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Anthera's Varespladib Meets Primary Endpoint in Phase 2 FRANCIS Trial for the Treatment of Acute Coronary Syndrome

... of all-cause mortality, non-fatal stroke, non-fatal myocardial infarction, unstable angina, and a subset of revascularization following the initial event. ... at rest or upon minimal exertion. This condition is also referred to as unstable angina. If the chest pain is associated with heart muscle damage and heart ...

VIA Pharmaceuticals Announces Positive Results of Phase 2 Studies of VIA-2291 in Patients With Serious Cardiovascular Disease

... safety data in 191 patients with ACS, who recently had a heart attack or unstable angina. Patients were treated once daily for 12 weeks with one of three ... level of hs-CRP at the baseline as a result of the recent heart attack or unstable angina. In the CEA trial, a statistically significant reduction from ...

Anthera Pharmaceuticals Advances Global Development Strategy for Varespladib in Patients With Acute Coronary Syndrome With the Initiation of FRANCIS Trial

... cardiovascular death, non-fatal stroke, non-fatal myocardial infarction, unstable angina, and a subset of revascularization following the initial event. ... at rest or upon minimal exertion. This condition is also referred to as unstable angina. If the chest pain is associated with heart muscle damage and heart ...

VIA Pharmaceuticals Completes Enrollment in Phase 2 Acute Coronary Syndrome (ACS) Trial

... effect in the target population, patients with recent heart attack or unstable angina, and we remain on track to deliver data from this key trial later ... data in patients with ACS who have experienced a recent heart attack or unstable angina. The study includes measures of leukotrienes, biomarkers of ...

Plavix(R) Indications Expanded in Japan to Include Patients with Acute Coronary Syndrome for Whom Percutaneous Coronary Intervention Is Being Planned

... between myocardial oxygen supply and demand from coronary artery disease. unstable angina, non-ST segment elevation myocardial infarction (myocardial ... Association 4 ACC/AHA 2007 Guidelines for the Management of Patients With unstable Angina/Non-ST-Elevation Myocardial Infarction: Circulation 116: 803 - ...

RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment Delayed the Time to Relapse in Patients with Bipolar I Disorder

... in patients with conditions and medical conditions that could affect metabolism or hemodynamic responses. (e.g. Recent Myocardial infarction or unstable cardiac disease) Extrapyramidal Symptoms (EPS): The overall incidence of EPS-related adverse events in patients treated with 25 mg and 50 mg ...

New Studies Show Popular Heartburn Medications Moderate the Effect of Taking Widely Prescribed Heart Drug

... with each of the four most popular PPIs." The adverse cardiovascular events that were measured in the study include myocardial infarction, unstable angina, transient ischemic attack/stroke, coronary revascularization or cardiovascular death. The analysis is one of a series by Medco and ...

New Analysis Evaluated Impact of Genetic Variation on Response to Prasugrel

... life-threatening and fatal bleeding.(3) About Acute Coronary Syndromes Acute coronary syndromes, which is comprised of heart attacks and unstable angina (chest pain), affects nearly 1.5 million people in the United States annually.(4) Coronary heart disease, which can result in ACS, is the ...

CRESTOR(R) Reduced CV Risk in Patients Achieving Low LDL and hsCRP Targets in New JUPITER Analysis

... 20mg on reducing major cardiovascular (CV) events (combined risk of myocardial infarction, stroke, arterial revascularization, hospitalization for unstable angina, or death from CV causes). JUPITER was a long-term, randomized, double-blind, placebo-controlled, large-scale study of 17,802 patients ...

Following Encouraging Results Anthera to Continue IMPACTS Trial for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease

... MACE. ACS is a heart condition characterized by chest pain occurring at rest or upon minimal exertion. This condition is also referred to as unstable angina. If the chest pain is associated with heart muscle damage and heart tracing abnormalities, it is typically classified as a heart attack or ...

Dronedarone (Multaq(R)) Reduced the Incidence and Duration of Hospitalization in Patients with Atrial Fibrillation

... hospitalization by 37 percent (p<0.001), dronedarone reduced the incidence of first non-AF related CV hospitalization (e.g. myocardial infarction or unstable angina by 14 percent (p=0.016). Dronedarone did not increase the incidence of non-cardiovascular hospitalizations in comparison to the placebo arm. ...

CRESTOR Demonstrates Dramatic CV Risk Reduction in a Large Statin Outcomes Study

... (CV) events (defined in this study as the combined risk of myocardial infarction, stroke, arterial revascularization, hospitalization for unstable angina, or death from CV causes) by a dramatic 44% compared to placebo (p<0.001) among men and women with elevated hsCRP but low to normal ...

VIA Pharmaceuticals Completes Patient Visits in Phase 2 Acute Coronary Syndrome (ACS) Trial

... in the MDCT sub-study. The study is designed to establish dose and safety data in patients with ACS who have experienced a recent heart attack or unstable angina. The study includes measures of leukotrienes, biomarkers of inflammation, as well as medical imaging of the coronary vessels to evaluate the ...

Anthera Completes Special Protocol Assessment With FDA and Receives EMEA Scientific Advice on Development Path Toward Varespladib Approval

... coronary syndrome is a heart condition characterized by chest pain occurring at rest or upon minimal exertion. This condition is also referred to as unstable angina. If the chest pain is associated with heart muscle damage and heart tracing abnormalities, it is typically classified as a heart attack or ...

Building a New and Better Ankle

... qualified orthopaedic surgeon who feels the procedure may be appropriate. "Some patients have such deformity of the ankle or have an ankle that is so unstable that total ankle replacement is not indicated," explains Cracchiolo. Signs that you may be a candidate for a total ankle replacement include: ...

Kiwifruit: Antioxidant Power in Quantity and Quality

... of the American College of Nutrition. Antioxidants include vitamins and phytochemicals called flavonoids that may have the power to neutralize unstable molecules called free radicals, which may be linked to chronic disease and aging. Consumption and increased absorption of antioxidants may help ...

Video: Major Independent Trial Demonstrates Significant Anticancer Benefit of Zometa(R) in Women With Early-Stage Breast Cancer

... factors produced by cancer cells overstimulate osteoclasts and osteoblasts, causing excessive erosion of bone and/or the abnormal buildup of new but unstable bone. Laboratory research has suggested that Zometa may also have anticancer effects, including helping to protect against the return and spread ...

Lotrel, a Single-Pill Combination for Treating High Blood Pressure, Reduced Cardiovascular Events by 20% in High-Risk Patients

... of commonly used high blood pressure medicines in the reduction of a composite endpoint including heart attacks, strokes, hospitalizations for unstable angina and cardiovascular deaths in high blood pressure patients at high cardiovascular risk. In October 2007, the study was stopped early because ...

Filter Fails to Improve PCI Outcomes in Acute Coronary Syndromes

... failed to show that it can reduce rates of major cardiovascular complications in patients with acute coronary syndromes, a condition that encompasses unstable angina and a type of heart attack known as non-ST-elevation myocardial infarction (NSTEMI). Although the EZ FilterWire captured debris in the ...

Study Shows That Low-Molecular Weight Heparin (LMWH) was Associated with Reduced Hospital Costs of Venous Thromboembolism (VTE) Treatment Compared with Unfractionated Heparin (UFH)

... the treatment of 130 million patients in 96 countries. Lovenox(R) is approved in the United States for the prophylaxis of ischemic complications of unstable angina and non-Q-wave (non-ST-segment elevation) myocardial infarction when concurrently administered with aspirin and for the prophylaxis of deep ...

CHMP Recommends Expanded Use of Angiox(R) (Bivalirudin) in Europe for Patients With Acute Coronary Syndromes

... information available at http://www.angiox.com . In the United States, Angiomax is indicated for use as an anticoagulant in patients with unstable angina undergoing percutaneous transluminal coronary angioplasty (PTCA) and with provisional GPI in patients undergoing PCI. The most common adverse ...

VIA Pharmaceuticals Presents Data at American Heart Association Meeting Showing VIA-2291 Significantly Reduces Inflammation in Preclinical Model of Atherosclerosis

... vascular inflammation, we believe VIA-2291 may have the potential to reduce the major adverse cardiac events that occur as a result of the rupture of unstable plaque. We are encouraged that these data support VIA-2291 as a potential, powerful anti-inflammatory compound for the vascular system." ...

Study Protocols Will be Amended in Two Small Early-Phase Prasugrel Studies

... Cardiovascular disease is the leading cause of death in the U.S. and worldwide, killing 16.7 million people each year.(i) Acute heart attacks and unstable angina, called acute coronary syndrome, affect more than 840,000 Americans each year and 800,000 in Europe.(ii,iii) Utilizing current medical ...

Biopure Announces 2007 Third Quarter Financial Results

... Council. This study is designed to assess the safety and tolerability of Hemopure, compared to standard therapy, for the emergency treatment of unstable trauma patients in hospital. The company hopes to see acceleration in the rate of patient enrollment with the revised protocol. Possible Transaction ...

AtheroGenics Reports ARISE Trial Results for AGI-1067

... cardiovascular death, resuscitated cardiac arrest, myocardial infarction, stroke, need for coronary revascularization and admission to hospital for unstable angina. About AtheroGenics, Inc. / AstraZeneca Collaboration AtheroGenics and AstraZeneca have a worldwide collaboration covering the ...

MGI Pharma Announces Positive Results from a Pivotal Phase 3 Study of Aquavan Injection in Patients Undergoing Bronchoscopy

... limits activity or severe diabetes with systemic complications), and 6% were P4 (having systemic disease that is a constant threat to life, such as unstable angina pectoris, myocardial infarction, or cerebrovascular accident within the past six months). The most frequently observed sedation-related ...

Acuity One-Year Findings Meet All Primary Endpoints in Favor of Angiomax (Bivalirudin) Alone Treatment Group

... bleeding complications remain evident even in high-risk patients. In the U.S., Angiomax is indicated for use as an anticoagulant in patients with unstable angina undergoing percutaneous transluminal coronary angioplasty (PTCA) and with provisional GPIIb/IIIa inhibition in patients undergoing PCI. ...

CSL Therapy That Mimics 'Good' Cholesterol May Reduce Plaque Volume in Coronary Arteries

... the amount of plaque in the coronary arteries of patients with a recent episode of acute coronary syndrome (ACS). ACS is the term used to describe unstable angina and myocardial infarction (heart attack). It is estimated to be responsible for up to 600,000 admissions to the hospital per year in the US. ...

CSL Therapy That Mimics “Good” Cholesterol May Reduce Plaque Volume in Coronary Arteries

... therapeutic potential of this treatment and will consult with international experts to evaluate next steps.” ACS is the term used to describe unstable angina and myocardial infarction (heart attack). It is estimated to be responsible for up to 600,000 admissions to hospital per year in the US. ...

Schering-Plough Addresses Major Milestones and Challenges in Treatment of Patients With Chronic Hepatitis C

... therapy may exacerbate cardiac disease that has led to fatal and nonfatal myocardial infarctions. Patients with a history of significant or unstable cardiac disease should not be treated with REBETOL. It is advised that complete blood counts (CBC) be obtained at baseline and at weeks 2 and 4 of ...

Sciele Pharma Announces Successful Completion of New Sular Formulation Clinical Trial Program

... and Women's Health. The Company's Cardiovascular/Diabetes products treat patients with high cholesterol, hypertension, high triglycerides, unstable angina and Type 2 diabetes, and its Women's Health products are designed to improve the health and well-being of women and mothers and their babies. ...

SkyePharma and Sciele Pharma Announce Successful Completion of New Sular Formulation Clinical Trial Programme

... Diabetes and Women's Health. The Company's Cardiovascular/Diabetes products treat patients with high cholesterol, hypertension, high triglycerides, unstable angina and Type 2 diabetes, and its Women's Health products are designed to improve the health and well-being of women and mothers and their babies. ...

Schering-Plough Announces Hepatitis C Data Presentations at Digestive Disease Week (DDW) 2007 Annual Meeting

... therapy may exacerbate cardiac disease that has led to fatal and nonfatal myocardial infarctions. Patients with a history of significant or unstable cardiac disease should not be treated with REBETOL. It is advised that complete blood counts (CBC) be obtained at baseline and at weeks 2 and 4 of ...

Data Suggest that Pegasys May be an Option in Hepatitis C Patients Unable to Tolerate Peg-Intron

... 6 months after treatment ends -- You are breastfeeding -- You have hepatitis caused by your immune system (autoimmune hepatitis) -- You have unstable or severe liver disease before or during treatment -- You are allergic to alpha interferons or any of the ingredients in PEGASYS and COPEGUS -- ...

Pegasys Study Authors Conclude that Patients Successfully Treated for Hepatitis C Can be Considered ''Cured''

... 6 months after treatment ends -- You are breastfeeding -- You have hepatitis caused by your immune system (autoimmune hepatitis) -- You have unstable or severe liver disease before or during treatment -- You are allergic to alpha interferons or any of the ingredients in PEGASYS and COPEGUS -- ...

Nuvelo Announces Publication of Phase 2 rNAPc2 Study Results in Journal of American College of Cardiology

... in the formation of a blood clot. The clot blocks the flow of blood to the heart muscle depriving it of oxygen (ischemia), which can result in unstable angina or heart attack. About rNAPc2 A novel anticoagulant, rNAPc2 is a recombinant protein that has been shown to have a potential anticoagulant ...

Lipitor Reduced the Risk of Coronary Events by Half and Stroke by Nearly One-Third in High-Risk Patients with Type 2 Diabetes Who Experienced a Recent Stroke

... coronary events by 51 percent, compared with placebo. Coronary heart disease events include cardiac death, heart attack, resuscitated cardiac arrest, unstable chest pain, revascularization, or chest pain requiring emergency hospitalization. Major coronary events include cardiac death, heart attack, or ...

Point of Care Cardiac Analyzers Yield Rapid Cardiac Marker Results

... of patients presenting with acute coronary syndrome (ACS) who have negative 12-lead EKGs. About 30% of patients previously considered to have unstable angina are now given a diagnosis of myocardial infarction without ST-segment elevation based on their cardiac troponin levels. Troponin levels ...
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