Syndrome in Medical Technology

Lexicon's Drug Candidate LX1032 for Carcinoid Syndrome Receives Orphan Drug Designation From EMEA

... symptoms associated with carcinoid syndrome . LX1032 is designed to reduce serotonin ... will include up to 28 patients with carcinoid syndrome who are symptomatic despite treatment with ... Medicines Agency. About Carcinoid syndrome ...

USC Keck School of Medicine's Dr. Alan Epstein Receives Prestigious National Cancer Institute RAID Award for Breakthrough IL-2 Molecule Therapeutic

... side effects, especially that of capillary leak syndrome where leakage of fluid from the blood results in ... edema and multiple organ failure. Capillary leak syndrome affects as many as 65% of patients and can lead ... that eliminates the side effect of capillary leak syndrome while retaining the cytokine and therapeutic ...

Ironwood and Forest Present Additional Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

... linaclotide in 419 patients with irritable bowel syndrome with constipation (IBS-C). Previous analyses of ... linaclotide. About Irritable Bowel syndrome with Constipation (IBS-C) IBS-C is a chronic ... 3 program for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic ...

RISPERDAL(R) CONSTA(R) (Risperidone) Long-Acting Treatment Delayed the Time to Relapse in Patients with Bipolar I Disorder

... psychosis. Neuroleptic Malignant syndrome (NMS) is a rare and potentially fatal side effect ... psychosis. Neuroleptic Malignant syndrome (NMS): NMS, a potentially fatal symptom complex, ... problems. Tardive Dyskinesia (TD): TD is a syndrome of potentially irreversible, involuntary, ...

Anthera's Varespladib Meets Primary Endpoint in Phase 2 FRANCIS Trial for the Treatment of Acute Coronary Syndrome

... to patients within 96 hours of an Acute Coronary syndrome (ACS) event, met its primary endpoint of a ... in C-reactive protein. About Acute Coronary syndrome Acute coronary syndrome is a heart condition characterized by chest pain ...

Ironwood Announces Linaclotide European Licensing Agreement with Almirall

... linaclotide for the treatment of irritable bowel syndrome with constipation (IBS-C) and other ... in United States. About Irritable Bowel syndrome with Constipation (IBS-C) IBS-C is a chronic ... 3 program for the treatment of irritable bowel syndrome with constipation (IBS-C) and chronic ...

Schering-Plough Announces Results of the Early ACS Trial

... routinely in patients with Acute Coronary syndrome (ACS), at least 12 hours prior to angiography, ... in Non-ST-Segment Elevation Acute Coronary syndrome (EARLY ACS) study, which was designed to ... for the treatment of patients with acute coronary syndrome (unstable angina/non-ST-segment-elevation ...

Following Encouraging Results Anthera to Continue IMPACTS Trial for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease

... in preventing the development of acute chest syndrome in hospitalized sickle cell disease patients. Enrolled patients are at-risk for acute chest syndrome based on the combination of pain (vaso-occlusive ... (secretory phospholipase or sPLA2). Acute chest syndrome is a life-threatening complication of sickle cell ...

Lexicon Presents Clinical Data on LX1032 for Carcinoid Syndrome at European Neuroendocrine Tumor Society Meeting

... trial of LX1032 in patients with carcinoid syndrome in the first quarter of 2009. A copy of the ... 5-7 in Granada, Spain. About Carcinoid syndrome and LX1032 Carcinoid syndrome is a chronic condition that is the result of ...

Diabetes Patients with High Triglycerides and Low HDL Cholesterol Get the Most Benefit From Fenofibrate Treatment: New Data From the FIELD Study

... ) are key criteria of the metabolic syndrome according to the old definition of the US ... is the metabolic syndrome? The metabolic syndrome is characterised by a clustering of ... Although the definition of metabolic syndrome varies among different guidelines, one of the ...

Lenetix Launches Screening Study of New Down Syndrome Test

... abnormalities. Risk assessment for Down syndrome is routinely offered to patients in the first ... status non-invasively, detecting not only Down syndrome (Trisomy 21), but other aneuploidies such as ... an improved, non- invasive prenatal test for Down syndrome because they fear the risks of amniocentesis," ...

Continued Overall Survival Advantage Reported From Pivotal Trial of VELCADE(R) (Bortezomib) for Injection Based Therapy in Patients With Previously Untreated Multiple Myeloma

... thrombocytopenia, neutropenia, tumor lysis syndrome and hepatic events. Women of childbearing ... lung infiltration and Acute Respiratory Distress syndrome in patients receiving VELCADE. Some of these ... of Reversible Posterior Leukoencephalopathy syndrome (RPLS) in patients receiving VELCADE. RPLS is a ...

Prolonged Progression-Free Survival Demonstrated by VELCADE(R) (Bortezomib) for Injection Based Induction Regimens in Transplant-Eligible Previously Untreated Multiple Myeloma Patients

... thrombocytopenia, neutropenia, tumor lysis syndrome and hepatic events. Women of childbearing ... lung infiltration and Acute Respiratory Distress syndrome in patients receiving VELCADE. Some of these ... of Reversible Posterior Leukoencephalopathy syndrome (RPLS) in patients receiving VELCADE. RPLS is ...

Novel VELCADE(R) (Bortezomib) for Injection Based Four-Drug Combination Was Well Tolerated In Previously Untreated Multiple Myeloma Patients

... thrombocytopenia, neutropenia, tumor lysis syndrome and hepatic events. Women of childbearing ... lung infiltration and Acute Respiratory Distress syndrome in patients receiving VELCADE. Some of these ... of Reversible Posterior Leukoencephalopathy syndrome (RPLS) in patients receiving VELCADE. RPLS is ...

Phase III Trial Results Show Elitek(R) (rasburicase) Significantly Reduced Plasma Uric Acid Levels versus Allopurinol in Adults with Hematologic Cancers at Risk for Tumor Lysis Syndrome

... at high or potential risk for tumor lysis syndrome (TLS) demonstrated that Elitek(R) (rasburicase) ... allopurinol alone (p=0.06). Tumor lysis syndrome is a potentially life-threatening metabolic ... cancers, particularly leukemia or lymphoma. The syndrome develops when a particularly large volume of ...

TorreyPines Therapeutics Muscarinic Agonist NGX267 Meets Primary Endpoint in a Phase II Clinical Trial in Patients with Xerostomia

... of Medicine and Director of the Penn Sjogren's syndrome Center. "NGX267 appears to be efficacious, safe ... trials in a larger group of Sjogren's syndrome patients. This will help us better elucidate the ... associated with primary or secondary Sjogren's syndrome were enrolled at three sites in the United ....

Ironwood and Forest Present Positive Phase 2b Study Results for Linaclotide in Patients With Irritable Bowel Syndrome With Constipation

... and efficacy in 420 patients with irritable bowel syndrome with constipation (IBS-C). Analysis of the ... of North America. About Irritable Bowel syndrome (IBS) One out of six adults in developed ... for the treatment of irritable bowel syndrome with constipation, chronic constipation, and ...

Ironwood and Collaborators Present Preclinical Data Demonstrating That Cyclic GMP Alleviates Intestinal Pain

... for its potential to treat irritable bowel syndrome with constipation (IBS-C) and other ... of North America. About Irritable Bowel syndrome (IBS) One out of six adults in developed ... linaclotide for the treatment of irritable bowel syndrome with constipation, chronic constipation, ...

Ironwood and Forest to Present Positive Data From Linaclotide Phase 2b IBS-C Study at ACG Annual Scientific Conference

... and efficacy in 419 patients with irritable bowel syndrome with constipation (IBS-C) in a plenary session ... outside of North America. About Irritable Bowel syndrome (IBS) One out of six adults in developed ... for the treatment of irritable bowel syndrome with constipation, chronic constipation, and ...

Olanzapine Long-Acting Injection (LAI) Shown to Maintain Treatment Benefit in Schizophrenia for up to Six Months

... was assessed using the Positive and Negative syndrome (PANSS), PANSS-derived BPRS, and the Clinical ... each other. About Olanzapine LAI Post-Injection syndrome Analysis As with all medications, there are ... was to review the Olanzapine LAI Post- Injection syndrome cases observed in olanzapine LAI clinical trials ...

Seventy Years Old and Going Strong With Down Syndrome and No Dementia: The Case of 'Mr. C' Causes Major Interest in the Scientific Community

... is almost a given for people with typical Down syndrome over 65 yeas of age. 'Mr. C,' while remaining ... paints an optimistic picture for people with Down syndrome who are aging, and says that an ordinary person with Down syndrome ought to be able to make it to seventy, once you ...

FDA Files Application To Convert ONTAK(R) (Denileukin Diftitox) to Full Approval for Use in Cutaneous T-Cell Lymphoma (CTCL)

... onset of symptoms in patients with vascular leak syndrome was delayed, usually occurring within the first ... monitored on an outpatient basis. This syndrome is usually self- limited and treatment should be ... to predict and may predispose patients to the syndrome (see PRECAUTIONS, Laboratory Tests). Visual ...

Olanzapine Long-Acting Injection (LAI) Data Presented at First Annual Schizophrenia International Research Society Conference

... fully from Post-Injection Delirium/Sedation syndrome (PDSS), which describes a range of signs and ... fatal condition known as Neuroleptic Malignant syndrome (NMS) has been reported with olanzapine. If signs ... cumulative dose of antipsychotic increase. The syndrome may remit, partially or completely, if ...

Preliminary Analyses from Phase 2 Genzyme Study Highlight Efficacy and Safety of Clofarabine in Older Adult AML Patients

... disorder such as myelodysplastic syndrome (MDS), poor health performance, or intermediate ... for signs and symptoms of tumor lysis syndrome and cytokine release (e.g., tachypnea, ... develop into systemic inflammatory response syndrome (SIRS)/capillary leak syndrome, and organ ...

Shire Announces Approval of ELAPRASE(R) (idursulfase) in Brazil

... First and Only Treatment for Hunter syndrome Now Approved in 40 Countries ... is a tremendous milestone for the many Hunter syndrome patients in Brazil, who will now have access to ... More information about ELAPRASE and Hunter syndrome is available at http://www.elaprase.com or ...

New AMITIZA 8 mcg Phase III Studies Demonstrated Overall Symptom Improvement in Adult Women with Irritable Bowel Syndrome with Constipation (IBS-C)

... relief of overall symptoms of Irritable Bowel syndrome with Constipation (IBS-C). These results were ... 58 million Americans have Irritable Bowel syndrome (IBS), and IBS-C accounts for approximately ... North America. About Irritable Bowel syndrome with Constipation (IBS-C) IBS is a disorder ...

White Nose Syndrome: Is Pennsylvania Next?

... New York and New England. Although White-Nose syndrome (WNS) has not been found in Pennsylvania - and ... to bats. Just mentioning the words White Nose syndrome (WNS) to Pennsylvania Game Commission biologist ... hoping for the best. "My hope is that white-nose syndrome stops in New York and New England," she said. "If ...

New Data on SEROQUEL XR(TM) in Treatment of Both Major Depressive Disorder and Generalized Anxiety Disorder Presented at APA Annual Meeting

... sometimes referred to as Neuroleptic Malignant syndrome (NMS), has been reported in association ... dyskinesia (TD), a potentially irreversible syndrome of involuntary dyskinetic movements, may develop ... patient and requires clinical experience with the syndrome under assessment. The CGI improvement scale can ...

NAFLD AND NASH Linked to Metabolic Syndrome and Cardiovascular Disease

... (NASH), are associated with the metabolic syndrome and pose an increased risk of cardiovascular ... liver transplantation. In turn, the metabolic syndrome is a combination of risk factors, including high ... between NAFLD, NASH, and the metabolic syndrome is a great cause for concern because people with ...

DSMB Supports Continuation of Anthera Phase II Impacts Trial for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease

... in preventing the development of acute chest syndrome in hospitalized sickle cell disease patients. Enrolled patients are at-risk for acute chest syndrome based on the combination of pain (vaso-occlusive ... drug status for the prevention of acute chest syndrome in patients with sickle cell disease in December ...

NPS Reports Successful GATTEX(TM) Extension Study

... study of GATTEX(TM) (teduglutide) for short bowel syndrome (SBS) patients who are dependent upon parenteral ... and effective potential therapy for short bowel syndrome patients dependent on Parenteral Nutrition. This ... pathway for GATTEX. About Short Bowel syndrome (SBS) SBS is a highly disabling condition that ...

Microbia and Forest Laboratories Announce Preliminary Results of Linaclotide Phase 2b Studies

... its effects in patients with irritable bowel syndrome with constipation (IBS-C). Preliminary analysis ... typical daily activities. About Irritable Bowel syndrome (IBS) One out of six adults in developed ... of chronic constipation, irritable bowel syndrome with constipation, and other functional ...

FDA Grants Priority Review for Daiichi Sankyo, Lilly Drug, prasugrel

... for treatment of patients with acute coronary syndrome being managed with percutaneous coronary ... for prasugrel, for patients with acute coronary syndrome being managed with percutaneous coronary ... initially for patients with acute coronary syndrome who are managed with PCI. Prasugrel works by ...

Update on Progression of Phosphagenics and Nestle Nutrition's Phospha E(R) Trial

... Phospha E(R) in the management of metabolic syndrome is advancing at three sites in ... associated with metabolic syndrome. Metabolic syndrome is characterized by a group of risk factors ... About Metabolic Syndrome Metabolic syndrome is characterised by a group of metabolic ...

Joslin Study Identifies Key Factor That Links Metabolic Syndrome; Finding May Help Millions at High Risk of Cardiovascular Disease

... liver as a key factor in the cause of metabolic syndrome and its associated atherosclerosis, disorders ... not only an understanding of how metabolic syndrome occurs, but also pinpoint a target for treatment ... into the role of the liver in the metabolic syndrome and provides guidance for future therapies," ...

Anthera's A-001 Receives Orphan Drug Status for the Prevention of Acute Chest Syndrome in Patients With Sickle Cell Disease

... drug status for the prevention of acute chest syndrome in patients with sickle cell disease. A-001 is currently being evaluated for acute chest syndrome in a Phase II clinical trial in the United States ... cure." About Acute Chest Syndrome Acute Chest syndrome (ACS) primarily affects children suffering ...

SEROQUEL XR(TM) Receives Approval From FDA for Maintenance Treatment of Schizophrenia

... is measured on 30-item Positive and Negative syndrome Scale (PANSS) scale. Each symptom was rated on a ... sometimes referred to as Neuroleptic Malignant syndrome (NMS), has been reported in association ... dyskinesia (TD), a potentially irreversible syndrome of involuntary dyskinetic movements, may develop ...

Milnacipran Demonstrated Significant Improvement in Pain and the Core Symptoms of Fibromyalgia Syndrome, Data Show

... other core symptoms associated with fibromyalgia syndrome (FMS), according to Phase III data presented this ... pain of fibromyalgia, as well as the broader syndrome of fibromyalgia. Furthermore, data from a ... analyses for the treatment of both fibromyalgia syndrome and the pain of fibromyalgia. Pain ...

Obesity-Related Hormone is Higher in Children with Down Syndrome

... The researchers studied 35 children with Down syndrome and 33 of their siblings. All of the children ... before obesity occurred. The children with Down syndrome had significantly higher body mass index, a ... not respond to the hormone properly. Because Down syndrome is a chromosome disorder, children with ...

Plavix(R) Indications Expanded in Japan to Include Patients with Acute Coronary Syndrome for Whom Percutaneous Coronary Intervention Is Being Planned

... (sNDA) for the indication of "Acute coronary syndrome (unstable angina pectoris, non-ST ... 100,000 patients develop an acute coronary syndrome (ACS) and elect to undergo PCI every year in ... SNY) and BMS (NYSE: BMY ). About Acute Coronary syndrome Acute ...