Isis Highlights New Data on Antisense Drugs to Treat Type 2 Diabetes and Obesity at ADA Scientific Sessions

... by reducing levels of targets in peripheral tissues such as liver and fat without affecting the ... of FGFR4 with antisense drugs in peripheral tissues could be a unique therapeutic approach for the ... that reduced mRNA target levels in specific tissues and provided therapeutic benefit such as improved ...

Tengion Launches Second Phase 2 Clinical Trial of Regenerated Human Organ

... body's natural ability to regenerate organs and tissues using a patient's own cells, hold the promise to ... seeks to augment or replace diseased or defective tissues or organs. The Company's patented technology ... progenitor (healthy) cells across a variety of tissues and organs and to unlock these cells' potential ...

Getting More From Whole-Transcript Microarrays

... job. The scientists explored a publicly available dataset of 11 human tissues that were analyzed on both the Affymetrix Gene 1.0 ST and the Affymetrix ... differential splicing in human tissues, where typically a small number of tissues exhibit a distinct pattern. However, we believe it could be useful in a ...

PEAK Surgical Announces Completion of First PRECISE Clinical Study, Receipt of Medical Design Excellence Award for PEAK(R) Surgery System and Achievement of Over 1,000 Surgeries Using PEAK PlasmaBlade(TM)

... For decades, surgeons have relied on scalpels to cut skin and delicate tissues and have used electrosurgical devices to cut and coagulate fat and other ... temperature reduction results in significantly less damage to surrounding tissues compared to traditional electrosurgery. The PlasmaBlade is also able to ...

ESBATech's Antibody Fragment Enters Phase I/IIa Clinical Development in Osteoarthritis with the Potential for Disease-Modifying Activity

... their smaller molecular weight. In fact, they are capable of penetrating tissues not accessible to conventional monoclonal antibodies, such as avascularized tissues like cartilage. By delivering high amounts of ESBA105 directly to the ...

Molecular Marker Identifies Normal Stem Cells as Intestinal Tumor Source

... that normal stem cells can act as the source of tumors in mature solid tissues MEMPHIS, Tenn., Dec. 17 /PRNewswire-USNewswire/ -- Scientists ... one; but until now the link between normal and cancer stem cells in solid tissues like the intestine was not known," said Richard Gilbertson, M.D., Ph.D., ...

PEAK Surgical Receives 510(k) Clearance to Market PEAK(R) Surgery System for Use in Expanded Indications

... tissue charring and the ability to work close to delicate and sensitive tissues with the PlasmaBlade, which is especially important in gynecologic ... temperature reduction results in significantly less damage to surrounding tissues compared to traditional electrosurgical devices. The PlasmaBlade is also ...

Mpex Pharmaceuticals Presents New Data on MP-376 in Cystic Fibrosis

... with aerosol dosing and has anti-inflammatory properties in pulmonary tissues in addition and unrelated to its antibacterial effects. Detailed results ... the importance of achieving high Cmax:MIC ratios in pulmonary tissues to avoid resistance development in bacteria. -- Activity in biofilms: ...

Shire Announces Approval of ELAPRASE(R) (idursulfase) in Brazil

... sufficient amounts of this enzyme, cellular waste products accumulate in tissues and organs, which then begin to malfunction, leading to severe clinical ... up of GAG in cells throughout the body interferes with the way certain tissues and organs function, leading to severe clinical complications and early ...

Coley Pharmaceutical Group Diversifies Pipeline with First-in-Class TLR Antagonist for the Treatment of Systemic Lupus Erythematosus

... of autoantibodies, abnormal antibodies produced against the body's own tissues or organs. In SLE, these autoantibodies bind to DNA and/or RNA, and their ... produces antibodies that cause inflammation, pain and damage to various tissues and organs in the body. SLE is a leading cause of kidney disease, stroke, ...

Spectrum Pharmaceuticals Announces Presentation of SPI-1620 Data at the AACR-NCI-EORTC International Conference

... concentration of paclitaxel in tumors, and no significant change in normal tissues compared to saline treated animals. It was concluded that, in mice, ... significantly enhanced the uptake and delivery of paclitaxel to the tumor tissues without affecting other organs. About SPI-1620 The American Cancer ...

FAU Receives Patent for Invention Which Induces and Restores Cardiac Muscle Function

... are thought to be caused by improper signaling between cells and tissues as a result of abnormal genes. Observing cardiac mutant Mexican axolotls ... muscle tissue in areas of human hearts that require these cells and tissues for restoration of normal function. "The issuance of this patent marks a ...

Radius' Investigational Bone Anabolic Agent, BA058, Increased Bone Mineral Density (BMD) at Key Fracture Sites in Phase 2 Clinical Trial in Postmenopausal Osteoporosis

... by acting primarily on target cells in bone and kidney, whereas PTHrP and its analogs regulate cell proliferation and differentiation in developing tissues and appear to play an important role in regulating bone remodeling in adults. While both peptides have demonstrated the ability to increase bone ...

TWO NEW KLRI PEER-REVIEWED PUBLICATIONS: Hormone Therapy May Reduce Atherosclerosis in Women Close to Menopause; Growth Hormone May Increase Risk of Diabetes, Improve Lipid Profile in Men

... effects of GH therapy have not been studied extensively. The body naturally secretes growth hormones to fuel growth through childhood and maintain tissues and organs. Their use as an anti-aging therapy stems from the natural decrease of growth hormones secreted by the body as we reach middle ...

Dry Mouth Linked to Prescription and Over the Counter Drugs

... by patients include constant thirst and difficulty eating, swallowing, or speaking. Foamy or stringy saliva, irritation of the tongue, burning of the tissues inside the mouth, painful ulcerations and dentin hypersensitivity (extreme sensitivity in one or more teeth) are also dry mouth symptoms. Over time, ...

CRi Oosight(TM) Instrument Crucial in IVF Breakthrough Demonstrating a Correlation Between Non-Invasive Egg Metrics and Pregnancy

... clinicians extract new disease-specific information from biological samples in the physiological, morphological, and biochemical context of intact tissues and organisms. CRi's award-winning innovations are being recognized for their novel and groundbreaking capabilities in academic research to ...

Three Surgeons in East Texas Are Successfully Integrating a Novel Stem Cell Procedure for Spine Surgeries

... is virtually limitless for treatments of degenerative diseases since adult stem cells have the remarkable potential to differentiate and become new tissues such as bone, tendon, cartilage and heart muscle. Photo: http://www.ereleases.com/pr/2009-TexarkanaNeurologicalAssociates.jpg About ...

Celladon Provides MYDICAR(R) Program Update of First-In-Human Trial for Advanced Heart Failure at American Society of Gene Therapy Annual Meeting

... associated with the types of inflammatory reactions observed in trials involving adenoviral vectors, which are known to induce acute inflammation of tissues due to activation of the body's immune system. Patients with heart failure may assess eligibility to participate in the CUPID trial and download ...

Bethesda-Based NHSi Wins $2M Grant for Blood Technology

... the quality of red blood cells stored for transfusion. Red blood cells' diminished capacity to deform and perfuse narrow capillary networks in tissues is believed to be a major cause of transfusion side effects. Before dispensing a unit of blood to the patient, the NHSi device evaluates the ...

Myelin Removal Beads: Premium Efficiency for Neural Cell Separations and Antibody Stainings

... and recovery of target cells." The novel product is suited for myelin removal from single-cell suspensions obtained from human, mouse, and rat tissues and is especially recommended prior to cell separations and cell stainings with Anti-Prominin-1 , CD133, Anti-PSA-NCAM, Anti-A2B5, or CD11b ...

New NIH-Funded Study Shows Masimo Rainbow SET(R) May Help Clinicians Assess Oxygenation in Children With Sickle Cell Disease

... cell disease is an inherited blood disorder characterized by abnormally-shaped red blood cells that compromise vital blood and oxygen supply to the tissues and organs, causing life-threatening complications. The presence of carboxyhemoglobin and methemoglobin in a sickle cell patient's blood reduces ...

RAPAFLO(TM) (silodosin) Provides Rapid and Sustained Benign Prostatic Hyperplasia (BPH) Symptom Relief in as Little as Three Days

... with high affinity to the alpha (1A) receptors concentrated in the prostate. The antagonism of these receptors cause the smooth muscles in these tissues to relax and results in improved urine flow and a reduction in BPH symptoms. The binding affinity for the alpha (1B) receptors that cause smooth ...

Paloma Pharmaceuticals Presents at the Association for Research in Vision and Ophthalmology 2009 Meeting

... and insensitive branches of the PI3K/Akt/mTOR pathway. Inhibitors of TORC2 may have beneficial effects without toxicity to normal tissues since loss of TORC2 in genetically altered mice does not appear to affect normal tissue. TORC1 antagonists such as rapamycin (Sirolimus) have shown ...

Bayer and Regeneron Extend Development Program for VEGF Trap-Eye to Include Central Retinal Vein Occlusion

... occurring protein in the body whose normal role is to trigger formation of new blood vessels (angiogenesis) to support the growth of the body's tissues and organs. It has also been associated with the abnormal growth and fragility of new blood vessels in the eye and vascular permeability and edema. ...

BioMarin Initiates Phase 1/2 Clinical Trial for GALNS for Morquio A Syndrome

... Morquio patients around the world," said Henry Fuchs, M.D., Chief Medical Officer of BioMarin. "GALNS has been shown in mice to reach important tissues including cartilage and different zones of the bone such as bone marrow, calcified bone and importantly, the growth plate. Our experiments have also ...

Novagali Pharma Completed a New Phase II With Cyclokat(R) in Dry Eye

... recruitment has been already completed. Cyclokat(R) is a proprietary ophthalmic emulsion enabling an optimal penetration of Cyclosporine in tissues of the eye surface that benefit from Novasorb(R), Novagali(R) cationic emulsion technology. About Novagali Pharma : http://www.novagali.com ...

Osprey Pharmaceuticals U.S.A., Inc. Initiates Phase Ib Clinical Trial in IgA Nephropathy

... is the most common primary cause of kidney disease and occurs as a result of the deposition of Immunoglobulin A in the kidney. The injured kidney tissues secrete a variety of inflammatory mediators including CCL2. CCL2 in the tissue causes CCR2-expressing leukocytes to become activated and to migrate ...

Watson Announces United States Availability of RAPAFLO(TM) (silodosin), a Novel New Treatment in Benign Prostatic Hyperplasia (BPH)

... 1a receptors concentrated in the prostate, bladder base and neck and seminal vesicles. It regulates the receptors, causing smooth muscles in these tissues to relax, resulting in improved urine flow and a reduction in BPH symptoms. The binding affinity for the alpha 1B receptors that regulate smooth ...

QuatRx Completes Enrollment of Ophena(TM)(Ospemifene Tablets) Final Pivotal Phase 3 Study in Women with Postmenopausal Vaginal Atrophy

... characterized by symptoms including vaginal dryness, sexual pain (dyspareunia) and irritation. Declining estrogen levels during menopause can cause tissues of the vaginal lining to grow thinner and to lose elasticity, a condition known as vaginal atrophy. Dryness and irritation associated with reductions ...

Radius Initiates Phase 2a Clinical Trial of RAD1901 in Menopausal Hot Flashes

... molecules have the ability to stimulate or block estrogen's activity in different types of tissue, functioning as estrogen receptor agonists in some tissues and as estrogen receptor antagonists in others. Currently available SERMS are approved for the treatment and prevention of breast cancer and ...

MultiCell Technologies Signs Liver Stem Cell R&D Agreement To Develop Products for the Study of Liver Cancer

... research and development agreement with Maxim Biotech, Inc. to develop products for the study of liver stem cells and liver cancer. Tumor tissues are composed of a mixture of cells with some tumor cells exhibiting stem cell-like properties (cancer stem cells). Cancer stem cells are thought to ...

YM BIOSCIENCES ANNOUNCES NIMOTUZUMAB PRESENTATIONS TO BE MADE AT THE 100TH ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH AND EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY

... Nimotuzumab's requirement for bivalent binding (similar to conditions that make Herceptin(R) effective), limits the accumulation of nimotuzumab to tissues with higher EGFR density (principally occuring in tumors). "This research, together with the accumulating clinical data on nimotuzumab, demonstrate ...

Quark Pharmaceuticals Presents at Asia TIDES Conference

... Quark with freedom to operate in the siRNA intellectual property arena, as well as the ability for non-invasive delivery of siRNA to other target tissues including the eye, ear, lung, spinal cord and brain. PF-4523655 (RTP801i-14), currently in Phase II clinical trials, is a synthetic, chemically ...

Freezing Prostate Cancer Does a Man's Body Good

... can be found at www.SIRmeeting.org . About Prostate Cancer Prostate cancer, the most common non-skin cancer in America, forms in the tissues of the prostate (a gland in the male reproductive system found below the bladder and in front of the rectum). Prostate cancer affects one in six men, ...

Neuralstem's Human Stem Cells Integrate into Nervous System of Rats with Animal Model of ALS

... SOD-1 rats. The rats had been injected with a tracing material to track and characterize the synaptic connections. 40 days after transplantation, the tissues were examined. In the rats receiving live-cell grafts, a large number of host motor neurons had been contacted by human neurons differentiated from ...

Scientists Discover Why Teeth Form in a Single Row

... "tooth competent." Classical experiments, however, found that the developing tooth mesenchyme was capable of inducing tooth formation from epithelial tissues that normally would not participate in tooth development. Researchers confirmed that it was indeed the mesenchyme that carried tooth initiation ...

Got Pain?

... finger pain. Common hand and finger problems can include arthritis in the base of the thumb, Dupuytren's Disease (a thickening of tissues causing the fingers to curl toward the palm) and nerve pain, explains Dr. Osterman. But new treatments, like arthroscopy, collagenase injections, ...

Applying Clinical Findings to the Practice of Medicine

... of my research is that connecting tendon to bone is like connecting rope to cement," stated Dr. Thomopoulos. "The mechanical properties of the two tissues are that different." His award-winning paper, "Structure, Biomechanics, and Mechanobiology in the Attachment of Tendon to Bone" aims to ...

Breast Cancer Patients May Have a New Treatment Option When Cancer Spreads

... of orthopaedic surgery. "This procedure would also deliver a higher dose to the bone metastases and a lower dose to the spinal cord and other normal tissues than conventional external beam radiation therapy, potentially improving the clinical outcome," she explains. "The negligible dose to the spinal cord ...

Aching Back? Cholesterol Medication Might Help

... reveal the findings of a team of researchers from National Taiwan University Hospital. In one study, the researchers removed nucleus pulposus tissues from six human patients. (Nucleus pulposus is the jelly-like substance in the middle of the spinal disc.) The patients, ages 23 to 29, were ...