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Thyroid in Medical Technology

deCODE Breakthrough in Thyroid Cancer May Enable More Targeted Risk Assessment and Earlier Intervention

... (SNPs) conferring substantial increased risk of thyroid cancer. The two SNPs, located on chromosomes ... SNPs, putting them at a 5.7-times greater risk of thyroid cancer than individuals who carry no copies of ... and they associate with altered levels of key thyroid hormones. "This is an important discovery ...

New Nexavar Data Presented in Multiple Tumor Types at 44th American Society of Clinical Oncology Annual Meeting

... cancer research, Dallas, TX. (abstract #8014). thyroid Cancer A Phase 2 Study of Sorafenib in Metastatic thyroid Carcinoma Findings from this single-arm Phase 2 ... partial responses) in patients with advanced thyroid cancer. In the study, Nexavar was well-tolerated; ...

Exelixis Reports Encouraging Phase 1 Data for XL184 at ASCO

... in Patients with Medullary thyroid Cancer CHICAGO, June 1 /PRNewswire-FirstCall/ ... and radiotherapy. "Patients with medullary thyroid cancer are a highly underserved population as ... multiforme are ongoing. About Medullary thyroid Cancer The American Cancer Society estimates ...

'Second Thoughts about Fluoride,' Reports Scientific American

... teeth, bones, the brain and the thyroid gland," reports Scientific American editors ... alter endocrine function, especially in the thyroid -- the gland that produces hormones regulating ... who chaired the NRC committee thusly, "The thyroid changes do worry me." Fluoride in foods, ...

Updated Phase 1 Data for Exelixis' XL184 Demonstrate Pharmacodynamic and Clinical Anti-Tumor Activity

... in patients with medullary thyroid cancer- SAN FRANCISCO, Oct. 23 ... the cutoff. Of seven patients with medullary thyroid cancer (MTC), three have had partial responses ... a marker frequently elevated in medullary thyroid cancer, and six of the seven patients had a ...

You May Have a Thyroid Problem and Not Know It - Particularly If You're Over 60, Says a New Harvard Medical School Report

... -- Doctors often mistake the symptoms of thyroid disease for another disorder such as heart ... from Harvard Medical School. The symptoms of thyroid diseases are so wide-ranging, particularly in older men and women, that doctors often overlook thyroid disorder as the cause and instead focus on ...

Video: Phase III Study Data With Vandetanib (Zactima(TM)) in Patients With Advanced Non-Small Cell Lung Cancer (NSCLC) Presented at American Society of Clinical Oncology

... with other anti-cancer therapies in a range of tumor types, including thyroid cancer. Results from the ZEPHYR (300mg monotherapy study in EGFR ... NSCLC, Phase III) and ZETA (300 mg monotherapy in advanced medullary thyroid cancer, Phase III) studies will be available during the second half of ...

Siemens Medical Solutions Diagnostics Inks Agreement with KreLo Medical Diagnostics to Expand Thyroid Immunoassay Menu

... mimic the activity of TSH, leading to an elevated production of thyroid hormone. Left untreated, Graves' disease can lead to miscarriage, birth defects, thyroid eye disease and can be life-threatening. Studies have shown that the ...

Is Your Hair Taking a Break?

... weight loss (including gastric bypass surgery), the death of a loved one, starting or stopping oral contraceptives, iron deficiency, and chronic thyroid diseases can trigger this type of hair loss. "When I evaluate patients' hair and their recent medical history, I am able to determine if their ...

New Study Evaluating the ADHD Medication VYVANSE(R) (lisdexamfetamine dimesylate) CII Demonstrated No Change in the Pharmacokinetic Profile of VYVANSE When Coadministered with Prilosec OTC(R) 40 mg (20 mg X 2), a Commonly Used Proton Pump Inhibitor (PPI)

... child has advanced disease of the blood vessels (arteriosclerosis); symptomatic heart disease; moderate to severe high blood pressure; overactive thyroid gland (hyperthyroidism); known allergy or unusual reactions to drugs called sympathomimetic amines (for example, pseudoephedrine); seizures; ...

Type 2 Diabetes: An Epidemic Among America's Youth

... endocrinologists, physicians whose advanced, specialized training enables them to be experts in the care of endocrine diseases such as diabetes, thyroid disorders, growth hormone deficiency, osteoporosis, cholesterol disorders, hypertension and obesity. ...

Taking a Hard-Line Approach to Cardiovascular Risks in the Diabetes Patient

... endocrinologists, physicians whose advanced, specialized training enables them to be experts in the care of endocrine disease such as diabetes, thyroid disorders, growth hormone deficiency, osteoporosis, cholesterol disorders, hypertension and obesity. ...

Diabetes Experts Issue New Recommendations for Inpatient Glycemic Control - Call for Systemic Changes in Hospitals Nationwide

... endocrinologists, physicians whose advanced, specialized training enables them to be experts in the care of endocrine disease such as diabetes, thyroid disorders, growth hormone deficiency, osteoporosis, cholesterol disorders, hypertension and obesity. For more information, please call the AACE ...

Methadone Frequently Causes Menopausal Symptoms in Young Women

... replacement, vitamin and mineral supplementation. Florida Detox and Wellness Institute tests and treats estradiol, progesterone, testosterone, thyroid and dehydroepiandrosterone, DHEA, hormone deficiencies, caused by opiate pain medication. Clinical research by Florida Detox and Wellness ...

Ground-Breaking Combination of All-Oral Agents Demonstrates Potential as Hepatitis C Treatment Regimen

... (hypertension, supraventricular arrhythmias and myocardial infarction), hypersensitivity (including anaphylaxis), endocrine disorders (including thyroid disorders and diabetes mellitus), autoimmune disorders (including idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, ...

Roche and Pharmasset Initiate Phase IIb Clinical Trial of R7128, Most Advanced Nucleoside Polymerase Inhibitor in Development for Chronic Hepatitis C

... (hypertension, supraventricular arrhythmias and myocardial infarction), hypersensitivity (including anaphylaxis), endocrine disorders (including thyroid disorders and diabetes mellitus), autoimmune disorders (including idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, ...

Update on FDA Advisory Committee Meeting on Liraglutide for the Treatment of Type 2 Diabetes

... permitted approvability. Finally, the Advisory Committee unanimously supported approvability of liraglutide with regard to risk of papillary thyroid cancer. "We remain convinced that liraglutide has a positive benefit/risk profile and represents an important advance for people ...

QuatRx Completes Enrollment of Ophena(TM)(Ospemifene Tablets) Final Pivotal Phase 3 Study in Women with Postmenopausal Vaginal Atrophy

... that is in Phase 2 as an oral treatment for the symptoms of secondary hypogonadism and other conditions in men. Sobetirome, a novel, selective thyroid receptor beta agonist, is in Phase 1 as a potential treatment for dyslipidemia. Becocalcidiol, a novel Vitamin D analogue, is in Phase 2 clinical ...

Joint Statement from the American Diabetes Association and American Association of Clinical Endocrinologists on the NICE-SUGAR Study on Intensive Versus Conventional Glucose Control in Critically Ill Patients

... endocrinologists, physicians whose advanced, specialized training enables them to be experts in the care of endocrine disease, such as diabetes, thyroid disorders, growth hormone deficiency, osteoporosis, cholesterol disorders, hypertension and obesity. For more information, please call the AACE ...

Shire Withdraws European Application for DAYTRANA(TM) (Methylphenidate Transdermal System)

... child has advanced disease of the blood vessels (arteriosclerosis); symptomatic heart disease; moderate to severe high blood pressure; overactive thyroid gland (hyperthyroidism); known allergy or unusual reactions to drugs called sympathomimetic amines (for example, pseudoephedrine); seizures; ...

March 2009 Mayo Clinic Health Letter Highlights Knee Repair Surgery, Anxiety Disorder and Preventing Blood Clots

... occur on their own, independent of other health concerns. Or anxiety can be a symptom of several health conditions, such as heart or lung disease, thyroid problems -- even dietary problems. Treating the underlying condition can help reduce or manage the anxiety. When anxiety is the primary concern, ...

New England Journal of Medicine Publishes Results From the Landmark ATHENA Trial with Multaq(R) (dronedarone) in Atrial Fibrillation

... investigator of the ATHENA trial said "The clinical benefits observed with dronedarone in ATHENA occurred without a significantly higher rate of thyroid or pulmonary disorders compared with placebo reported within the study period." About the ATHENA Study The landmark ATHENA study is the ...

New Study Shows that PEGASYS(R) Regimen Provides Higher Sustained Virological Response Rates for Hepatitis C Patients

... (hypertension, supraventricular arrhythmias and myocardial infarction), hypersensitivity (including anaphylaxis), endocrine disorders (including thyroid disorders and diabetes mellitus), autoimmune disorders (including idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, ...

Recent Study Demonstrated VYVANSE(R) (lisdexamfetamine dimesylate) CII Provided Improvements in Behavior, Inattention, and Math Test Scores from 1.5 Hours up to 13 Hours following Administration in Children with ADHD

... child has advanced disease of the blood vessels (arteriosclerosis); symptomatic heart disease; moderate to severe high blood pressure; overactive thyroid gland (hyperthyroidism); known allergy or unusual reactions to drugs called sympathomimetic amines (for example, pseudoephedrine); seizures; ...

Study Published in Journal of Clinical Psychiatry Showed Once-Daily VYVANSE(R) (lisdexamfetamine dimesylate) Significantly Improved ADHD Symptoms in One of the Largest Controlled Stimulant Trials in Adults with ADHD

... child has advanced disease of the blood vessels (arteriosclerosis); symptomatic heart disease; moderate to severe high blood pressure; overactive thyroid gland (hyperthyroidism); known allergy or unusual reactions to drugs called sympathomimetic amines (for example, pseudoephedrine); seizures; ...

Lilly and Deciphera Pharmaceuticals Announce Licensing and Collaboration Agreement

... is one of the most frequently mutated members of the kinase family across all cancers, and is particularly common in malignant melanomas, colon, and thyroid cancers. The V600E mutant form of BRAF kinase in particular has been associated with increased tumor aggressiveness and decreased survival rates in ...

American Heart Journals Publishes Results From ERATO Trial Showing Dronedarone (Multaq(R)) Improves Ventricular Rate Control in Patients With Permanent Atrial Fibrillation

... after seven days. Values returned to baseline within one week after treatment discontinuation with no impact on renal function. No evidence of thyroid or pulmonary fibrosis was observed with dronedarone and no Torsade de Pointes was reported during the six-month follow-up. ERATO (The Efficacy and ...

Prescription Sleeping Pill Use Tied to Cancer

... that took sleeping pills compared to none in the placebo groups. Lab animals given high doses of hypnotic drugs are known to have developed kidney, thyroid and testicular cancers and suffer chromosome damage, which is a sign of carcinogenicity. Although a direct causal link between cancer and sleeping ...

Multaq(R) (dronedarone) Granted FDA Priority Review for Patients with Atrial Fibrillation

... potassium and sodium channels and has anti-adrenergic properties. Dronedarone does not contain the iodine radical and did not show any evidence of thyroid or pulmonary toxicity in clinical trials. About sanofi-aventis Sanofi-aventis, a leading global pharmaceutical company, discovers, develops and ...

Long-Term Pegylated Interferon Alfa-2b Therapy in Stage III Melanoma Demonstrated Significant and Sustained Impact on Relapse-Free Survival

... (low white blood cell count), thrombocytopenia (low platelet count) and neutropenia (low neutrophil count); thyroiditis (inflammation of the thyroid gland); and autoimmunity (production of antibodies against the body's own tissues). About Peg-IFN Interferon is a protein produced naturally by ...

ATHENA Clinical Results with Dronedarone (Multaq(R)) Highlighted at the World Cardiology Congress

... potassium and sodium channels and has anti-adrenergic properties. Dronedarone does not contain the iodine radical and did not show any evidence of thyroid or pulmonary toxicity in clinical trials. Based upon this new clinical data, sanofi-aventis plans to submit a registration dossier to the European ...

ATHENA Clinical Results for Dronedarone (Multaq(R)) Highlighted at the World Cardiology Congress

... potassium and sodium channels and has anti-adrenergic properties. Dronedarone does not contain the iodine radical and did not show any evidence of thyroid or pulmonary toxicity in clinical trials. Based upon the new ATHENA clinical data, sanofi-aventis plans to submit a registration dossier to the ...

PEGASYS(R)/COPEGUS(R) Show Benefit in Hard-to-Treat Latino Population with Hepatitis C

... (hypertension, supraventricular arrhythmias and myocardial infarction), hypersensitivity (including anaphylaxis), endocrine disorders (including thyroid disorders and diabetes mellitus), autoimmune disorders (including idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, ...

Landmark ATHENA Study Findings With Multaq(R) (dronedarone) Shows 24% Reduction In Cardiovascular Hospitalization or Death in Patients With Atrial Fibrillation

... potassium and sodium channels and has anti-adrenergic properties. Dronedarone does not contain the iodine radical and did not show any evidence of thyroid or pulmonary toxicity in clinical trials. About sanofi-aventis in Cardiology and Thrombosis Sanofi-aventis' unmatched experience in the treatment ...

Results of the Phase III Pivotal Study of VYVANSE(TM) (Lisdexamfetamine Dimesylate) for the Treatment of ADHD in Adults Presented at National Scientific Meeting of Psychiatrists

... child has advanced disease of the blood vessels (arteriosclerosis); symptomatic heart disease; moderate to severe high blood pressure; overactive thyroid gland (hyperthyroidism); known allergy or unusual reactions to drugs called sympathomimetic amines (for example, pseudoephedrine); seizures; ...

Siemens Healthcare Diagnostics Launches B12, Folate, and Ferritin Tests on Its Dimension vista Intelligent Lab System

... and Transferrin testing by nephelometric methodology. The Dimension Vista Intelligent Lab system menu offers panels for anemia, cardiac disease, thyroid disorders, therapeutic drug monitoring, protein testing, drugs-of-abuse testing, and routine and specialty chemistry testing. About Siemens ...

Roche responds to announcement of 'IDEAL' hepatitis C trial results

... (hypertension, supraventricular arrhythmias and myocardial infarction), hypersensitivity (including anaphylaxis), endocrine disorders (including thyroid disorders and diabetes mellitus), autoimmune disorders (including idiopathic thrombocytopenic purpura, thrombotic thrombocytopenic purpura, ...

Exelixis Initiates Phase 1/2 Trial of XL184 in Patients With Non-Small Cell Lung Cancer

... as of the June 22, 2007 cutoff; further data were also provided for six additional patients after the cutoff. Of seven patients with medullary thyroid cancer (MTC), three had partial responses (two confirmed and one unconfirmed) as of the date of the AACR-NCI- EORTC Conference. In addition, as of ...

AstraZeneca Completes Enrollment in First Phase III Study of the Investigational Drug Vandetanib (ZACTIMA)(R) in Non-Small Cell Lung Cancer

... either alone or in combination with standard chemotherapy (docetaxel). (1)(2) Vandetanib is also being evaluated as a treatment option in medullary thyroid cancer and has been awarded Food and Drug Administration (FDA) orphan drug status and fast track designation for this indication. About ...

Biological Psychiatry Publishes Study Showing VYVANSE Demonstrated Significant Efficacy for Treatment of ADHD for up to 12 Hours After Administration

... child has advanced disease of the blood vessels (arteriosclerosis); symptomatic heart disease; moderate to severe high blood pressure; overactive thyroid gland (hyperthyroidism); known allergy or unusual reactions to drugs called sympathomimetic amines (for example, pseudoephedrine); seizures; ...
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