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Triglyceride in Medical Technology

Essentialis Meets Primary Endpoint in Phase 2b Trial of DCCR for Treatment of Hypertriglyceridemia and is Granted Extensive Patent Coverage in the US

... its primary endpoint of statistically significant triglyceride reduction in a 90-patient Phase 2b trial of DCCR ... DCCR-treated subjects, irrespective of baseline triglyceride levels. In subjects with elevated LDL-C at ... demonstrated the therapeutic utility of DCCR as a triglyceride lowering agent with a superior profile to ...

Isis and Collaborators Present New Research at the ATVB Annual Conference

... significantly decreases hepatic lipogenesis, triglyceride content and triglyceride secretion" Isis collaborator, G. Li from ... knock down of apolipoprotein F decreases liver triglyceride levels" S. Khetarpal from University of ...

Diabetes Patients with High Triglycerides and Low HDL Cholesterol Get the Most Benefit From Fenofibrate Treatment: New Data From the FIELD Study

... dyslipidemia, that is, the combination of high triglyceride (2.3 mmol/L-200mg/dL or higher) and low ... risk is almost 50% higher for patients with high triglyceride (>2.3 mmol/L-200mg/dL) than those with lower ... and <1.3 mmol/L-50mg/dL in women) and elevated triglyceride (greater than or equal to 1.7 mmol/L-150mg/dL ) ...

Surface Logix Presents Positive Phase 1 Repeat-Dose Trial Data on SLx-4090 at The 16th International Symposium on Drugs Affecting Lipid Metabolism

... significantly decreased plasma levels of both triglyceride and LDL-cholesterol compared to placebo. These ... in Dyslipidemia SLx-4090 is a novel microsomal triglyceride transfer protein (MTP) inhibitor being developed ... with 25% of these patients having elevated triglyceride levels. In addition, there is an increasing ...

DOV 21,947 Demonstrates Significant Body Weight and BMI Reductions in Drug- Compliant Subjects in Phase Ib Clinical Study

... a statistically significant reduction in plasma triglyceride levels, as described more fully below. Further ... DOV 21,947 treated subjects had lowered plasma triglyceride levels compared to placebo treated subjects (p<0.015). This reduction in mean triglyceride levels was noted following two weeks of treatment ...

DOV Pharmaceutical, Inc. Announces Successful Phase Ib Results for DOV 21,947

... and produced a significant decline in plasma triglyceride levels. The Company intends to initiate a Phase ... a significant and sustained reduction in both triglyceride levels and body weight in animal models of ... subjects (p<0.015). This reduction in mean triglyceride levels was noted following two weeks of treatment ...

ALP Life Sciences, LLC Announces Nanoveson(TM) Patent Filing and Whitepaper Availability on Proposed Therapy for Non-Alcoholic Fatty Liver Disease (NAFLD) and Comorbid Diseases

... therapy utilizes only natural compounds. The therapy triggers liver triglyceride remodeling into bile phospholipids and lipid membrane fusion and ... therapy may improve enterohepatic circulation by removing excess triglyceride deposits in the liver and improving bile flow; having a positive ...

New Analysis Shows Troubling Trend in Triglyceride Levels May Be Linked to Rising Rates of Obesity

... Studies have shown that the risk of developing heart disease doubles when triglyceride levels are above 200 mg/dL. When triglycerides are above 200 mg/dL and HDL ... and other healthcare professionals should closely monitor patients' triglyceride levels in an effort to improve preventive care. Patients, for their part, ...

Ion Mobility Diagnostic Test from Quest Diagnostics is First to Provide Direct Physical Measurement of Lipoprotein Particles, Cardiovascular Disease Indicators, Study Finds

... concentration and size regardless of the particle's lipid, protein, triglyceride and cholesterol content. Quest Diagnostics funded the study, which is ... reported, rather than indirectly calculated, LDL levels for patients whose triglyceride levels are more than 400 mg/dl. Triglyceride levels above 400 mg/dl can ...

Imaging Results From the ADAGIO-LIPIDS Reveal That Effects of Rimonabant on Cardiometabolic Risk Profile Include Loss of Visceral Fat and Mobilization of Liver Fat

... a study conducted in 799 patients with abdominal obesity and with the high triglyceride - low HDL-cholesterol dyslipidemia. Patients were randomized to moderate ... increased by 7.4% with rimonabant compared to placebo (p<0.0001) whereas triglyceride levels were reduced by 18% with rimonabant compared to placebo (p<0.0001). ...

People With Diabetes May Have All-Natural Citrus Supplement To Help Lower Blood Glucose and Cholesterol Levels

... symptoms including increased blood glucose, insulin, cholesterol and triglyceride levels. Half of the animals were then given Diabetinol(TM) for 42 days. ... showed improvements in each blood glucose, insulin, and cholesterol and triglyceride levels. Taken together, these studies suggest that Diabetinol(TM) may ...

Mayo Clinic Proceedings Contributors Highlight Research Findings About Cardiovascular Benefits Associated With Omega-3 Fatty Acids

... at least 500 milligrams (mg) per day. "Patients with high triglyceride levels can benefit from treatment with 3 to 4 grams daily of DHA and EPA," says Dr. O'Keefe. "Research shows that this dosage lowers triglyceride levels by 20 to 50 percent." About two meals of oily fish can provide ...

ArtJen Announces Major Clinical Trial of Its Patented Weight Loss Product FBCx

... body weight in patients with type 2 diabetes. -- Lowered both triglyceride and LDL (bad) cholesterol levels in patients who began the study with elevated triglyceride levels. -- Blood work findings indicate an insulin sensitivity increase ...

New Results From ARTEN Study of Nevirapine Plus Tenofovir and Emtricitabine (TDF/FTC) Versus Boosted Protease Inhibitor Regimen of Atazanavir/Ritonavir Plus TDF/FTC Revealed

... ratio in patients receiving nevirapine decreased from baseline (-0.24) and increased in patients receiving ATV/r (+0.13) (p =0.0001). The mean triglyceride levels decreased from baseline in the nevirapine group 0.2 mg/dL and increased 28.1 mg/dL in the ATV/r group (p <0.0001). Mean increases in LDL ...

FDA Advisory Committee Votes in Favor of Zyprexa for Two Adolescent Indications

... baseline and follow-up lipid evaluations in patients using Zyprexa, is advised. Clinically significant, and sometimes very high, elevations in triglyceride levels and modest mean elevations in total cholesterol have been observed with Zyprexa use. Potential consequences of weight gain should be ...

Pistachios Offer Protective Benefits Against Heart Disease, Type II Diabetes and Obesity

... fat present in the bloodstream that is linked to diet and lifestyle factors) compared to pretzel eaters. Subjects who ate pistachios had an average triglyceride level of 90 mg/dl versus 132 mg/dl for the pretzel eaters. Triglycerides of 150 mg/dl or higher are associated with an increased risk for heart ...

Sequoia Pharmaceuticals Presents Proof of Clinical Concept of SPI-452, a Novel Pharmacokinetic Enhancer

... (PIs). SPI-452 was generally safe and well tolerated, with few side effects. Furthermore, there were no statistically significant changes in triglyceride and low- density lipoprotein (LDL) cholesterol levels in subjects receiving SPI-452 compared with placebo, which may indicate that SPI-452 has a ...

FDA Issues a Complete Response Letter for Lilly's Olanzapine LAI for Treatment of Schizophrenia in Adults

... including baseline and follow-up lipid evaluations in patients using olanzapine, is advised. Significant, and sometimes very high, elevations in triglyceride levels have been observed with olanzapine use. Significant increases in total cholesterol have also been seen with olanzapine use. Potential ...

Colesevelam HCl Lowered LDL Cholesterol in Pediatric Patients With Heterozygous Familial Hypercholesterolemia

... insulin). Ask your doctor if Welchol is right for you. Welchol is not for everyone, especially those with intestinal blockage, those with blood triglyceride levels of greater than 500 mg/dL, or a history of pancreatitis (inflammation of the pancreas) due to high triglyceride levels. Welchol has not been ...

New Data Shows Prescription Omega-3 Acid Ethyl Esters Reduced the Incidence of Death in Heart Failure Patients

... cause some health problems. Important safety information for LOVAZA (omega-3-acid ethyl esters) LOVAZA, along with diet, helps to lower very high triglyceride levels. If you are allergic to fish, you should not take LOVAZA. Talk to your doctor about any medications you are taking, especially those that ...

Olanzapine Long-Acting Injection (LAI) Shown to Maintain Treatment Benefit in Schizophrenia for up to Six Months

... associated with the use of olanzapine in clinical trials were somnolence, weight gain, eosinophilia, elevated prolactin, cholesterol, glucose and triglyceride levels, glucosuria, increased appetite, dizziness, akathisia, parkinsonism, dyskinesia, orthostatic hypotension, anticholinergic effects, transient ...

Amarin Proceeding to Phase 3 With AMR101 for Hypertriglyceridemia

... Numerous studies have demonstrated the safety, tolerability and efficacy of Ethyl-EPA in lowering plasma triglycerides in patients with high triglyceride levels of varying degrees of severity. In Japan, an Ethyl-EPA prescription product has been approved for the treatment of high triglycerides and has ...

Olanzapine Long-Acting Injection (LAI) Data Presented at First Annual Schizophrenia International Research Society Conference

... including baseline and follow-up lipid evaluations in patients using olanzapine, is advised. Significant, and sometimes very high, elevations in triglyceride levels have been observed with olanzapine use. Potential consequences of weight gain should be considered prior to starting olanzapine. Patients ...

New Discovery of Key Difference in Bile Acid Metabolism in Patients with Type 2 Diabetes May Suggest Underlying Disorder

... studied in Fredrickson Type I, III, IV, and V dyslipidemias. Welchol is contraindicated in individuals with bowel obstruction, those with serum triglyceride (TG) concentrations of >500 mg/dL, or with a history of hypertriglyceridemia-induced pancreatitis. The effect of Welchol on cardiovascular ...

Abbott's Phase III Sub-Group Analysis Shows Investigational TriLipix(TM) in Combination with CRESTOR(R) Improves Key Lipids in Patients with Mixed Dyslipidemia and Type 2 Diabetes

... 20mg had an increase in HDL of 17.6 percent and decrease in triglycerides of 42.4 percent compared to an HDL increase of 12.2 percent and triglyceride decrease of 26.8 percent with rosuvastatin 20mg alone. LDL decreased 37.4 percent with the combination compared to 6.1 percent with TriLipix 135mg ...

Welchol(TM) Lowered A1C by a Mean 1 Percent or Greater When Added to Metformin-, Insulin-, or Sulfonylurea-Based Therapy in 47 Percent of Patients Evaluated

... studied in Fredrickson Type I, III, IV, and V dyslipidemias. Welchol is contraindicated in individuals with bowel obstruction, those with serum triglyceride (TG) concentrations of >500 mg/dL, or with a history of hypertriglyceridemia-induced pancreatitis. The effect of Welchol on cardiovascular ...

Omega 3 Fatty Acids Bound to Phospholipids has Potential Benefit for Attention-Deficit Hyperactivity Disorder (ADHD)

... an inert atmosphere at a temperature lower than 60 degrees C. The omega 3 fatty acids, EPA and DHA can be extracted maintaining their position on the triglyceride chain using this patented process and keeping their natural proportions and composition. This patented innovation, called vectorization, uses a ...

Continued Funding to Help Advance 'Exciting Moment' in Diabetes Research

... from the Foundation's initial grant led to the discovery of five new genes associated with type 2 diabetes, as well as one for obesity and one for triglyceride levels (a component of blood cholesterol). The discoveries were found with the use of a new and powerful approach to diabetes research developed ...

Statement from Eli Lilly and Company: Response to Connecticut Attorney General News Release

... including baseline and follow-up lipid evaluations in patients using olanzapine, is advised. Significant, and sometimes very high, elevations in triglyceride levels have been observed with olanzapine use. Modest mean increases in total cholesterol have also been seen with olanzapine use. Potential ...

FDA Advisory Committee Supports Efficacy and Safety of Zyprexa(R) Long-Acting Injection (LAI) for Schizophrenia Treatment

... including baseline and follow-up lipid evaluations in patients using olanzapine, is advised. Significant, and sometimes very high, elevations in triglyceride levels have been observed with olanzapine use. Modest mean increases in total cholesterol have also been seen with olanzapine use. Potential ...

CASTLE Study Showed Similar Efficacy Between Once-Daily REYATAZ(R) (atazanavir sulfate)/ritonavir and Twice-Daily lopinavir/ritonavir at 48 Weeks in Previously Untreated HIV-Infected Adult Patients

... or equal to 240 mg/dL. * Less than one percent of patients in the REYATAZ/r arm vs. four percent of patients in the lopinavir/r arm had triglyceride levels greater than or equal to 751 mg/dL. Safety and Tolerability * 26% of patients in the REYATAZ/r arm and 30% of patients in the ...

Photo: Welchol(TM) (colesevelam HCl) Receives FDA Approval to Reduce Blood Glucose in Adults with Type 2 Diabetes

... been studied in Fredrickson Type I, III, IV, and V dyslipidemias. Welchol is contraindicated in individuals with bowel obstruction, those with serum triglyceride (TG) concentrations of >500 mg/dL, or with a history of hypertriglyceridemia-induced pancreatitis. The effect of Welchol on cardiovascular ...

Vanda Presents Phase III Iloperidone Efficacy Data

... for physicians and patients as a potential new treatment option." Iloperidone and ziprasidone showed similarly low effects on glucose, cholesterol, triglyceride and prolactin levels compared to placebo. Iloperidone also had a similar akathisia profile to placebo, whereas ziprasidone was associated with a ...

Ardea Biosciences, Inc. Announces New Clinical Development Program Directed Toward the Treatment of Gout

... serious adverse events or clinically significant laboratory or ECG abnormalities. Furthermore, a trend toward a reduction in plasma cholesterol and triglyceride levels was reported. Further analysis of the data from the MAD study showed a statistically significant, exposure-dependent reduction in serum uric ...

Metabolex Begins Phase 2 Trial of MBX-8025 for Treatment of Dyslipidemia

... contribute to cardiac risk. We believe this trial will provide us crucial evidence in assessing the ability of MBX-8025 to lower Apo B-100, LDL and triglyceride levels, as well as raise HDL levels, improve insulin sensitivity and reduce body weight," said David B. Karpf, M.D., the chief medical officer of ...

Ardea Biosciences, Inc. Presents Results of Phase 1 Studies of RDEA806, a Novel NNRTI for HIV, at 47th ICAAC

... or rash, side effects that have been observed with other NNRTIs that are currently marketed or in development. Furthermore, plasma cholesterol and triglyceride levels, which have been shown to increase with many HIV drugs, were stable or decreased during RDEA806 dosing. The systemic exposure of RDEA806 ...

AMT Presents Positive Results of Phase I/II Study with Lead Product at Annual Meeting of American Society of Gene Therapy

... presented at the ASGT was to investigate if AMT-010 reduces the elevated triglyceride (fat) levels and the associated risk of pancreatitis in Complete ... The primary endpoints of the study were either median fasting plasma triglyceride (TG) levels after administration of AMT-010 equal to or less than 10 ...

Analyzers Offer Point-of-Care Lipid Panels

... activity. All of these factors contribute to serum cholesterol and triglyceride levels and highly correlate with risk of untoward vascular and cardiac ... kits and devices to determine LDL, HDL, total cholesterol and triglyceride levels now offer inexpensive, accurate, reimbursable, easily used and ...

Liponex Inc. Reports Phase I/II Clinical Trial Data for CRD5

... the 3 gram dose; and 11 patients completed the 5 gram dose. The primary endpoints for the trial were safety and an increase in serum HDL, with triglyceride and LDL reductions as secondary endpoints. After receiving and reviewing a letter from the Principal Investigator of CRD5’s Phase I/II trial ...
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(Date:4/20/2014)... Mothers give a newborn baby a gift of ... system. But antibiotics, used to fend off infection, ... leaving already-vulnerable premature babies more susceptible to dangerous ... neonatology researchers at The Children,s Hospital of Philadelphia ... revealing how gut microbes play a crucial role ...
(Date:4/18/2014)... decades, scientists have used techniques like X-ray crystallography and ... into the atomic structure of molecules, but such efforts ... demand large quantities of a specific molecule and often ... making it all but impossible to peer into the ... those problems may soon be a thing of the ...
(Date:4/18/2014)... Durham, NC Seeds that sprout as soon as they,re ... plants need to be more careful. In the wild, a ... rainy day would risk disaster. More than just an insurance ... out that seed dormancy has long-term advantages too: Plants ... give rise to more species, finds in a team of ...
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(Date:4/18/2014)... news release is available in French . ... could revolutionize surgical practice and regenerative medicine. A team ... et Chimie (CNRS/ESPCI Paris Tech) and Didier Letourneur from ... Paris 13), has just demonstrated that the principle of ... in vivo to repair soft-tissue organs and tissues. This ...
(Date:4/17/2014)... Men who show signs of chronic inflammation in non-cancerous ... actually having prostate cancer than those with no inflammation, ... researchers from the Johns Hopkins Kimmel Cancer Center. , ... stronger for men with so-called high-grade prostate cancer ... indicating the presence of the most aggressive and ...
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(Date:4/17/2014)... Diego School of Medicine report that older women, plucky ... loss are more likely to be compassionate toward strangers ... in this month,s issue of the International Journal ... associated with better health and well-being as we age, ... the outcomes of individuals whose deficits in compassion put ...
(Date:4/17/2014)... Pediatrician-in-Chief Jon McCullers, MD, was recently invited to ... Nature Reviews Microbiology , one of the ... world-renowned infectious disease specialist, and chair of the ... Health Science Center, analyzed the epidemiology and microbiology ... pandemics, as well as more recent 2009 novel ...
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