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Variation in Medical Technology

New Analysis Evaluated Impact of Genetic Variation on Response to Prasugrel

... In the substudy, researchers examined how variation in cytochrome P450 (CYP) genes affected the ... who took prasugrel. Our findings showed that variation in the CYP2C19 gene did not appear to influence ... designed to examine whether there is a genetic variation in DNA that could affect patient response to ...

St. Jude Finds More Than 100 Gene Variations Linked With Response to Leukemia Treatment

... Sciences chair. "We focused on genomic variation that is inherited and affects all cells in the ... and excretion. In almost all cases, gene variation predicting faster elimination of the drugs from ... effectively to overcome the patient's own genetic variation and reduce the chance of treatment failure." ...

Genetic Variation Associated with Treatment Response in a Clinical Study of a New Atypical Antipsychotic Fiaptatm (iloperidone)

... journal Pharmacogenomics suggests that a genetic variation in the Ciliary Neurotrophic Factor gene (CNTF) ... placebo. Patients were also studied for a genetic variation in the CNTF gene. CNTF is a neurotrophic factor ... step towards understanding the role of genetic variation in antipsychotic treatment response and ...

Versatility of 454 Sequencing(TM) Demonstrated in Three Publications in Science Last Week

... Mapping Reveals Extensive Genomic Structural variation in Humans", "Wasp Brain Gene Expression Supports ... Sequencing. Previous studies of human genomic variation tended to look at changes called single ... Mapping Reveals Extensive Genomic Structural variation in Humans," published today suggests ...

Gene Findings Unlocking Reasons for Neuroblastoma Risk

... neuroblastoma. A second genome-wide study found that a copy number variation (CNV) -- a missing stretch of DNA -- along a structurally weak location on ... ( http://dx.doi.org/10.1038/ng.374 ) Diskin et al, "Copy number variation at 1q21.1 associated with neuroblastoma," Nature , published June 18, ...

ViroPharma Announces Completion of Enrollment in Phase 3 Study of Maribavir in Stem Cell Transplant Patients

... data. The company intends to file its supplemental NDA, NDS and MAA variation for this additional opportunity as soon as possible following receipt ... third quarter of 2009 and our goal to file our supplemental NDA and MAA variation for prevention of CMV disease after liver transplant as soon as possible ...

University of Michigan Study Shows SEQUENOM's MassARRAY Technology Identifies HPV Infections Missed by Standard Hybridization Test

... facilitates a number of nucleic acid analysis applications including single nucleotide polymorphism (SNP) genotyping and allelotyping, copy number variation analysis, quantitative gene expression analysis, quantitative methylation marker analysis, comparative sequence analysis of haploid organisms, SNP ...

Hand Washing with 4% CHG Antiseptic Kills Flu Viruses

... Skin Cleanser and Hibistat Healthcare Personnel Hand Antiseptic Towelettes have been tested and found to be effective against a variation of the A H1N1 Swine Flu Virus, when used according to package instructions. The strain tested was Swine Flu Influenza A H1N1 A/Swine/Iowa/15/3. ...

New Studies Presented at European Society of Anaesthesia Further Validate Masimo PVI(TM) for Noninvasive and Continuous Fluid Monitoring

... at the Hamamatsu University School of Medicine in Hamamatsu-City, Japan, compared the accuracy of Masimo PVI measurements with Stroke Volume variation (SVV) obtained via an invasive catheter (Flo Trac(R)) in 13 patients. After analyzing data recorded at five points--in the supine position, lateral ...

Genomic Health Study Shows Breast Cancers in Men Display Very Similar Gene Signatures to Those in Women

... quantitative gene expression by gender status in estrogen receptor (ER) positive tumor specimens. As with female breast cancer, a wide inter-patients variation was observed in gene expression in male breast cancer. The proportion of tumors with low risk of recurrence based on the Recurrence Score(R) was 53.6 ...

Autism Genes Discovered; Help Shape Connections Among Brain Cells

... Nature , published online April 28, 2009. ( http://dx.doi.org/10.1038/nature07999 ) Glessner et al, "Autism genome-wide copy number variation reveals ubiquitin and neuronal genes," Nature , published online April 28, 2009. ( http://dx.doi.org/10.1038/nature07953 ) About The ...

DaVita Abstracts Accepted Into National Kidney Foundation's 2009 Spring Symposium

... John Robertson, Debbie Benner, Ronald Levine DaVita Inc., El Segundo, CA -- Title: Day-To Day, Week-To-Week, and Day-Of-Week variation in Tests of Anemia and Iron Status in Hemodialysis Patients Authors: David B. Van Wyck(1), Harry Alcorn(1), Resmi Gupta(2) ...

Studies Show Combination Laser Therapy Effective At Clearing Acne, Reducing Oil Production

... negatively impact one's quality of life, and my patients are so happy that there is finally a treatment that can help this condition." Another variation of PDT therapy that is being investigated uses the photosensitizer topical methyl-aminolevulinic acid (MAL) with either PDT or red light. Dr. ...

Transgenomic and Power3 Medical Complete Agreement for Exclusive License of Neurodegenerative Biomarker Test

... Transgenomic Transgenomic is a global biotechnology company that provides unique products and services of automated high sensitivity genetic variation and mutation analysis. Their offerings include systems, products, discovery and laboratory testing services to the academic and medical research, ...

Verification Studies of IntelligentMDx's Proprietary Molecular Diagnostic Assay Process Have Been Completed

... limited number of true negatives assessed. Precision and robustness testing showed that the test was highly precise and robust with inconsequential variation observed in day-to-day and tech-to-tech testing. Analysis of the standard quantitative curves for each plate run (n=14) showed an average slope is ....

Vical Signs Binding Letter of Intent for Sales and Marketing of Allovectin-7(R) in Turkey

... 125 will be treated with their physician's choice of either of two chemotherapy agents, dacarbazine or temozolomide. The primary endpoint is a variation of progression-free survival, specifically comparison of objective response rates at six months or more after randomization. The study will also ...

Pharmacyclics Announces Completion of Phase 1 Clinical Trial of Factor VIIa Inhibitor PCI-27483

... cancer, and is associated with a worsened prognosis." In the recently completed study, PCI-27483 increased the INR with minimal intra-subject variation and a half-life of ten hours. At the highest subcutaneous dose of PCI-27483 evaluated, a mean (+/-standard error) peak INR of 2.72 (+/- 0.24) was ...

Diagenic Announces Launch of First Breast Cancer Gene-Expression Blood Test

... and US cohorts, also had similar good diagnostic and predictive performance in the Indian population. BCtect(TM) is not affected by ethnic variation or menopausal state of the patient, allowing for widespread use to diagnose breast cancer at an early stage." The TaqMan Array manufactured for ...

Variant of Mad Cow Disease May Be Transmitted by Blood Transfusions, According to Animal Study

... the four recorded cases of vCJD acquired by blood transfusion in humans. In addition to the stage of infection in the donor, factors such as genetic variation in disease susceptibility and the blood component transfused may influence the transmission rate by transfusion in both sheep and humans. "The ...

febit and TGen Collaborate to Study New DNA Capture Method

... contribution to the efficiency and effectiveness of the translational process. TGen's vision is of a world where an understanding of genomic variation can be rapidly translated in a manner tailored to individual patients. http://www.tgen.org Contact: febit holding gmbh ...

Precise Low-Dose Drug Monitoring Essential for Long-Term Kidney Transplant Success

... emphasized the importance of using an accurate and precise test to monitor patients on low-dose treatment regimens. "At low doses, even the slightest variation in blood-level readings could be devastating to transplant patients. The consequence for the laboratory is twofold: it must have accurate, precise ...

Markers in Blood and Spinal Fluid, and a New Imaging Agent, Show Promise for Early Detection of Alzheimer's

... In addition, Arendt found that the test results did not vary with dementia severity as measured by the Mini Mental State Exam. "The lack of variation suggests that this test may be useful in the early stages of Alzheimer's," Arendt said. "A larger trial is underway with results expected by late ...

Soyfoods Do Not Impact Sperm Count

... stress factors, medications, or lifestyle issues that might also affect sperm counts in these men. It is well known that of all semen parameters, variation in count (#s of sperm/cc seminal fluid) is highly variable from day to day and seasonally in all men. This is most clear when one considers the ...

Interleukin Genetics Launches Enhanced Heart Health Genetic Test Report Format

... made up of fat, cholesterol, and other substances found in the blood. When plaque builds up in the arteries, the condition is called atherosclerosis. variation in interleukin genes has shown to be associated with different degrees of CAD risk. Over time, CAD can weaken the heart muscle and lead to heart ...

International Team Locates Key Player in Muscle Regeneration

... differentiate into specific types of muscle fibers that eventually fuse to reconstitute muscle tissue. The researchers discovered that cdk9-55, a variation of the gene cdk9, is induced specifically when satellite cells begin differentiation and is necessary for the genetic reprogramming required to ...

Halozyme Therapeutics Announces Phase I Clinical Trial Results Demonstrating that the Combination of Recombinant Human Hyaluronidase (rHuPH20) With Humulin R(R) and with Humalog(R) Yields Faster, More Physiologic Insulin Kinetics and Better Predictability

... 0.0020) and 26% for Humulin R (p = 0.0265) -- The inter-subject variability for both PK and GD parameters, as quantitated by the coefficient of variation (CV) and used as an indication of predictability, improved when rHuPH20 was co- administered. For example for insulin PK: -- The CV for ...

Anpath Group, Inc. Announces Addition of MRSA and VRE Claims for Its EnviroTru(R) Disinfectant

... Methicillin Resistant Staphylococcus aureus (MRSA) is a bacterium responsible for difficult-to-treat infections in humans. MRSA is a resistant variation of the common bacterium Staphylococcus aureus. It has evolved an ability to survive treatment with beta-lactam antibiotics, including penicillin, ...

Ion Mobility Diagnostic Test from Quest Diagnostics is First to Provide Direct Physical Measurement of Lipoprotein Particles, Cardiovascular Disease Indicators, Study Finds

... as well as plasma ApoA1 and ApoB. Results showed that the ion mobility technique was very precise in measuring LDL particle size, producing a variation of less than one percent over approximately 48 preparations of the same sample. The HDL and LDL concentrations varied less than 20 percent in these ...

NARSAD Researchers Identify Specific Genes and Family Traits Linked to Schizophrenia, Bipolar Disorder and Depression

... to Relieve Depression (STAR*D) ( http://www.nimh.nih.gov/health/trials/practical/stard/index.shtml ) trial. What the team found was a link between a variation in the gene TREK1 and poorer response to antidepressant treatment. This is especially significant because people with depression often require more ...

Video: The Journal, Human Genetics, Publishes Results Supporting Interleukin Genetics' Heart Health Test

... is a major regulator of inflammation. This paper from a collaborative team of international researchers, demonstrates that people with specific variation patterns in the IL1B gene had higher levels of IL-1beta and C-reactive protein (CRP). Studies from our group and others have found that these same ...

Transgenomic Establishes Collaboration With the National Cancer Institute to Investigate Mitochondrial Genome and Associated Nuclear Genes in Cancer Cell Lines

... About Transgenomic: Transgenomic is a global biotechnology company that provides unique products and services of automated high sensitivity genetic variation and mutation analysis. Their offerings include systems, products, discovery and laboratory testing services to the academic and medical research, ...

Vical Promotes Melanoma Awareness Month With Allovectin-7(R) Video Report

... 125 will be treated with their physician's choice of either of two chemotherapy agents, dacarbazine or temozolomide. The primary endpoint is a variation of progression-free survival, specifically comparison of objective response rates at six months or more after randomization. The study will also ...

Karmanos Cancer Institute Research Supports Role of Inflammation to Determine Lung Cancer Risk, Particularly in African-American Women

... was given at the American Association for Cancer Research (AACR) Annual Meeting in San Diego, CA. The study's goal was to determine whether variation in genes in the inflammatory pathway contribute to the risk of non-small cell lung cancer, and whether there are differences by race, according to ...

Transgenomic Announces New Contracts for Phase II Trials With Two Major Pharmaceutical Companies

... Transgenomic: Transgenomic is a global biotechnology company that provides unique products and services for automated high sensitivity genetic variation and mutation analysis. Their offerings include systems, products, discovery and laboratory testing services to the academic and medical research, ...

Abbott's HUMIRA(R) (adalimumab) Receives FDA Approval For Moderate to Severe Chronic Plaque Psoriasis

... Development, Abbott. In April 2007, Abbott simultaneously submitted a supplemental Biologics License Application (sBLA) with the FDA and a Type II variation to the European Medicines Agency (EMEA) seeking approval to market HUMIRA (adalimumab) as a treatment for chronic plaque psoriasis. EMEA approval ...

Multiple Studies Presented at San Antonio Breast Cancer Symposium Reinforce Clinical Utility of Oncotype DX(R)

... breast cancers including ductal, lobular, or mixed, as well as in a number of special histologic subtypes. The study found considerable variation in gene expression both within and between these rarer special subtypes of estrogen receptor-positive invasive breast cancer. About Oncotype ...

Anastrozole Confirmed Superior in Breast Cancer Prevention

... women with invasive breast cancer. Hormone-responsive breast cancers require estrogen stimulation in order to grow. Tamoxifen, a synthetic variation of estrogen, binds to hormone receptors on hormone-sensitive cancer cells, preventing estrogen from attaching to the cells. Anastrozole, on the other ...

FDA Clears Advanced Test for Monitoring Metastatic Colorectal Cancer

... differs from the current standard of care because it can be used much earlier than traditional imaging (e.g., CT scans), and is not subject to the variation observed with other blood tests, called serum tumor markers. In August 2004, a clinical study using the CellSearch test in metastatic breast cancer ...

ARCA Discovery Announces Data Demonstrating Potential for Bucindolol as Targeted Therapy in Heart Failure, Atrial Fibrillation, and Ventricular Arrhythmia

... from a Phase 3 trial published in the July 25, 2006 edition of the Proceedings of the National Academy of Sciences shows that a common genetic variation in the beta-1 adrenergic receptor may help doctors identify heart failure patients who may benefit most from bucindolol. Data presented at the 2005 ...

Evidence of Benefit Lacking for Many Common Ways of Treating Osteoarthritis of the Knee

... of the knee joint) improve scores on patient questionnaires used to measure pain and function. However, the evidence is uncertain because of variation in study quality and difficulty determining whether changes in scores translate into real clinical improvements for patients. "Millions of Americans ...
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(Date:7/30/2014)... potential effects of climate change on the world,s ... wrong factors, according to a new paper by ... University of Queensland, and other organizations. The authors ... missing the point when it comes to climate ... change scientists focus on the "direct" threats of ...
(Date:7/30/2014)... Society of America (ESA) has elected ten new Fellows ... Fellow acknowledges outstanding contributions to entomology in one or ... The following Fellows will be recognized during Entomology 2014 ... held November 16-19, 2014 in Portland, Oregon. , ... the Department of Plant, Soil and Entomological Sciences at ...
(Date:7/30/2014)... joint venture between The University of Texas at San ... Center at San Antonio, has selected the winners of ... from UTSA and Lei Huang from the Health Science ... engineered ferritins for tracking and protecting neural stem cells ... focused on finding a treatment for stroke through stem ...
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