Swissmedic Grants Debiopharm Marketing Authorisation for Moapar(R), a New Therapeutic Avenue for the Treatment of Sexual Deviations
... prescribed for a reversible reduction
of serum
testosterone to the level of castration in adult men suffering ... and safety profile. Triptorelin
decreased serum
testosterone to the level of castration in all patients.
Concurrent with the decrease in
testosterone levels, the treatment reduced
deviant sexual ...
Swissmedic Grants Debiopharm Marketing Authorisation for Moapar(R), a New Therapeutic Avenue for the Treatment of Sexual Deviations
... prescribed for a reversible reduction
of serum
testosterone to the level of castration in adult men suffering ... and safety profile. Triptorelin
decreased serum
testosterone to the level of castration in all patients.
Concurrent with the decrease in
testosterone levels, the treatment reduced
deviant sexual ...
Ferring Pharmaceuticals Launches Phase IIIB Trial of Degarelix as Intermittent Therapy
... in combining the rapid, sustained suppression of
testosterone that degarelix offers in this treatment. IADT ... levels of testosterone.(1)(2) Suppression of
testosterone to castrate levels occurred significantly faster ... group achieved a 90 percent decrease in median
testosterone levels compared with the leuprolide group, which ...
FDA Accepts Complete Response Submission to New Drug Application for NEBIDO(R)
... intramuscular injection, an investigational
testosterone preparation for the treatment of male ...
NEBIDO is a novel, long-acting injectable
testosterone preparation for the treatment of male ... NEBIDO is expected to be the first long-acting
testosterone preparation available in the U.S. in the growing ...
Novel Testosterone Gel Significantly Improves Insulin Sensitivity and Sexual Function in Hypogonadal Men With Type 2 Diabetes and Metabolic Syndrome
... New Data Highlights the Need for
testosterone Screening in At-Risk ... with Tostran(R), a topical, metered dose 2%
testosterone gel,
significantly improves insulin sensitivity ... regulatory authorities later this year.
The
testosterone replacement In hypogonadal men with either ...
New Subset Analysis of AndroGel(R) Data Highlights Efficacy - Regardless of BMI
... obese men are at an increased risk of
having low
testosterone levels, so these new findings provide ... body
of evidence surrounding the benefits of
testosterone therapy for those who
are hypogonadal, men are ... they are
experiencing can be attributed to low
testosterone and, therefore, are left
undiagnosed and ...
Research Explains How Advanced Prostate Cancer Becomes Resistant to Androgen-Deprivation Therapy
... Hutchinson
Center.
The researchers found that
testosterone levels were four times higher
in metastatic ... which disrupt the conversion of progesterone
to
testosterone precursors, as well as inhibitors of enzymes that perform
subsequent steps in
testosterone production: AKR1C3 and 17BHSD3.
For the study, ...
Indevus Presents Successful Phase III NEBIDO(R) Data at American Urological Association
... 94 Percent of Men Maintained Normal
testosterone Levels Throughout ... in the Phase III study
had previously used other
testosterone treatments.
"An estimated four to five million ... of
Urology at Harvard Medical School. "Low
testosterone is associated with
other significant health ...
Indevus Reports Additional Positive Phase III Trial Data for NEBIDO(R)
... undecanoate), a
long-acting injectable
testosterone therapy under development for the
treatment of ... demonstrated a
rapid achievement of steady state
testosterone levels, minimal excursions
outside of the normal ... of patients
maintaining a eugonadal (normal)
testosterone range. NEBIDO met its primary
endpoints, a ...
Testosterone May Improve Mental Function, From the Harvard Men's Health Watch
... mental processes.
However, research suggests that
testosterone levels may affect men's
cognitive performance, ... cognitive impairment and dementia in others.
testosterone levels decline with age, just when memory begins ... found some connections. For instance, higher
testosterone levels in
midlife have been linked to better ...
Indevus Announces Submission of New Drug Application
... intramuscular
injection, a long-acting
testosterone therapy intended to treat male
patients with ... of NEBIDO in over 75 countries to date. The U.S.
testosterone therapy market is currently estimated to be ... pharmacokinetic
guidelines for the approval of
testosterone therapy products for male
hypogonadism. The trial ...
Methadone Frequently Causes Menopausal Symptoms in Young Women
... -- Methadone medication frequently depresses estradiol, progesterone and
testosterone hormone levels to menopausal levels, even in women less than thirty years ... old, who we detoxed from methadone arrived with estradiol, progesterone or
testosterone hormone levels, in the post menopausal range."
A 1975 University ...
Dendreon Presents Preclinical Data Demonstrating Activity of TRPM8 Agonist, D-3263, in Benign Prostatic Hyperplasia
... study, BPH was induced in rats through subcutaneous injection of
testosterone propionate (TP). One week after initiation of BPH, either D-3263, ... is a known inhibitor of 5-alpha reductase, the enzyme that converts
testosterone to DHT, D-3263 is not an inhibitor of this enzyme suggesting that the two ...
BN ImmunoTherapeutics Announces Positive Mature Phase II Results From Newly Acquired Prostate Cancer Vaccine
... treatment. Hormone therapy slows the tumor growth by
stopping or blocking
testosterone from entering the cancer cells. Prostate
cancer cells are typically dependent on
testosterone or other androgens as
growth factors. Thus, although initially effective, ...
Bavarian Nordic Announces Positive Mature Phase II Results From Newly Acquired Prostate Cancer Vaccine
... treatment. Hormone therapy slows the tumor growth by
stopping or blocking
testosterone from entering the cancer cells. Prostate
cancer cells are typically dependent on
testosterone or other androgens as
growth factors. Thus, although initially effective, ...
Debiopharm Moves Towards a New 6-Month Formulation of Decapeptyl(R) to Further Help Prostate Cancer Patients
... results showed that 97.5% of patients achieved castrate levels
of serum
testosterone 28 days after the first injection and that 93% of the
patients maintained serum
testosterone levels below castrate level (defined
as < 1.735 nmol/L or 50 ng/dL) from ...
Sexual Function Affected by Stem Cell Transplant According to Long-Term Study
... lining that can contribute to sexual dysfunction in women. For
males,
testosterone levels and the cavernosal arteries of the penis are
affected, eroding ... improve by one to two years after treatment, but that methods
such as
testosterone replacement, erectile-function medications, and other
adaptive strategies ...
Is Your Hair Taking a Break?
... hair loss) for women of non-childbearing age only, and the anti-androgens spironolactone and flutamide that work by blocking the male hormone
testosterone at the cellular level of the hair follicle. These oral medications also may be an option for women who may not want to spend time applying minoxidil ...
Salvacyl(R), Developed by Debiopharm, is Launched in two European Countries
... substance triptorelin, a gonadotropin
releasing hormone (GnRH) agonist analogue. The product will be prescribed for
the reversible reduction of serum
testosterone to the level of castration in
order to lower sexual drive in adult men suffering from sexual deviations.
"This is a great accomplishment for ...
Neurocrine Biosciences Presents Elagolix Data
... information on changes in prostate size, weight, hormone levels and cell immunohistochemistry. The data reveal that transient inhibition of plasma
testosterone and intra-prostatic androgens results in the reduction of prostate weight, a reduction in epithelial proliferation and suppression of prostate ....
BIOCOM's 4th Annual DeviceFest Honors Companies
... diseases and disorders associated with aging, including insulin resistance, diabetes, neuropathy, cardiovascular disease, Alzheimer's and declining
testosterone levels. Flexiciser received the "Life Changing" award for its device designed to improve movement to individuals who are unable to maintain the ...
Auxilium Pharmaceuticals, Inc. Announces XIAFLEX(TM) Meets Primary Endpoint With Statistical Significance (p<0.001) in CORD I Pivotal Phase III Study for Dupuytren's Contracture
... developing and marketing to urologists, endocrinologists,
orthopedists and select primary care physicians. Auxilium markets Testim(R)
1%, a topical
testosterone gel, for the treatment of hypogonadism through
its approximately 190-person sales and marketing team. Auxilium has four
projects in clinical ...
Prostate Cancer Treatment Offers Results Without Side Effects
... dysfunction), incontinence (urine leakage) or a host of other
side effects. He went on a raw food diet, had his dental amalgams removed
and took
testosterone blockers, which also eliminated his libido. He joined
a clinical trial, but his cancer began to spread and he lost an alarming
amount of weight.
...
Watson Announces Positive Data for Its New Investigational Products for Benign Prostatic Hyperplasia and Overactive Bladder
... is a synthetic hormone known as a luteinizing hormone releasing
hormone (LHRH) agonist, which suppresses the production of
testosterone in
the testicles. The growth of the prostate is regulated in part by the level
and activity of testosterone. TRELSTAR(R) is available in a 4-week ...
Dendreon Presents Preclinical Data Demonstrating Activity of Trp-p8 agonist, D-3263, in Benign Prostatic Hyperplasia
... Meeting in Orlando, Fla., on
Wednesday, May 21, 2008, at 2:50 PM ET.
In a preclinical study, BPH was induced through subcutaneous injection
of
testosterone propionate (TP). One week prior to initiation of
testosterone, either D-3263 or finasteride, a current treatment for BPH,
was administered daily for ...
MacroChem Announces Presentation of Pexiganan Phase 3 Study Results for Topical Treatment of Diabetic Foot Infection
... infection, which has already completed two
Phase 3 trials. Our other clinical stage product candidate, Opterone(R), is
a topically applied SEPA-based
testosterone cream designed to treat male
hypogonadism. Our pipeline of clinical-stage and early-stage product
candidates is based on our SEPA, MacroDerm(TM) and ...
Clinical Update - Decapeptyl(R)/Trelstar(R) 6-Month Formulation in Advanced Prostate Cancer
... of triptorelin 6-month
formulation in 120 patients with advanced prostate cancer, showed that
97.5% of patients achieved castrate levels of serum
testosterone 28 days
after the first injection and that 93% of the patients maintained serum
testosterone levels below castrate level (defined as < or equal to ...
Male Birth Control Pill, Blackberry Extract for Gingivitis, Skin Cancer and Digestive Health Top List of New Medical Discoveries
... inhibits infertility by utilizing a non-steroidal
hormonal therapy known as a selective androgen receptor modulator. "Past clinical studies using
testosterone for male contraception were
not effective at preventing pregnancy without producing significant
negative side- effects," said James Dalton, Ph.D., ...
MacroChem Acquires Rights to Pexiganan, a Novel Topical Anti-Infective for Treatment of Diabetic Foot Infections, From Genaera
... onychomycosis, a condition commonly known as nail
fungus. Our other clinical stage product candidate, Opterone(R), is a
topically applied SEPA-based
testosterone cream designed to treat male
hypogonadism. In addition to EcoNail and Opterone, our pipeline of
early-stage product candidates is based on our SEPA, ...
Study Shows Combination Therapy Incorporating AVODART(R) and Tamsulosin Provides Continuous Symptom Improvement Over 2 Years
... first and only dual 5ARI for the treatment of enlarged
prostate, inhibits both the type I and type II isoenzymes responsible for
the conversion of
testosterone into dihydrotestosterone (DHT). DHT is the
primary male hormone responsible for the enlargement of the prostate.
AVODART provides the power to ...
New Study Presented at WorldSleep 2007 Demonstrates Ramelteon Has Sustained Efficacy Over Six Months in Adults With Chronic Insomnia
... children or adolescents. The effects in these
populations are unknown. Avoid taking ROZEREM with alcohol. ROZEREM has been associated with decreased
testosterone levels and
increased prolactin levels. Health professionals should be mindful of any
unexplained symptoms possibly associated with such changes in ...
Auxilium Pharmaceuticals, Inc. Receives Clearance to Resume Clinical Trials for XIAFLEX(TM)
... developing and marketing to urologists, endocrinologists,
orthopedists and select primary care physicians. Auxilium markets Testim(R)
1%, a topical
testosterone gel, for the treatment of hypogonadism through
its approximately 190-person sales and marketing team. Auxilium has four
projects in clinical ...
Auxilium Announces New Data That Show Total Testosterone Blood
Levels Increase Significantly Following Switch from AndroGel(R) to
Testim(R)
... of hypogonadal men after switching
brands of
testosterone replacement gel therapy. Total ... at , records of 370
hypogonadal men on once-daily
testosterone gel replacement therapy
(Testim or AndroGel) were ... or patient preference.
"Patients using
testosterone replacement gel therapy sometimes
will fail to ...
Repros' Androxal Shows Highly Statistically Significant Positive
Effects in Men with Secondary Hypogonadism
... at month three who showed morning total
serum
testosterone concentrations within the normal ... in the 12.5mg and 25mg treatment arms with
total
testosterone in the physiological range at month three ... 0.0001). At
month three, the mean improvement in
testosterone levels was 184.3
and 259.2 ng/dl for both the ...
Indevus Reports Positive Data From Phase III NEBIDO Trial
... a long- acting injectable
testosterone therapy under
development for the treatment of ... pharmacokinetic guidelines for the
approval of
testosterone therapy products for male
hypogonadism.
The ... and an
outlier analysis (based on the maximum
testosterone concentrations
during the steady state dosing ...
New Poll Shows Men, Women Incorrectly Blame Symptoms of Low
Testosterone on Normal Aging
... believe their male
partner's symptoms of low
testosterone negatively impact their
relationship, treatment ... of
the relationship.
Low testosterone, or
testosterone deficiency associated with
hypogonadism, is a ... gland that inhibits
hormone secretion and
testosterone production in men. As many as
five million men ...
Repros' Proellex Shows Statistically Significant Improvement in
Primary Endpoint in Phase 2 Trial in the Treatment of Uterine
Fibroids
... other program in late clinical
development, is designed to restore normal
testosterone production
by the testes and is being tested in a non-pivotal U.S. Phase 3
clinical trial for the treatment of
testosterone deficiency in men
due to secondary hypogonadism.
For more information, ...
Repros Reports That Proellex Has Demonstrated Superior Efficacy and
Safety in Endometriosis When Compared to Standard of Drug Care
... program in late clinical development, is designed to restore
normal
testosterone production by the testes in men and has
recently completed a six-month U.S. non-pivotal Phase 3 clinical
trial for the treatment of
testosterone deficiency due to secondary
hypogonadism. According to industry sources, ...
New Analysis of WHI Data Shows Reduced Levels of Coronary Artery
Calcification, a Predictor of Cardiovascular Events, in Women aged
50-59 taking Estrogen Therapy
... Pharmaceuticals, Inc., BioSante's licensee, and
LibiGel(R) (transdermal
testosterone gel) in Phase III development
by BioSante for the treatment of female sexual dysfunction (FSD).
Also in development is Bio-T-Gel(TM), a
testosterone gel for male
hypogonadism, and an oral contraceptive using BioSante ...