKnow results were routinely ... drug dosing was adjusted based on positive viral studies using ImmuKnow results as an adjunct ....

HIV/AIDS Research Network Recommends Use of Abbott RealTime Viral Load Test for NIH-Sponsored Clinical Trials

... have been recommended as a standard protocol for viral load testing in HIV/AIDS clinical trials ... in 2009 and beyond that have a primary focus on viral load measurements. The recommendation applies to ... network laboratories in the United States. viral load testing is a monitoring tool used to ...

Corgenix, Tulane Announce Award of NIH Grant Extending Hemorrhagic Fever Virus Product Development Program

... for developing test kits for the detection of viral hemorrhagic fever (VHF). The National ... proteins for Lassa virus and developed several viral detection products which were deployed in Africa ... MPH, Director, Global Field Operations, Global viral Forecasting Initiative, San Francisco, a ...

New Study Shows Probiotic Strain Effective in Boosting Immune Response to Flu Virus

... showed a 1709% increase in TNF-alpha levels upon viral challenge after subjects took Sustenex for a ... increased production of TNF-alpha in response to viral exposure indicates a heightened immunological ... Bacillus coagulans Increased Immune Response to viral Challenge, published in Postgraduate Medicine , ...

Schering-Plough Highlights Hepatitis C Clinical Data Presentations at the European Association for the Study of the Liver (EASL) Annual Meeting

... (HCV RNA) with at least a 2 log10 reduction in viral load at treatment week 12 and undetectable virus ... to treatment (less than a 2 log10 reduction in viral load at week 12) were discontinued from the ... were G3 and 53.1 percent had high baseline viral load (greater than or equal to 600,000 IU/mL), ...

Ground-Breaking Combination of All-Oral Agents Demonstrates Potential as Hepatitis C Treatment Regimen

... inhibitor, shows significant potency in reducing viral load in patients with hepatitis C - NUTLEY, ... polymerase inhibitor resulted in significant HCV viral load reduction in patients with HCV. Roche is ... or ribavirin -- experienced a median reduction in viral levels of -4.8 to -5.2 log(10) IU/mL in the ...

Roche and Pharmasset Initiate Phase IIb Clinical Trial of R7128, Most Advanced Nucleoside Polymerase Inhibitor in Development for Chronic Hepatitis C

... and commercializing novel drugs to treat viral infections. Pharmasset's primary focus is on the ... have compensated liver disease and evidence of viral replication and liver inflammation). PEGASYS ... multiforme major, and infections (bacterial, viral and fungal). About Roche Hoffmann-La ...

InterMune Reports Presentation of Triple Combination Study of ITMN-191 at European Association for the Study of the Liver (EASL)

... the ITMN-191 900 mg q12h dosing cohort. viral rebound was not observed in any patient receiving ... of the study, said, "Based on the totality of the viral kinetic data, the q12h and q8h regimens delivered ... 24-week treatment durations. We believe that the viral kinetic and safety results reported today provide ...

ANA598 Demonstrates Potent Antiviral Activity at all Dose Levels in Completed Phase Ib Study in Hepatitis C Patients

... levels. At 200 mg bid (twice-daily), the median viral load reduction was 2.4 log10 (range of 0.4 to ... the 12 genotype 1a patients who received ANA598, viral load was still declining at the end of the three ... bid, respectively. No patient showed evidence of viral rebound while on ANA598. ANA598 was ...

Final Results of Boceprevir Phase II HCV SPRINT-1 Study Showed Significantly Higher SVR Rates Compared to Standard of Care in Treatment-Naive Genotype 1 Hepatitis C Patients

... in the lead-in arms discontinued treatment due to viral breakthrough. "These results are very ... REBETOL regimen was associated with increased viral breakthrough during treatment, higher relapse ... discontinuations for boceprevir patients due to viral breakthrough were fewer in the 28- and 48-week ...

SAFC Biosciences(R) and Vivalis Collaborate to Optimize Cell Culture Media for Vaccines Production

... of EX-CELL(TM) EBx (R) cell growth and viral production media designed exclusively to support ... enable EB66 licensees in the development of viral vaccine therapeutics. In addition, Vivalis plans ... for the safe, cost effective manufacturing of viral vaccines and recombinant proteins for human and ...

Data from Phase 2 Study of Peramivir in Patients Hospitalized with Influenza Presented at the XI International Symposium on Respiratory Viral Infections

... the XI International Symposium on Respiratory viral Infections taking place in Bangkok, Thailand, ... objectives of the study included evaluation of viral shedding, mortality, clinical relapse and time to ... endpoint was driven by resolution of fever. viral shedding (time weighted change from baseline ...

Idenix Pharmaceuticals and GlaxoSmithKline Sign Worldwide License Agreement for IDX899, a Novel NNRTI for the Treatment of HIV

... needed to address the increasing prevalence of viral resistance and side effects associated with this ... oral administration of IDX899 achieved mean viral load reductions of 1.8 log(10), after seven days ... development of drugs for the treatment of human viral and other infectious diseases. Idenix's current ...

Idenix Pharmaceuticals Initiates Proof-of-Concept Study of IDX184 for the Treatment of Hepatitis C Virus (HCV)

... development of drugs for the treatment of human viral and other infectious diseases, today announced ... of 10 mg/kg/day of IDX184 produced a mean viral load reduction of 2.3 log10 after four days of ... development of drugs for the treatment of human viral and other infectious diseases. Idenix's current ...

ANA598 Demonstrates Potent Antiviral Activity in an Early Clinical Study in HCV-Infected Patients

... Phase Ib trial demonstrated a 2.5 log10 median viral load decline after three days Conference ... At the end of the treatment period, the median viral load decline was 2.5 log10 (>99%), with a ... ANA598 were genotype 1a and demonstrated a median viral load decline of 1.6 log10, while five patients ...

Tibotec Presents Interim Findings for TMC435, an Investigational Genotype 1 Hepatitis C Treatment, at the AASLD Liver Meeting 2008

... 90 percent of patients achieve undetectable viral load in Phase IIa trial within 28 days of ... In the 75 mg four-week triple therapy arm, no viral breakthrough was observed; 9/9 patients achieved ... C recurrence after liver transplantation. J viral Hepat. 2007 Nov;14 Suppl 1:89-96. Roche B, ...

Anadys Pharmaceuticals Announces Single Dose Safety and Pharmacokinetics Results for ANA598 in Healthy Volunteers

... Inhibitor ANA598 have the Potential to Overcome viral Resistance", Anadys will present the results ... genotype 1b animals dosed over four days, maximum viral load reductions of 2.2 and 2.6 log10 were ... hours after the initial dose. In one animal the viral load reduction was sustained throughout the ...

Analysis of Long-Term Vicriviroc Data Provides Evidence of Sustained Viral Suppression, Increased CD4 Cell Counts and Tolerability in Treatment-Experienced HIV-Infected Patients

... CCR5 receptor antagonist, demonstrated sustained viral suppression and increased CD4 cell counts and was ... background therapy may provide durable viral suppression and sustained elevated CD4 counts in ... long-term. Median change from baseline viral load (HIV RNA) was -2.1, -2.2, -2.3, -2.3 (log10) ...

Long-Term Study Evaluates Boosted PREZISTA(R) Vs. Lopinavir/Ritonavir as Part of HIV Combination Therapy in Treatment-Naive Adults

... ritonavir (r) once daily reached an undetectable viral load (<50 copies/mL) at week 96, compared with 71 ... the PREZISTA/r arm reached an undetectable viral load ( lopinavir/r arm, (p=0.012). -- Of patients with baseline viral load greater than and equal to 100,000 ...

Anadys Pharmaceuticals Announces Successful Outcome of ANA598 Healthy Volunteer Study and Finalization of Study Design for Phase Ib Trial in HCV Patients

... and two on placebo. Anadys expects to have viral load data from all three cohorts in the first ... Inhibitor ANA598 have the Potential to Overcome viral Resistance", Anadys will present the results ... infection, leading to a greater than 2 log viral load decline in each of two genotype 1b infected ...

FDA Approves First Hepatitis B Viral Load Test

... B virus DNA in a patient's blood. Doctors may use viral load testing results to establish a baseline ... to bring that same level of standardized viral load measurement to Hepatitis B treatment." ... in the patient's blood, it is critical for viral load monitoring tests to be able to quantify very ...

Idenix Pharmaceuticals Announces Completion of Proof-of-Concept Study for IDX899 in Treatment-Naive HIV-Infected Patients

... that the 100 mg/day cohort achieved a mean plasma viral load reduction of 1.87 log10 after seven days of ... receiving IDX899 in this trial achieved potent viral suppression at all doses tested," said ... 400 mg, 200 mg and 100 mg of IDX899 achieved mean viral load reductions of 1.78, 1.78, 1.84 and 1.87 ...

Favourable Six Months Follow-Up Results From Intercell's Phase II Therapeutic Hepatitis C Program

... a statistically significant reduction of viral load in the blood of chronically infected ... end of IC41 vaccination revealed an even greater viral load decline of 0.46 log (p=0.001). ... was most pronounced in patients with high initial viral load (> 2 million copies/ml). A parallel study ...

Abbott's Kaletra(R) Tablet Dosed Once-Daily or Twice-Daily Demonstrated Similar Clinical Results Across Race and Gender Lines

... and females who achieved an undetectable HIV viral load were similar. In addition, the proportions ... and non-whites who achieved an undetectable HIV viral load were similar. Specifically, 72 percent of ... of the twice-daily treated patients achieved a viral load <50 copies/mL. The once-daily regimen ...

Ardea Biosciences Reports Additional Positive Phase 2a Results for Lead HIV Candidate, RDEA806, Demonstrating Up to 1.9 Log Reduction in Plasma Viral Load with Once-Daily Dosing

... resulted in significant reductions in plasma viral load that were consistent with results previously ... end point was the change from baseline in plasma viral load. Top-line results from all four cohorts ... following: -- The median reduction in plasma viral load at nadir was 1.9 - 2.1 log copies/ml ...

Positive Phase I/II Data of IDX899 Confirm Potent Antiviral Activity and Favorable Safety Profile in Treatment-Naive HIV-Infected Patients

... once-daily IDX899 achieved a mean plasma viral load reduction of approximately 1.8 log(10) after ... receiving placebo had a 0.05 log10 viral load increase over the same treatment period. No ... showing that IDX899 offers potent viral suppression combined with a promising safety ...

Schering-Plough To Initiate Phase III Studies With HCV Protease Inhibitor Boceprevir in Previously Untreated Hepatitis C Patients and Those Who Failed Prior Treatment

... this study, in the 28-week treatment arm, rapid viral response (RVR) criteria at 4 weeks of boceprevir ... HCV genotype 1 subtype 1a versus 1b, and baseline viral load. Professor Jean-Pierre Bronowicki, M.D., ... by achieving at least a 2 log decrease in viral load by week 12 of peginterferon and ribavirin ...

BARACLUDE(R) (Entecavir) Treatment Resulted In Greater Viral Load Suppression Compared to Adefovir at 96 Weeks In Antiviral-Naive Adult Chronic Hepatitis B E-Antigen Positive Patients

... (primary endpoint). Suppression of viral load to undetectable levels is a measure of ... E.A.R.L.Y. study is an open-label, randomized, viral kinetics study of 69 antiviral-naive chronic ... adefovir. All patients in this study had a high viral load at study entry.(1) Of the 49 patients who ...

Idenix Pharmaceuticals Presents Positive Preclinical Data on HCV Programs at The Annual Meeting of The European Association for the Study of the Liver (EASL)

... development of drugs for the treatment of human viral and other infectious diseases, today announced ... of 10 mg/kg of IDX184 resulted in a mean viral load reduction of 2.3 log10 (n=5) after four days ... of drugs for the treatment of human viral and other infectious diseases. Idenix's current ...

Romark Announces Presentation of New Data for Nitazoxanide in Chronic Hepatitis C at EASL 2008

... SVR in a limited subset of patients with low viral load. In this randomized, controlled study, ... tablet twice daily for 24 weeks. Baseline viral loads and other disease characteristics were ... HCV RNA did not show significant reductions in viral load or alanine aminotransferase (ALT) ....

Schering-Plough Highlights PEGINTRON(TM) and Boceprevir Data Presentations at European Association for the Study of the Liver (EASL) Annual Meeting

... Saturday, April 26, 4:45 p.m. Hall A. Sustained viral response (SVR) is dependent on baseline ... et al. Platelet count predicts sustained viral response (SVR) in the retreatment of previous ... EPIC3 program. Poynard, T. et. al. Impact of viral load and cirrhosis on treatment outcome in HCV ...

Schering-Plough Initiates Phase II Study With Vicriviroc in Treatment-Naive HIV-Infected Patients

... demonstrated potent and sustained viral suppression through 48 weeks of treatment.(4, 5) ... of the study is the mean change from baseline in viral load (log10 HIV RNA) at week 48 of treatment. A ... exhibits potent, sustained suppression of viral replication in treatment-experienced adults: ...

Vical Receives NIH Grant for an Immunotherapeutic Herpes DNA Vaccine; Herpes Experts at University of Washington and University of Texas to Conduct Preclinical Development

... with the goal of reducing or eliminating periodic viral flare-ups and the associated viral shedding and transmission. "HSV-2 infection is ... sufficient to reduce or eliminate periodic viral flare-ups and the associated viral shedding and ...

BARACLUDE(R) (entecavir) Data Continue to Demonstrate Low Incidence of Resistance Through Five Years of Treatment in Nucleoside-naive Chronic Hepatitis B Patients

... treatment gap of less than or equal to 35 days. viral load reduction in chronic hepatitis B patients ... able to achieve and maintain an undetectable viral load (HBV DNA <300 copies/mL) through year ... patients achieved undetectable viral load ( breakthrough due to BARACLUDE ...

Ardea Biosciences Reports Positive Phase 2a Results for Lead HIV Candidate, RDEA806, Demonstrating up to 2.0 Log Reduction in Plasma Viral Load

... tested so far produce robust reductions in plasma viral load and are well tolerated. "These preliminary ... endpoint is the change from baseline in plasma viral load. Preliminary results, which include those ... log placebo-adjusted mean reduction in plasma viral load. -- Patients receiving 600 mg once daily ...
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