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Uterine in Medical Technology

Wyeth Reports Publication of Phase 3 Data for Bazedoxifene/Conjugated Estrogens, an Investigational Compound Being Studied for the Treatment of Menopausal Symptoms

... atrophy when compared to placebo. In this study, uterine bleeding was not statistically different from ... Estrogens (BZA/CE): Incidence of uterine Bleeding in Postmenopausal Women (Archer DF, et ... evaluate the effect of treatment with BZA/CE on uterine bleeding, trial participants were asked to record ...

Society of Gynecologic Oncologists 40th Annual Meeting on Women's Cancer to Include Sessions on Robotics Surgery

... the treatment of gynecologic malignancies such as uterine and cervical cancer," explains Dr. M. Patrick ... for the patient. Patients who suffer from uterine and cervical cancer are the most viable ... for women suffering from ovarian cysts, abdominal uterine bleeding and fibroids. Patients selected for ...

Bionovo Announces Development Plans for Menopausal Hot Flash Drug Candidate, Menerba (MF101), Following FDA Meetings

... between treatment groups and placebo, and no uterine abnormalities were observed during the study. The ... been shown to increase the risk for breast and uterine cancers. It has been shown that the increased risk of breast and uterine cancers is associated with ER alpha activation ...

New International Study Shows Women With Symptomatic Fibroids Delaying Treatment Despite Substantial Burden on Quality of Life

... of a seven-country study measuring the effects of uterine fibroids and associated symptoms on quality of ... symptoms severe enough to affect QoL. uterine fibroids are benign tumors made up of fibrous and muscular tissue in the uterine wall. They occur in one third of women over ...

Society of Interventional Radiology Applauds Report's Uterine Fibroid Embolization Recommendations

... College of Obstetricians and Gynecologists that uterine fibroid embolization "is a safe and effective ... the woman choose her best treatment option. uterine fibroids are benign tumors that can cause ... to 40 percent of women age 35 and older have uterine fibroids of a significant size; ...

Bionovo's Drug Candidate for Menopausal Symptoms Shows Effect on Neural Pathways Related to Temperature Regulation

... many serious health risks, such as breast and uterine cancer," said Isaac Cohen, Bionovo's chairman ... been shown to increase the risk for breast and uterine cancers. It has been shown that the increased risk of breast and uterine cancers is associated with estrogen ...

FDA Clears ExAblate Fertility Enhancement Study in Women With Uterine Fibroids

... in women with non-hysteroscopically resectable uterine fibroids who are diagnosed with unexplained ... sites will enroll a total of 650 women with uterine fibroids who are diagnosed with unexplained ... the study visits. "While the link between uterine fibroids and infertility isn't fully understood, ...

BiPar Sciences Expands Clinical Development of BSI-201, A Novel PARP Inhibitor, With Phase 2 Trial in Uterine Cancer

... DNA repair portfolio, for the treatment of uterine carcinosarcoma or malignant mixed mullerian ... study in patients with recurrent or advanced uterine carcinosarcomas will evaluate BSI-201 ... PARP over-expression was particularly intense in uterine mixed mullerian tumors, a cancer for which there ...

Radius Initiates Phase 2a Clinical Trial of RAD1901 in Menopausal Hot Flashes

... effects on the central nervous system while protecting against breast and uterine tissue stimulation," said Louis O'Dea, MD, Chief Medical Officer of ... with a simultaneous bone-protective effect, without stimulating breast or uterine tissues. RAD1901 is distinctive from other SERMs in its unique biological ...

Bionovo's VG101 Shows Greater Efficacy Than Estrogen in the Treatment of Vaginal Dryness

... the risks for a number of potentially fatal diseases including breast and uterine cancers, heart disease, stroke and blood clots," said Dr. Tagliaferri. ... receptor alpha, which is known to be implicated in both breast and uterine tumor formation. Phase 1/2 clinical testing of VG101, under the ...

Bionovo's MF101 Shows Statistically Significant Improvement in Sleep Disturbance from Hot Flashes

... ER alpha agonists that have been shown to increase the risk for breast and uterine cancers. It has been shown that the increased risk of breast and uterine cancers is associated with ER alpha activation and that ER beta blocks the ...

Meditrina Pharmaceuticals, Inc. Opens Investigational New Drug (IND) Application for Phase IIb Clinical Trial With MPI-676 in Endometriosis

... prior to endometrial ablations in premenopausal women with abnormal uterine bleeding. Meditrina recently completed a global licensing agreement to ... where endometrial stroma and glands that are normally present in the uterine cavity are found in other parts of the body. Endometriosis lesions can be ...

Bionovo Discovers New Estrogen Regulatory Elements for Breast Cancer and Osteoporosis Drugs

... can be useful for many indications in women's health such as breast and uterine cancer, osteoporosis, menopausal symptoms, vaginal atrophy, endometriosis, uterine fibroids and other disorders. This platform provides Bionovo the ...

CeloNova BioSciences Announces Positive Results from European Study of Embozene(TM) Microspheres for Treatment of Uterine Fibroids

... released data from THE SPHERE, an 11 center, 8 country European study of uterine fibroid embolization using the Company's Embozene(TM) Microspheres. The ... Embolization is a minimally invasive procedure for uterine fibroids during which an Interventional Radiologist injects microspheres ...

PEAK Surgical Receives 510(k) Clearance to Market PEAK(R) Surgery System for Use in Expanded Indications

... study evaluating the PlasmaBlade in hysterectomies. "We expect that the clinical study we are conducting will show less collateral thermal injury to uterine tissue and less post operative pain, due to the lower temperature associated with the PlasmaBlade compared with traditional electrosurgery." ...

New Analyses Indicate that Divigel(R) (estradiol gel) 0.1% Is a Valuable Option for Certain Postmenopausal Women With Hot Flashes

... revealed that Divigel(R) is an effective treatment for the relief of moderate to severe hot flashes in postmenopausal women regardless of ovarian or uterine status. The second abstract used the same patient population to evaluate the effect of age (<50 years, 50-59 years, greater than or equal to 60 ...

Debiopharm Moves Towards a New 6-Month Formulation of Decapeptyl(R) to Further Help Prostate Cancer Patients

... is now marketed worldwide for the treatment of advanced prostate cancer, endometriosis, precocious puberty, in-vitro fertilisation programs, and uterine fibroids. Current licensee sales are in excess of US $400M. About Debiopharm Group Debiopharm Group is a global biopharmaceutical development ...

Light Sciences Oncology Raises $40.1 Million in Series C Financing

... therapeutic applications of the versatile Litx platform to include benign neoplasms such as benign prostatic hyperplasia (BPH), neurofibromas, and uterine fibroids, as well as vascular disease and dermatology. The company has positioned itself for growth with a strong portfolio of intellectual property, ...

Light Sciences Oncology Begins Clinical Trials of Litx Therapy in Patients with Enlarged Prostate

... therapeutic applications of the versatile Litx platform to include benign neoplasms such as benign prostatic hyperplasia (BPH), neurofibromas, and uterine fibroids, as well as vascular disease and dermatology. The Company has positioned itself for growth with a strong portfolio of intellectual property, ...

EntreMed Commences Phase 2 Study With MKC-1 in Ovarian/Endometrial Cancers

... inner lining of the uterus (endometrium). The American Cancer Society estimates that there will be approximately 39,000 new cases of cancer of the uterine body diagnosed in the U.S. in 2007, resulting in approximately 7,400 deaths. There are currently four basic types of treatment for endometrial cancer ...

Tapestry Announces Strategy to Focus on TPI 287 Clinical Program

... known to be resistant to taxanes. Taxane sensitive cell lines in which TPI 287 has shown activity include cell lines derived from breast cancer, uterine cancer and non-small cell lung cancer. Taxane resistant cell lines in which TPI 287 has shown activity include cell lines derived from breast cancer, ...

Tapestry Pharmaceuticals Presents Data on TPI 287 at the AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics

... known to be resistant to taxanes. Taxane sensitive cell lines in which TPI 287 has shown activity include cell lines derived from breast cancer, uterine cancer and non-small cell lung cancer. Taxane resistant cell lines in which TPI 287 has shown activity include cell lines derived from breast cancer, ...

Wyeth Presents New Phase 3 Data and Updates Regulatory Timing for NDA Filing of Bazedoxifene/Conjugated Estrogens

... of estrogens with SERMs to create a distinct clinical profile, which may provide relief of hot flashes and vaginal dryness as well as bone and uterine protection." Update on NDA Filing Wyeth plans to submit its New Drug Application (NDA) to the U.S. Food and Drug Administration for ...

Tapestry Initiates Phase 2 Trial of TPI 287 for the Treatment of Advanced Pancreatic Cancer

... known to be resistant to taxanes. Taxane sensitive cell lines in which TPI 287 has shown activity include cell lines derived from breast cancer, uterine cancer and non-small cell lung cancer. Taxane resistant cell lines in which TPI 287 has shown activity include cell lines derived from breast cancer, ...

Progesterone Therapy and Preterm Birth: More Evidence Helps Identify Women Who Can Benefit

... substantially between singleton and twin gestations. For example, progesterone may be more effective against some pathway that does not involve the uterine over- distention seen in twin pregnancy. "We need more research into the underlying causes of prematurity to help women with other risk factors," ....

Tapestry Reports Second Quarter 2007 Results

... known to be resistant to taxanes. Taxane sensitive cell lines in which TPI 287 has shown activity include cell lines derived from breast cancer, uterine cancer and non-small cell lung cancer. Taxane resistant cell lines in which TPI 287 has shown activity include cell lines derived from breast cancer, ...

Repros' Proellex Shows Statistically Significant Improvement in Primary Endpoint in Phase 2 Trial in the Treatment of Uterine Fibroids

... oral drug being developed to relieve symptoms of uterine fibroids. This study suggests that treatment with ... significant reduction in symptoms associated with uterine fibroids compared to the placebo group. After ... to provide a major improvement in treating uterine fibroids." About Repros Therapeutics Inc. ...

One-Third of Patients Discontinue Common Breast Cancer Therapy

... Breast Cancer Incidence In High Risk Women). uterine malignancies consist of both endometrial ... of 2.20 for tamoxifen vs. 0.71 for placebo) and uterine sarcoma (incidence rate per 1,000 women years of ... Some of the strokes, pulmonary emboli, and uterine malignancies were fatal. Health care providers ...

Bionovo's MF101 Shows Positive Safety, Tolerability and Efficacy in Phase 2 Trial

... tissue. Safety analyses showed no cases of endometrial hyperplasia or uterine cancer during the trial and there were no differences in incidence of ... ER alpha agonists that have been shown to increase the risk for breast and uterine cancers. It has been shown that the increased risk of breast and ...

Common Preterm Labor Drug Has More Side Effects Than Alternative, Finds Study from Packard Children's Hospital and Stanford

... called tocolytics, are thought to work by relaxing overactive uterine muscles and halting ongoing cervical changes that may lead to delivery. ... the study's primary outcome--preventing delivery for 48 hours with uterine quiescence. But there were no significant differences in the treatments' ...

Tapestry Pharmaceuticals to Present Data on TPI 287 at the 2007 AACR Annual Meeting

... known to be resistant to taxanes. Taxane sensitive cell lines in which TPI 287 has shown activity include cell lines derived from breast cancer, uterine cancer and non-small cell lung cancer. Taxane resistant cell lines in which TPI 287 shows greater activity include lines derived from breast and ...

Repros' Androxal Shows Highly Statistically Significant Positive Effects in Men with Secondary Hypogonadism

... compound, a PRM (progesterone receptor modulator), has recently completed a successful three month U.S. Phase 2 clinical trial for the treatment of uterine fibroids, a condition that affects numerous women of childbearing age in the U.S. and results in a significant number of hysterectomies each year. ...

Columbia Laboratories Reports Positive Results from Multi-dose Pharmacokinetic Study of Vaginally-administered Lidocaine

... of these women, assuming positive data in current and future clinical studies." About Dysmenorrhea Dysmenorrhea is characterized by recurrent uterine cramping and pain before and during menses. This common, painful women's health condition seriously affects 12% of all menstruating women in the U.S. ...

Peer Reviewed Journal Article Indicates Repros' Proellex Exhibits Potential for New Approach to the Treatment and Prevention of Breast Cancer

... for a new indication for Proellex. We are well down the road of preparing a complete dossier for NDA submission for Proellex in the treatment of uterine fibroids, which is expected around the end of 2008. Though not a trivial task, this new indication could be developed with a specific focus on ...
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